Gene AurA (Human)

AurA

Species: Human
Alias: MGC34538, BTAK, STK7, STK15, AURORA2, AURA, AIK, AurA, STK6, ARK1, AURKA
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 20q13.2-q13.3,

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
AurA.NA RNA Sugen Kinome 2554 None Fasta, JSON
AurA.AA Protein Sugen Kinome 403 None Fasta, JSON
AurA.kin_dom Protein Kinase Domain Sugen Kinome 251 None Fasta, JSON

Protein domain

Protein domains of AurA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AurA.AA Aur 133-383 62 2.5e-242 647.77 In-house 1-257 (257) Show / Hide 
Range on Protein: 133-383
Range on HMM: 1-257/257
Sequence Identity: 62% (161 aa)

FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL--SKFDE
||||.||||||||||||||.|...|| ||||.|| |..| ..|||||||..|||||.|||||..||||||..|.|||||||| |..|.||||.   .|||
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

QRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSVHAP-SSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPP
||.|.|. ...||| ||||| .|||||||||.||. . |..||.|||||||.| ..||.|.||||||.||||.||.|||.|||.|.|||||||...|.||
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FEA-NTYQETYKRIS-RVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
||. ....|||.||. .|...||......|.||||..|.|.|.||  | ....||||
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase AurA.AA AGC 133-383 25 5.4e-112 290.36 In-house 1-395 (395) Show / Hide 
Range on Protein: 133-383
Range on HMM: 1-395/395
Sequence Identity: 25% (101 aa)

FEIGRPLGKGKFGNVYLAREK------QSKFILALKVLFKAQ---------LEKAGVEHQ------LRREVEIQSHLR----------HPNILR-LYGYF
||. ...||| || |||.|.|      ... . |.||| |.          .|.. .||       ...| .| ....          ||.| . |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

HDATR--VYLILEYAP--------LG--TVYRELQ---KLSKFDEQRTATYITE-------LANALSYCHS-KRVIHRD-IKPENLLLGSAGELKIADFG
.| ..  .|...||.|         |    .  ||   |  .|||.|.  |. |       .. || | || . .|||| .||||.|| . | .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

WSVHAPSS----------------------------------------------------RRTTLCG--TLDYLPPEMIEGRMHDEKVDLWS--LGVLCY
 .   ...                                                    | .|.||  | .|..||..    ..  .| ||  ||.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EFLVGKPPFEANT----------YQETYKRIS--------RVEFTFP--------DFVTEGARDLISRLLKHNPSQRPM----------LREVLEHPWI
|.|.|.||| ...            |....|         .|.| ||        ..... |.|||..||. .|..|.             |. .||| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase AurA.AA S_TKc 133-383 34 1.8e-103 350.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 133-383
Range on HMM: 1-231/231
Sequence Identity: 34% (91 aa)

FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPL--GTVYRELQKLSK---
.||.|..||| || ||..|.| .. | |.|..            ..|||..| .. .|||| .||..|.| ...|...||..   |.... ..|  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE-KVDLWSLGVLCYEFL
   |.| ... |. ....|| ||||...||||.||||.|| .  ..||.||| . .      ||.|||..|..||..    ..  |.| ||.|.. ||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

VGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLE-------HPWI
.|.|||.  ..|...|.|           .. |.|.|...|. .|..||   |.|.       |||.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AurA.AA CAMK 138-383 20 2.9e-93 300.85 In-house 1-425 (425) Show / Hide 
Range on Protein: 138-383
Range on HMM: 1-425/425
Sequence Identity: 20% (86 aa)

PLGKGKFGNVYLAREKQSK------------FILALKVLFKAQLEK-------------------------AGVEHQLRREVEIQSH-------LRHPNI
 ||.| || |.|...|...               | |.. | .| .                         .  ....|||.|| ..       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRLYGYFHDAT-------------------RVYLIL---EYAPLG----TVYRELQKLSK---------------FDEQRTATYITELANALSYCHSKRV
..|| .. |..                   ..|...   ||.. |     ..  ... ..               |.|. ...|.  .. |. ||||. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENLLLGSA-----------------GELKIADFGWSVHAPSSR-------------------------RTTLCGTLDYLP-PEMIEG------
.|||.||||.|| .                  . .||.||| . . ...                           .| |||. | . ||...|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------RMHDEKVDLWSLGVLCYEFLVGKPPFEAN-------------TYQETYKRISRVEFTFPDF------------------------VTEGARD
        . ...|.| ||.||..|  |.|.|||..              ...|....| . ...||..                        |.. ..|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISRLLKHNPSQRPMLREVLEHPWI
||...|. .|..|. . ..|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AurA.AA CAMKL 133-383 31 3.1e-87 278.42 In-house 1-297 (297) Show / Hide 
Range on Protein: 133-383
Range on HMM: 1-297/297
Sequence Identity: 31% (93 aa)

FEIGRPLGKGKFGNVYLARE-KQSKFILALKVLFKAQLEKAGVEHQ------------LRREVEIQSHLR---HPNILRLYGYFHDATR------VYLIL
..||. |||| || | ||.  .  .   | |.. |  . .  . ..            .|||..|...|.   |||| .||  . . .       .||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAPLGT--VYRELQKL----SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAG--ELKIADFGWS-----V-HAPSSRRTTLCGTLDYL
||.. |    .  ..|      ...|  .  | . .  |..||||....||||||||.|| . |   .||.||| |     .   |    .| ||.. | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEMIEG--RMHD-EKVDLWSLGVLCYEFLVGKPPFEANTYQ-------ETYKRISRVEFTFP--DFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
.||...|  . .|  ||| ||.||. |  ..|. ||.. ||.       . |..| .  . .|   .|   .||||...|..||..|| . ....||| 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase AurA.AA Pkinase 133-383 31 6.8e-86 296.45 Pfam 1-293 (293) Show / Hide 
Range on Protein: 133-383
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR--EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLG----TVY-----RE
..|||..|.| || ||....| .  | |.|.. |   || ... ..||  |..|  .|.||||.|||..|.| ...|...||.. |      .     ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

LQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL----KIADFGWSV---HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLW
  ... |.|.    |..... .| ||||...||||.||||.|. . |..    ||.||| .    . ..|  ||.|||..|..|| |  |.... ||| |
HGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGVLCYEFLVGKPPFEAN------TYQETYKRISRVEFTFPDFVT---------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
|.|...||.| |.|||         . .. ..|| . .. |. . .                     | ..|.|...|. .|..||  ...|.|||.
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AurA.AA MARK 133-383 36 3.8e-84 274.94 In-house 1-262 (262) Show / Hide 
Range on Protein: 133-383
Range on HMM: 1-262/262
Sequence Identity: 36% (95 aa)

FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFH--DATR-VYLILEYAPLGTVYRELQKL--SK
..... .|.| .. |.||. | ..   |.|.. | .| .      ..||.|| ..| |||| .|. ..   . .. .|||.|||. | .|  ...    .
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAG--ELKIADFGWSVHA-PSSRRTTLCGTLDYLPPEMIEGRMHD-EKVDLWSLGVLCYEFL
  |  . .. . .  |..|||||...||||||||.|. . |    ||.|||.|..  | .. .| |||. | .||.....  |  ||| |||||. |  .
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

VGKPPFEANT--YQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
.|. ||.. |  | | ||.| | ....|..|  ..|.||.|||..||..|| . |...|||.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase AurA.AA PLK 133-383 35 8.3e-82 266.19 In-house 1-258 (258) Show / Hide 
Range on Protein: 133-383
Range on HMM: 1-258/258
Sequence Identity: 35% (92 aa)

FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL-SKFDEQ
.|.|..|||| |  .| ...  .| ..| ||  |. ..| .    ...|.||.. |.||||.... .| |.  ||. |||.. ..  . . .   .. | 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

RTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEGRM--HDEKVDLWSLGVLCYEFLVGKP
 .  |.. ....| | |..|.||||.|. ||.| .  ..||.||| .  .  .  |. |.|||  |  ||  .|    |. .|| ||||.  | .|.|||
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFEANTYQETYKRISRVEFTFPDF--VTEGARDLISRLLKHNPSQRPMLREVLEHPWI
|||... .||||||   ...||.   .   |.||| ..|. ||..|| . ..|.||. 
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase AurA.AA RSK 136-383 32 3.8e-80 272.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 136-383
Range on HMM: 1-278/278
Sequence Identity: 32% (91 aa)

GRPLGKGKFGNVYLAREK---QSKFILALKVLFKAQLEKAGV-EHQLRREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK---
 . ||.| .| |.| |..   ... | | ||| || . .. .     ..|..| .. . ||.| .|.  |.. . .|||.|| . |  .. |||      
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSVH-APS--SRRTTLCGTLDYLPPEMIE---GRM-HDEKVDLWSLGV
|.| . . |. |.. |... |.. .||||.|||| |. .    |..|. ||| .    ..  ..  | |.|..|..|||.    ..  ||. .|.|||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LCYEFLVGKPPFEA---NTYQETYKRISRVE--FTFP--DFVTEGARDLISRLLKHNPSQRPM-----LREVLEHPWI
| || |.|.||| .   |. .|. ||| . .  .|.|  ..... |.|||...|. .|..|.      . |...|||.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase AurA.AA CAMK-Unique 133-383 23 1.4e-74 245.53 In-house 1-363 (363) Show / Hide 
Range on Protein: 133-383
Range on HMM: 1-363/363
Sequence Identity: 23% (84 aa)

FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK-AQLEKAGVE----------------HQLRREVEIQSHLRHPNILRLYGY----FHDAT-------
 . .|..|.| || || .  .  . . | |.. | .. .|....                 .|.||..|   . ||||..||..    |.|..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------RVYLILEYAPLGTVYRELQK--------------------LSKFDE--QRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----
        . |...||.. |... ..||                      .| |    |......|. |..| ||. ..|||.|.||... . .      
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

-----------LKIADFGWSVHAPSSRRT----TLCGTLDYLPP--------------EMIEGRMHDEKV----DLWSLGVLCYEFLVGKPPFEANTYQ-
           .|..||| ..|  ...      | |||..|. |              |.|...  |...    |.|||||. |. |.|.|||....   
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------ETYKRISRVEF-TF-------PDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
       |....|.  .. .|       ||.....| |.. ....  |..|  . | |||.||
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase AurA.AA Ciliate-E2 133-383 24 2.4e-73 249.97 In-house 1-365 (365) Show / Hide 
Range on Protein: 133-383
Range on HMM: 1-365/365
Sequence Identity: 24% (91 aa)

FEIGRPLGKGKFGNVYLARE-----------------------KQSKFILALKVLFKAQLEKAGVEHQLRREVE----------IQSHLRHPNILRLYGY
... . .|.| || ||...                        |. ..| |.|.. | |.|    | .. ||..          |...| ||||...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FH--DATRVYLILEYAPLGTVYRELQKL-----------SKFDEQRTATYITELAN---------------ALSYCHSKR-VIHRDIKPENLLLGSAGEL
|   | . .||..||.  |. .  ...             .|.|.  .........               || |.|||  .|||||||||.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGWSVHAPSSRR---------------------------------TTLCGTLDYLPPEMIEGRM---------HDEKVDLWSLGVLCYEFLVGKPP
||.||| |  .  ..                                   |.|||. |..||...|           .|.|.|.|||||. ||.| ||||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEANTYQETYKRISRVEFTFPDF------------------VTEGARDLISR----LLKHNPSQRPM-LREVLEHPWI
|        .. |   .. || .                  ... . |||..    .|. .|..|.    ..|.|||.
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AurA.AA PLK-Unclassified 133-383 34 3.2e-70 239.58 In-house 1-264 (264) Show / Hide 
Range on Protein: 133-383
Range on HMM: 1-264/264
Sequence Identity: 34% (91 aa)

FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL-------
 ..|..|||| |  .|.. .  .| |.| |.  |. |.|      |  | .|.. | |.|| . .  | |   ||. ||| | ||.   . .        
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPS--SRRTTLCGTLDYLPPEMIEGRM--HDEKVDLWSLGVLCYE
 .  |  .  | . ...|| | |..|.|||| |. |..|..  |.||.||| ..      ... | |||  |  ||  .|.   |. .|| ||.|.  | 
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

FLVGKPPFEANTYQETYKRISRVEFTFPDFVT--EGARDLISRLLKHNPSQRPMLREVLEHPWI
.|.||||||..  . |||.|   .. ||. ..    |.||| . |. ||.||| . . ..||. 
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase AurA.AA Pkinase_Tyr 133-276 30 2.3e-21 73.01 Pfam 1-156 (270) Show / Hide 
Range on Protein: 133-276
Range on HMM: 1-156/270
Sequence Identity: 30% (48 aa)

FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEKAG-VEHQLRREVEIQSHL-RHPNILRLYGYFH-DATR--VYLILEYAPLGTVYRELQ
 ..|. ||.| ||.||... |    . |   | |.| | .  .       . ||..| ..| .||||.||||    .     .|...||.|.|  .  |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFG
|      ... ..   . .. |....| .||. ||||.   | |... .  ||.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase AurA.AA TyrKc 133-378 23 6.6e-17 50.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 133-378
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL--RHPNILRLYGYFHDA-------TRVYLILEYAPLGTVYRELQ
 . |. || | || ||... |       ..|  |   | |  .  ..|| .| ..|  .||||.||||.  .          .....||.|.|     |.
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KLSK-FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSS-------RRTTL----CGT----LDYLPPEMIEGRMHD
|  . .  .    . .  |.  .| |||..||||.   | |.|. .  ||.||| |    .           .     .|     .  ..|| |  ..  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EKVDLWSLGVLCYEFL-VGKPPFEA-----NTYQETYKRISRVEFTFPDFV---------TEGARDLISRLLKHNPSQRP---MLREVL
.| | || ||...| .  |..| .       . || .... . .   .            ..   .....  ...|..||    ..| .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AurA.AA Pkinase_Tyr 296-343 31 0.899233 3.24 Pfam 181-231 (270) Show / Hide 
Range on Protein: 296-343
Range on HMM: 181-231/270
Sequence Identity: 31% (16 aa)

LPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPP-FEANTYQETYKRI-SR
..|| |  .   .| | || |||..| .  |. | ..  . .| |..|  .
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED