Gene BCKDK (Human)

BCKDK

Species: Human
Alias: BCKDK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 16p12.3,

Classification

Group: Atypical
Family: PDHK
Subfamily: BCKDK

Sequence

Name Sequence Type Origin Length Description Download
BCKDK.AA Protein Sugen Kinome 412 None Fasta, JSON
BCKDK.NA RNA Sugen Kinome 2097 None Fasta, JSON
BCKDK.kin_dom Protein Kinase Domain None 138 None Fasta, JSON

Protein domain

Protein domains of BCKDK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
BCDHK_Adom3 BCKDK.AA BCDHK_Adom3 68-223 30 1.1e-66 231.08 Pfam 1-199 (199) Show / Hide 
Range on Protein: 68-223
Range on HMM: 1-199/199
Sequence Identity: 30% (61 aa)

VRLTPTMMLYAGR-SQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTD-F--------------PPIKDQAD----
 .|.   |.. ||     ..|.|||... .|||.|.||||.....||... ..| |..|...|...|..|.  |              ||.|.. |    
TPLSLRQMMQFGRPNPCEKTLFKSAQFCHEELPIRLAHRIRELQNLPYGLNKMPHIQQVYNWYYQSFEELRECFPKPISELKHLRYYEPPPKTLEDWLHD

-EAQYCQLVRQLLDDHK-DVVTLLAEGLRESR-KHI----EDEK----LVRYFLDKTLTSRLGI---RMLATHHLAL-----HEDK----PDFVGIICT
 . ..|...|...|.|  .||. .|.|..| . ...    ....     . ||||  ..|| ||   |||...|.||     |. .    ||.||||||
YNEKFCDMLRDIKDRHDRNVVPTMAQGVLEWKCRYYGQDNQPDDLHWFQIQYFLDRFYMSRIGINFIRMLIGQHIALFEFNYHNPHHFEHPDYVGIICT
Kinase BCKDK.AA PDHK 264-403 55 1.3e-104 353.86 In-house 1-140 (140) Show / Hide 
Range on Protein: 264-403
Range on HMM: 1-140/140
Sequence Identity: 55% (77 aa)

FIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPM
..||.|...|.||.|||||||||.|.|.|||.|......|..|.||.|..||||||..|...||...|...||..||||||.||||||||||......||
YVPMHLYHMLFELFKNAMRATMEHHEDRPYNYPPIKVMVALGDEDLTIKMSDRGGGVPHRKIDRLFNYMYSTAPRSTQDPRMSPLFGHLDMHETSRAAPM

HGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHI
||||.|||..|.||.|..|.|||.|..|.|||....|. .
HGFGYGLPICRLYAKYFQGDLQLYSMEGYGTDAVIYLKAL
Kinase BCKDK.AA HATPase_c 264-403 19 4.5e-20 72.08 Pfam 1-120 (120) Show / Hide 
Range on Protein: 264-403
Range on HMM: 1-120/120
Sequence Identity: 19% (29 aa)

FIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAH------KDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSG
  | .|  .. .|. ||...| |.        . . ...   | ...|...| | ||.       .|..|. . ...| ..                   
GDPDRLHQVVWNLVDNAIKHTPEG--------GHITVRVHRDDDHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPD-------------------

AQSGPMHG--FGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHI
.      |  .|.||  .|...| .||.....|  | || . ..|   
SR-RKYGGGLTGLGLYICRRIVEQHGGTIWVESEPGGGTTFTFTLPLE
Kinase BCKDK.AA HATPase_c 264-404 21 4.6e-18 67.25 SMART 1-130 (130) Show / Hide 
Range on Protein: 264-404
Range on HMM: 1-130/130
Sequence Identity: 21% (32 aa)

FIPMPLDYILPELLKNAMRATMESHLD---TPYNVPDVVITIANNDVDLIIRISDRGGGIAH------KDLDRVMDYHFTTAEASTQDPRISPLFGHLDM
  |..|  .| .||.|| ..| |.| |   .. . ..  ||.  .    .|...| | ||.       .|..|. .  ..|.....            .|
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH----RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPS------------RM

HSGAQSGPMHG--FGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHID
.....|    |  .| ||. .....| .||.....      | ....|.   
CPDSRSRKYGGGLTGLGLSICKRIVEQHGGTIWVE------TTFTFTLPLER
Kinase BCKDK.AA PDHK 264-336 39 9.6e-17 57.31 In-house 1-72 (125) Show / Hide 
Range on Protein: 264-336
Range on HMM: 1-72/125
Sequence Identity: 39% (29 aa)

FIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTA
..|  |  .| || |||||||.|.| . .   | . . ..  . || |..||||||.  . .||   | . ||
YVPSHLYHMLFELFKNAMRATVEHHENRK-IYPPIKVMVTLGKEDLTIKMSDRGGGVPLRKIDRLFNYMYSTA
Kinase BCKDK.AA PDHK 362-403 47 1.9e-11 38.21 In-house 84-125 (125) Show / Hide 
Range on Protein: 362-403
Range on HMM: 84-125/125
Sequence Identity: 47% (20 aa)

PMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHI
|. |||.||| .| || |  | |.| |..| |||  . |. .
PLAGFGYGLPICRLYAKYFQGDLKLYSMEGYGTDAVIYLKAL