Gene BMPR1A (Human)

BMPR1A

Species: Human
Alias: CD292, BMPR1A, ALK3, ACVRLK3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 10q22.2,

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
BMPR1A.kin_dom Protein Kinase Domain Sugen Kinome 288 None Fasta, JSON
BMPR1A.AA Protein Sugen Kinome 532 None Fasta, JSON
BMPR1A.NA RNA Sugen Kinome 3631 None Fasta, JSON

Protein domain

Protein domains of BMPR1A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp BMPR1A.AA Activin_recp 59-138 24 9.3e-26 87.13 Pfam 1-121 (121) Show / Hide 
Range on Protein: 59-138
Range on HMM: 1-121/121
Sequence Identity: 24% (30 aa)

LKCY-CSGH-------CPDDAIN-----NTCIT----------NGHCFAIIEEDDQG--ETTLAS----GCMKYEGSD-----FQCKD-----SPKAQLR
|||| |.|.       |.... |     .||.|          .|.|.. .|..|..   ... .    ||.  ....     |.||.     ||  . .
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

RTIEC-CR-TNLCNQYLQPTL
...|| |  |..||  |.|..
HNHECWCCETDYCNRNLTPPP
Kinase BMPR1A.AA Type1 234-521 71 2.6e-273 750.06 In-house 1-290 (290) Show / Hide 
Range on Protein: 234-521
Range on HMM: 1-290/290
Sequence Identity: 71% (208 aa)

IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLK
|||....|||||||||.||||||.||||.||...|.||||||||||||.|||||||||||||.|..||||||.|||||||.|||||.|.. ||||. .|.
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

LAYSAACGLCHLHTEIYGTQ--GKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIY
||||.||||.|||.||.|||  |||||||||.|||||..||||.||||||||||....||...|.. |.|||||||||||||||..|.|.|. |.|||||
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

SFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTL
||||..||.||||..|||||.||||||..||.|||.||||.||||..||| . |||.|..|.|.. |||.|||..||..|.|||||||||
SFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase BMPR1A.AA STKR 234-521 57 2.9e-215 701.77 In-house 1-312 (312) Show / Hide 
Range on Protein: 234-521
Range on HMM: 1-312/312
Sequence Identity: 57% (179 aa)

IQMVRQVGKGRYGEVWMGKWRG----EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGT-GSWTQLYLITDYHENGSLYDFLKCATLDT
||.....|||||||||.|||||    |.||||.|....|.|||||||||||..|||||||.|||||.|.| |||||..|||.|||||||.|.||. |.|.
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

RALLKLAYSAACGLCHLHTEIY--GTQ--GKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVP-------LNTRVGTKRYMAPEVLDESL
. ....|.|.||||.|||.||.  |||  .||||||||.||||||.|..|.|||||.|||.....|||..|..        ||.|||||||||||||...
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

NKNHFQP-YIMADIYSFGLIIWEMARRCITGG------IVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWN-SDECLRAVLKLMSECWAHNPA
| ..|.  . ..|.|..||. ||.||||..||      ||.|||.|.| .||..||.|||..|||.||.|| ..|||. .....| . |.| ||| |.|.
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

SRLTALRIKKTL
 |||||..|||.
ARLTALCVKKTM
Kinase BMPR1A.AA TKL 240-521 29 2.1e-110 373.12 In-house 1-364 (364) Show / Hide 
Range on Protein: 240-521
Range on HMM: 1-364/364
Sequence Identity: 29% (111 aa)

VGKGRYGEVWMGKWRG----------EKVAVKVFFTTE-------------------------EASWFRETEIYQTVLMR---HENILGFIAADIKGT--
.|.|..|||. |||||          . ||||.| ...                         ||||||..|......|.   |.||. |..... ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIY--GTQGKPAIAHRDLKSKNILIKKNGS--------------C
       |.|.||.....|...|||...|         ....|...|.|...||...   .|  ||.|.||||||||||...|.               |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

