Gene ALK1 (Human)

ALK1

Species: Human
Alias: ACVRLK1, HHT, ORW2, ALK-1, ALK1, ACVRL1, HHT2, SKR3, TSR-I
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 12q12-q13,

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
ALK1.AA Protein Sugen Kinome 503 None Fasta, JSON
ALK1.kin_dom Protein Kinase Domain Sugen Kinome 288 None Fasta, JSON
ALK1.NA RNA Sugen Kinome 4263 None Fasta, JSON

Protein domain

Protein domains of ALK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp ALK1.AA Activin_recp 32-103 16 4e-14 48.33 Pfam 1-121 (121) Show / Hide 
Range on Protein: 32-103
Range on HMM: 1-121/121
Sequence Identity: 16% (20 aa)

VTCT-CESPH------CK--G-------PTCR-----------GAWCTVVLVREEGR--HPQEHR----GCGNLHR-------ELCRG----RPTE---F
..|  |. ..      |.           ||            ...|.| . . ...  ..|  |    ||  |..       . |..    ....   .
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

VNHYC-CD-SHLCNHNVSLVL
 ||.| |. ...||.|.. ..
HNHECWCCETDYCNRNLTPPP
Kinase ALK1.AA Type1 202-489 70 2.1e-268 736.48 In-house 1-290 (290) Show / Hide 
Range on Protein: 202-489
Range on HMM: 1-290/290
Sequence Identity: 70% (205 aa)

VALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALR
....||.||||||||||| |.||.||||||.||||.|||||||||.||..||.|||||||.||....|.|||||||.|||||||||.|.|.||... .||
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

LAVSAACGLAHLHVEIFGTQ--GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIW
||.|.||||||||.||||||  |||||||||.||.|..||.|.|||||||||||.|.| .|..|||.|||||||||||||||||.....||||||..||.
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

AFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTL
.||||.||||||..|.||||||..|.||.||||||||||.|||||....|.||||....|.....|..|.||||.||.||.|||||||||
SFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase ALK1.AA STKR 202-489 57 3.8e-211 688.28 In-house 1-312 (312) Show / Hide 
Range on Protein: 202-489
Range on HMM: 1-312/312
Sequence Identity: 57% (178 aa)

VALVECVGKGRYGEVWRGLWHG----ESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSR-NSSTQLWLITHYHEHGSLYDFLQRQTLEP
. |.||.|||||||||.| |.|    |.||||||.||||||||||||||.|...||.|||.|||.||... .| ||.||||.|||.|||.|.|.|.|. .
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

HLALRLAVSAACGLAHLHVEIF--GTQ--GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIG-------NNPRVGTKRYMAPEVLDEQI
| ..|.| |.|||||||| ||.  |||  .||||||||.||.|.|||....|||||.|||..|..... .||.       .|..|||||||||||||...
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

RTDCFES-YKWTDIWAFGLVLWEIARRTIVNG------IVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLA-ADPVLSGLAQMMRECWYPNPS
  .|||| .|..|..|.|||.||||||....|      ||..|..||||.|||.||||||.||||...| |.||||   ..|.. .....|.|||...|.
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARLTALRIKKTL
||||||..|||.
ARLTALCVKKTM
Kinase ALK1.AA TKL 208-489 26 9.40000000001e-106 357.64 In-house 1-364 (364) Show / Hide 
Range on Protein: 208-489
Range on HMM: 1-364/364
Sequence Identity: 26% (102 aa)

VGKGRYGEVWRGLWHG----------ESVAVKIFSSRD-------------------------EQSWFRETEIYNTVL---LRHDNILGFIASDMTSRN-
.|.|..|||..| |.|          . ||||.|.|..                         |.||||..|.. ...   |||.||. |..... ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------SSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIF--GTQGKPAIAHRDFKSRNVLVKSNLQ--------------C
        ...||.... |...|||...|.     .|. .|.| ..|.|...|| ...  .|  ||.|.||| ||.|.||..|..              |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

CIADLGLAVMHSQGSDYLDIG---------------NNPRVGTKRYMAPEVLDEQIRTDC----------FESYKWTDIWAFGLVLWEIARRTIVNGIVE
.|.|.||. ..|| ..  |..               .....||.|.||||||..|. ...          ||  . .|...||.|||||. | .      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------

DYR-PPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAA-------DPVLSGLAQMMRECWYPNPSARLTALRIKKTL
 |. .|.......|| ||.| ..||.... |.||..          .... .... | .|| ..|..|.....|.|.|
PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ALK1.AA Type2 202-489 39 2.3e-99 328.73 In-house 1-315 (315) Show / Hide 
Range on Protein: 202-489
Range on HMM: 1-315/315
Sequence Identity: 39% (125 aa)

VALVECVGKGRYGEVWRGLWHGE-----SVAVKIFSSRDEQSWFRETEIYNT-VLLRHDNILGFIASDM---TSRNSSTQLWLITHYHEHGSLYDFLQRQ
  | | .||||.|.||.. ||..      ||||||. .| |||  | .|| . ....|.||| ||...       .   ..||.| .|..|||.|.| . 
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

TLEPHLALRLAVSAACGLAHLHVEIF-GTQ---GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDY--------LDIGNNPRVGTKRYMAPEV
|.  | ..|.| |.| |||||| ||  ..|    ||.|||||.||.|||||... |||||.|||.  . |.           |  |   |||.|||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LDEQIR-TDCFESYKWTDIWAFGLVLWEIARRTIVNG---IVEDYRPPFYDVVPND-PSFEDMKKVVCVDQQTPTIPNRLAADPVLS-GLAQMMRECWYP
|.  .  .|| .. | .|. |.||||||.. |. . .    | .|..||   | .  ||||||. .|  . . |..|.   . | .  .|   . .||  
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

NPSARLTALRIKKTL
 . |||||. ..  .
DAEARLTAQCVQERM
Kinase ALK1.AA Pkinase 202-489 20 4.2e-62 217.44 Pfam 1-293 (293) Show / Hide 
Range on Protein: 202-489
Range on HMM: 1-293/293
Sequence Identity: 20% (67 aa)

VALVECVGKGRYGEVWRGLWHGES--VAVKIFSSRDEQSWFRET-----EIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHG----SLYDFLQ
  .....|.| .|.|... ..|..  |||||.. |.| ||...|     ||.    |.|.||. .. . ..    .. ..... |.|.|    .|.|...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---RQTL--EPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQC----CIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVL
   . ..  ... . . .   ..||...| .         | ||| |. |.|...| ..    .|.| |||  ..      .  .. ..|| .||||||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVI

DEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVL-----------------SGL
      .. .  .  |.|..|..|.| . .           |||.. . ....  |.....| . ..|.  ..   ...                  . .
R-----GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

AQMMRECWYPNPSARLTALRIKKT--L
 . .. |. ..|. |.||  |..   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ALK1.AA TK 202-408 16 1.2e-30 99.37 In-house 1-387 (486) Show / Hide 
Range on Protein: 202-408
Range on HMM: 1-387/486
Sequence Identity: 16% (64 aa)

VALVECVGKGRYG---EVWRGLWHG---------------------------ESVAVKIFS---SRDEQSWFR-----------------ETEIYNTVLL
. |..  |.| .|   ||..|.|.|                           . ||||.     . ...  |                  | .. .  |.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHDNILGFIASDMTSRNSS--------TQLWLITHYHEHGS----LYDFLQRQ-----------------------------------------------
.|.||. ...  . .....          ..... | .||.    | |.|..                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------TLEPHLALR-------------------LAVSAACGLAHLHVEIF-GTQGKPAI---AHRDFKSRNVLVKSNLQ-----------CCIAD
          .|  .  |.                    .. .|||...||   . .      |    |||   ||.|| .|..           | |||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEF------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIAD

LG--------LAVMHSQGSDYLDIGNNPRV-------------------GTKR---YMAPEVLDEQIRTDC---FESYKWTDIWAFGLVLWEI
 |        ||  . ...||   ..  .                    |.|    .||||.|.... . .         .|.|.|| ..|||
FGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase ALK1.AA MLK 202-408 24 4.2e-30 101.69 In-house 1-229 (291) Show / Hide 
Range on Protein: 202-408
Range on HMM: 1-229/291
Sequence Identity: 24% (62 aa)

VALVECVGKGRYGEVWRGLWHGES-----VAVKIFS-------SRDEQSWFRETEIYNTVLLRHDN----ILGFIASDMTSRNSSTQ-LWLITHYHEHGS
  . | .|.| .|.||.| |...      ||||..        . ....|  |.|..    |.| |    |  | .      ..... . ....| |.||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGV----CLQPPCHFCIVMEYCEGGS

LYDFLQRQT---------------LEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKS------NLQCCIADLGLAV-MHSQGSDYL
||..|  ..                 ...|.. |.  | |.. ||      . ...| ||| ||.|.|.        .... |.| |..  .|. . .  
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLH-----SMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-T--

DIGNNPR-VGTKRYMAPEVLDEQIRTDCFESYKWT---DIWAFGLVLWEI
   | .   || ..|||||.        |.. |..   |.| .|.||||.
---NMMSNAGTYAWMAPEVIQQ------FRCEKYSEKCDVWSWGVVLWEM
Kinase ALK1.AA TKL-Unique 204-489 27 3.5e-29 100.13 In-house 1-290 (290) Show / Hide 
Range on Protein: 204-489
Range on HMM: 1-290/290
Sequence Identity: 27% (86 aa)

LVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETE-IYNTV----LLR-HDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQ-------
 .. .| | ||.| .| |.|..||.|.|.   | | .....  .| |     |. |.||. ...  |    .  .. ... | ..||||| |.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----RQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSN-----LQCCIADLGLAVMHSQGSDYLDIGNN-----PRVGTKRYM
      .| . . ...|  .| |. .||     . ..| |.||| ||.|.|| .|     ..  |.| ||.   |. ..   ....      |.|. |.|
NNNNNCKLNMQQRVKMAIDIAQGMYYLH-----HCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APEVLDE---QIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCV--DQQTPTIPNRLAADPVLSGLAQMMREC
|||||     |. . .       |...|| |||||| |.|       |. |. ..     ..|  ...| .  . . |.|||..        .   ...|
APEVLRMNFCQYSEKS-------DVYSFGIVLWEIATRKI----TKTYKKPYQGM-----DQEQWCEMVHYMEENYRPPIPNHC-----PKEYRDLIQQC

WYPNPSARLTALRIKKTL
| ..|| | .   | . |
WHHDPSQRPSFDEIIHRL
Kinase ALK1.AA S_TKc 202-491 20 4.5e-26 93.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 202-491
Range on HMM: 1-231/231
Sequence Identity: 20% (62 aa)

VALVECVGKGRYGEVWRGLWHG--ESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEH--GSLYDFLQRQT----
  ... .||| .|.|... ...  . ||.|| .    ..  || .|      .|.||  .. .  .     . |.... | ..  |.|.|.....     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCF
   . .  | ...   .|.|...|        .  | ||| |  |.|. .  .  |.| |||              .  .||  |||||||         
RFPFPE-HARFYMYQICCALEYCH-------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------

ESYK--WTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK-
 .|     |.|..| .|.| . .          .|||.         . | |...                  . . ...| |.  .|. |.||  . . 
-GYGKCKCDWWSCGCILYEMLCG----------YPPFP-------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------TLQK
          
EWDIKCHPWF
Kinase ALK1.AA STE 202-482 18 4.1e-18 60.65 In-house 1-348 (359) Show / Hide 
Range on Protein: 202-482
Range on HMM: 1-348/359
Sequence Identity: 18% (68 aa)

VALVECVGKGRYGEVWRGLWH-----------------GESVAVKIFSSRDEQS---------------WFRE---TEIYNTVLLR--HDNILGFIASDM
  ..|..||| .|.| ... |                 || .|.|. . .....                 ..    ||     ..  |.||  .. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TSR--NSS-TQLWLITHYHEHGSLYDFLQR-----QTL-----------EPHLALRLAVSAACG-LAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQC
     ... ..||..  | . ||| |....     ..|           |. .| . ...   | |..||           | ||| |. |.|.     .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIA-YICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----V

CIADLGLAVMHSQGSD------------YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESY-KWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPN
 ..| |..   .. ..              .  .|  |||  .|||||.. . ..     |    ||| .|....| |          . .||. |  | 
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMA----------TGKPPWHDMHPM

DPSFEDMKKVVCVD---------QQTPTIPNRLA--------------ADPVLSGLAQMMRECWYPNPSARLTA
   |. ... ....         .. |..|..|                . . . . . .. |   .|. | ||
RAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA
Kinase ALK1.AA Frk 202-408 30 4.5e-17 55.41 In-house 1-195 (260) Show / Hide 
Range on Protein: 202-408
Range on HMM: 1-195/260
Sequence Identity: 30% (65 aa)

VALVECVGKGRYGEVWRGLWHGES-VAVKIF--SSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQ---RQTLE
. |.  .| |..|||| |||  .  ||||     . | . . ||  |     |||  ..   |           ...||   .|||| ..||   ..  .
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKK--LRHPKLIQLYAVCTV----EEPIYIITELMRHGSLQEYLQAINDKGRQ

PHLALRLAVSA--ACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAV-MHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFES
 ..   . ..|  | |.| |  . .         |||   |||||  .. | ||| |||  .  .  |  .   . |.  | . |||     .... | .
CQMQQLVDMAAQVAAGMAYLESQNY--------IHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIK-WTAPEA----ANYNKF-T

YKWTDIWAFGLVLWEI
 |  |.|.||..| ||
IK-SDVWSFGILLTEI
Kinase ALK1.AA UTK 202-408 24 6.2e-17 54.47 In-house 1-233 (296) Show / Hide 
Range on Protein: 202-408
Range on HMM: 1-233/296
Sequence Identity: 24% (62 aa)

VALVECVGKGRYGEVWRGLWHGES-------VAVKIFS----SRDEQS----WFRET-EIYNTVLLR-HDNILGFIASDMTSRNSSTQLWLITHYHEHGS
|.| .. |.|..||| .. .  .|       ||||  .    ...|.     . .|. |.     .. | |.|....  . .      ....| | | |.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP----WMIVTEYMENGD

LYDFLQ--RQTLE-------PHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSN-------LQCCIADLG---LAVMHS-------QG
| ..|.  |.|..        |  |  |.  |.|...||   |         |||   ||.|| ..       ..| |||.|   .. . .       ..
LRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF--------VHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYW

SDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWT---DIWAFGLVLWEI
..|.   .. .  . | ||||.|...         . |   |.|.|| |.|||
ESYYYMAQHQDRWPIRWMAPEALTHHT--------RFTTKSDVWSFGVVCWEI
GS ALK1.AA GS 172-202 61 7.6e-17 63.21 SMART 1-31 (31) Show / Hide 
Range on Protein: 172-202
Range on HMM: 1-31/31
Sequence Identity: 61% (19 aa)

SMLGDLLDSDCTTGSGSGLPFLVQRTVARQV
... |.....||.|||||||.|||||||||.
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
Kinase ALK1.AA TyrKc 202-489 24 8e-17 49.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 202-489
Range on HMM: 1-280/280
Sequence Identity: 24% (77 aa)

VALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLL--RHDNILGFIASDMTS-RN--SSTQLWLITHYHEHGSLYDFLQRQT--L
. | .  | | .|||..| |  . ||||   .  ..   || .|     |  .|.||. ...  ... ||  .. .|.... | .||.| |.|..    |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCK--LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

EPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQG------SDYLDIGN--NPR-VGTKRYMAPEVLDEQI
 .   |  .. .||| ..||           . |||   ||.||..|... |.| ||.  .  .      .|| .     . . .   | ||||..    
CMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

RTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADP-----VLSGLAQMMRECWYPNPSARL
.. .| .   .|.|.|| ..|||  .           .| .... .. | ... . |      |  || .   |       . . |.|..||  .|. | 
NYGKFTTK--SDVWSFGVCMWEIFTYG---------QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPEDRP

TALRIKKTL
|   |.. .
TFSEIHECF
TGF_beta_GS ALK1.AA TGF_beta_GS 172-200 58 3.1e-16 56.43 Pfam 1-29 (29) Show / Hide 
Range on Protein: 172-200
Range on HMM: 1-29/29
Sequence Identity: 58% (17 aa)

SMLGDLLDSDCTTGSGSGLPFLVQRTVAR
....|.....||.|||||||.|||||.||
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
Kinase ALK1.AA Pkinase_Tyr 202-314 23 2.5e-12 42.38 Pfam 1-128 (270) Show / Hide 
Range on Protein: 202-314
Range on HMM: 1-128/270
Sequence Identity: 23% (31 aa)

VALVECVGKGRYGEVWRGLWH------GESVAVKIF--SSRDE----QSWFRETEIYNTVLL-RHDNILGFIASDM-TSRNSSTQLWLITHYHEHGSLYD
. . .  |.| .|||..| |.      .  ||||.   .. .|    .. .|| .|  .  | .|.||. ...  .  .. .  |..... | .||.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQ--LGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLD

FLQRQ-----TLEPHLALRLAVSAACGLAHLH
.|...      | ..  |  ..  |.|...|.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase ALK1.AA Pkinase_Tyr 328-408 32 1.4e-08 29.7 Pfam 134-207 (270) Show / Hide 
Range on Protein: 328-408
Range on HMM: 134-207/270
Sequence Identity: 32% (27 aa)

HRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYL-DIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEI
|||   ||.||..|... |.| |||  . .  ||    . . .    . ||||.. . .    | .   .|.|.|| ..|||
HRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGK-LPIKWMAPECINYGK----FTTK--SDVWSFGVLMWEI
Kinase ALK1.AA UTK 464-489 19 7e-06 16.1 In-house 271-296 (296) Show / Hide 
Range on Protein: 464-489
Range on HMM: 271-296/296
Sequence Identity: 19% (5 aa)

LAQMMRECWYPNPSARLTALRIKKTL
. ..|..||...|. | .. .. ...
VYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ALK1.AA TK 464-489 26 0.000102 10.9 In-house 461-486 (486) Show / Hide 
Range on Protein: 464-489
Range on HMM: 461-486/486
Sequence Identity: 26% (7 aa)

LAQMMRECWYPNPSARLTALRIKKTL
....|..|| ..|. | |   ... |
YYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ALK1.AA Pkinase_Tyr 464-489 30 0.013191 9.45 Pfam 245-270 (270) Show / Hide 
Range on Protein: 464-489
Range on HMM: 245-270/270
Sequence Identity: 30% (8 aa)

LAQMMRECWYPNPSARLTALRIKKTL
. ..|..|| ..|. | |   |   |
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ALK1.AA MLK 463-479 29 0.286055 0.32 In-house 265-281 (291) Show / Hide 
Range on Protein: 463-479
Range on HMM: 265-281/291
Sequence Identity: 29% (5 aa)

GLAQMMRECWYPNPSAR
.....| .|| ..|. |
HWKKLMKQCWNQDPHKR