Gene BRD4 (Human)

BRD4

Species: Human
Alias: BRD4, MCAP, CAP, HUNKI
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 19p13.2,

Classification

Group: Atypical
Family: BRD

Sequence

Name Sequence Type Origin Length Description Download
BRD4.AA Protein Sugen Kinome 1362 None Fasta, JSON
BRD4.NA RNA Sugen Kinome 5198 None Fasta, JSON

Protein domain

Protein domains of BRD4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
BROMO BRD4.AA BROMO 56-166 42 6.4e-53 183.04 SMART 1-118 (118) Show / Hide 
Range on Protein: 56-166
Range on HMM: 1-118/118
Sequence Identity: 42% (51 aa)

PKRQTNQLQYLLRVVLKTLWKH--------QFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV
...  ...| ||..|.. . .|        ..||||.||||...||.||||.|||.|||..||||.|||..|....| ..||. ||.||..||.|. .. 
DPK-QKKCQELLKEVMCHKHDHGDPMNRGRPYAWPFMQPVDRKELNYPDYYDIIKNPMDLKTIKKKLENHQYQSMEEFVDDFMLMFNNCMTYNEPDSEVY

LMAEALEKLFLQKINELPT
 ||. |.|.|..|..|.| 
KMAKKLQKFFEEKWREFPP
Bromodomain BRD4.AA Bromodomain 67-152 37 7.9e-31 102.96 Pfam 1-89 (89) Show / Hide 
Range on Protein: 67-152
Range on HMM: 1-89/89
Sequence Identity: 37% (33 aa)

LRVVLK--TLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW-NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEA
.. ...  ....| ...||..||| .. ..||||.|||.|||. ||...|.||.|  | .| . |.. |..||..||.|...|  .|. 
CDQIMDMKYIMEHPICEPFWHPVDPDRDEYPDYYDIIKHPMDLSTIQQKLKNNKYRNNIAEFWHDMELMWHNCMTYNGPDSPIYKDARK
BROMO BRD4.AA BROMO 350-459 45 7.8e-48 166.14 SMART 1-118 (118) Show / Hide 
Range on Protein: 350-459
Range on HMM: 1-118/118
Sequence Identity: 45% (54 aa)

VSEQLKCCSGILKEMFAKKHAA---------YAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVV
 .. .| |. .|||....||           |||||..|||.  |...||.||||.|||..||| ||| ..|....|| .|..|||.||..||.||.|| 
DPK-QKKCQELLKEVMCHKHDHGDPMNRGRPYAWPFMQPVDRKELNYPDYYDIIKNPMDLKTIKKKLENHQYQSMEEFVDDFMLMFNNCMTYNEPDSEVY

AMARKLQDVFEMRFAKMPD
 ||.|||..|| .....|.
KMAKKLQKFFEEKWREFPP
Bromodomain BRD4.AA Bromodomain 357-445 41 2.4e-30 101.35 Pfam 1-89 (89) Show / Hide 
Range on Protein: 357-445
Range on HMM: 1-89/89
Sequence Identity: 41% (38 aa)

CSGILK--EMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYR-DAQEFGADVRLMFSNCYKYNPPDHEVVAMARK
|. |..  ... ..    ..|| .|||..  .. ||.||||||||.|||. ||. ..||   .|| .|..||..||..||.||... ..|||
CDQIMDMKYIMEHP---ICEPFWHPVDPDRDEYPDYYDIIKHPMDLSTIQQKLKNNKYRNNIAEFWHDMELMWHNCMTYNGPDSPIYKDARK