Gene AurC (Human)

AurC

Species: Human
Alias: AIE2, AIK3, STK13, AurC, aurora-C, AURKC
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 19q13.43,

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
AurC.NA RNA Sugen Kinome 1261 None Fasta, JSON
AurC.AA Protein Sugen Kinome 309 None Fasta, JSON
AurC.kin_dom Protein Kinase Domain Sugen Kinome 251 None Fasta, JSON

Protein domain

Protein domains of AurC.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AurC.AA Aur 43-293 63 2e-238 637.25 In-house 1-257 (257) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-257/257
Sequence Identity: 63% (163 aa)

FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKS--EKLDE
||||.|||||||||||||| |..|||.||||.||.||.|...||||||||.|| ||.|||||..|.||||. |.||||||||.|||||||||.   ..||
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

QRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-FRGEVKIADFGWSVHTP-SLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPP
||.|... ....||.||| |..|||||||||.||. . |..||.|||||||.| . ||.|.||||||.||||.||...|.|||.||.|||||||..|.||
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FES-ASHSETYRRIL-KVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWV
|||  .|.|||.||. |||..|| . . .|.||||..|...| .|..|.||..|||.
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase AurC.AA AGC 43-293 24 4.3e-104 269.45 In-house 1-395 (395) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-395/395
Sequence Identity: 24% (99 aa)

FEIGRPLGKGKFGNVYLARLKESH------FIVALKVLFKSQ---IEKEGLEHQLRRE------------IEIQAHLQ----------HPNILR-LYNYF
||. ...||| || |||.| |...       . |.||| |.    | |.  ...  .|             .| ....          ||.| . |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

HDARR--VYLILEYAP---------RG-ELYKELQ---KSEKLDEQRTATIIEE-------LADALTYCHD-KKVIHRD-IKPENLLLGFRGEVKIADFG
.| ..  .|...||.|          | ||.  ||   |. ..||.|.  .. |       .. || | |. ...|||| .||||.||  .| .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

WSVHTPSL----------------------------------------------------RRKTMCG--TLDYLPPEMIEGRTYDEKVDLWC--IGVLCY
 .   ..                                                     | .|.||  | .|..||..    |.  .| |.   |.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLVGYPPFESAS----------HSETYRRIL------KVDVRFP----------LSMPLGARDLISRLLRYQPLERLP----------LAQILKHPWV
|.|.||||| . .          . |.. .|.      . .|.||           ..   |.|||..||   | .||             .| .||| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase AurC.AA S_TKc 43-293 32 1e-97 331.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-231/231
Sequence Identity: 32% (87 aa)

FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPR--GELYKELQKSEK---
.||.|..||| || ||..| |... |||.|..            ..||||.|  . .|||| .|| .|.|  ..|...||..   |.|.. ..|  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDE-KVDLWCIGVLCYELL
   ..| ... .. ....|| |||....||||.||||.||    ..||.||| . .      .|.|||..|..||..    |.  |.| | .|.. ||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

VGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILK-------HPWV
.|||||.   . .....|.          .  |.|.|...|.. | .|.   ..|.       |||.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AurC.AA CAMK 48-293 21 1.7e-91 295.07 In-house 1-425 (425) Show / Hide 
Range on Protein: 48-293
Range on HMM: 1-425/425
Sequence Identity: 21% (90 aa)

PLGKGKFGNVYLARLKESH------------FIVALKVLFKSQIEK-------------------------EGLEHQLRREIEIQAHLQ-------HPNI
 ||.| || |.|.. |..               || |.. |... .                         .  ....||||||  .||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRLYNYFHDAR-------------------RVYLIL---EYAPRGEL----YKELQKSEK---------------LDEQRTATIIEELADALTYCHDKKV
..|| .. |..                   ..|...   ||.. |||    .  ... ..               ..|. .....  ...|. |||....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENLLLGFR-----------------GEVKIADFGWSVHTPSLR-------------------------RKTMCGTLDYLP-PEMIEG------
.|||.||||.||  .                 . .||.||| . . ..                            ||.|||. | . ||...|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------RTYDEKVDLWCIGVLCYELLVGYPPFESA-------------SHSETYRRILKVDVRFPLSMPLG------------------------ARD
        . |..|.| | .||..| .|.|||||..              . .|....|.| . .|| ..  .                        ..|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISRLLRYQPLERLPLAQILKHPWV
||...|.. | .|. ..|.|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AurC.AA CAMKL 43-293 31 4.6e-85 271.38 In-house 1-297 (297) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-297/297
Sequence Identity: 31% (95 aa)

FEIGRPLGKGKFGNVYLARL-KESHFIVALKVLFKSQIEKEGLEHQ------------LRREIEIQAHLQ---HPNILRLYNYFHDARR------VYLIL
..||. |||| || | ||.  .     || |.. |. | ..   ..            .||||.|. .|.   |||| .||  . . .       .||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAPRGE--LYKELQKS----EKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRG--EVKIADFGWSVH-TP-----SLRRKTMCGTLDYL
||.. ||  |.  ..|     ....|  .  .   . .|. |||.....||||||||.||  .|   .||.||| | . .|         || ||.. | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEMIEG--RTYD-EKVDLWCIGVLCYELLVGYPPFESASHS-------ETYRRILKVDVRFP--LSMPLGARDLISRLLRYQPLERLPLAQILKHPWV
.||...|  . ||  ||| | .||. | ...|| ||. ....       . |..| .   ..|  ....  .||||...|   | .|  . ||..|||.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase AurC.AA Pkinase 43-293 30 3.5e-84 290.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLR-REIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRG----ELYKELQ--KS
..|||..|.| || ||... | .  |||.|.. |. .... ... .| .||.| ..|.||||.||| .|.| ...|...||.. |    .|.  ..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EKL--DEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV----KIADFGWSV---HTPSLRRKTMCGTLDYLPPEMIE-GRTYDEKVDLWCI
 ..  .|.    .. ... .| |||....||||.||||.|.  .|..    ||.||| .    . ..   .| |||..|..|| |  |. |. ||| | .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLCYELLVGYPPFESA------SHSETYRRILKVDVRFPLS---------------------MPLGARDLISRLLRYQPLERLPLAQILKHPWV
|...||.| |.||| ..      .. . ..||.. ...|. .                     ..  ..|.|...|.. | .|.  .|||.|||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AurC.AA MARK 43-293 36 5.1e-79 257.95 In-house 1-262 (262) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-262/262
Sequence Identity: 36% (95 aa)

FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFH--DARR-VYLILEYAPRGELYKELQKS--EK
..... .|.| .. |.||. | ..  ||.|.. | .. .      ..|||||  .|.|||| .|. ..   . .. .|||.|||..||||  ...    .
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRG--EVKIADFGWSVHTPSLR-RKTMCGTLDYLPPEMIEGRTYD-EKVDLWCIGVLCYELL
| |  . .|   .  |. |||.| ..||||||||.|.  .|   .||.|||.|.. |. .  .| |||. | .||..... ||  ||| |  ||. | ..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

VGYPPFESAS--HSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWV
.|| ||. ..    | |..||. . ..|  .. ..|.||.|||   | ||  . .|.||||.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase AurC.AA Ciliate-E2a 43-293 30 8.7e-79 231.54 In-house 1-275 (275) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-275/275
Sequence Identity: 30% (85 aa)

FEIGRPLGKGKFGNVYLARLKESHFI-VALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQ
... . .|||.|| ||||..|.  .  .. |.  | ...|.| | .. .|| |   | ||||..|| .. | .  ||..||   ||||...... ...| 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKE-YFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

--RTATIIEELA-DALTYCHDKKVIHRDIKPENLLLG---FRG----EVKIADFGWSVHT-PSL--RRKTMCGTLDYLP------PEMIEGRTYDEKVDL
    . |.  |  ..| |.| ....|||.||||.|.    . .    ..||.||| .    .    .....|||  |..      .| .... ||.|.|.
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM

WCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSM-----PLGARDLISRLLRYQPLERLPLAQILKHPWV
| .||  | ||.|.|||.  ...|.   . |    |  .      .. . ||....| ..| .|.  .|.|.|||.
WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase AurC.AA Ciliate-E2 43-293 24 3.1e-77 262.92 In-house 1-365 (365) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-365/365
Sequence Identity: 24% (92 aa)

FEIGRPLGKGKFGNVYLARL-----------------------KESHFIVALKVLFKSQIEKEGLEHQLRREIE----------IQAHLQHPNILRLYNY
... . .|.| || ||...                        |   .|.|.|.. |.|||    | .. |||.          |. .|.||||...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FH--DARRVYLILEYAPRGELYKELQKS-----------EKLDEQRTATIIEELAD---------------ALTYCHDKK-VIHRDIKPENLLLGFRGEV
|   |   .||..||.  |.|.. ....           ....|.  ..|......               || |.| |. .|||||||||.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGW--SVHTP-------SLRR------------------------KTMCGTLDYLPPEMIEGRT---------YDEKVDLWCIGVLCYELLVGYPP
||.|||    ....       ...                         .| |||. |..||...|           ||.|.|.|..||. ||.| |.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FESASHSETYRRILKVDVRFP------------------LSMPLGARDLISR----LLRYQPLERLP-LAQILKHPWV
|        .. |.. ...||                  .. .. . |||..    .| ..| .|.    |||.||| 
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AurC.AA CAMK-Unique 43-293 23 6.4e-77 253.41 In-house 1-363 (363) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-363/363
Sequence Identity: 23% (84 aa)

FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFK--SQIEKEGL---------------EHQLRREIEIQAHLQHPNILRLYNY----FHDAR-------
 . .|..|.| || || .  .|   . | |.. |   ...|  .               . .|.||..|   . ||||..|| .    |.|..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------RVYLILEYAPRGELYKELQK--------------------SEKLDE--QRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGE-----
        . |...||.. |.|....||                      .. |    |..|. .|. |. | |.....|||.|.||...  ..      
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

-----------VKIADFGWSVHTPSLRRK----TMCGTLDYLPP--------------EMIEGRTYDEKV----DLWCIGVLCYELLVGYPPFESASHS-
           .|..||| ..|  . .      |||||..|. |              |.|... ||...    |.| .||. |..|.|.|||....   
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------ETYRRILKVDV-RFPLSMPLG-------ARDLISRLLRYQPLERLPLAQILKHPWV
       |....|.| |. .|. .|  |       | |.. ... . |  |......|.|.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase AurC.AA PLK 43-293 36 1.5e-73 238.89 In-house 1-258 (258) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-258/258
Sequence Identity: 36% (93 aa)

FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKS-EKLDEQ
.|.|..|||| |  .| ..  ... ..| ||  || ..|...   ...||||.  |.||||......| |.  ||. |||.....|   . .   .| | 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

RTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSL--RRKTMCGTLDYLPPEMIEGRT--YDEKVDLWCIGVLCYELLVGYP
 .  ..  .. .| | |....||||.|. ||.|    .|||.||| ..       |.||||||  |  ||  .|    .. .|| | .|.  | ||.| |
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFESASHSETYRRILKVDVRFPLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWV
|||...  |||.|| . . .|| .      |.||| ..|.  | ||. . ||| ||. 
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase AurC.AA RSK 46-293 31 1.2e-70 241.05 In-house 1-278 (278) Show / Hide 
Range on Protein: 46-293
Range on HMM: 1-278/278
Sequence Identity: 31% (89 aa)

GRPLGKGKFGNVYLARLK---ESHFIVALKVLFKSQIEKEG--LEHQLRREIEIQAHLQ-HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK--
 . ||.| .| |.| | .    .  | | ||| |. | .    ..|  ..|..| .. | ||.| .|.  |..   .|||.|| . |||.. ||| .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRH-TMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-LDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGF---RGEVKIADFGWSVH-TPS--LRRKTMCGTLDYLPPEMIE----GRTYDEKVDLWCIG
 ..| . . .. |.. |. . |....||||.|||| |.     .|..|. ||| .    ..   . .| |.|..|..|||.     ....|. .|.|  |
CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VLCYELLVGYPPFES---ASHSETYRRILKVD--VRFP--LSMPLGARDLISRLLRYQPLERLP-----LAQILKHPWV
|| ||.|.|.||| .   ....|. .||.| .  ...|   ..   |.|||...|   |  ||      ...|..||| 
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase AurC.AA Pkinase_Tyr 43-186 31 1.3e-23 80.64 Pfam 1-156 (270) Show / Hide 
Range on Protein: 43-186
Range on HMM: 1-156/270
Sequence Identity: 31% (50 aa)

FEIGRPLGKGKFGNVYLARLK----ESHFIVALKVLFKSQIEKEG-LEHQLRREIEIQAHL-QHPNILRLYNYFH-DARR--VYLILEYAPRGELYKELQ
 ..|. ||.| ||.||....|    . .  || |.| | .  .|  .   . ||..|  .| .||||.|||     . .   .|...||.| | |.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----SEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFG
|     ..|. ..   .  . |... | ..|. ||||.   | |..  . |||.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase AurC.AA TyrKc 43-291 23 1.1e-18 69.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 43-291
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHL--QHPNILRLYNYFHDA-------RRVYLILEYAPRGELYKELQ
 . |. || | || ||....|     || |.| ..       .  ..||..|  .|  .||||.||| .  .          .....||.| | | . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KSEK-LDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSL-------RRKTM----CGT----LDYLPPEMIEGRTYD
|... |  .    .    |.   | |.|..||||.   | |.| .. |||.||| |    .          ...    .|     .  ..|| |  ... 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EKVDLWCIGVLCYELL-VGYPPFES-----ASHSETYRRILKVDVRFPLSM---------PLGARDLISRLLRYQPLERLPLAQILKHP
.| | |  ||...|..  | .| .       | .| .... . . . .            |    .....  ...| .|   ..| .  
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AurC.AA Pkinase_Tyr 206-251 33 0.303009 4.84 Pfam 181-228 (270) Show / Hide 
Range on Protein: 206-251
Range on HMM: 181-228/270
Sequence Identity: 33% (16 aa)

LPPEMIEGRTYDEKVDLWCIGVLCYELLV-GYPP-FESASHSETYRRI
..|| |  . . .| | |  |||..|..  |  | ..  | .| |..|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI