Gene CDK2 (Human)

CDK2

Species: Human
Alias: p33(CDK2, p33(CDK2), CDK2, p33CDK2, p34CDK2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 12q13.2,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK2

Sequence

Name Sequence Type Origin Length Description Download
CDK2.AA Protein Sugen Kinome 346 None Fasta, JSON
CDK2.kin_dom Protein Kinase Domain Sugen Kinome 331 None Fasta, JSON
CDK2.NA RNA Sugen Kinome 2469 None Fasta, JSON

Protein domain

Protein domains of CDK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK2.AA CDC2 4-334 57 1.5e-232 722.84 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-334
Range on HMM: 1-301/301
Sequence Identity: 57% (199 aa)

FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG--VPSTAIREISLLKELN-HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMD-ASAL-TG
.||.|||||||||||||.... |...||||||||..|.||  ||||||||||.||||. ||||||| ||||  ||||.|||.|..||||.||      . 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT--HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM
.|. |.|||..|.|||..|||..|..||||||||.||...|.||.||||||||||.|.||||  ||||||||||||||||||.|||.||.||.|||||||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

HLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDF
...                                             ||...||.|||||||||.|||.||||.|  |||||..||||..||.| .||.
FMD---------------------------------------------VTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDL

SKVVPP---------LDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
||..|          ||..|..||.|||.|||.||||||.||.||.|
SKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDK2.AA CDK 4-334 49 2.3e-194 627.46 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-334
Range on HMM: 1-284/284
Sequence Identity: 49% (181 aa)

FQKVEKIGEGTYGVVYKARNKLTG-----EVVALKKIRLDT-----ETEGVPSTAIREISLLKELNHPNIVKLLDVIHTE-----------NKLYLVFEF
..|.|||||||||||||||.|.||     ..|||||||...     | ||.|.|||||||||||| |||||||.||.||.           ||||.|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA-----IKLADFGLARAFGV------PVRTYTHEVVTLWYRAP
...||||.||           ||.|..|||.||..|||....||||||||.|||  |      .|.||||||||||.      |.|||||||||||||||
MDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

EILLGCKYYS--TAVDIWSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDSEIDQLFRIFRTLGT
|.|||.| ||  |..|.||.||||||| ..                                             |||..||||||||||||.|||..||
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTD---------------------------------------------VTRKPLFPGDSEIDQLFKIFRICGT

PDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
|.| .|||||..|||                         ||..|| |||.|||||..|| ||.|
PTEDNWPGVTKLPDY------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDK2.AA CMGC 4-334 26 1.1e-158 525.76 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-334
Range on HMM: 1-513/513
Sequence Identity: 26% (150 aa)

FQKVEKIGEGTYGVVYKARNKLTG--------------EVVALKKIRLDT---------ETEGVPSTAIREISLLKELN-----------------HPNI
.....||||||||||||.|.|.|.              |.||.|||...          | .|.|..|.|||..||.||                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLLDVIHTEN-----------------KLYLVFEFLHQDLKKFMDASA--------------------------LTGIPLPLIKSYLFQLLQGLA--FC
|||.|.....|                 .||||||.. .||.....                                ... .|. | .|.|.||.  .|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

HSHR--VLHRDLKPQNLLINTE--------------------GAIKLADFGLARAFGVP---------------------VRTYTHEVVTLWYRAPEILL
|||.  ..||||||.|.||| .                    | .|..||||||.....                     .|.|||.|||.|||||||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GCKYYS---------TAVDIWSLGCIFAEMHL----VGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDSE------
|.|.|.         |..|.||.||||||| .    .                                             .... ||||.||      
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSL--------------------------------------------IFRGKPLFPGHSEYPNDDK

-----IDQLFRIFRTLGTPD---------------EVVWPGVTSMPDYKP--------------S------------FPKWARQDFSKVVPP--------
     |||||.||..||||.               |  ||.....|.|..              |            ||.| ........|.        
NGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNN

---------------------------LDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
                           .|.... ||..||.|||.|||.|. ||.||.|
KKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CDK2.AA CDK5 4-196 70 2.2e-147 469.03 In-house 1-192 (287) Show / Hide 
Range on Protein: 4-196
Range on HMM: 1-192/287
Sequence Identity: 70% (137 aa)

FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPL
..|.|||||||||.||||||| |.|.||||..||| | |||||||||||.||||| |.||| | ||||.|.|| |||||. |||||.||     .. ...
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG-EMDMHI

IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM
|||...|||.||||||.|.||||||||||||||..|  ||||||||||||.|||.|.|||||||||.| .|.| | ||| .|.|| |||||||
IKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEM
Kinase CDK2.AA CDK7 4-195 47 1e-113 304.31 In-house 1-195 (288) Show / Hide 
Range on Protein: 4-195
Range on HMM: 1-195/288
Sequence Identity: 47% (94 aa)

FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR----LDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGI
..|...||||....||||. . ||..|| |||.     .    |.  |||||| .|.|. |.|.. |.|..     ..|||.|.  ||      . .   
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAE
|   ||.|  ..|||| .|| . .||||||| |||.| .| .|.|||||||..| | | ||| ||| |||||| | | . | |.||.|| ||||||
P-AHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAE
Kinase CDK2.AA PCTAIRE 4-196 60 3.9e-101 342.29 In-house 1-191 (291) Show / Hide 
Range on Protein: 4-196
Range on HMM: 1-191/291
Sequence Identity: 60% (116 aa)

FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPL
. |..| |||||  ||| | |||. .|||| |||. | || | |||||.||||.| | ||| | |.|||.  | ||||.. .|||..||     ..    
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCG-NIMNMHN

IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM
.| .||||| |||.||  ..||||||||||||| .|  ||||||||||  || .|| ||||||||| |..|.|   ||| .|.|  ||||.||
VKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEM
Kinase CDK2.AA PFTAIRE 4-196 58 2.8e-100 339.47 In-house 1-191 (287) Show / Hide 
Range on Protein: 4-196
Range on HMM: 1-191/287
Sequence Identity: 58% (112 aa)

FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPL
..|.|| |||.|  |||.. .... .|||| |||. | ||.| ||||| ||||.| | ||| | |.|||.  | .|||..| ||...|| .   |.    
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQE-EGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMD-KHPGGMHPNN

IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM
.. .||||| ||..||  ||||||||||||||   |  ||||||||||  || .|| ||||||||| | .|||   ||| .|.|  |||| ||
VRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEM
Kinase CDK2.AA S_TKc 4-334 25 1.2e-99 338.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-334
Range on HMM: 1-231/231
Sequence Identity: 25% (89 aa)

FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ---DLKKFMDASAL----
.....|||.|..|.|||.|.| ||..||.|.|.          ...|||..||. .|||||||.||... ..||.|.|.. .   ||.....        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST-AVDIWSLGCIFAE
 ..|   ...|. |....|..||||...||||||.|.|...   ||..|||||| .       |. ..|.||.|||.|     |.. ..|.||.|||..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD
|   |             .  . .  ..                                                                        
MLC-GYPPFP--------QMQMMFKKIG------------------------------------------------------------------------

FSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA-------HPFF
        ...........|..||.||..|  ||.       ||.|
--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDK2.AA PITSLRE 4-196 48 2.4e-95 323.06 In-house 1-200 (295) Show / Hide 
Range on Protein: 4-196
Range on HMM: 1-200/295
Sequence Identity: 48% (97 aa)

FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAIREIS-LLKELNHPNIVKLLDVI--HTENKLYLVFEFLHQDLKKFMDASA--L
||.. .|.||||||||.|..|.|.|.||||.. ..   | || | |..|||. .|..|.|||||... ..   . .| |.|.|..  |||  |.      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM
    .. ||. . ||| | .. |.. ..|||||  |||.. .|  |..|||||| .| |.. ||  ||||||||||.||||| |||.||.|| ||||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF
Kinase CDK2.AA Pkinase 4-196 39 2.6e-86 297.85 Pfam 1-205 (293) Show / Hide 
Range on Protein: 4-196
Range on HMM: 1-205/293
Sequence Identity: 39% (81 aa)

FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR--EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-----DLKKFMDASAL
.....|||.|..|.|||...| ||..||.|.|....| .... |..|  ||...|.|||||||.|.|. ......|.|.|..       ||. .. ... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI----KLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL
...  .   .|.|. |.|.||..|||....||||||.|.||. .| |    |..|||||. |   . . .|. ..|.||.|||...|..||...||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIFAEM
|||..||
GCILYEM
Kinase CDK2.AA CDK4 4-196 51 2e-84 286.81 In-house 1-202 (290) Show / Hide 
Range on Protein: 4-196
Range on HMM: 1-202/290
Sequence Identity: 51% (105 aa)

FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE--GVPSTAIREISLLKEL---NHPNIVKLLDVIHT------ENKLYLVFEFLHQDLKKFMD
.|.|  |||| || ||.||   ||  ||||..|  .. |  |.|   |||||... |   .|||||||.|| |.      | |. .|||   .||. ..|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

ASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCI
     |.| . ||   .||| |. | ||||. ||||||||.|.. .| .||||||||| ..      |  ||||||||||.||   || | ||.||.|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCI

FAEM
||||
FAEM
Kinase CDK2.AA CRK7 4-195 38 9.7e-83 281.19 In-house 1-245 (343) Show / Hide 
Range on Protein: 4-195
Range on HMM: 1-245/343
Sequence Identity: 38% (94 aa)

FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE---TEGVPSTAIREISLLKELNHPNIVKLLDVIHT--------ENK--LYLVFEFLHQDLKKF
..... ||||||| ||||.|| ||| |||||.|.| |    || | |||||| .|..|||.|||.| ...          . |   |.|||    ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV--RTYTHEVVTLWYRAPEILLGCKYY--------
..  ..  . .  .|... ||| |.. ||   .||||.|  |.|.|  | .|.||||||| .      | ||  |.|||||.|| ||| . |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STAVDIWSLGCIFAE
                               ...|.|| |||..|
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGE
Kinase CDK2.AA CDK5 248-334 50 6.7e-41 126.65 In-house 197-287 (287) Show / Hide 
Range on Protein: 248-334
Range on HMM: 197-287/287
Sequence Identity: 50% (46 aa)

RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK---PSFPKWARQD-FSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
| |||| .. |||.|||. .||| |  ||..| .||||     .|..  .  ....|| ||| |. ||..|| ..||.|||||||| ||.|
RPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK2.AA CDK7 251-334 39 4.6e-32 82.34 In-house 203-288 (288) Show / Hide 
Range on Protein: 251-334
Range on HMM: 203-288/288
Sequence Identity: 39% (34 aa)

FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP--SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
.||||.|||| |||.||||| |  ||....|.||    .||  .|  . ..     .|   |.. |.  .| ||...  .| .|.|
LPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK2.AA CDK4 247-334 42 1.3e-29 98.56 In-house 205-290 (290) Show / Hide 
Range on Protein: 247-334
Range on HMM: 205-290/290
Sequence Identity: 42% (37 aa)

RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
||.||.| || ||| .||   |.| |  ||   |.|    .||    . | ...| ... |  || .|| |.. ||.|| ..| ||.|
RRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP--WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK2.AA PCTAIRE 248-334 40 1.8e-28 97.66 In-house 195-291 (291) Show / Hide 
Range on Protein: 248-334
Range on HMM: 195-291/291
Sequence Identity: 40% (39 aa)

RALFPGDS------EIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPLD---EDGRSLLSQMLHYDPNKRISAKAALAHPFF
|.||||          |||  ||| ||||||  ||||.|...... .||..  | .  . | ||   ...  ||...| | . .|.|| .|. ||.|
RPLFPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase CDK2.AA PITSLRE 246-334 43 1.9e-26 93.36 In-house 202-295 (295) Show / Hide 
Range on Protein: 246-334
Range on HMM: 202-295/295
Sequence Identity: 43% (41 aa)

TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP--SFPKWARQDFSKVVP---PLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
| . ||.|.|||||. .||  .||| |  |||.|..|  |   .||.       | .|    . . | .|| ||| |.| .||.| .|| ||.|
TMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK2.AA PFTAIRE 248-334 35 5.4e-26 88.5 In-house 195-287 (287) Show / Hide 
Range on Protein: 248-334
Range on HMM: 195-287/287
Sequence Identity: 35% (33 aa)

RALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK---WARQDFSKVVPPLD--EDGRSLLSQMLHYDPNKRISAKAALAHPFF
...|||     ||| .||..|||| |  ||||...| |||   .      .   ...| ..   .. .|...|| . | .|.||..|. ||.|
QPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDK2.AA Pkinase_Tyr 4-151 28 2.2e-23 79.83 Pfam 1-160 (270) Show / Hide 
Range on Protein: 4-151
Range on HMM: 1-160/270
Sequence Identity: 28% (47 aa)

FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDTETEGVPSTA------IREISLLKEL-NHPNIVKLLDVIH-TENK--LYLVFEFLHQ-DLK
 .. .|.||| .|.|||.. |     |.  || |...     ||  . .      .||....|.| .|||||.|. |.   .    .|.|.|.    ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KFMDAS--ALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARA
..  .       .... . .. .|  .|... .|..  ||||   | |.. .. .| .||||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CDK2.AA Pkinase 245-334 26 1.7e-22 80.65 Pfam 206-293 (293) Show / Hide 
Range on Protein: 245-334
Range on HMM: 206-293/293
Sequence Identity: 26% (25 aa)

VTRRALFPGD----SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
...| .|||.    . .||...|.|..|.| .  ||   |.....  .. | .. .... . ..|....... .|..||.||..|. .| ||.|
LCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CDK2.AA CRK7 246-334 31 9.4e-19 61.12 In-house 248-343 (343) Show / Hide 
Range on Protein: 246-334
Range on HMM: 248-343/343
Sequence Identity: 31% (30 aa)

TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW-----ARQDFS--KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
|....|.|  |..||  |..  |.|   .|| |. .| ..   ||       | .|.  |    ....   || .|| .|| ||..|. .| |..|
TKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK2.AA TyrKc 4-334 17 3.1e-15 23.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-334
Range on HMM: 1-280/280
Sequence Identity: 17% (66 aa)

FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL--NHPNIVKLLDVIHTE-------NKLYLVFEFLHQ-DLKKFMDA
 .. .|.||| .|.|||.. |   . || |... |.         .||......|  .|||||.|. |. ..         |..|.|.    |||..  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP------VRTYT-----HEV--VTLWYRAPEILLGCKYY
.  . ....   |. .|  .| .. ||... ||||   | |.. .. .| .||||.|. .          .|.     ..   . .   ||| .  .| .
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-F

STAVDIWS----------------LG-----CIFAEMHLVGTQHHARCCGEH----RRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDS
.|. |.||                 |     .  .|..    | . . . ..                                                
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------------------

EIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
                                        |    .   ..  .. .|  |.||..| . ..   | .|
----------------------------------------F----VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CDK2.AA Pkinase_Tyr 167-190 41 0.748433 3.51 Pfam 180-201 (270) Show / Hide 
Range on Protein: 167-190
Range on HMM: 180-201/270
Sequence Identity: 41% (10 aa)

WYRAPEILLGCKYYSTAVDIWSLG
|. ||| .  .| ..|. |.|| |
WM-APECINYGK-FTTKSDVWSFG