Gene TEL1 (Bakers Yeast)
TEL1
Sequence
Protein domains of TEL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| TAN | TEL1.AA | TAN | 1-158 | 34 | 1.7e-59 | 208.1 | Pfam | 1-168 (168) | Show / Hide |
Range on Protein: 1-158 Range on HMM: 1-168/168 Sequence Identity: 34% (58 aa) MEDHGIVETLNFLSSTKIKERNNALDELTTILKEDP---------ERIPTKALSTTAEALVELLASEHTKYCDLLRNLTVSTTNKLSLSENRLSTISYVL |..| |....| |.|.|||.||.|||.| |||..| .|.. |.... .|||......|..||| . ... .. .....||||||...|.| MSTHDINKCCNLLQSDKIKDRNDALDNLEHILKSNPRNSQFHHNRNRLNDKQWHKIFEALFRCIEKEKRKYC--RNRNKKKSQSTANSSENRLSSCAYAL RLFVEKSCE--RFKVKTLKLLLAVVPELMVKDGSKSLLDAVSVHLSFAL-DALIKSDPFKLKFMIHQWIS |||||..|. .||.|....... ...... ..|.||....||..| .| .|... |.. ..| |||.. RLFVECGCHDIKFKRKHYMAIVDHITDTFPDPDSGSLCEPCSVDYSKCLLSTLLSYPPHWCHLMRHQWEH |
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| Kinase | TEL1.AA | PI3Kc | 2462-2755 | 32 | 4.5e-120 | 406.13 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 2462-2755 Range on HMM: 1-336/336 Sequence Identity: 32% (109 aa) ALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSKLHTNDK------------------------ |.. .||||||. | |.|...||..|.|| |..|| .|.||..|.||| |.||.| |...||||..|.|...| AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM -ITFDQARKGMKAVQTKSNEERLKAYLKITN-EIKPQLRNFFFDSFPDP-LDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGI |...||...|. .|.....|.|| ... |. . .| |...| . |||| .||.||....|. .|. ..|.||||.||||..||.||. ||. .|||.| MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH AFDQGKLLPIP-----ELVPFRLTRDIVDGFG----VTGVDGLFRRSCERVYAVLRKDYVKVMCVLNILKWDPL-YSWVMS--PVKKYEHLFEEEHEITN .|..|...| . |.||||||.|.|.. | ..|..|.||. |.|.| ..||. ..|...... .||. .| |. ..|.... |...| .. IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDH--LS FDNVSKFISN-----NDRNENQESYRALKGVEEKLMGN ....... . ....|.. . ... . ...... DEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
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| Kinase | TEL1.AA | PI3_PI4_kinase | 2459-2704 | 25 | 1.3e-95 | 328.77 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 2459-2704 Range on HMM: 1-300/300 Sequence Identity: 25% (78 aa) TQKALMKGSNDDLR--QDAIMEQVF-----------------------QQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSKLH .. ... ..|||| ||. |.| . . .||....|...|. ......|...|.||. |.||.| |.|..|.|... . WY-PFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYM TNDKITFDQARKGMKAVQTKSNE------ERLKAYLKITNEIKPQLRNFFFDSFPDP-LDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILL--DCST ...|. ... ...|......... .... ...|... || |...| ...||. .|.||...... .| ..|.||||.||||..||.. |..| VKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTT GEPIHIDLGIAFD--QGKLLPIPELVPFRLTR------DIVDGF------GVTGVDGLFRRSCERVYAVLRKDYVKVMCVL-------NILKWDPLYSWV |. .||| |..|. ..| .. ||.||||.|. ..|... ...| .|.||..|...|..||.. . .|..| ... .|.| .| GHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWR M . S |
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| Kinase | TEL1.AA | ATM | 2461-2708 | 46 | 6.3e-87 | 277.77 | In-house | 1-254 (304) | Show / Hide |
Range on Protein: 2461-2708 Range on HMM: 1-254/304 Sequence Identity: 46% (119 aa) KALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQ--------ILSKLHTNDKITFDQARKGMKAVQT . |.|| |||||||.| |||| | .|| | | | ||||||| ..|..|. . . || | | | | || RQLVKG-RDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLINNEDGAHKRYRPNDFSAF-QCQKKMMEVQK KSNEERLKAYLKITNEIKPQLRNFFFDSFPDPLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQGKLLPIPELVPFRL || ||. .. . .| | | . | || ||| . ||. || |||||||||||||| |||. | .|||||.||.|||.|| || ||||| KSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRL TRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNILKWDPLYSWVMSPVK ||||||| |.|||.| ||| ||. |.| .. . .| .|||. | | |.| TRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLK |
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| Kinase | TEL1.AA | PIKK | 2429-2694 | 32 | 1.6e-77 | 263.82 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 2429-2694 Range on HMM: 1-290/290 Sequence Identity: 32% (95 aa) YIVSVNETVGITTTGLSLPKIVTFNISDGTTQKALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQI .| . . | . .. . || .. .|| | || .|||||. ..|.|| .|. ||.|. . .| ||||.|.|.... |.|| | |...|. | RIRFMDRMVTVMAH-KQKPKKIYIRGHDGKEYPYLCKG-HEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEI LSKLHT-----NDKITFD-------------------QARKGMKAVQTKSNEERLKAYLKITNE-IKPQLRNFFFDSFPDPLDWFEAKKTYTKGVAASSI . .. ... .. |. . . .| .. .|.... .. . . ....| .|||| .|.|... || .| ... YKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCM VGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFD-QGKLLPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNIL |||||||||||..||..| .||| .|||.| .| ... || ||.|||||||..|.. |..||.|.|||.|| | ..|.. ..| |. . VGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | TEL1.AA | ATR | 2429-2694 | 34 | 1.9e-58 | 197.62 | In-house | 2-267 (267) | Show / Hide |
Range on Protein: 2429-2694 Range on HMM: 2-267/267 Sequence Identity: 34% (92 aa) YIVSVNETVGITTTGLSLPKIVTFNISDGTTQKALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQI || .. | | .. | || ... ||| .| ||||.| .. . .|.... | | . .||| |.|| ...|||.| | .|. | YIAGFDDMVEILAS-LQKPKKISLKGSDGKFY-IMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPI LSKLHTNDKI--TFDQARKGMKAVQTKSNEERLKAYLKITNEIKPQL-RNFFFDSFPDPLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTG | ||. |. .| | |. | . . |..|.. .. .| . ...| |||| .|. ... | . |. ..||||.|||||| .|||.| .| LDKLWKEKKQYMQFYQLRQCMDK-KSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKING EPIHIDLGIAFDQGKLLPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNIL | .|.| . | .|. . .||.||||||. .| |.| . .||||| || . ..|. .| |.. ECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | TEL1.AA | FRAP | 2587-2704 | 43 | 4.4e-33 | 116.24 | In-house | 133-251 (251) | Show / Hide |
Range on Protein: 2587-2704 Range on HMM: 133-251/251 Sequence Identity: 43% (52 aa) WFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQG-KLLPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYV ||| . ||. | |..||||||||||. ||.|. || .||| | |. . .||..|||||| .| ..|..| .| || | |.| . WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE KVMCVLNILKWDPLYSWVM || || .|||. | . SVMAVLEAFVYDPLFYWRL |
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| Kinase | TEL1.AA | SMG1 | 2584-2646 | 50 | 1.2e-21 | 68.31 | In-house | 180-242 (242) | Show / Hide |
Range on Protein: 2584-2646 Range on HMM: 180-242/242 Sequence Identity: 50% (32 aa) PLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQGKLLPIPE | .|. . | . | |.||||.||||||| |.|.| ||| .||| | |..|| | .|| PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
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| Kinase | TEL1.AA | DNAPK | 2603-2704 | 33 | 1.1e-19 | 68.17 | In-house | 199-301 (301) | Show / Hide |
Range on Protein: 2603-2704 Range on HMM: 199-301/301 Sequence Identity: 33% (35 aa) IVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFD-QGKLLPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNILKWDPLYS | ..||| ||||||| . ..|. | || | .| . ||.||| |||||| . .. |... . .||| . .. ||. ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD WVM |. WKN |
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| Kinase | TEL1.AA | FATC | 2755-2787 | 54 | 1.1e-17 | 59.7 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2755-2787 Range on HMM: 1-33/33 Sequence Identity: 54% (18 aa) NGLSVESSVQDLIQQATDPSNLSVIYMGWSPFY ..|||| |..|||.||||.||...| ||.|.. EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | TEL1.AA | FRAP | 2463-2526 | 34 | 2.2e-09 | 30.75 | In-house | 5-67 (251) | Show / Hide |
Range on Protein: 2463-2526 Range on HMM: 5-67/251 Sequence Identity: 34% (22 aa) LMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLH |.|| .|.||| | | .|. |.|. . .| |. | ..|| ..|.| | . || LLKG-HEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLH |
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| Kinase | TEL1.AA | DNAPK | 2463-2531 | 37 | 4.8e-09 | 28.87 | In-house | 36-103 (301) | Show / Hide |
Range on Protein: 2463-2531 Range on HMM: 36-103/301 Sequence Identity: 37% (26 aa) LMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSK . || ||||| || || | .. | .| ||| ..|. | || | | | || . CYKGI-EDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDILNN |
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| Kinase | TEL1.AA | SMG1 | 2502-2525 | 45 | 0.223661 | 0.14 | In-house | 64-87 (242) | Show / Hide |
Range on Protein: 2502-2525 Range on HMM: 64-87/242 Sequence Identity: 45% (11 aa) RTYKVVPLGPKAGIIEFVANSTSL | | | ||| ..|.| .| | | RHYSVTPLGTRSGLIQWVDGATPL |
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