Gene AAK1 (Human)

AAK1

Species: Human
Alias: KIAA1048, AAK1, MGC138170
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 2p12-p13.3,

Classification

Group: Other
Family: NAK
Subfamily: BIKE

Sequence

Name Sequence Type Origin Length Description Download
AAK1.AA Protein Sugen Kinome 961 None Fasta, JSON
AAK1.kin_dom Protein Kinase Domain Sugen Kinome 265 None Fasta, JSON
AAK1.NA RNA Sugen Kinome 5210 None Fasta, JSON

Protein domain

Protein domains of AAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AAK1.AA BIKE 46-310 76 1.1e-216 726.19 In-house 1-267 (267) Show / Hide 
Range on Protein: 46-310
Range on HMM: 1-267/267
Sequence Identity: 76% (206 aa)

VTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG
|||.|.|||||||.|||||...|.|||||||.|||||||.||.||.|||...|||||||||.|..||... ..|||..|||..||. ||||.||||||.|
VTVEEQLAEGGFAMVFLVRDHKGNKCALKRMYVNNEHDLNVCCREHQIMKQCSGHKNIVGYVDCYINCIG-NGVWECMILMEYCRH-QVVNMMNQRLQQG

--FTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRG--HYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITT
  |||.||||||||.||||.|||.|.|||||||||||||||||.|  ||||||||||||||.|||..|||.|.|||.||||..||||||..|||||.|||
QYFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQKHGVNYVKDEIEKYTTMCYRAPEMIDLYSGKEITT

KADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYF
|||||||||.|||||.|.|||||||.|||||||||||||.||..||||||||||||..|||||||||..
KADIWALGCMLYKLCFFCLPFGESQLAICDGNFTIPDNSKYSREMHCLIRYMLEPDMEKRPDIYQVSHV
Kinase AAK1.AA NAK 46-311 52 3.9e-177 594.76 In-house 1-299 (299) Show / Hide 
Range on Protein: 46-311
Range on HMM: 1-299/299
Sequence Identity: 52% (156 aa)

VTVDEVLAEGGFAIVFLVR----------TSNGMKCALKRMFVN-NEHDLQVCKREIQIMRDLSGHKNIVGYIDSSIN-NVSSGDVWEVLILMDFCRGGQ
.|| ..||||||..|.||.          .||| |.|||||... .|.||..|||||..|. |..|.|||.||||.|| ...| ..|||..|| .|..|.
YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGS

VVNLMNQRLQ-TG--FTENEVLQIFCDTCEAVARLHQCKT--PIIHRDLKVENILL---HDRGHYVLCDFGSATNKFQNPQT-EGVNA---VEDEIKKYT
...|||.||. .|  ||| |.||||||.||.|...|||..  ||||||.|.|||||   |. |.|.||||||.|... .|..  ....   |.|.|.|||
LWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYT

TLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFG-------ESQVAICDGNFT--IPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFS
|..||||||..|||...|..|.|||||||.|||.|..|.||.       .|..||..||..  |||||||||.||.||||||.|||..||.||||... 
TPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase AAK1.AA NAK-Unclassified 46-307 29 1.9e-106 359.94 In-house 1-399 (405) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-399/405
Sequence Identity: 29% (118 aa)

VTVDEVLAEGGFAIVFLVR---------------TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSIN-NVSSGDVWEVLILMDFC
.|.   ||||||. |.||.                ||. . .||||..  |  |   |||| .|. . .|.||| |||..|.  . . .  ||..|| .|
YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREIDVMKRFRNHPNIVKYIDHHIMRENHNNQSYEVFMLMEYC

RGGQVVNLMN------QRL--QTGFTENEVLQIFCDTCEAVARLHQCKT--------------------------------------------PIIHRDL
 .| .. .||      |||  || |.| |.|||. |.|.... .||                                               |.||||.
SRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLIHRDI

KVENILLH---------------------------------------------------------DRG-HYVLCDFGSATNKFQNPQTEG-VNAVEDEIK
|.||.|.                                                          . .  |.||||||..  .  . .    . ..|.| 
KIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIENRQEMQYLQDWIN

KYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFG-ESQVA-------ICD--GNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV
..||. ||||||..||.. .|  | |||||||.|||.|..| ||  . | .       |    |....|.|..|| . | ||. || .||. || ||||
MHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEFPSNHNYSNQLHNLIKIMLNEDPIQRPNIYQV
Kinase AAK1.AA GAK 48-310 39 4.9e-69 228.54 In-house 3-277 (277) Show / Hide 
Range on Protein: 48-310
Range on HMM: 3-277/277
Sequence Identity: 39% (110 aa)

VDEVLAEGGFAIVFLVRTSN-GMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNV--SSGDVWEVLILMDFCRGGQVVNLMN-QRLQ
|  |.|||||| |..      |   |||||  . .   .    || .|  |.|| |||  .|.|      |   . | |.|| .| ..| | ..     .
VRCVIAEGGFAFVYVAQDVQTGREYALKRMLSHDMQANRAIINEICMMKKLQGHENIVQFCDASYISREESNQSQAEYLLLMEYCKFSQLVDCLKRMECY

TGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQT----EGVNAVEDEIKKYTTLSYRAPEMVNLYSGKII
  |    || ||  .| ||. .|  | ||||||.|.|| |.   .   |||||||| |   |          .||||. ..||  || |||. |||   |
KPFSCDCVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNWPI

TTKADIWALGCLLYKLCYFTLPF-GESQVAICDGNFT--IPD-NSRYSQDMHCLIRYMLEPDPDKRPDIYQV-SYF
  | ||||.||.|| .||   ||   .  .|  || .  ||    .|.   | ||| .| ..|| |.|| .|  | 
GHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNYMKPIPPQDNQYMC-FHDLIRACLQVNPDERLDIAMVVEYM
Kinase AAK1.AA S_TKc 46-313 24 1.3e-47 165.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-313
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

VTVDEVLAEGGFAIVFLVRTSN-GMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRG--GQVVNLMNQRL
 .. ... .|.|. |...|  . | ..|.|..        .  .|||||..   .|.||| ..|.  .        .. . |..| |  | .  .. .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRG

Q----TGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKI
      .|.| ..  ... .|.|.. .|.    ||||||| ||||| .  |  .||||.|.                      |. |.|||..       
RHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL------G

ITT-KADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSY-------FSFK
 .. |.|.|..||.|| ...   ||   . .. .           |...  .|| .|. ||.||| . ..           . 
YGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AAK1.AA CAMK 51-307 18 3.9e-40 126.54 In-house 1-419 (425) Show / Hide 
Range on Protein: 51-307
Range on HMM: 1-419/425
Sequence Identity: 18% (79 aa)

VLAEGGFAIVFLVRTS-NG------------MKCALKRMFVN----------------------------NEHDLQVCKREIQIMRDLSG------HKNI
.| .|.|..|.|..   ..             |.| | .  .                            ...|..  .|||.||. |.|      |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGYIDSSINNV---------SSGD--VWE----VLILM---DFCRGG----QVVNLMNQRLQ-------------TGFTENEVLQIFCDTCEAVARLHQC
.  ..   ..          .  .  . .    . . |   ..| ||     . .   .. .               ||| |. ..|   |.||. .|..
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

KTPIIHRDLKVENILLHDR-----------------GHYVLCDFGSATNKFQ------NPQTEGVNAVEDE-----------IKKYTTLSYRA-PEMVNL
.  |.||||| ||||| |.                 .   ..||| |. ...      ..  .| . . ..                |..| | ||..| 
N--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

YS-----------GKIITTKADIWALGCLLYKLCYFTLPFGESQV------------------AICDGNFT-IPD----------------------NSR
 .            . .. |.|.|..|..|| .   ..|| ..                     |. |... .|.                      .  
KGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-F

YSQDMHCLIRYMLEPDPDKRPDIYQV
 ||.  .||| ||..||.||. | |.
VSQECKDLIRKMLQVDPEKRMTIEQC
Kinase AAK1.AA Ciliate-E2 46-307 18 1.5e-36 123.02 In-house 1-359 (365) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-359/365
Sequence Identity: 18% (72 aa)

VTVDEVLAEGGFAIVFLVRT-SNGM------------------KCALKR--MFVNNEHDLQVCKREIQIMR---------------DLSGHKNIVGYIDS
  . ... .|.|..|....  ...                   |.. |   | .... ...  |.||.|||                .  |.||. ..  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY--

SINNVSSGDVWE------VLILMDFCRGGQVVNLMNQR-LQT--------GFTENEVLQIFCDTCE---------------AVARLHQCKTPIIHRDLKV
        ....      . . |..| ||    ..... ..          |||.|...|.   ..               |.  ||. .  |||||.| 
--------ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKP

ENILLHDRGHYVLCDFGSAT-NKFQNPQTEGVNAVEDEIKKYT------------------------TLSYRAPEMVNLYS------GKIITTKADIWAL
||||.       ..||| .. .. .| .. . .    ...                           |. | |||..|  .      .|  ..|.|||.|
ENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

GCLLYKLCYFTLPFGESQVAICDGNFTIP----------------DNSRYSQDMHCLIRY----MLEPDPDKRPD-IYQV
|..|| ...  .||   |  |..... .|                ..   ||..  ||.     ||. ||.||.. . |.
GVILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase AAK1.AA Pkinase 46-310 22 7.1e-36 127.92 Pfam 1-293 (293) Show / Hide 
Range on Protein: 46-310
Range on HMM: 1-293/293
Sequence Identity: 22% (71 aa)

VTVDEVLAEGGFAIVFLVRTSNGMK-CALKRMFVNNEHDLQVCK----REIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGG----QVVN
 .. ... .|.|. |.. .  .  |  |.|.. . .|.. .       .|||||. | .|.||| ..|.  .   .....   . |..|.||        
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---KDHIY---MVMEYCEGGLYVMDLFD

LMNQRLQTGF--TENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHY----VLCDFGSATNKFQNPQTEGVNAVEDEIKKYT----TLSYR
..  . ...|  .|.|.  ..  ...... .|..   ||||||| ||||....||      .||||.|  .            .     .|    |. |.
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------Y-NNS-MTTFCGTPWYM

APEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES---------QVAICDGNFTIPDNSRYS---------------------QDMHCLIRYMLEP
||| ..  .|. ...|.|.|..||.|| ..   .|| ..         |.   ..   .. .. ..                     ...  .|...|..
APEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

DPDKRP---DIYQVSYF
|| |||   .| |  .|
DPKKRPTAEQILQHPWF
Kinase AAK1.AA TKL-ciliate1 124-307 22 2.2e-35 118.59 In-house 76-275 (279) Show / Hide 
Range on Protein: 124-307
Range on HMM: 76-275/279
Sequence Identity: 22% (45 aa)

ILMDFCRGGQVVNLMNQRLQ--TGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATN-KFQNPQTEGVNAVEDEIKKY
| | .| .|  . ..    .      .   . .  |    .  ||. . |.||||||..|||.     |  |.|.. ..  |   ...   ..  |... 
IIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRN

TTLSYRAPEMVN--LYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNS------------RYSQDMHCLIRYMLEPDPDKRPDIYQ
||  ..|||     ..... |..|.||.|.| ..| ||    || ....   ..   ...               ..| .| |.  ... .| |||.  .
TTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPF-QQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNE

V
.
I
Kinase AAK1.AA Ciliate-E2-Unclassified 47-307 19 3e-32 109.17 In-house 2-346 (352) Show / Hide 
Range on Protein: 47-307
Range on HMM: 2-346/352
Sequence Identity: 19% (68 aa)

TVDEVLAEGGFAIVFLVRTSNG-----MKCALKRMFVNNEHDLQVCKREIQIMRDLSGHK-NIVG----------YIDSSINNVSSGDVWE----VLILM
.. ... .|||..|.... ..      || . | . ..    ...  .....|  .  .| ...           .   ... |   .. .    . | |
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DFCRGG---QVVNLM-----------NQRLQTG-FTENEVL-----QIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRG---HYVLCDFGSATNKFQ
..|.||   |  . .           ....|.  |||....     ..|   ...   ||. .  |||||.| ||||... |   .  ..|||.. .  |
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

NPQTEGVNA-------VEDEIKKYT-TLSYR----APEMV--NLYSGKIITTKADIWALGCLLYKLCYFTLPFG---------------------ESQVA
|.. .  |         .....  . |..|     |||.   . |...    |.|||.||..|| ... ..||.                     . .  
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

ICDGNFTIP---------DNSRYSQDMHC-LIRYMLEPDPDKRPDIYQV
|...|. .|         . |   .|.   |.. ||. .|.||... |.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI
Kinase AAK1.AA MPSK 47-304 32 4.7e-32 112.3 In-house 2-274 (281) Show / Hide 
Range on Protein: 47-304
Range on HMM: 2-274/281
Sequence Identity: 32% (90 aa)

TVDEVLAEGGFAIVFLVRT-SNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDS-SINNVS---SGDVWEVLILMDFCRGGQVVNLMNQR
.. . |.|||| .| ||   . | . ||||       | .  .||.   . .  |.||.. .|  ..          . |....  .   |   . .  .
YFMQRLGEGGFSYVDLVENLHDGHFYALKRIQCHEQQDQNQAQREAEMHCQFD-HPNIIRLVDWGCLKGREDIVINTKHEIWLVLPYFKHGTLWDHLQRM

LQTG--FTENEVLQIFCDTCEAVARLHQCK-TPIIHRDLKVENILLHDRGHYVLCDFGSATN-KFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGK
 . |   ||  ...||   || .  .|  .  |  |||.|  ||.| | .  |. |.|| .    |        |  |.     ...|||||     |  
KDKGDCMTEDQIWWIFLGVCEGLKAIHEAMPKPYAHRDMKPTNICLGDDFQPVIMDLGSMNEACIQVKGQRQACALQDWAAERCSMVYRAPELFHVQSHC

IITTKADIWALGCLLYKLCYFTLPF------GES-QVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDI
.|  . ||| ||| ||  |||  |.      | |   |.  .|| ||.||||||||| || ||.  ||  || |
VIDERTDIWSLGCVLYAMCYFHSPYDMIYQRGDSVHLAVQNRNFNIPENSRYSQDMHQLISYMMRVDPMERPHI
Kinase AAK1.AA CAMKL 46-199 23 5.4e-20 60.36 In-house 1-177 (297) Show / Hide 
Range on Protein: 46-199
Range on HMM: 1-177/297
Sequence Identity: 23% (45 aa)

VTVDEVLAEGGFAIVFLVRT-SN-GMKCALKRMFVN----NEHDLQV-----------CKREIQIMRDLS--GHKNIVGYIDSSINNVSSGDVWE-----
 .. ..| .|.|. | | .  .. | | | | .  .    ... ..             .||||||. |.  .|.||.             .|.|     
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLY----------EVIETPEHD

-----VLILMDFCRGGQ--VVNLMNQRLQTG--FTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRG--HYVLCDFGSAT
     . . |  | ||     .   ..   .  ..|.|  ..|.  ..||. .|...  |.|||.| ||||| ..|     ..||| ..
IETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSN
Kinase AAK1.AA CAMKL 222-307 31 6e-15 43.99 In-house 196-291 (297) Show / Hide 
Range on Protein: 222-307
Range on HMM: 196-291/297
Sequence Identity: 31% (32 aa)

TLSYRAPEMVNL----YSGKIITTKADIWALGCLLYKLCYFTLPFGESQV------------AICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIY
...| |||...     | |.    |.|||..| .|| . . .||| .  .             |  | . .|  .. | | . ||| ||...|.||| | 
SPPYMAPEIFQGNNKPYDGP----KVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIH

QV
|.
QI
Kinase AAK1.AA TyrKc 46-312 18 9.2e-10 -64.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-312
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

VTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDL-SGHKNIVGYIDSSINNVSSGD------VWEVLILMDFCRGGQVVNLM
.| ...| || | .|.. . .  ...| | .  .    ..   ||..||. |   |.|||  .      | . .      .  ..|.| .. .|   .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLY-----GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

-NQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQN-PQTEGVNAVEDEIKK----YTT--LSYR--AP
 . | .  ..  . |..  . ..  . ||.   ..|||||   |.|......   .||| . .      |     . .| ..|     .   | .|  ||
RKHRPK--LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAP

EMVNLYSGKIITTKADIWALGCLLYKLCYF-TLPFGE--------SQVAICDGNFTIPDNSRY---------SQDMHCLIRYMLEPDPDKRPDIYQVSYF
|       .. ||| |.|. | ... .. .   |  .        ..|  .  .   ..   .         ...|. ...   . ||..||   .. . 
ECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HE

SF
 |
CF