Gene BRAF (Human)

BRAF

Species: Human
Alias: RAFB1, BRAF1, B-raf 1, MGC138284, BRAF, MGC126806
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 7q34 -q36,

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
BRAF.NA RNA Sugen Kinome 3069 None Fasta, JSON
BRAF.AA Protein Sugen Kinome 806 None Fasta, JSON
BRAF.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of BRAF.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD BRAF.AA RBD 155-227 55 1.6e-39 139.72 Pfam 1-77 (77) Show / Hide 
Range on Protein: 155-227
Range on HMM: 1-77/77
Sequence Identity: 55% (43 aa)

PIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQD---GEKKPIGWDTDISWLTG-EELHVEVL
....|.|||.||.||..|.|.||||.|.|.....|| |.||.|||..|   |||||. |.||||||.| .||.||.|
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL
RBD BRAF.AA RBD 155-227 50 3.7e-36 127.35 SMART 1-76 (76) Show / Hide 
Range on Protein: 155-227
Range on HMM: 1-76/76
Sequence Identity: 50% (38 aa)

PIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQD---GEKKPIGWDTDISWLTGEELHVEVL
 ...|.||..||||| .|.|.||.|.|.|....||| ||||.|.|...   |||||. |...||.|.|.||.||..
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR
C1_1 BRAF.AA C1_1 235-283 32 6.5e-17 65.75 Pfam 1-55 (55) Show / Hide 
Range on Protein: 235-283
Range on HMM: 1-55/55
Sequence Identity: 32% (18 aa)

HNFVRK-TFFTLAFCDFCRKLL-----FQGFRCQTCGYKFHQRCSTEVPLMCVNY
|..|.. .|   .||. |....     .||..||.|.|..|.||.. || .|   
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 BRAF.AA C1 235-280 29 5.4e-16 60.39 SMART 1-61 (61) Show / Hide 
Range on Protein: 235-280
Range on HMM: 1-61/61
Sequence Identity: 29% (18 aa)

HNFVRKTFFTLAFCDFCRKLLFQ---------GFRCQTCGYKFHQRCSTEVPL-------MC
|......| . ..|. |||....         |.||. |.||.|..|.. ||.       ||
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 BRAF.AA C1_3 246-273 20 9e-06 16.12 Pfam 1-30 (30) Show / Hide 
Range on Protein: 246-273
Range on HMM: 1-30/30
Sequence Identity: 20% (6 aa)

AFCDFCRKLLF--QGFRCQTCGYKFHQRCS
 .|. | . .    ...| .| . .|..| 
FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA
Kinase BRAF.AA RAF 497-756 70 1.5e-203 666.28 In-house 1-282 (282) Show / Hide 
Range on Protein: 497-756
Range on HMM: 1-282/282
Sequence Identity: 70% (198 aa)

ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA---FKNEVGVLRKTRHVNILLFMGYSTKPQ---LAIVTQWCEGSSLYHHLHIIET--KF
..|..|||||||||||.|.||||||||||||..|||.|.||   |||||.|..||||.||||||||..|||   .||||||||.||||||.|..||  ||
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

EMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS--GSHQFEQLSGSILWMAPEVIR-----------MQDKNPYSF
.|..||||.||..|||||||||.||||||||||||||||.|||||||||.|||.|||  |..||||....||||||||||           |||.|||||
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

QSDVYAFGIVLYELMTGQLPY-SNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIEL
|||||.||||.|||||...|| ..|.||||||||.|||||.|||||||..|||||.|||..|.|..|.|||||.|||..|..
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase BRAF.AA RAF 497-754 59 3.6e-186 624.79 In-house 1-275 (275) Show / Hide 
Range on Protein: 497-754
Range on HMM: 1-275/275
Sequence Identity: 59% (164 aa)

ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP-QQLQAFKNEVGVLRKTRHVNILLFMGYSTKP---QLAIVTQWCEGSSLYHHLHIIET-KFEMI
...|.|||.|.|||||.|.||||||||.||.. ||| .||||||||| ...||||.||.||||| .||   ..|||||||.||.||||.|  .| ||.| 
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

KLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-SRWS--GSHQFEQLSGSILWMAPEVIRMQ---------DKNPYSFQSDV
..|.||.|..||||||||| ||||||||.|||||....|.|.||||.||| .||.  ...|..| .|.|.|||||||||.         |.||.||||||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
||||.|.||||.|..||..|....|||.||.||||..|.||.|..|||.||.|..||......|||.|.||...|
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase BRAF.AA TKL 503-754 27 1.6e-101 343.55 In-house 1-364 (364) Show / Hide 
Range on Protein: 503-754
Range on HMM: 1-364/364
Sequence Identity: 27% (104 aa)

IGSGSFGTVYKGKWHG-----------DVAVKMLNVT------------------------APTPQQLQAFKNEVG-VLRKTRHVNILLFMG--------
||||.||.||||||.|           |||||.....                        .|...... |..|.  .....|| ||..|||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-YSTKP-----QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA--------KSIIHRDLKSNNIFLHEDLT--------------V
 .. .|     ||.||...|.| ||.|.||       . .....|...|.||.|||.        . ||||||||.||...|..|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFGLATVKS------------------RWSGSHQFEQLSGSILWMAPEVIRMQDK-------------NPYSFQSDVYAFGIVLYELMTGQLPYSNI
||.||||....|                  . ... .     |.. ||||||.|.|..              .|| ..|||.|||||.|..|...||...
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

NNRDQI------IFMVGRG--YLSPDLS---------KVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
.....|      .......   | | .             ..||. ||.|| .| . . ..|| | .||  .
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase BRAF.AA Pkinase 497-754 26 5.5e-83 286.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 497-754
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

ITVGQRIGSGSFGTVYKGKWHGD---VAVKMLNVTAPTPQQLQAFKN--EVGVLRKTRHVNILLFMGYS-TKPQLAIVTQWCEGS----SLYHHLH-IIE
...|..|||||||.|||....|.   |||| ...    ....|.  .  |. .... .| ||. . ..  .|. . .|. .|||     .|.....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKF--EMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTV----KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDV
..|  ..  ......|...|..|.|...|||||||. ||..... ..    ||.||||| ... .  .. .  . |.. .|||||||  . ..|.  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YAFGIVLYELMTGQLPYSNI-----NNRDQIIFMVGRGYLSPDLSKVRS----------------NCPKAMKRLMAECLKKKRDERPLFPQILAS--I
...|..|||...|..|...      .. .|.|...... |. | .. .|                | ....| ..  ||.|.  .|| ..||| .  .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase BRAF.AA TKL-Unique 499-754 33 8.1e-75 254.87 In-house 1-290 (290) Show / Hide 
Range on Protein: 499-754
Range on HMM: 1-290/290
Sequence Identity: 33% (100 aa)

VGQRIGSGSFGTVYKGKWHGD-VAVKMLNV-TAPTPQQLQAFKNEVGVLRKTR-HVNILLFMGYSTK-----PQLAIVTQWCEGSSLYHHLH--------
..  ||.|..|.||||||.|. ||.| ...   . .. .| |.||| .. | . | ||...|||...     |.. ||.  |.|.||| .||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-IIETKFEMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHED-----LTVKIGDFGLATVKSRWSGSHQF-------EQLSGSILWMAPEVIRM
 . ..|. | . ...|.. ||||.||| ..  |||||||| |. . ..     . .|| ||||....|. . .          .   ||..||||||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

QDKNPYSFQSDVYAFGIVLYELMTGQL------PYSNINNRDQIIFMVGR--GYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
   . || .||||.|||||.|. |...      ||... ...|.. ||      . | ..   ..|||  . |. .| .   ..|| | .|. ..
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIP---NHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase BRAF.AA KSR 497-754 37 2.1e-69 235.75 In-house 1-272 (272) Show / Hide 
Range on Protein: 497-754
Range on HMM: 1-272/272
Sequence Identity: 37% (102 aa)

ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVT-APTPQQ-LQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWCEG-SSLYHHLHIIETKFEMIK
.  | .|| | ||.|..| |||.||.| ..        . | .|| ||  ...||| || ||||.   | .||||.  | |  .||||.|   .|. | .
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

LIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK---SRWSGSHQFEQLSGSILWMAPEVIRM------QDK---NPYSFQSDVY
 ..||.| .||| ||||| ||| |||| |||.     | | ||||  ..       .. .     |    .||| ||        ..   .|.| .||||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

AFGIVLYELMTGQLPYSNINNRDQIIFMVGRG-YLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
||| ..||...| .|. .     .||. ...|  . ..|. |   | . || .. .|     .||| | .|.  .
AFGTIWYEMICGEWPFKY-QCAESIIWQMCQGEGMRQVLRNVQ--CGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase BRAF.AA Dicty4 497-756 36 4.3e-68 226.24 In-house 1-277 (277) Show / Hide 
Range on Protein: 497-756
Range on HMM: 1-277/277
Sequence Identity: 36% (105 aa)

ITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPT--PQQLQAFKNEVGVLRKTRHVNILLFMGYST----KP-QLAIVTQWCEGSSLYHHLHI-----
|...||||.||||.||||.| | .||||.|| .  .     |..|..||  . | || ||.||||..|    .|  . |||  .   .||  ||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

---IETKFEMIKL-IDIARQTAQGMDYLHA--KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLS--GSILWMAPEVIRMQDKNPYSF
   |.  .. ||  . .|. .|.|| .||.    |||||||| |.   ....||..||||.... . . .|.. | .  |. .|||||| .   ..||  
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHE-DHKDNQMTACGTPCWMAPEVMM---HQPYNE

QSDVYAFGIVLYELMTGQLPYS-NINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS--IEL
 .||| |||||.|. |.| ||.  . . .|... |..  | | ..   ..||.  |.|...|. .    || |..|.     | 
KADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIP---DWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase BRAF.AA MLK 497-754 33 4e-67 229.3 In-house 1-291 (291) Show / Hide 
Range on Protein: 497-754
Range on HMM: 1-291/291
Sequence Identity: 33% (99 aa)

ITVGQRIGSGSFGTVYKGKWHG-D-----VAVKMLNVTA----PTPQQLQAFKNEVGVLRKTRHVN----ILLFMGYSTKP-Q-LAIVTQWCEGSSLYHH
|.. . ||||||| |.||.|.. |     ||||. . ..     |  . ..|. |.  ||. .| |    |  |.| ...| . ..||...|||.|||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHIIETKFE-------------MIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHE------DLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL
|| ...| .             .  ....| | |.||.|||..    |||||||| || ..|      ..|.|| |||... ...   .  . .  |.  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYA

WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
|||||||     ..||  .||. .|.||.|..|...||.....  .|...|.   | |    ..|.||. .|.|| .| . .  .|| | ||.   
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRP---PIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase BRAF.AA TK 497-754 17 1.4e-66 221.91 In-house 1-486 (486) Show / Hide 
Range on Protein: 497-754
Range on HMM: 1-486/486
Sequence Identity: 17% (85 aa)

ITVGQRIGSGSFG---TVYKGKWHG----------------------------DVAVKMLNVT-APTPQQLQA--------------FKNEVGVLR--KT
||.|. .|.| ||   .||||.|.|                            .||||||  . | .... ..              . .|  ...  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHVNILLFMGYSTKPQ-------------LAIVTQWCEGSS----LYHHLHIIETK--------------------------------------------
.| ||. . |..|...             . ||. .... .    | ..|.    |                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FEMIKLIDIARQTAQGMDYLHAK------SIIHRDLKSNNIFLHEDLT-----------VKIGDFGLAT
                               . |  |. ...| |.|| |||.|       ..||||   |. ..|...           .||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VKS----RWSGSHQFEQLSGS----------------------------ILWMAPEVIRMQD------KNPYSFQSDVYAFGIVLYELMT-G-QLPYSNI
..|    |  .|..    ..|                            | |||||... .       .. .. .|||..||....|..| | . .| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NN--------RDQIIFMVGRG-YLSPD---------LSKVR-SNCP--------------KAMKRLMAECLKKKRDERPLFPQILASI
.|         .... .. ||  | .          . . .  .||              ... .|| .| ... ..|| | |..  .
SNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase BRAF.AA S_TKc 497-757 23 3.2e-59 203.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 497-757
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

ITVGQRIGSGSFGTVYKGKWHG---DVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEG--SSLYHHLHIIETK----
 .... ||.|.||.|||.....    ||.|...         . ...|. .|.| .| ||  . ..     | .|.  |.|   .|.....   ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSF-QSDVYAFGIV
 |       ...|......|.| . |||||||  ||.| |  ..||.|||||..            . |.  .|||||.      .|..  .|....|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

LYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA------SIELL
|||...|. |..   . .... ..|               .. .| ..  ||.|  ..||   ..|.      . . .
LYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BRAF.AA TyrKc 497-754 31 5.8e-55 189.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 497-754
Range on HMM: 1-280/280
Sequence Identity: 31% (91 aa)

ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT--RHVNILLFMGYSTK--------PQLAIVTQWCEGSSLYHHLHIIET
|| |. .|.| ||.||||.|  .||||||.  |     ...| .|  ...|   .| ||. . |. |.        ..| ||.  ... .| ..|.  . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRW-----SGSHQFE----QLS--GSILWMAPEVIRMQDKNPYSF
|. | .|.... | |.||.||| | .|||||   |. ..|..||||.||||.           |..        .      | |||||.|   ... ...
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT

QSDVYAFGIVLYELMT-GQLPYSN-----INNRDQIIFMVGRGYLSPDLSKVRSN-------CPKAMKRLMAECLKKKRDERPLFPQILASI
.|||..||....|..| || ||..     ..|.. .|  | .||    . .  ..       ||..| ..| .| . . ..|| | .|   .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYR---MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase BRAF.AA TK-Unique 497-754 29 9.5e-54 183.7 In-house 1-294 (294) Show / Hide 
Range on Protein: 497-754
Range on HMM: 1-294/294
Sequence Identity: 29% (89 aa)

ITVGQRIGSGSFGTVYKGKWHG-------D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP--QLAIVTQWCEGSSLYHHLH---
..||..||.|.||.|..|.  |       .  ||||||.  |   .. . .|.      ...| ||. ..|..||.  .  |.  .|....| |.|.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

----------IIE------TKFEM---IK---LIDIARQTAQGMDYLHA--KSIIHRDLKSNNIFLHEDLTVKIGDFGLAT-VKSRWSGSHQFEQLSGSI
          ..       ... .   |.   |. .| | |.|| ||.   | |.|||| . |..| ||...||.|||.|. |  .   | . .|   .|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

LWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNC-PKAMKRLMAECLKKKRDERPLFPQILASI
 |||||...  ... .. .|||..||....|..| |. ||... ..| |. .. .||  |    ....| ...|  || .|......||| | ||.  .
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMP----QPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase BRAF.AA STE 497-745 21 2.8e-52 180.0 In-house 1-346 (359) Show / Hide 
Range on Protein: 497-745
Range on HMM: 1-346/359
Sequence Identity: 21% (75 aa)

ITVGQRIGSGSFGTVYKGKWH----GD--------------VAVKMLNVTAPTP---------------QQLQAFKNEVGVLRKTR--HVNILLFMGYST
 .  ..||.|.||||||.. |    ..              .|.| .|.   ..               ...| ...|. ...| .  | ||  . |.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KP--------QLAIVTQWCEGSSLYHHLH-IIETKF-------------EMIKLIDIARQTAQG-MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA
|         .| |.  ...| ||   ..   ....             | . .. |.||. .| ..||| . |||||.|. ||.|     ||. |||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQ-IAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

T--VKSRW------------SGSHQFEQLSGSILWMAPEVIRMQD---KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD---QIIFMVGRG------
.  ..|              ... .   . |.  |||||||. ..   ...|....|.. .|... |. ||. |... ..     .|.|. . .      
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----YLSPDLSKVRS----------------NCPKAMKRLMAECLKKKRDERP
      .| |    |                .. . .|  .. ||.|  ..||
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP
Kinase BRAF.AA Pkinase_Tyr 497-638 36 4.1e-47 160.19 Pfam 1-158 (270) Show / Hide 
Range on Protein: 497-638
Range on HMM: 1-158/270
Sequence Identity: 36% (57 aa)

ITVGQRIGSGSFGTVYKGKWH-------GDVAVKMLNVTAPTPQ-QLQAFKNEVGVLRKT-RHVNILLFMGYST---KP-QLAIVTQWCEGSSLYHHLHI
|| |. .|.|.||.||||.|.        .||||||. .|  .|  ...| .|. ....  .| ||. ..|  |   .| |. ||.  ... .|...|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

I---ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA
    . .. |  |.....| |.||.||..| .|||||   |. ..|...|||.|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase BRAF.AA Pkinase_Tyr 659-754 29 2.5e-21 72.83 Pfam 180-270 (270) Show / Hide 
Range on Protein: 659-754
Range on HMM: 180-270/270
Sequence Identity: 29% (29 aa)

WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLP-YSNINNRDQIIFMV-GRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
|||||.|.      .. .|||..||....|..| |. | | .. | . .. ..  .||    . .   |||. . .|| .| ... ..|| | .|.  .
WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYR---MPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL