Gene CDK3 (Human)

CDK3

Species: Human
Alias: CDK3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 17q25.1,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK2

Sequence

Name Sequence Type Origin Length Description Download
CDK3.AA Protein Sugen Kinome 305 None Fasta, JSON
CDK3.kin_dom Protein Kinase Domain Sugen Kinome 283 None Fasta, JSON
CDK3.NA RNA Sugen Kinome 1595 None Fasta, JSON

Protein domain

Protein domains of CDK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK3.AA CDC2 4-286 68 2.5e-238 740.94 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-301/301
Sequence Identity: 68% (207 aa)

FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEG--VPSTAIREISLLKELK-HPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMD-STPG-SE
.||.|||||||||||||.|...|.|.||||||||. |.||  ||||||||||.||||| |||||.| ||.|. .|||.|||.|..||||||| | |  ..
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYT--HEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEM
.|..|.|||..|.||||.|||..|..||||||||.||.. |.||.||||||||||.|.||||  ||||||||||||||||.|.|.|.||.||||||||||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---VTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPN---------LEPEGRDLLMQLLQYDPSQRITAKTALAHP
   ||.|.||.|||||||||.|||.||||.|.|||||||||||| .||.|....|..|.||         |.|||.|||||.|||||..||.||.||.||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHP

YF
||
YF
Kinase CDK3.AA CDK5 4-286 63 6.00000000001e-200 638.08 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 63% (183 aa)

FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHL
..|.|||||||||.||||.|.||. .||||..||| | |||||||||||.|||||||.||||| ||.| |.|| |||||. |||||||||  | |. .|.
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG-EMDMHI

IKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMV-TRKAL
|||...|||.|..|||.|.| ||||||||||||  |  ||||||||||||.| |.|.|||||||||.| .|.||| |.| .|.||.|||||||. . . |
IKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPL

FPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYK---GSFPKWTRKG-LEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF
||| .. |||.|||...|||.||.||..|.|||||     .|..  .  ...|||.|. .|.||| ..||..| |||.|| || ||||
FPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK3.AA CDK 4-286 55 4.1e-198 639.63 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-284/284
Sequence Identity: 55% (178 aa)

FQKVEKIGEGTYGVVYKAKNRETG-----QLVALKKIRLDL-----EMEGVPSTAIREISLLKELKHPNIVRLLDVVHNE-----------RKLYLVFEF
..|.||||||||||||||....||     |.|||||||..      | ||.|.|||||||||||| |||||.|.||.| .           .|||.|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGA-----IKLADFGLARAFGV------PLRTYTHEVVTLWYRAP
. .|||||||           ||.|..|||.|...|||....||||||||.|||. |      .|.||||||||||.      |.|||||||||||||||
MDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

EILLGSKFYT--TAVDIWSIGCIFAEMVT---RKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQL
|.||||| |.  |..|.||.|||||||.|   ||.||||||||||||.|||..|||.||.|||||.||||                        |||...
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKM

LQYDPSQRITAKTALAHPYF
|.|||..||.|. || ||||
LCYDPKKRISAEQALQHPYF
Kinase CDK3.AA CMGC 4-286 30 3.9e-163 540.64 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 30% (155 aa)

FQKVEKIGEGTYGVVYKAKN--------------RETGQLVALKKIRLDLEME----------GVPSTAIREISLLKELK-----------------HPN
.....||||||||||||...              .||...||.|||...  .|          |.|..|.|||..||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRLLDVVHNER-----------------KLYLVFEFLSQDLKKYMDSTPG-----SELPL-------------HLIKSYL------FQLLQGVS--FCH
||.|.|... .                  .||||||.. .||..|......       .||             |.||...      .|.|.|.   .||
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SHR--VIHRDLKPQNLLINEL--------------------GAIKLADFGLARAFGVP---------------------LRTYTHEVVTLWYRAPEILLG
||.  .|||||||.|.|||.                     | .|..||||||.....                     .|.|||.|||.||||||||||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SKFYT---------TAVDIWSIGCIFAEMVTR--------KALFPGDSE-----------IDQLFRIFRMLGTPS---------------EDTWPGVTQL
.| ||         |..|.||.|||||||.|.        | ||||.||           |||||.||..||||.               |..||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PDY----------------KGS----------FPKWTRKGLEEIVPN-----------------------------------LEPEGRDLLMQLLQYDPS
|.|                . .          ||.| .| .....|.                                   . |...|||...|||||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRITAKTALAHPYF
.||||. ||.||||
KRITAEQALQHPYF
Kinase CDK3.AA CDK7 4-286 45 2.3e-151 406.62 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-288/288
Sequence Identity: 45% (132 aa)

FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIR-LDLEME---GVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSEL
..|...||||....||||   .||| || |||. |    |   |.  |||||| .|.|..|.|.. |.|.      ..|||.|.  ||            
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTR
| | ||.|  ..|||. .|| . . |||||| |||.|| | .|.|||||||..| | | ||| ||| |||||| | | . |.|.||.||.||||||   |
PAH-IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLR

KALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG--SFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF
   .||||.|||| |||. ||||.| .||......||    .||  .|  |..|      .  ||.  ..  .|..|.|.  .| .|||
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK3.AA PFTAIRE 4-286 52 2.1e-139 469.39 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 52% (152 aa)

FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHL
..|.|| |||.|  |||.. . ..|.|||| |||. | ||.| ||||| ||||.||| ||| | |..| .. | .|||..  ||..|||. ||  .  . 
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQE-EGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGG-MHPNN

IKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALF
.. .||||| | |.||  || ||||||||||| ..|  ||||||||||  || .|| ||||||||| | .||||  | | .|.| .|||| ||.. ...|
VRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAF

PGD-SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPK---WTRKGLEEIVPNLE--PEGRDLLMQLLQYDPSQRITAKTALAHPYF
||     ||| .||..|||| |||||||..|| ||    .    . | |....| ..  |.. ||.|..||. | .|. |. |. ||||
PGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDK3.AA PCTAIRE 4-286 52 2.1e-137 462.8 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-291/291
Sequence Identity: 52% (154 aa)

FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHL
. |..| |||||  ||| . . |. ||||| |||. | || | |||||.||||.||| ||| | |..| .. | ||||.. .|||.|||   |. .  | 
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDC-GNIMNMHN

IKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALF
.| .||||| |  .||  .. ||||||||||||| |  ||||||||||  || .|| ||||||||| |..|.||  | | .|.| .||||.|| | ..||
VKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLF

PGDS------EIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG-SFPKWTRKGLEEIVPNLE---PEGRDLLMQLLQYDPSQRITAKTALAHPYF
||          |||  |||.||||.| |||||. .....  .||..  . |    | |.    .. ||| .|||| . .|. |  |. ||||
PGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase CDK3.AA PITSLRE 4-286 47 8.8e-134 450.75 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-295/295
Sequence Identity: 47% (141 aa)

FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLD--LEMEGVPSTAIREIS-LLKELKHPNIVRLLDVV--HNERKLYLVFEFLSQDLKKYMDSTP--G
||.. .|.||||||||.||...|.  ||||.. ..   | || | |..|||. .|..|.||||| .. .|   |  | |.|.|..  |||  |.      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

SELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEM
 .  .  ||. . ||| ||.. |.. ..|||||  |||..  |  |..|||||| .| |.. ||  ||||||||||.|||.| |.|.||.||.||||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

VTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG--SFPKWTRKGLEEIVP---NLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF
.| | ||.|.|||||. .|| ..|||.|  |||.| ||  |   .||.     | ...|    .   | ||| |.| |.| .||||  || ||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK3.AA CDK4 4-286 47 1.2e-121 410.38 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-290/290
Sequence Identity: 47% (141 aa)

FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEME--GVPSTAIREISLLKELK---HPNIVRLLDVVH---NER---KLYLVFEFLSQDLKKYMD
.|.|  |||| || ||.|   .||. ||||..|  .. |  |.|   |||||... |.   |||||.|.|| |     |   |. .|||   .||. |.|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

STPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCI
  | . .|   ||   .||| || | ||||.|||||||||.|..  | .||||||||| ..      |  ||||||||||.|| |  | | ||.||.|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLLQSY-YNTPVDMWSVGCI

FAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF
||||  |..||.| || ||| .|| . |.| || ||    ||   ..||    . .....| ..  | ||| . | |... |..|  .| ||||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP--WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK3.AA Pkinase 4-286 34 2e-114 391.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 34% (105 aa)

FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIR--EISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQ-----DLKKYMD---S
.....|||.|..|.|||.... ||..||.|.|... | .... |..|  ||...|.|.|||||||.|........|.|.|..       ||. |.    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAI----KLADFGLARAF-GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWS
.. . .. . .|.|. |.|.|. .|||...|||||||.|.||.. | |    |..|||||. |   . . .|. ..|.||.|||...|.. |...||.||
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGCIFAEMVTRKALFPGD----SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHP
.|||..||.... .|||.    . .||...|.| .|.| .  ||     ....  .. | .. ...  .|...|..|..  .|..||..|.||. .| ||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase CDK3.AA S_TKc 4-286 32 9.40000000001e-114 385.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 32% (96 aa)

FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQ---DLKKYMDSTPG----
.....|||.|..|.|||.....||..||.|.|.          ...|||..||. .|||||.|.|| ..  .||.|.|....   ||..|... ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

SELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTT-AVDIWSIGCIFAE
. .|   ...|. |..... .||||..|||||||.|.|..|   ||..|||||| .       |. ..|.||.|||.|     |.. ..|.||.|||..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALA-------HPYF
|.... .||      |....|...|                                    ||..|.....||.||..|.||  ||.       ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDK3.AA CRK7 4-286 36 8.60000000001e-112 377.69 In-house 1-343 (343) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-343/343
Sequence Identity: 36% (126 aa)

FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLE---MEGVPSTAIREISLLKELKHPNIVRLLDVVHN--------ERK--LYLVFEFLSQDLKKY
..... ||||||| |||||| .||..|||||.|.| |    || | |||||| .|..|.|.|||.| ..|          . |   |.|||    ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPL--RTYTHEVVTLWYRAPEILLGSKFY--------
..|    .  .  .|... ||| |.  ||   ..|||.|  |.|.|  | .|.||||||| .      | ||  |.|||||.|| ||| . |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKW--TRKGL
                              ....|.|| |||..|  |.|..|.|  |..||  |..  |.|  . || |..|| ..   ||   .|. .
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

EEIVP-----NLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF
|| .      .. .|  ||| ..| .||. |.||. .| |..|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK3.AA Pkinase_Tyr 4-151 30 3e-26 89.53 Pfam 1-160 (270) Show / Hide 
Range on Protein: 4-151
Range on HMM: 1-160/270
Sequence Identity: 30% (51 aa)

FQKVEKIGEGTYGVVYKAKNR----ETGQLVALKKIRLDLEMEGVPSTA------IREISLLKEL-KHPNIVRLLDVVH-NERK--LYLVFEFLSQ-DLK
 .. .|.||| .|.|||.. .    .|.. || |...     ||  . .      .||....|.| .|||||||. |.   ..   .|.|.|.    ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KYMDST--PGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARA
.|  .   ..  |... . .. .|  .| .. .|.. |||||   | |..| . .| .||||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CDK3.AA TyrKc 4-286 23 1.5e-16 44.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKEL--KHPNIVRLLDVVHNE-------RKLYLVFEFLSQ-DLKKYMDS
 .. .|.||| .|.|||.. .   . || |... |          .||......|  .|||||||. |.  .         |..|.|. .  |||.|  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

TPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVP------LRTYT-----HEV--VTLWYRAPEILLGSKFY
. .  |..    |. .|  .| .. ||...|||||   | |..| . .| .||||.|. .          .|.     ..   . .   ||| .   . .
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF

TTAVDIWSIGCIFAEMVTRKALFPGD--------SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPS
||. |.|| |    |. |. .  . .        .|. .. .  ...  | .|  | .                      .   .|  ..  |  ..||.
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------------F-VCCPDEMYQIMKQCWHEDPE

QRITAKTALAHPYF
.| | ..   | .|
DRPTFSEI--HECF
Kinase CDK3.AA Pkinase_Tyr 167-188 45 3.958212 1.06 Pfam 180-199 (270) Show / Hide 
Range on Protein: 167-188
Range on HMM: 180-199/270
Sequence Identity: 45% (10 aa)

WYRAPEILLGSKFYTTAVDIWS
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WM-APECINYGK-FTTKSDVWS