Gene AKT1 (Human)

AKT1

Species: Human
Alias: MGC99656, RAC, RAC-ALPHA, PRKBA, Akt, PKB, AKT1, c-Akt, PKBalpha
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 14q32,

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
AKT1.AA Protein Sugen Kinome 480 None Fasta, JSON
AKT1.kin_dom Protein Kinase Domain Sugen Kinome 259 None Fasta, JSON
AKT1.NA RNA Sugen Kinome 3008 None Fasta, JSON

Protein domain

Protein domains of AKT1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH AKT1.AA PH 6-108 31 4.8e-22 82.14 Pfam 1-92 (92) Show / Hide 
Range on Protein: 6-108
Range on HMM: 1-92/92
Sequence Identity: 31% (33 aa)

IVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERP-RPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQ
..|||||||.| ..|.|..|.| |.| .. . ||...      . |   ...  ||. |.... ||..| ||. ..    . .|. |..||...| .|||
VIKEGWLHKKG-KRKSWKKRWFVLFN-NCLYYYKDDK------YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR---RTYYFQAESEEEMNDWMQAIQ

TVAD
 .. 
SACR
PH AKT1.AA PH 6-110 24 2.4e-19 71.51 SMART 1-82 (82) Show / Hide 
Range on Protein: 6-110
Range on HMM: 1-82/82
Sequence Identity: 24% (26 aa)

IVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQT
..|||||.|..    .|..|.| |.| .... ||..        .|   ...  |.. . .     .| |.. ..    . .|. |..||..|| .||| 
VIKEGWLYKKS--K-RWKKRWFVLFN-DCLYYYKDK--------KPKGSIPLSDCTVRE-P-----CFEIHH-DR----TYYFQCESEEEMQEWMQAIQK

VADGL
... .
AIHNN
Kinase AKT1.AA Akt 150-408 62 3.7e-210 678.13 In-house 1-264 (264) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-264/264
Sequence Identity: 62% (165 aa)

FEYLKLLGKGTFGKVILVKEKATGRYY-AMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSED
|..||.||||.||||.|||.|.|...| |||.|||..|..|..|.||.||...||. .|||.. |.|||||.|.|.|||.|.||||||.||.|.|.||||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RARFYGAEIVSALDYLHSEKNVVYRD-LKLENLMLDKDGHIKITDFGLCKEG-IKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG-LGVVMYEMMCG
|||||.|||..|...||| ||..||| ||.||...||||||..||||||||. |||. ..|||||||||||||.|..|....|||||| ||.||||||||
RARFYCAEIILAIEHLHS-KNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

RLPFYNQDHEKLFELILMEEIRFP--RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF
|.|||||||...|..|......||  ... ||.|.|.||||.||||.|||||..||.||..| .|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase AKT1.AA AGC 150-408 37 1.9e-201 527.0 In-house 1-395 (395) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-395/395
Sequence Identity: 37% (150 aa)

FEYLKLLGKGTFGKVILVKEK------ATGRYYAMKILKKEV-IVAKD--EVAHTLTE------------NRVLQNSR----------HPFLTA-LKYSF
|| ||..|||.||||.||..|      .||.|||||.|||.. || |.  .|.||.||             ..|.. .          |||..  |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTHDR--LCFVMEYAN---------GG-ELFFHLS---RERVFSEDRARFYGAE-------IVSALDYLHSEKNVVYRD-LKLENLMLDKDGHIKITDFG
|. |.  |.|||||..         || |||.||    .|..|.|.||||| ||       ||.||.||||......|| ||.||..||.|||||.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEGIKDG--------------------------------------------------ATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWG--LGVVMY
|||||..||                                                  .. .||||  ||||.|||.|    ||.|.|||.  ||..||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMCGRLPFYNQ----------DHEKLFELIL------MEEIRFP----------RTLGPEAKSLLSGLLKKDPKQRLGGGSED-----AKEIMQHRFF
||..|. |||..          .....|..|.      .....||          | . ||||.|...||.|||..||| | .|     |.||..| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase AKT1.AA SGK 150-408 48 1.2e-157 490.77 In-house 1-283 (283) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-283/283
Sequence Identity: 48% (139 aa)

FEYLKLLGKGTFGKVILVKEKAT------------------GRYYAMKILKKEVIV-------AKDEVAHTLTEN-RVLQNSRHPFLTALKYSFQTHDRL
|..||..||| |||| .|| |..                  .  ||||.|.|. |.       .| |. |...|   .|.| .|||.  |.|.||| . |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED
 |||.|.||||.|.|| ||. |.||||||| ||||.||.|||| ....||||| ||..|| .||...|||||||||||.  | .||||||||||||||  
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHS-QDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSE-DAKEIMQHRFF
  ..|.|||| || |.|||| |  |||..... ... |. .....|.   ..|..|. |||.||||.||  |.  |. || .| ||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRL--GTKRDFMEIKNHPFF
Kinase AKT1.AA PKC 150-408 52 1.1e-143 468.7 In-house 1-262 (262) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-262/262
Sequence Identity: 52% (139 aa)

FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSED
|. || |||| ||||.|.. | | .|||.|.|||.||.  | |  |.|| ||| . ..|||||.|  .||| ||| ||||| ||| | ||  . | |.| 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP
.||||.|||..|| .|| ||...||||||.| .||..|||||.|||.|||.. .|.| .||||||.|.|||.|.  .|| .|||| .|| |||||.|. |
HARFYAAEIICALQFLH-EKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSP

FYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSED---AKEIMQHRFF
|  .| . ||. |.......||.|  ||.|...|...|.|..||| . ..   ...|..| ||
FHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase AKT1.AA RSK 153-408 43 2.2e-126 426.18 In-house 1-278 (278) Show / Hide 
Range on Protein: 153-408
Range on HMM: 1-278/278
Sequence Identity: 43% (121 aa)

LKLLGKGTFGKVILVKEK---ATGRYYAMKILKKEVIVAKDE-VAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV---
||.||.| .||| |....   .||..||||.||| .||...  ..||.|| ..|. .. |||.  |.|.||| . |  .||| .||||| ||..|.    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK---DGHIKITDFGLCKEG-IKDGATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLG
||||.|.|| ||||.|...||. . ...||||.|| ..|    .||||.||||.||.. ....  ..|||.| ||.|||.|     .. ...|.||| ||
FSEDEACFYMAEIVLAVEHLHQQG-IIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VVMYEMMCGRLPFYN---QDHEKLFELILMEE--IRFP--RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF
|.||||  |..||..   ........ |.  .   ..|   .| .|||.|....|..||..|||.| .||.|| || .|
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase AKT1.AA AktR 150-408 44 3.2e-123 415.66 In-house 1-268 (268) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-268/268
Sequence Identity: 44% (118 aa)

FEYLKLLGKGTFGKVILVKEK-ATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSE
|...|.||||.||||.||..|  ....||||..||. |. .    ||.||  ...  ..|||.  |.|.||| . | |.|||  |||||.||.... |||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK-EGIK-DGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMC
..|||| |.|. ||.|||.. |..||||| ||..||.|||.||||||| | .... .  . ..|||||||.|||..     ....|||| .|.. |||. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRLPFYNQDHEKLFELILMEE-IRFPRT--LGPEAKSLLS-GLLKKDPKQRLGGGSEDAKEIMQHRFF
|  |||..... .|..|. .. ..|| .  . ...|.|.  .||.|.|..||| ......||  | .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase AKT1.AA Eta 150-408 52 5.5e-120 404.91 In-house 1-261 (261) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-261/261
Sequence Identity: 52% (137 aa)

FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSED
|...| |||| ||||.| . | |.  ||.|.|||.||.  |.|  |.|| |.|    .|||||.|  .|||.||| ||||| |||.| |.. | | | | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP
||||| ||...|| .|| ...|.||||||.|..||..|| |. |||.||||| .| |  ||||||.|.|||.|.. .|| .|||| .||.|||||||. |
RARFYAAEVTCALMFLH-QHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPP

FYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGS--EDAKEIMQHRFF
|  .  . ||| || ... .|  |  || |.| . . | |..|||      . ..| || ||
FEADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase AKT1.AA PKA 150-408 45 1.4e-116 393.6 In-house 1-263 (263) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-263/263
Sequence Identity: 45% (121 aa)

FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA-LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSED
|| ...||.|.||.| |...| .|.|||||.|||. ||    | |...|...||| .|||.   ....||. . | .||||..|||.| .| ... ||..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RARFYGA-EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGR
 |.|| | .||.||.|||| .| .||||| ||...||.|||||||||  |. ..|  |. | ||||||||||..     .|..|||| ||.. |||. | 
HAKFYAASQIVLALEYLHS-QNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDD-RTW-TLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGY

LPFYNQ--DHEKLFELILMEEIRFPRTLGPEA---KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF
 |||.   |  ...| |.  .|.||| . . |   |.|.. || .|...|.|  ....  |  |..|
PPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase AKT1.AA Pkinase 150-408 32 9.60000000001e-113 385.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-293/293
Sequence Identity: 32% (99 aa)

FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL-TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGG----ELFFHLS--RE
.. .. .|.|.||.| . ..| ||. .|.||.||. .  . ...|.. .| ..... .||.   |...|...|....||||..||    .|| ..|  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RVF--SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI----KITDFGLCKEG-IKDGATMKTFCGTPEYLAPEVLE-DNDYGRAVDWWG
..|  ||. ..||  .|...|.|.|| .....||||.||...|..|||    ||.||||.|   .  .  |.||||||.|.||||.  ...||..||.|.
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVVMYEMMCGRLPFYNQ------DHEKLFELILMEEIRFPRTLG---------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF
.|...|||.|||.||...      |. .....|.. ...|..                        .|.|......|.||||.|..     |..|.|| .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase AKT1.AA Alpha 150-408 48 1.1e-112 380.68 In-house 1-259 (259) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-259/259
Sequence Identity: 48% (127 aa)

FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSED
| .|. |||| ||||.|   | |   || ||||| ||.  | |  |..| |||   .. |||...   ||| ||| ||||| ||| | .|. .   | | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP
 | || |||  .| .|| || ..|||||| | ||| .|||||.|||.|||.. ...| .||||||.|.|||.   . ||..||||  || .|||| |  |
HAVFYAAEIAIGLFFLH-EKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPP

FYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF
|   | . ||. |   .  .|. .  ||...  |.| | | .||| |... ..| .| ||
FDGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase AKT1.AA Delta 150-408 48 2.2e-112 379.68 In-house 1-259 (259) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-259/259
Sequence Identity: 48% (125 aa)

FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSED
| ..|.|||| ||||.|.  | . .|||.| |||.|..  |.|  |. | |||   ..||||. |  .|||.. | ||||| |||.| .|.   . |.| 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP
|||||..||...| .||. |...||||||.|..||.|||||| |||.||| .   .. .||||||.|.|||... . | ..||||  ||.||||. |  |
RARFYACEIICGLQFLHK-KGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSP

FYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF
|  .| ..||. |....  .||..  |||..|..|...||..|||     . .| || ||
FHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase AKT1.AA S_TKc 150-408 37 1e-109 371.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-231/231
Sequence Identity: 37% (102 aa)

FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANG--GELFFHLSRERV---
.| |...|||.|||| ....| |||..|.||.|           |.. | ..|.. .||..  |...||. |.|..||||..|  |.|| .. . .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR-AVDWWGLGVVMY
   |.| .|||| ..|..||.|.||  ....|||| ||..||.  ||||.||||...        .||||||.|.|||||    ||. ..||| .|...|
RFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDA--KEIMQHRFF
||.||. ||.  .....|..|.           ||||......|.|||..|..     .   .|..| .|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AKT1.AA S_TK_X 409-476 30 2.9e-22 81.22 SMART 1-79 (79) Show / Hide 
Range on Protein: 409-476
Range on HMM: 1-79/79
Sequence Identity: 30% (24 aa)

AGIVWQHVYE--KKLSPPFKPQVT----SETDTRYFDEEFTAQMITITPPDQDDSMECVDSER------RPHFPQFSYSA
.|| |...|   |.. |||||...    |.|||..||.||| . ..   ||.. ...... .       ...|..|.|..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase AKT1.AA TyrKc 150-408 21 1.1e-13 -1.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 150-408
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS--RHPFLTALKYSFQTH-------DRLCFVMEYANGGELFFHLS
 . .| || | ||.| . . |   .  | | ||..       ..  . | |.. .   .|| . .|     ..       . |. ||||. .| |  .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RERV-FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD-------GATMKTF--CGTP----EYLAPEVLEDNDY
. |  .. .    .   | .  .||||  |.. |||   | ........||.||||....  |          .|.   .|        .|||.. .. .
KHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GRAVDWWGLGVVMYEMM-CGRLPFYN-----QDHEKLFELILMEEIRFPRTL---------GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF
  . | |  ||.|.|..  |  | ..      . . ..|..   . . .             .|  .. .   . ||..|        .||  |..|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HECF
Kinase AKT1.AA Pkinase_C 428-478 35 2.2e-12 46.86 Pfam 1-46 (46) Show / Hide 
Range on Protein: 428-478
Range on HMM: 1-46/46
Sequence Identity: 35% (18 aa)

QVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASG
||.|.|||..||.||| .  . ||||.. ...  ..    .| .|.|... 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQE----PFRGFTYVNPD
Kinase AKT1.AA Pkinase_Tyr 150-361 23 2e-10 35.92 Pfam 1-228 (270) Show / Hide 
Range on Protein: 150-361
Range on HMM: 1-228/270
Sequence Identity: 23% (56 aa)

FEYLKLLGKGTFGKVILVKEKATGRYY----------AMKILKKEVIVAKDE--VAHTLTENRVLQNS-RHPFLTALKYSFQ-THDR--LCFVMEYANGG
 . .| ||.| ||.| .      |...          | |.| ||    ...   .  . | ... .  .|| .  |        .   .. ||||. .|
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG

ELFFHLSR----ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT--MKTFCGTP-EYLAPEVLEDNDY
 |  .| .    .. ..  .   . ..| ....||.| || . |||   | ........||.||||..   .|.    ... .  |   .|||.. .. .
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES-KNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKF

GRAVDWWGLGVVMYEMMC-GRLP-FYNQDHEKLFELI
  . | |  ||.|.|..  |. | ... . | ..|.|
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI