Gene ACTR2B (Human)

ACTR2B

Species: Human
Alias: ACVR2B, hActR-IIB, ACTR2B, Hs.23994, ACTR-IIB, MGC116908
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 3p21-p22,

Classification

Group: TKL
Family: STKR
Subfamily: STKR2

Sequence

Name Sequence Type Origin Length Description Download
ACTR2B.AA Protein Sugen Kinome 512 None Fasta, JSON
ACTR2B.kin_dom Protein Kinase Domain Sugen Kinome 289 None Fasta, JSON
ACTR2B.NA RNA Sugen Kinome 11373 None Fasta, JSON

Protein domain

Protein domains of ACTR2B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp ACTR2B.AA Activin_recp 27-117 22 1.4e-23 79.89 Pfam 1-121 (121) Show / Hide 
Range on Protein: 27-117
Range on HMM: 1-121/121
Sequence Identity: 22% (27 aa)

RECIYYNANW------EL--ERTNQSGLERCEGEQDK------RLHCYASWRNSSGT--IELVKK----GCWLDDFNCYDR--QECVA----TEEN---P
..|...| .|          | ..... . || . ||        .||.||.....   .|....    ||| .. ||...  ..|..    ....   .
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

QVYFC-CCEGNFCNERFTHLP
.. .| |||...||  .|..|
HNHECWCCETDYCNRNLTPPP
Kinase ACTR2B.AA Type2 190-478 60 1.5e-217 725.19 In-house 1-315 (315) Show / Hide 
Range on Protein: 190-478
Range on HMM: 1-315/315
Sequence Identity: 60% (191 aa)

LQLLEIKARGRFGCVWKAQLMND-----FVAVKIFPLQDKQSWQSEREIFSTP-GMKHENLLQFIAAEKR---GSNLEVELWLITAFHDKGSLTDYLKGN
.||.|....||||||||||..|.     .||||||| ||||||| |..|.|.| .|.|||.||||.||||   . ....|.||.|.||.||||.|||| .
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

IITWNELCHVAETMSRGLSYLHEDVP-WCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPP--------GDTH--GQVGTRRYMAPEV
.|.|.|.|..|..| |||..|||... ||....|||.|||||.||||||.|.|.|...||||||.||.|||.|        ||||  |||||||||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LEGAINFQ--RDAFLRIDMYAMGLVLWELVSRCKAAD--GPVDEYMLPFEEEIGQH-PSLEELQEVVVHKKMRPTIKDHWLKHPGLA-QLCVTIEECWDH
||||.|||  ||||...|||||||||||.||||....  ..|.||..|||||.||| ||.|..||.||.|..||...|||..|||.. .|| |||.||||
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

DAEARLSAGCVEERV
||||||.|.||.||.
DAEARLTAQCVQERM
Kinase ACTR2B.AA STKR 190-478 48 9.3e-197 641.06 In-house 1-312 (312) Show / Hide 
Range on Protein: 190-478
Range on HMM: 1-312/312
Sequence Identity: 48% (151 aa)

LQLLEIKARGRFGCVWKAQLMN----DFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGS-NLEVELWLITAFHDKGSLTDYLKGNIITW
.||.|....||.|.|||.....    . ||||||| .|.|||. |.||..||.|.|||.||||||....  ......||||..| .||| |||| ..|.|
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

NELCHVAETMSRGLSYLHEDVP-WCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHG---------QVGTRRYMAPEVLEGAI
.|.|. |..| .||..||.... |. ...|||.|||||.||||.|.|.|.|...||||||.|..|.....|.|.         ||||.||||||||.||.
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

NFQ--RDAFLRIDMYAMGLVLWELVSRCKAAD-----GPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWL-KHPGLAQLCVTIEECWDHDAE
|||  ..||.|.||||||||.||...||....     ..|.||..||......|||.|..|.||..|..||.|...|. .||.....| |.|||||||.|
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARLSAGCVEERV
|||.| ||....
ARLTALCVKKTM
Kinase ACTR2B.AA Type1 190-471 38 1.9e-118 322.38 In-house 1-283 (290) Show / Hide 
Range on Protein: 190-471
Range on HMM: 1-283/290
Sequence Identity: 38% (109 aa)

LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCH
.|..|.  .||.| ||...   . ||||||   | .||  |.||..|  |.||| |.||||  ....   .||||| .| .||| |||. .... .... 
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

VAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPG--KPPGDTHGQVGTRRYMAPEVLEGAINFQR-DAFLRIDM
 | ..  || .|| ..  .  |  || |||||.||||.. |.... . ||.|||||..    . .  .  .|||.||||||||.  .|..  ... . |.
LAYSCACGLAHLHMEI-FGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADI

YAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA
|..|||.||   ||.  .  |..| ||. . . . || |. ..||  .|.||.|   | .|| ....    .||| . ..||..|
YSFGLVMWEIARRCEVGG-IVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTA
Kinase ACTR2B.AA TKL 196-478 25 3e-90 306.15 In-house 1-364 (364) Show / Hide 
Range on Protein: 196-478
Range on HMM: 1-364/364
Sequence Identity: 25% (96 aa)

KARGRFGCVWKAQLMN----------DFVAVKIFPLQD-------------------------KQSWQSEREIFSTPGMK---HENLLQFIAAEKRGSN-
  .|.||.|.|.....            ||||.|. ..                         ..||  ..|.. .  |.   |.|..||... ..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------LEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVP-WCRGEGHKPSIAHRDFKSKNVLLKSDLT-------------
         . .|.... ....||| .||      |. .|. |  ..||..||| . | ||.    || |.||| ||||.|.....|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT----KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-AVLADFGLAVRFEPGKPPGD-----------------THGQVGTRRYMAPEVLEGAINFQ-----------RDAFLRIDMYAMGLVLWELVSRCKAADG
 . ..||||. .... .   |                 |. |.|| |.||||||.|..|..           .... ..|.|..|.||||...||.    
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

PVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLK-------HPGLAQLCVTIEECWDHDAEARLSAGCVEERV
   .| .|....|.|.| .|| ...|..|..||.|...|.        .. . ...  ...|||||.|.|.|. .. .| 
--PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ACTR2B.AA Pkinase 190-478 19 1e-61 216.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 190-478
Range on HMM: 1-293/293
Sequence Identity: 19% (64 aa)

LQLLEIKARGRFGCVWKAQLMNDF--VAVKIFPLQDKQSWQSER-----EIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKG----SLTDYLK
......  .| ||||.|..  ..   |||||...... ||. ..     ||     ..|.| .... .  .    . ...... ....|    .| ||..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---GNII--TWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTA----VLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEV
   .. .  ...|.....  . ||| |.|.            .| ||| |. |.|.... .      ..|||||  |.   . . ... .||..||||||
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM-----------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV

LEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGL-----------------AQ
    |.....   ..||...|..|.|....            .|| ... .|..  . ..... ....|.  | . ....                    
----IRGGQYYGPKVDMWSCGCILYEMLCGR-----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE

LCVTIEECWDHDAEARLSAGCVEER--V
..  |. |.. | . |..| .. .   .
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ACTR2B.AA MLK 190-399 23 4.8e-24 80.38 In-house 1-232 (291) Show / Hide 
Range on Protein: 190-399
Range on HMM: 1-232/291
Sequence Identity: 23% (58 aa)

LQLLEIKARGRFGCVWKAQLMNDF-----VAVKIFP-------LQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLE-VELWLITAFHDKGSLTDY
.|..|.   | || |||..  |       ||||..          . ..|. |.|.     ..|.|    | . . ... .  .. ... . ..||| ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LKGN---------------IITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKS------DLTAVLADFGLAVRFEPGKPPGDT
|.|.               ...   .   |  ..||..|||.. |        . | ||| ||.|.|.        ..|.. .|||..  .        .
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAP--------KPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWH-------Q

H-----GQVGTRRYMAPEVLEGAINFQRDAFLRI-DMYAMGLVLWELVSR
.     .. || ..|||||..    |. . . .  |..  |.||||...|
MCTNMMSNAGTYAWMAPEVIQQ---FRCEKYSEKCDVWSWGVVLWEMLTR
Kinase ACTR2B.AA S_TKc 190-480 19 4.3e-23 83.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 190-480
Range on HMM: 1-231/231
Sequence Identity: 19% (59 aa)

LQLLEIKARGRFGCVWKAQLMN--DFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDK--GSLTDYLKGNI----
 ..|..  .| ||.|.|..  .    ||.|| .    .. ..|..| .    .|.|. ... .         .|.... . |   |.| ||.| .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQR
   ..  . ....  . ..| |.|.          .  | ||| |  |.|| .  .  ..||||| ..         . ..||. |||||||        
RFPFPE-HARFYMYQICCALEYCHS----------H-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL-------G

DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEE--
  . ..|... | .|.|.....   .                       |. .. ||..              ...  |. |.. | | |..|  . .  
YGKCKCDWWSCGCILYEMLCGYPPFP-----------------------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----RVSL
        .
WDIKCHPWF
Kinase ACTR2B.AA STE 190-372 19 6.1e-19 63.61 In-house 1-236 (359) Show / Hide 
Range on Protein: 190-372
Range on HMM: 1-236/359
Sequence Identity: 19% (50 aa)

LQLLEIKARGRFGCVWKAQLM-----------------NDFVAVKIFPLQDKQS---------------WQSE---REIFSTPGMK--HENLLQFIAAEK
....|.  .| || | ||  .                 ....|.|. .|.....                . .   .||     ..  |.|  ... .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

RGSNL---EVELWLITAFHDKGSLTDYLKGNIIT---------------WNELCHVAETMSRG-LSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDL
....    . |||..  . | |||.| .| . ..                .......    .| |.|||.         |.  | ||| |. |.||    
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS---------HH--IIHRDIKPANILL----

TAVLADFGLAVRFEP---GKPPGD--------THG-----QVGTRRYMAPEVLEG
 . |.|||.. ....   ..            | .      |||  .|||||...
-VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQ
Kinase ACTR2B.AA LRRK 313-468 30 7e-15 49.06 In-house 183-339 (351) Show / Hide 
Range on Protein: 313-468
Range on HMM: 183-339/351
Sequence Identity: 30% (54 aa)

HKPSIAHRDFKSKNVLL-KS-----------DLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLE--GAINFQRDAFLRIDMYAMGLVLWELVS
|.|.| ||| || |.|| .|           . .| .||||.   |    ..| . | ||. ..||||..   | ...       .|.|. |..||||..
HNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTE----KVDCYSFGMILWELLT

RCKAADGPVDEYMLPFEE-EIGQHPSLEELQEVVVHKKMRPTIKDHWLKHP-----GLAQLCVTIEECWDHDAEAR
|            .||.| .   | ...|..|  . .. ||||. |   .|      . .|   |..||.|| . |
RQ----------HHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQH-YCPPCQPWHMYQDL---IQHCWQHDPKKR
Kinase ACTR2B.AA TK 190-371 12 1.9e-14 44.09 In-house 1-358 (486) Show / Hide 
Range on Protein: 190-371
Range on HMM: 1-358/486
Sequence Identity: 12% (45 aa)

LQLLEIKARGRFG---CVWKAQLMND---------------------------FVAVKIFPL--QDKQSWQSE-------------REIFSTPGMK----
..|..   .| ||    |.|... ..                            ||||.  .   . |  . .             .|      |.    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HENLLQFIA-AEKRGSN-------LEVELWLITAFHDKGS----LTDYLKGN-----------------------------------------------
 |.|......   . ...       ..  ..... . ..|.    | |||. .                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------IITWNELCHVAETMSRGLSYLHED---VPWCRGEGHKPSIAHRDFKSKNVLLKSDLT-----------AV
                              ..|  .|.  .   ..|..|||.              . . |||    |.|. ....           . 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF--------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

LADFGLAV-------RFEPGKPPGDTHGQVGTRR-------------------------YMAPEVLE
.|||||.        |  . .    .... ||.|                         .||||.|.
IADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLN
Kinase ACTR2B.AA C8 313-393 31 5.9e-14 44.92 In-house 140-226 (226) Show / Hide 
Range on Protein: 313-393
Range on HMM: 140-226/226
Sequence Identity: 31% (27 aa)

HKPSIAHRDFKSKNVLLKSDLTAV----LADFGLAVRFEPGKPPGDTHGQ--VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVL
|   | ||| | .| |.. | . .    |.|||.|   .  |    ..    .||  |.|||....  |  ..   . |.. .||||
HCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase ACTR2B.AA CAMK 317-372 26 4e-13 37.93 In-house 200-294 (425) Show / Hide 
Range on Protein: 317-372
Range on HMM: 200-294/425
Sequence Identity: 26% (25 aa)

IAHRDFKSKNVLLKSD-----------------LTAVLADFGLAVRFEPGKPPG---------------------DTHGQVGTRRYMA-PEVLEG
|.||| |  |.|| ..                  .  ..|||.| .|.||.                          . ..||  ||| ||||.|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG
Kinase ACTR2B.AA TyrKc 190-478 19 2.7e-12 -23.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 190-478
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLE-------VELWLITAFHDKGSLTDYLKGNI-
..|...  .| || |.|...    ||||      ..   .| .| .  | .|.|.......       .         |.... . ..|.| |||. .  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGV----CTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-ITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPG------KPPGDTHGQVGTR-----RYMAPEV
 ... .|.. .   ..| .|||.             . |||    |.|.....|.  .||||.   . .      |   .. .  |..     | ||||.
KLCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LEGAINFQRDAFLRI-----DMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHP-----GLAQLCVTIEE
.          . ..     | .. | ..||. ...          . | ...| |  | .|. | | . ...|  ...    |       . .   ...
I----------NYGKFTTKSDVWSFGVCMWEIFTYG----------QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQ

CWDHDAEARLSAGCVEERV
||..|.| | .   . |. 
CWHEDPEDRPTFSEIHECF
Kinase ACTR2B.AA Pkinase_Tyr 190-303 18 6.7e-07 24.0 Pfam 1-129 (270) Show / Hide 
Range on Protein: 190-303
Range on HMM: 1-129/270
Sequence Identity: 18% (25 aa)

LQLLEIKARGRFGCVWKAQLM------NDFVAVKIF----PLQD--KQSWQSEREIFSTPGM-KHENLLQFIAAEK-RGS-NLEVELWLITAFHDKGSLT
.....   .| || |.|. .       .  ||||.       ..  ...  .| .| ..  . .|.|.......   .|  |   ...... .  .|.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQ--LGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLL

DYLKGN-----IITWNELCHVAETMSRGLSYLHE
|||. .      .|  .|.. .   ..|..||..
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase ACTR2B.AA CAMK 195-250 15 0.006032 4.53 In-house 1-106 (425) Show / Hide 
Range on Protein: 195-250
Range on HMM: 1-106/425
Sequence Identity: 15% (16 aa)

IKARGRFGCVWKAQLM-NDF-------------VAVKIFP-------------------------------LQDKQSWQSEREIFST---PG--MKHENL
.  ||.|| | ...   .               ||.|| .                                .|... ..| || ..    |  ..|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LQFIAA
.... .
IKLYEV
Kinase ACTR2B.AA Pkinase_Tyr 319-343 40 0.042188 7.74 Pfam 134-158 (270) Show / Hide 
Range on Protein: 319-343
Range on HMM: 134-158/270
Sequence Identity: 40% (10 aa)

HRDFKSKNVLLKSDLTAVLADFGLA
|||   .|.|.......  .|||||
HRDLAARNCLVTENNVVKICDFGLA