Gene TOR1 (Bakers Yeast)
TOR1
Sequence
Protein domains of TOR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| HEAT | TOR1.AA | HEAT | 254-284 | 25 | 0.109014 | 9.71 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 254-284 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) ILDNIWRALRDPHLVIRIDASITLAKCLSTL ||. . ..|.||. .| | .|.. .. . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | TOR1.AA | HEAT | 590-615 | 19 | 69.242707 | 0.0 | Pfam | 6-31 (31) | Show / Hide |
Range on Protein: 590-615 Range on HMM: 6-31/31 Sequence Identity: 19% (5 aa) LSYIEHTDPRVRKLAALTSCEIYVKD |. ....|..||. |. . .... . LKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | TOR1.AA | HEAT | 670-699 | 23 | 2.498278 | 5.0 | Pfam | 2-31 (31) | Show / Hide |
Range on Protein: 670-699 Range on HMM: 2-31/31 Sequence Identity: 23% (7 aa) LRLLFTALHDESFNIQSVAMELVGRLSSVN | .|...|.|.. .... | . .|.|... LPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | TOR1.AA | HEAT | 711-741 | 19 | 29.610587 | 1.28 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 711-741 Range on HMM: 1-31/31 Sequence Identity: 19% (6 aa) LLELLTKLKFSTSSREKEETASLLCTLIRSS .|..| |. ..... .| ... |..|.. . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | TOR1.AA | HEAT | 752-782 | 25 | 0.00451 | 14.5 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 752-782 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) LLNVLLPKFQDTSSTVASTALRTIGELSVVG .|..|| ..|... | ..|....|.|. . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | TOR1.AA | HEAT | 793-824 | 34 | 5e-05 | 21.26 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 793-824 Range on HMM: 1-31/31 Sequence Identity: 34% (11 aa) LFPLIIKTFQDQSNSFKREAALKALGQLAASS ..|...| ..|. .. ||||...||||. . ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC |
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| DUF3385 | TOR1.AA | DUF3385 | 827-986 | 58 | 1e-93 | 322.47 | Pfam | 1-181 (181) | Show / Hide |
Range on Protein: 827-986 Range on HMM: 1-181/181 Sequence Identity: 58% (105 aa) VIDPLLDYPELLGILVNILKTE-NSQNIRRQTVTLIGILGAIDPYRQK--EREVTST-------TDISTEQNAPPIDIALLMQGMSP-SNDEYYTTVVIH ||||..|||.|||.|.|||||| ...||| |. ..|||||.|||. | | | .|. .|....||.|..||.|.|||.|| |||||| ||||. VIDPYYDYPQLLGVLFNILKTEFQNWPIRRETIKCMGILGALDPYKHKMNEIERHSDKHHIKFRDDQHQNQNNPCTDIMLMMQGYSPLSNDEYYPTVVIN CLLK-ILKDPSLSSYHT-AVIQAI----MHIF--QTLGLKC-VSFLDQIIPTILDVMRTCSQ-SLLEFYFQQLCSLIIIVR .|.. |||||||||.|| .|.||| |.|| .|.|||| |.||.||||..| |||||.. ||.||||||||.|. ||. SLMRLILKDPSLSSHHTVMVVQAITWWEMYIFSLKTMGLKCQVPFLPQIIPPFLQVMRTCPPCSLREFYFQQLCTLVSIVK |
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| HEAT | TOR1.AA | HEAT | 913-944 | 21 | 4.086174 | 4.26 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 913-944 Range on HMM: 1-31/31 Sequence Identity: 21% (7 aa) VIHCLLKILKDPSLSSYHTAVIQAIMHIFQTL .. .||| |.|| .. |..... .. . . ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC |
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| HEAT | TOR1.AA | HEAT | 1075-1105 | 16 | 49.697725 | 0.5 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 1075-1105 Range on HMM: 1-31/31 Sequence Identity: 16% (5 aa) ITPKIVQMAEFTSGNLQRSAIITIGKLAKDV | | .... . .. . ...|. ..|.|.. . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| FAT | TOR1.AA | FAT | 1461-1845 | 40 | 5.3e-179 | 599.58 | Pfam | 1-408 (408) | Show / Hide |
Range on Protein: 1461-1845
Range on HMM: 1-408/408
Sequence Identity: 40% (182 aa)
APLAAGAAWGLGEWDM--LEQYISVMK------------PKSP-----DKEFFDAILYL--HKNDYD--NASKHILNARDLLVTEISA-LINESYNRAYS
||||| |||.||.|| ...|||||| || |..||.||| | |.|..| |...| .||.||.||..| |..|||||.|.
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP
VIVRTQIITEFEEIIKYK-QLPPN--------SEKKLHYQNLWTKRLLGC-QKNVDLWQRVLRVRSLVIK--------------PKQDLQIWIKFANLCR
|.|| |...|.||||.|| |...| .|| | . |.|||.|| |.||. ||| |..|..|.. |..|...|||||||||
VMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCR
KSGRMRLANKALNMLL----EGGNDPSLPNTFKAPPPVVYAQLKYIWATGAYKEALNHLIGFTS-RLAHDLGLDPNNMIAQSVKLSSASTAPY-VEEYTK
|.||| |. |.|.||. . .... .|||...||.||| |||| .||..|| ||| ...||||...||.|...... . .. . ...|||
KHGRMQLCEKTLKMLYTYDPSEEDWHP-----RAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTK
LLA-RCFLKQGEWRIAT---Q-PNWRNTNPDAILGSYLLATHFDKNWYK-AWHNWALANFEVISMVQEETKLNGGKNDDDDDTAVNNDNVRIDGSILGSG
||| ||..|||.| .. | .||.....|.||..|..|||||..||| |||||||.||||... | . . . .
LLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQN------------------------
SLTINGNRYPL-ELIQRHVVPAIKGFFHSISLLET-SCLQDTLRLLT
. ..|..|||||.|.|||||.| . ...|||||||.
----------YTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
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| HEAT | TOR1.AA | HEAT | 1875-1905 | 25 | 0.806729 | 6.7 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 1875-1905 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) VLPQLISRIHQPDPTVSNSLLSLLSDLGKAH .|| |.. .. ||. | . .. |..| . . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| Rapamycin_bind | TOR1.AA | Rapamycin_bind | 1952-2051 | 64 | 4.5e-72 | 229.48 | Pfam | 1-100 (100) | Show / Hide |
Range on Protein: 1952-2051 Range on HMM: 1-100/100 Sequence Identity: 64% (64 aa) ELIRVAVLWHELWYEGLEDASRQFFVEHNIEKMFSTLEPLHKHLGNEPQTLSEVSFQKSFGRDLNDAYEWLNNYKKSKDINNLNQAWDIYYNVFRKITRQ ||||||.||||.|.||||.||||.| .|||||||..||||| | ..|.|..|.||...|||||..|.||. .||...|.|.|||||||||.|||.|..| ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ |
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| Kinase | TOR1.AA | FRAP | 2118-2368 | 62 | 9.40000000001e-163 | 546.98 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 2118-2368 Range on HMM: 1-251/251 Sequence Identity: 62% (157 aa) DYKYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHRDAKKIPLNIEHWVMLQMAPDYENLTL .| . |||||||||| |||||||.|.||.|. | |. | || | |||| ..||.|||.. || |.|||. |....| .|||. .|..|..||. |.| EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPL LQKIEVFTYALDNTKGQDLYKILWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKYPEKVPFRLT ..|.|.| |...||||.|| |.||||| .|| |.|||| ||||||.||| |||||||||||||.||.| |||..||||||||| |. |||.|||.||||| MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT RMLTYAMEVSGIEGSFRITCENVMRVLRDNKESLMAILEAFALDPLIHWGF |||. |||. |||| .|.||| ||.|.|..|||.||.|||| |||. | RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | TOR1.AA | PIKK | 2089-2358 | 45 | 4.90000000001e-135 | 454.9 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 2089-2358 Range on HMM: 1-290/290 Sequence Identity: 45% (131 aa) RIAKFEPLFSVISSKQRPRKFSIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIR ||. . . |. .||.|.| .|.|.||| | | .|||||.||| |||||.|.||.| .|.|| |||| |. | ||.|...||..||.|..| . ... RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK EHRDAKKIPLNIE--------------------HWVMLQMAPDYENLTLLQKIEVFTYALDNTKGQDLYKILWLKSRSSETWLERRTTYTRSLAVMSMTG . ...|.| ..| . .|.|....| ..| .| ||| ....||.. .. |..|.|. ..|.|.|||. ||||.|||.| | QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKYPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMRVLRDNKESLMAILEAF ||||||||||.|.|.|..||...|||||.||| | |.. ||||||||||... ||.. |.|| || .|| ||...|...|.||...|.| YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | TOR1.AA | PI3Kc | 2120-2419 | 28 | 1e-117 | 398.32 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 2120-2419
Range on HMM: 1-336/336
Sequence Identity: 28% (95 aa)
KYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHRDAKKIPLNIEHWVMLQM-----------
.|...| ||| ..||.|.|.|.....|.||..|.| ...| ||..||.|...||||..|.| . ..... ||.|.....|.|..|
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
----------APDYENLTLLQKIEVFTYALDNTKGQDLYKILWLKSRSS-ETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGD
...|...|.......|. |....|. .||. .| .. .. | | |.|...|||.|...| .||||.||||..|.|||. ||...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
CFEAAILREKYP----EKVPFRLTRMLTYAME----VSGIEGSFRITCENVMRVLRDNKESLMAILEAFALDPL-IHWGFDLPPQKLTEQTGIPLPLINP
.|. . ...... |.||||||... |.|. .|| .| || .|. ..|..| .....|...|... ||. ..| .. . . .. ..| .
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDHLSD
SELLRKG------AITVEEAANMEAEQQNETKNARAM
| ... .. ..... . . ... | . .
