Gene BRD3 (Human)

BRD3

Species: Human
Alias: RING3L, ORFX, KIAA0043, BRD3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 9q34,

Classification

Group: Atypical
Family: BRD

Sequence

Name Sequence Type Origin Length Description Download
BRD3.AA Protein Sugen Kinome 726 None Fasta, JSON
BRD3.NA RNA Sugen Kinome 5601 None Fasta, JSON

Protein domain

Protein domains of BRD3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
BROMO BRD3.AA BROMO 32-142 41 1.7e-48 168.38 SMART 1-118 (118) Show / Hide 
Range on Protein: 32-142
Range on HMM: 1-118/118
Sequence Identity: 41% (49 aa)

PGRKTNQLQYMQNVVVKTLWKH--------QFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIV
. .  ...| . ..|.. . .|        ..||||.||||...||.|||..|||||||..||||.|||..|.|. | ..||. ||.||..||.|  .. 
DPK-QKKCQELLKEVMCHKHDHGDPMNRGRPYAWPFMQPVDRKELNYPDYYDIIKNPMDLKTIKKKLENHQYQSMEEFVDDFMLMFNNCMTYNEPDSEVY

LMAQALEKIFLQKVAQMPQ
 ||. |.| |..| ...|.
KMAKKLQKFFEEKWREFPP
Bromodomain BRD3.AA Bromodomain 42-128 35 3.5e-27 91.03 Pfam 1-89 (89) Show / Hide 
Range on Protein: 42-128
Range on HMM: 1-89/89
Sequence Identity: 35% (32 aa)

MQNVV-VKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYW-SASECMQDFNTMFTNCYIYNKPTDDIVLMAQA
..... .|....| ...|| .||| .. ..|||..|||.|||. ||...|.||.|  .  | . |.. |..||..||.| ..|  .|. 
CDQIMDMKYIMEHPICEPFWHPVDPDRDEYPDYYDIIKHPMDLSTIQQKLKNNKYRNNIAEFWHDMELMWHNCMTYNGPDSPIYKDARK
BROMO BRD3.AA BROMO 308-417 41 7e-48 166.31 SMART 1-118 (118) Show / Hide 
Range on Protein: 308-417
Range on HMM: 1-118/118
Sequence Identity: 41% (49 aa)

LSEHLRYCDSILREMLSKKHAA---------YAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVV
 .. ...| ..|.|....||           |||||..|||.  |...||.||||.||||.|.|.|.....| ... |..|..|||.||..||.||.|| 
DPK-QKKCQELLKEVMCHKHDHGDPMNRGRPYAWPFMQPVDRKELNYPDYYDIIKNPMDLKTIKKKLENHQYQSMEEFVDDFMLMFNNCMTYNEPDSEVY

AMARKLQDVFEMRFAKMPD
 ||.|||..|| .....|.
KMAKKLQKFFEEKWREFPP
Bromodomain BRD3.AA Bromodomain 315-403 40 9.1e-30 99.47 Pfam 1-89 (89) Show / Hide 
Range on Protein: 315-403
Range on HMM: 1-89/89
Sequence Identity: 40% (37 aa)

CDSILR--EMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYP-DAQGFAADVRLMFSNCYKYNPPDHEVVAMARK
|| |..  ......    ..|| .||| .  |. ||.|||||||||||...|.. ..|    ..| .|..||..||..||.||... ..|||
CDQIMDMKYIMEHP---ICEPFWHPVDPDRDEYPDYYDIIKHPMDLSTIQQKLKNNKYRNNIAEFWHDMELMWHNCMTYNGPDSPIYKDARK