CIADLGLAVKFNSDTNEVDVP---------------LNTRVGTKRYMAPEVLDESLNKNH----------FQPYIMADIYSFGLIIWEMARRCITGGIVE
.|.|.||.  .. ..|  |                 ..|..||.|.||||||....| ..          |.    .|.||||...||.. ||.      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----P

EYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNS-------DECLRAVLKLMSECWAHNPASRLTALRIKKTL
.|..||. |...|| .|.| ..||.|.||| . ..|..       . |.. . ||| .||.|.| .|.....|.|.|
YYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase BMPR1A.AA Type2 234-521 39 7.1e-106 350.59 In-house 1-315 (315) Show / Hide 
Range on Protein: 234-521
Range on HMM: 1-315/315
Sequence Identity: 39% (125 aa)

IQMVRQVGKGRYGEVWMGKWRGE-----KVAVKVFFTTEEASWFRETEIYQT-VLMRHENILGFIAADI---KGTGSWTQLYLITDYHENGSLYDFLKCA
||.  ..||||.|.|| ..| ..      ||||.|   . .||  | .||.. ..|.||||| ||.|.     ... | .. |.|..|..|||.|.||  
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

TLDTRALLKLAYSAACGLCHLHTEIY-GTQ---GKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNE----VDVPLNTR----VGTKRYMAPEV
|.|   ....| |.| || |||.||. ..|    ||.|||||.||||.|.| ...|||||.|||..|  ....    .  |  |     |||.|||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LDESLNKNHFQPYIMA----DIYSFGLIIWEMARRCITGG---IVEEYQLPYYNMVPSD-PSYEDMREVVCVKRLRPIVSNRWNSDECLR-AVLKLMSEC
|.  .|   ||  ..|    |.|..||. |||. ||   .    | |||.|.   | .  || |||.|.|  || ||  .. |   . .   .  .. .|
LEGAVN---FQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDC

WAHNPASRLTALRIKKTL
| | .  ||||. ..  .
WDHDAEARLTAQCVQERM
Kinase BMPR1A.AA Pkinase 234-521 21 2e-60 211.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 234-521
Range on HMM: 1-293/293
Sequence Identity: 21% (72 aa)

IQMVRQVGKGRYGEVWMGKWRGEK--VAVKVFFTTEEASWFRET-----EIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENG----SLYDFLK
.. .|..|.| .|.|. ....|.   ||||..   .| ||...|     ||.    ..|.||. .. .        . .|....|.|.|    .|.|...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---CATL--DTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSC----CIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVL
     ..  . . . . .|  ..|| ..| .         | |||||. ||||..|| .    .|.| ||| .|.   .  .. ..|..|| .|||||| 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEV-

DESL-NKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECL-----------------RA
   . .. . ..   .|..|.|.|..||. .           .|... .  ...  |.....| .. .|. ........                   ..
--IRGGQYYGPK---VDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE

VLKLMSECWAHNPASRLTALRIKKT--L
 ..... |.. .|..|.||  |..   .
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase BMPR1A.AA TKL-Unique 236-521 29 2.5e-37 129.23 In-house 1-290 (290) Show / Hide 
Range on Protein: 236-521
Range on HMM: 1-290/290
Sequence Identity: 29% (93 aa)

MVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETE-IYQTV----LMR-HENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLK-------
 .  .| | ||.|  |||||..||.|.|.  .| | .....  .  |      . |.||. .... .. . .  .......| . ||||| |        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----CATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKN-----GSCCIADLGLAVKFNSDTNEVDVPLN------TRVGTKRY
      .|.    .|.|  .| |...||...     .| |.||||||.|.|.  |      .  |.| ||. ||||  |.  .  .      ||.|. |.
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE-----PP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLS-KFNSKINKMTNNEHKGTRNQTRCGSFRW

MAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCV--KRLRPIVSNRWNSDECLRAVLKLMSECWA
||||||  .   ....  . .|.|||| . ||.| |.||      |  || .|     . |  .|.| .  ...|| ..|... .       .|. .||.
MAPEVLRMNF--CQYS--EKSDVYSFGIVLWEIATRKIT----KTYKKPYQGM-----DQEQWCEMVHYMEENYRPPIPNHCPKE-----YRDLIQQCWH

HNPASRLTALRIKKTL
|.|  | .   | . |
HDPSQRPSFDEIIHRL
Kinase BMPR1A.AA MLK 234-440 27 2.2e-35 120.26 In-house 1-229 (291) Show / Hide 
Range on Protein: 234-440
Range on HMM: 1-229/291
Sequence Identity: 27% (67 aa)

IQMVRQVGKGRYGEVWMGKWRGEK-----VAVKVFF-------TTEEASWFRETEIYQTVLMRHEN----ILGFIAADIKGTGSWTQLYLITDYHENGSL
||  . .|.| .|.|| |.||..      |||| ..        |.. .|  |.|...   ..|.|    |  | .. .. .    ...... | |.|||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP---CHFCIVMEYCEGGSL

YDFLKCAT---------------LDTRALLKLAYSAACGLCHLHTEIYGTQGKP-AIAHRDLKSKNILIK------KNGSCCIADLGLAVKFNSD-TNEV
|..|. |.                |   ... |.  | |.  || .      .| .| ||||||.||||       ..| . |.| |.. ....  ||  
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM------APKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMM

DVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEM
.     . || ..|||||.     . . .  . .|..|.|...|||
S-----NAGTYAWMAPEVIQQ---FRCEKYSEKCDVWSWGVVLWEM
Kinase BMPR1A.AA S_TKc 234-525 20 2.6e-34 121.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 234-525
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

IQMVRQVGKGRYGEVWMGKWRG--EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHEN--GSLYDFLKCAT----
 ...|..||| .|.|. .....  ..||.|.       .  || .| .    .|.||  .. .        . ||....| ..  |.|.|..|       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHF
   ..     ...|  .|.| ..|        .  | |||||  |||. .     |.| ||| ..           .| .||  |||||||         
RFPFPE-HARFYMYQICCALEYCH-------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------

QPYIM--ADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKK-
 .|    .|..|.| |..||. ..       ..|. . ...                                . .. ... |.  .|. |.||  . . 
-GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

----TLAKMV
     .   .
EWDIKCHPWF
Kinase BMPR1A.AA TK 234-440 16 1.9e-27 88.47 In-house 1-387 (486) Show / Hide 
Range on Protein: 234-440
Range on HMM: 1-387/486
Sequence Identity: 16% (66 aa)

IQMVRQVGKGRYG---EVWMGKWRG---------------------------EKVAVKVFF---TTEEASWFR-----------------ETEIYQTVLM
|..... |.| .|   ||..|.|||                           ..||||.     .....  |                  | .. .  | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHENILGFIAADIKGTGSW--------TQLYLITDYHENGS----LYDFLK-CA----------------------------------------------
.|.||. ....  .| ..           ..... | ..|.    | |.|. |                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------TLDTRALLK-------------------LAYSAACGLCHLHTE---IYGTQGKPAI---AHRDLKSKNILIKKNGS-----------CCI
          .|.|. ||                     .. .|||. .||              |    ||||   |.|. .|.            | |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEF--------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKI

ADLG--------LAVKFNSD-----TNEVDVPLNTRV---------------GTKR---YMAPEVLDESLNKNH---FQPYIMADIYSFGLIIWEM
|| |        || . .||     ... .....                  |.|    .||||.|..     .       .  |..|||  .||.
ADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase BMPR1A.AA STE 234-441 20 2.5e-23 79.28 In-house 1-262 (359) Show / Hide 
Range on Protein: 234-441
Range on HMM: 1-262/359
Sequence Identity: 20% (57 aa)

IQMVRQVGKGRYGEVWMGKWR-----------------GEKVAVKVF--------------------FTTEEASWFRETEIYQTVL-MRHENILGFIAAD
 . ....||| .|.|  .. .                 || .|.|.                     ...|. .  .| .| .    | |.||  .. . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM-HPNIVKYYGCY

IKG---TGSWTQLYLITDYHENGSLYDFLK--CATLDT-------------RALLKLAYSAACG-LCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSC
.|.   ... ..|...  | ..||| |..|  . ....               . . ...   | | .||           | |||.|. |||.     .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----V

CIADLGLAVKFNSDTN------------EVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPY-IMADIYSFGLIIWEMA
 ..| |.. .....                .   || |||  .|||||..   ..   ..| . .||.|.|. |.|||
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMA
Kinase BMPR1A.AA TyrKc 234-521 24 2.2e-20 74.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 234-521
Range on HMM: 1-280/280
Sequence Identity: 24% (76 aa)

IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFF-TTEEASWFRETEIYQTVLM--RHENILGFIAADIKGTGSW---TQLYLITDYHENGSLYDFLKCAT--
|.. .. | | .|||. |.|. ..||||.    . ..   || .|        .|.||. .... ... . .    .|.... | ..|.| |.|.     
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCK--LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSD----TNEVDVPLNTRVGTK-----RYMAPEVLDES
| .. ||. .. .|||  .||           . ||||   |.|...|. . |.| ||. .  .|     ..      .. |.|     | ||||..   
LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

LNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDE-----CLRAVLKLMSECWAHNPASR
 |.. |   .  |..|||  .||.  ..         | ||..|.  . | ....| |   . .|.  |     .     |  .. ..|..||...|..|
-NYGKF--TTKSDVWSFGVCMWEIFTYG---------QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPEDR

LTALRIKKTL
 |   |.. .
PTFSEIHECF
Kinase BMPR1A.AA TK-Unique 234-441 21 4.9e-20 65.87 In-house 1-233 (294) Show / Hide 
Range on Protein: 234-441
Range on HMM: 1-233/294
Sequence Identity: 21% (54 aa)

IQMVRQVGKGRYGEVWMGKWRG--------EKVAVKVFF----TTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFL
. . ...|.|..|.|| |. .|         .||||        |...  ..| .... .  .|.||. .. . .| .    . ..|  | ..|.| ..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELG-DHPNIVQCLGCCTKSD---EPWMIIMEYCPCGNLQHYL

K---CA------------------------TLDTRALLKLAYSAACGLCHLHT---EIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDT
.   .|                        ... . |.  |.  |||. .|.    .|          |||| ..|.|.  .. | |.|.|.| . .  .
RTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI---------VHRDLCARNVLLTEDKVCKICDFGMARDVYT-N

NEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQP-YIMADIYSFGLIIWEMA
....         .|.||||.| .     | .  ..  |..||| ..||..
GVYSMMCSQGRIPIRWMAPESLKCY----HGMYHTTKSDVWSFGVLMWEIF
TGF_beta_GS BMPR1A.AA TGF_beta_GS 204-232 58 9.9e-17 58.04 Pfam 1-29 (29) Show / Hide 
Range on Protein: 204-232
Range on HMM: 1-29/29
Sequence Identity: 58% (17 aa)

ESLKDLIDQSQSSGSGSGLPLLVQRTIAK
....|.......||||||||||||||||.
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
Kinase BMPR1A.AA Pkinase_Tyr 234-346 24 2.2e-16 56.13 Pfam 1-128 (270) Show / Hide 
Range on Protein: 234-346
Range on HMM: 1-128/270
Sequence Identity: 24% (32 aa)

IQMVRQVGKGRYGEVWMGKWR------GEKVAVKVF--FTTEE----ASWFRETEIYQTVLM-RHENILGFIAADIKGTG-SWTQLYLITDYHENGSLYD
|.. .. |.| .|||..|.|.      . .||||.    ...|    .. .|| .|  .  . .|.||. .... ..  . .  |.|... | ..|.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQ--LGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLD

FLKCA-----TLDTRALLKLAYSAACGLCHLH
.|.        |..  ||. ..  |.|. .|.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
GS BMPR1A.AA GS 204-234 58 5e-15 57.18 SMART 1-31 (31) Show / Hide 
Range on Protein: 204-234
Range on HMM: 1-31/31
Sequence Identity: 58% (18 aa)

ESLKDLIDQSQSSGSGSGLPLLVQRTIAKQI
....|..... .||||||||||||||.|.||
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
Kinase BMPR1A.AA Dicty4 332-441 36 9.7e-13 38.99 In-house 115-211 (277) Show / Hide 
Range on Protein: 332-441
Range on HMM: 115-211/277
Sequence Identity: 36% (41 aa)

LKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPY-IMADI
...| .|| |. .||. .      | | |||||| |.|. ||    ..|.||.  .  ...  |  . | .||  .|||||.        .|||   || 
MRMAFDAARGMNWLHCCN------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDN-QMTACGTPCWMAPEVM-------MHQPYNEKADV

YSFGLIIWEMA
||||.. ||..
YSFGIVLWEIL
Kinase BMPR1A.AA Dicty4 234-266 45 3.3e-09 27.06 In-house 1-33 (277) Show / Hide 
Range on Protein: 234-266
Range on HMM: 1-33/277
Sequence Identity: 45% (15 aa)

IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTT
|.     ||| .|||  |.||| .||||... .
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNH
Kinase BMPR1A.AA TK 499-521 34 1.4e-05 13.87 In-house 464-486 (486) Show / Hide 
Range on Protein: 499-521
Range on HMM: 464-486/486
Sequence Identity: 34% (8 aa)

LMSECWAHNPASRLTALRIKKTL
|| .||...|. | |   ... |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase BMPR1A.AA TK-Unique 490-521 30 9.3e-05 12.48 In-house 262-294 (294) Show / Hide 
Range on Protein: 490-521
Range on HMM: 262-294/294
Sequence Identity: 30% (10 aa)

DEC-LRAVLKLMSECWAHNPASRLTALRIKKTL
..|  ... .||..|| ..| .| .   ||. |
EHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase BMPR1A.AA Dicty4 466-511 32 0.000128 11.52 In-house 223-263 (277) Show / Hide 
Range on Protein: 466-511
Range on HMM: 223-263/277
Sequence Identity: 32% (15 aa)

SYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASR
.|.  .. || | |||..     .| |.    .|. .|| |.| .|
PYMQFVRAVCNKKLRPPI-----PDWCPPSWKHLIQWCWDHDPQHR
Kinase BMPR1A.AA Pkinase_Tyr 360-440 28 0.000187 15.71 Pfam 134-207 (270) Show / Hide 
Range on Protein: 360-440
Range on HMM: 134-207/270
Sequence Identity: 28% (24 aa)

HRDLKSKNILIKKNGSCCIADLGLAVKF-NSDTN-EVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEM
||||  .|.|...|. . |.| |||    | |.   .       .   . ||||.. ..         .  |..|||  .||.
HRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPI---KWMAPECINYGK------FTTKSDVWSFGVLMWEI
Kinase BMPR1A.AA Pkinase_Tyr 498-521 37 0.000357 14.76 Pfam 247-270 (270) Show / Hide 
Range on Protein: 498-521
Range on HMM: 247-270/270
Sequence Identity: 37% (9 aa)

KLMSECWAHNPASRLTALRIKKTL
.|| .||...|. | |   |   |
DLMKQCWHYDPEDRPTFSEIHEQL
Kinase BMPR1A.AA MLK 498-511 50 0.067282 2.53 In-house 268-281 (291) Show / Hide 
Range on Protein: 498-511
Range on HMM: 268-281/291
Sequence Identity: 50% (7 aa)

KLMSECWAHNPASR
|||..||  .|..|
KLMKQCWNQDPHKR