Gene AlphaK1 (Human)

AlphaK1

Species: Human
Alias: ALPK3, KIAA1330, AlphaK1, MIDORI, MAK, FLJ21176
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 15q26,

Classification

Group: Atypical
Family: Alpha
Subfamily: Alpha-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
AlphaK1.kin_dom Protein Kinase Domain None 188 None Fasta, JSON
AlphaK1.AA Protein Sugen Kinome 1244 None Fasta, JSON
AlphaK1.NA RNA Sugen Kinome 5441 None Fasta, JSON

Protein domain

Protein domains of AlphaK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AlphaK1.AA Alpha-Unclassified 1021-1229 73 2e-178 586.73 In-house 1-215 (215) Show / Hide 
Range on Protein: 1021-1229
Range on HMM: 1-215/215
Sequence Identity: 73% (157 aa)

KSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILE
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||...|...|
KSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPPIFLIHRE

DKTIKGCISVEPYILGEFVKLSNNTK----VVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVF--TTNFGKRGI
||.||||||||||..|||||.||||.    .||.||.|..|...|.|..|...||.|.|.||||||..|.|.....||||||...|...  .||.|.|.|
DKNIKGCISVEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIRQRYQGFKTNCGMRFI

FYFFNNQHVECNEIC
.|.|||.||.||..|
DYWFNNHHVQCNHYC
Kinase AlphaK1.AA Alpha 1028-1229 32 6.2e-117 334.29 In-house 1-215 (215) Show / Hide 
Range on Protein: 1028-1229
Range on HMM: 1-215/215
Sequence Identity: 32% (72 aa)

QETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFT-DVERQMTAQHYVTEFNKRLYEQNI----------PTQIFYIPSTIL
|.|......|.......|.....|...|||.............. |..|||.. ||||||...|.|.|||.||.||..          |...|.......
QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSF-KYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYE

LILEDKTIKGCISVEPYILGEFVKLSNNTKVVK---TEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHS-----VDQKVFTTN
||..........|||.|..||..|..||...|.   ..........|..|.....||....||||| |    |.|...|||||||.     ...|....|
LIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQ-W----GVGEWKLTDPQIHCPAKLDQGMKFGDGN

FGKRGIFYFFNNQHVECNEIC
.|..|.|.||...||.||..|
CGYEGMFRFFYTHHVQCNHYC
Kinase AlphaK1.AA Alpha_kinase 1022-1229 29 3.3e-82 280.34 SMART 1-255 (255) Show / Hide 
Range on Protein: 1022-1229
Range on HMM: 1-255/255
Sequence Identity: 29% (77 aa)

SELWTAQETIVYLGDYLTVKKKGRQRNAFWVHH--------LHQEEILGRYVGKDYKEQKGLWHHFT--------DVERQMTAQHYVTEFNKRLYEQNI-
. .||.|||.|.. . ..   || .|...|..         .|..|.  .|..|.||..... ..|.        |||.||...|...|||. ..  |. 
DNKWTCQETCVKI-KEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQ-HNPC

PTQIFYIPSTILLIL------EDKTIKGC----------------ISVEPYILGEFVKLSNNTKVVKTEYKATE----------YGLAYGHFSYEFSNHR
| .|..||.......      .| .|...                ...||.. ||||| .||.  |... . |.          | .|..|..|| |||.
PKKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSNHQ

DVVVDLQGWVTGNGKGLIYLTDPQIHSVD---QKVFTTNFGKRGIFYFFNNQHVECNEIC
 .|.|.||....||. |.|.||||||. |   ..   .|.|..|| .||.. .  ||.||
MLVCDIQGVIHKNGD-LYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQ--CNQIC
Kinase AlphaK1.AA Alpha_kinase 1041-1229 30 5.6e-67 233.09 Pfam 1-225 (225) Show / Hide 
Range on Protein: 1041-1229
Range on HMM: 1-225/225
Sequence Identity: 30% (70 aa)

KKKGRQRNAFWVHHL--HQEEILGRYVGKDYKE----QKG------LWHHFTDVERQMTAQHYVTEFNKRLY-EQNIPTQIFYIPSTILLILEDKTI---
  .| .|..|... .  ....   ..| |.||.    ..        ...| |.. ||..|... .||..|. ..|.| .| .... |.. |||...   
FAQGAMRWCFRMFDTWDPNWRNNQNCVAKWYKKIKNYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHNKPDC

------------KGCISVEPYILG-EFVKLSNNTKVV----KTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKV---
            . ....|||| | |||| .||.  |    ... .. .|  |. ||.|..||.. .|.|.||... |.| ..||||||||..|..    
YQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGY-NNK-CYYLTDPQIHTKDGNYEMD

F---TTNFGKRGIFYFFNNQHVECNEIC
|   ..|.|..||..|| ||| .||.||
FDEGMGNLGQEGIEKFFQNQH-KCNHIC
Kinase AlphaK1.AA VWL 1129-1234 37 7.8e-16 43.76 In-house 106-206 (206) Show / Hide 
Range on Protein: 1129-1234
Range on HMM: 106-206/206
Sequence Identity: 37% (42 aa)

SVEPYILGEFVKLSNNTKVVKTEYKATEYGL---AYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQ-KVFTT-NFGKRGIFYFFNNQHV
.|| || |...|  ||   .       ||..   |  ||..  |     .||||    ||. |.  |||||||  || . |   | |  |.. ||   | 
FVENYIEGDYQKYNNNAGWCNQTDM--EYNQLSQAFSHFTWQYSQGYCMIVDLQ----GNEDGM--LTDPQIHCLDQSHKFGQGNLGYEGMLRFFMT-H-

ECNEICHRLSL
.||..| .| |
QCNKYCQKLQL
Kinase AlphaK1.AA VWL 1081-1101 47 0.063334 1.63 In-house 55-75 (206) Show / Hide 
Range on Protein: 1081-1101
Range on HMM: 55-75/206
Sequence Identity: 47% (10 aa)

DVERQMTAQHYVTEFNKRLYE
|.| |.  || | .|| |. |
DIESQFVCQHIVNCFNDRVSE