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | TOR1.AA | PI3_PI4_kinase | 2118-2368 | 32 | 8e-109 | 372.63 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 2118-2368 Range on HMM: 1-300/300 Sequence Identity: 32% (97 aa) DYKYVLKGHEDIR--QDSLVMQLF-----------------------GLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHR- .|....||..| | ||...||.. .|.|...|.|.....|.. .| | ||..|..|...||||..||| ..|... WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV DAKKIPLNIEHWVMLQMAPDYENLTLLQKIEVFTYALDNTKGQDLYKILWLKSRSS-ETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLML--DRITG | ...|.||.....|.||...|...|| |||.... .|.. .||. .| .. . |.|.|.|....||.|.|.. .||||.||||..|.|. |. || KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG KVIHIDFGDCFE-AAILREKYPEKVPFRLTR------MLTYAM------EVSGIEGSFRITCENVMRVLRDNKESLMAIL-------EAFALDPLIHWGF ...|||||.||. .. ... ||.||||.|. .. .|| ..|| .| || .|. ..|.|| .....|. | |... |.|. | HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | TOR1.AA | ATR | 2089-2358 | 31 | 1e-53 | 181.26 | In-house | 2-267 (267) | Show / Hide |
Range on Protein: 2089-2358 Range on HMM: 2-267/267 Sequence Identity: 31% (85 aa) RIAKFEPLFSVISSKQRPRKFSIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIR || |. . ...| |.|.| |.|||||| | . | ..|.|.| |. |.| ... | | .| .... | ||| ..... || | | . .. YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD EHRDAKKIPLNIEHWVMLQMAPDYENLTLLQKIEVFTYALDNTKGQDLYKILWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITG . ||. |.. | . .| || | . . .. | | | || ||..| |||.|||||| |...|.|.| KLWKEKKQ---YMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKING KVIHIDFGDCFEAAILREKYPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMRVLRDNKESLMAILEAF ..|.|. | | || ||||||. . ..| . .| || || .|...||... .|.....| ECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | TOR1.AA | ATM | 2250-2366 | 47 | 1.6e-36 | 113.97 | In-house | 133-248 (304) | Show / Hide |
Range on Protein: 2250-2366 Range on HMM: 133-248/304 Sequence Identity: 47% (56 aa) WLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAA-ILREKYPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMRVLRDNK | |.| |||| | |. |||||||||| |... ..||| | || || || ||||||| . | . |.|| || || | |.| . WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT--PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ ESLMAILEAFALDPLIHW | |. | | ||| | ETLLTIVEVLLYDPLFDW |
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| Kinase | TOR1.AA | DNAPK | 2244-2368 | 34 | 9.8e-21 | 72.04 | In-house | 177-301 (301) | Show / Hide |
Range on Protein: 2244-2368 Range on HMM: 177-301/301 Sequence Identity: 34% (43 aa) SRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKYPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMRV | . ||.| | . |. || ..||| |||| | | .| .| |||| | .| . || |||||| . | .| | .. |. STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA LRDNKESLMAILEAFALDPLIHWGF .| . |. . | ||.. | FRKDRNILTNFCDVFINDPSFDWKN |
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| Kinase | TOR1.AA | DNAPK | 2088-2179 | 36 | 1.3e-18 | 64.18 | In-house | 2-93 (301) | Show / Hide |
Range on Protein: 2088-2179 Range on HMM: 2-93/301 Sequence Identity: 36% (34 aa) IRIAKFEPLFSVISSKQRPRKFSIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGWVPN .||| |. |. | ||.. |.| | .. .. || || ||| . ||| | . |. | | |. | ||. ||. || | VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDN |
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| Kinase | TOR1.AA | SMG1 | 2236-2300 | 50 | 7.5e-18 | 55.58 | In-house | 169-233 (242) | Show / Hide |
Range on Protein: 2236-2300 Range on HMM: 169-233/242 Sequence Identity: 50% (33 aa) LYKILWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFE | | || . | | || ||||| |||.|||||| | ..| || |.|||. ||| LAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE |
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| Kinase | TOR1.AA | ATM | 2120-2176 | 43 | 2e-15 | 45.35 | In-house | 1-57 (304) | Show / Hide |
Range on Protein: 2120-2176 Range on HMM: 1-57/304 Sequence Identity: 43% (25 aa) KYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGW . . || .|.||| . | | . ||||. | || | | | .||| .|| | | RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW |
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| Kinase | TOR1.AA | SMG1 | 2097-2177 | 34 | 3.2e-13 | 40.0 | In-house | 1-81 (242) | Show / Hide |
Range on Protein: 2097-2177 Range on HMM: 1-81/242 Sequence Identity: 34% (28 aa) FSVISSKQRPRKFSIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGWV .. | .|.| ||||| | |. || ||. | .|| .|||. | || .|||. || ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV |
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| FATC | TOR1.AA | FATC | 2438-2470 | 63 | 7.8e-23 | 76.19 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2438-2470 Range on HMM: 1-33/33 Sequence Identity: 63% (21 aa) NELDVPEQVDKLIQQATSIERLCQHYIGWCPFW ..|.|..|||.|||.||..|.|||.||||||.| EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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