Gene MKK2 (Bakers Yeast)

MKK2

Species: Bakers Yeast
Alias: MKK2
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MKK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
MKK2.AA Protein Refseq_NP 506 `Member of MAP kinase pathway involving PKC1, BCK1, and SLT2. Shows functional redundancy with MKK1; Mkk2p [Saccharomyces cerevisiae]` Fasta, JSON

Protein domain

Protein domains of MKK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MKK2.AA STE7-Unclassified 214-481 47 1.6e-169 569.48 In-house 1-301 (301) Show / Hide 
Range on Protein: 214-481
Range on HMM: 1-301/301
Sequence Identity: 47% (142 aa)

ITTLGILGEGAGGSVAKCRLKN------GKKVFALKTINTMNTDPEYQKQIFRELQFNKSFK-SDYIVQYYGMFTDEQSS-SIYIAMEYMGGKSLE---A
...|..||.|..|.|.||..||      ..|..|.|.|.||..|.|..|||.|||....... ..|||.|||....|... .|.|.||||...||.   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

TYKNLLK----RGGRISERVIGKIAESVLRGLSYLHERK-VIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSL--AMTFTGTSFYMAPERIQGQ-----
.||....    |||.|.|.|.||||..|..||.||||.. .|||||||.|||.|.||..|.|||||.|...|.|  |.|..|...||.|||||||     
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

PYSVTCDVWSLGLTLLEVAGGRFPFE----SDKITQNVAP-----IELLTMILTFS-PQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLK-HP
.|||..|.||||||..|.| |..|.|    |....||..|     .|||..|..|. |.|.|.|| ||.|||.|..||..|.||..||||...|.|. ||
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPE-DIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

WI
||
WI
Kinase MKK2.AA STE7 214-481 43 1.8e-150 506.22 In-house 1-288 (288) Show / Hide 
Range on Protein: 214-481
Range on HMM: 1-288/288
Sequence Identity: 43% (129 aa)

ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFK-SDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRG-
. ..| ||.|..|.|.|.|.|.  |..|.|.|...|.|||.||||..||....... ..||||.||.| .| ...|.|.||||.| .|.  ||...|.. 
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GRISERVIGKIAESVLRGLSYLHE-RKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSL--AMTFTGTSFYMAPERIQG--QPYSVTCDVWSLG
    |||.|...|||| .|..||.|||| .|.||||.||.|||.|..|..||||||..|. |.|.  |.||.|...|||||||.|  | |.| .||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LTL-LEVAGGRFPFE-------SDKITQNV-----APIELLTMILTF-S-PQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLK-HPWI
.|. .|.| ||.|..       ..| ..|.     |. |.||.|... . |.|.       ..|. |..|...||.|| .|||...|..| ||.|
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP-------KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase MKK2.AA STE 214-481 29 8e-105 354.54 In-house 1-359 (359) Show / Hide 
Range on Protein: 214-481
Range on HMM: 1-359/359
Sequence Identity: 29% (108 aa)

ITTLGILGEGAGGSVAKCRLK------NGKKV---------FALKTIN---------------TMNTDPEYQKQIFRELQFNKSFK--SDYIVQYYGMFT
 . ....|.||.|.| |.. .        ..|         .| | .|               ..|...| ..|| .|... | ..  ...||.|||.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE---QSS--SIYIAMEYMGGKSLEATYKNLLKRG----------GRISERVIGKIAESVLRG-LSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSG
.|   ...  ...|.||||.| ||.  .|.  ..|          .|..| .|..|. ..|.| |.|||. ..|||||||.||||     .|||||||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

EAVNSLA----------------M--TFTGTSFYMAPERIQG------QPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIE----------LLT
  ..|.|                .  ||.||  .||||.||.      ..|.. ||.||||.|..| | |. |.   . ...  .|           .| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

MILT-FSPQLKDEPELD-------------ISWSKTFRSFIDYCLKKDARERPSPRQMLK--HPWI
.|.   .|.|.|. . .              .||. |. ||. ||.|| ..||.. |.||  ||.|
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MKK2.AA Pkinase 214-481 31 2.2e-94 324.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 214-481
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFR--ELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGK----SLEATYKNL
.......|.|. |.| ||. |.  |..|.|.|.  ..... ... .|  |.|  |......||..|..|.|  ...||. |||..|     .|      .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF----DY

LK--RGGRI--SERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEI----KLCDFGVSG---EAVNSLAMTFTGTSFYMAPERIQ-GQPYSVT
..  |.|..  ||... ...  .|||| |.|....||||.||.|||....|.|    |.||||..    .  || ..||.||..||||| |. ||.|.  
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

CDVWSLGLTLLEVAGGRFPFESD----KITQNVAPIELLTMILTFSPQLKDEPE------------LDISWSKTFRSFIDYCLKKDARERPSPRQMLKHP
.|.||.|..| |.. ||.|| ..    ...|..   . .  .| |. . ....             . . ||.....||..||.||  .||...| |.||
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

WI
|.
WF
Kinase MKK2.AA S_TKc 214-481 31 1.7e-85 291.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 214-481
Range on HMM: 1-231/231
Sequence Identity: 31% (87 aa)

ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGG--KSLEATYKNLLKRG
 . | ..|.|| |.| ||| |. ....|.| |.         ..| ||.|  |. . ..||..|..| |   ...|. |||..|   .|    |.  ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

GR--ISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQPYSV-TCDVWSLGLTLLEV
.|  ..| .. ...  ....| |.|....||||.||.||||.|  .||.||||.. .      .|| || .||||| .   .|.   ||.||.| .| | 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

AGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLK-------HPWI
. |. ||.         . ... .|.                |. ...||. ||.|| ..||.  . |.       |||.
LCGYPPFP--------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MKK2.AA STE20 214-481 35 1.4e-81 277.31 In-house 1-288 (288) Show / Hide 
Range on Protein: 214-481
Range on HMM: 1-288/288
Sequence Identity: 35% (106 aa)

ITTLGILGEGAGGSVAKCRLKNGKKV----FALKTINTMNTDP--EYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQS--SSIYIAMEYMGGKSLEATYK
 . |  .|.|. |.| |.. |  ...     | | .|  . |.  . .. |. | .. | .|. .||.||| .  . .  ....|.|||.|| ||   .|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

NLLKRGG-----RISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVN----SLA---MTFTGTSFYMAPERIQG----
. .|.|.     ...|  |  |   ||.||.|||....|||||| .||||.|.||.||.||||..   .    . .    || || ..|||| ||.    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-QPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMIL--TF-SPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKHPWI
 ..|   ||.|||| |..| | |. |.       .. |   . ||.  .  .| |||.     .||. |. |.| || ||  .||.. |.||||.|
DKGYDYKCDIWSLGITAIEMAEGEPPY------FDMHPMRAMFMIPKNQNPPPTLKDD-K-PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MKK2.AA MEK5 214-481 39 1.4e-70 240.81 In-house 1-254 (254) Show / Hide 
Range on Protein: 214-481
Range on HMM: 1-254/254
Sequence Identity: 39% (107 aa)

ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGR
|     || | ||.| |       |..|.| |  ..   | ||||  ||.      | ||. .|| |  |    | |  |.| | ||.  |.       .
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVI-LLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVEN--RISICTEFMDGGSLDM-YR-------C

ISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRF
| | ..|... .. .|| || . |..|||.|| |.| | .|.|||||||||   |||.. |. ||  ||||||| |. | .  ||||||. ..|.| |||
IPEHILGRMTVAIVKGLNYLWNLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRF

PFESDKITQ-NVAPIELLTMILTFSPQLKDEPELDI-SWSKTFRSFIDYCLKKDARERPSPRQMLKHPWI
|.   .  | ...||.||  |        . | | .  .|. |  ||  |..|  ..|| |.....||.|
PYPQIQRDQGELMPIQLLQCIVD-----EHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MKK2.AA MEK1 214-414 48 7.3e-67 227.47 In-house 1-195 (297) Show / Hide 
Range on Protein: 214-414
Range on HMM: 1-195/297
Sequence Identity: 48% (98 aa)

ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGR
. ..| ||.| || | ||| ..   . | | |  .   |  ..|| ||||      | ||| .|| | ..    | | |||| | ||.     .||. ||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIH-LEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDG--EISICMEYMDGGSLDQ----VLKKAGR

ISERVIGKIAESVLRGLSYLHER-KVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGR
| |...||..  |||||.||... |..|||.|| ||| | .||||||||||||  . |.|  | ||  ||.|||.||  |.|  |.||.|| | |.| ||
IPEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGR

FP
.|
YP
Kinase MKK2.AA CAMK 219-481 18 1e-62 200.61 In-house 1-425 (425) Show / Hide 
Range on Protein: 219-481
Range on HMM: 1-425/425
Sequence Identity: 18% (80 aa)

ILGEGAGGSVAKCRLKNGK------------KVFALKTINT--------------------------MNTDPEYQKQIFRELQFNKS-------FKSDYI
.||.|. | | .|. || .            . .| | |..                           ...|. .|...||..  |.        .   |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYYGMFTDEQ-----------------SSSIYIAM---EYMGGK----S-LEATYKN-----------LLKRGGRISERVIGKIAESVLRGLSYLHERK
.. | .. |..                  . .|. |   ||. |       ..   ..           .. . ||..||   ..   .. .. |.|...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDIKPQNILLNEK-----------------GEIKLCDFGVSGEAVNS-------------------------LAMTFTGTSFYMA-PERIQG-----
..|||.|| ||||...                 . ||..||| . .   .                         .  || ||  ||| || ..|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNV-------APIELLTMILTFSPQLKDEPELDIS-------WS-----------KTFR
         ..|.  ||.||.|  |     |..||..|.  . .        . ||. .|..   .  ...  .||       |.           .  .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SFIDYCLKKDARERPSPRQMLKHPWI
..|  .|..|  .|..  | |.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MKK2.AA Ciliate-E2 214-481 22 1.4e-61 210.15 In-house 1-365 (365) Show / Hide 
Range on Protein: 214-481
Range on HMM: 1-365/365
Sequence Identity: 22% (88 aa)

ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMN----------TDPEYQKQIF--RELQFNKSFKSDY-----------------------IVQYYG
.  . ..|.|. ||| ||. .. .| ||.| |.  .          .  .| . |.  ..... |. .. .                       |...| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

MFTDEQSSSIYIAMEYMGGKSLEATYKNL-LKRG------GRISERVIGKIAESVLR---------------GLSYLHERK-VIHRDIKPQNILLNEKGE
 | ... ..||. |||  |..|.   ||  .||.      ....|. |..| . .|.               .| |||... .|||||||.|||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKLCDFGVSGEAVNS---------------------------------LAMTFTGTSFYMAPERIQGQP---------YSVTCDVWSLGLTLLEVAGGRF
||..||| | .. ..                                 .. |. ||  ||||| ..|..         |.  ||.|||| .| |   |..
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFESDKITQNVAPIELLTMILT----FSPQLKDEPELD---------ISWSKTFRSFIDY----CLKKDARERPS-PRQMLKHPWI
||              .  |.     |... .... ..          .||.    .|      .|.||  .|.. . | |.|||.
PF--------------QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MKK2.AA MEK7 214-481 35 3.4e-61 206.34 In-house 1-269 (269) Show / Hide 
Range on Protein: 214-481
Range on HMM: 1-269/269
Sequence Identity: 35% (102 aa)

ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQ-FNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGG
.  .| .| |  | | |.| |    . | |.    .   |  | | . |    ... . |||| .|.|  .  |.. |.|| |.     .    ||||  
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQM-RRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTD--SDVWICMECMS-----TCCDKLLKR-I

RIS------ERVIGKIAESVLRGLSYLHER-KVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMT-FTGTSFYMAPERIQG-----QPYSVTCDVW
. .      |..|||.  ..   |.|| |   ..|||.|| |||| ..| |||||||.||  | | | |   |   |||||||         | .  |||
KHPKLDFIPEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVW

SLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTF---SPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKHPWI
||| || | | |..|..      .    | .| ||     .| |  ...   . |  |..|.| ||.|| |.||  |....|| |
SLGITLVELATGQYPYP-----GCDMEFEMMTKILNDNLEPPCL--PEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MKK2.AA Ciliate-E2-Unclassified 214-481 25 2.8e-57 196.6 In-house 1-352 (352) Show / Hide 
Range on Protein: 214-481
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDP-EYQKQIFRELQFN----KSFKSDYIVQ------------------YYGMFTDEQSSSIYI
 . . ..|.|. |.| ||. |. |...|.|... .. .   ....   |. ..    .. |. |..                   .. ......   |||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

AMEYMGGKSLEATYK-------------NLLKRGGRISERVIG-----KIAESVLRGLSYLHERK-VIHRDIKPQNILLNEKG---EIKLCDFGVS----
 |||. |..|.   |             . .|.. ...|. .      ...  .| ||.|||. . .|||||||.|||....|   .||..||| |    
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

-----GEAVN---------SLAMTFTGTSFYM----APERIQGQPYS----VTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPI----------ELLTM
         .          .. ||.||  ||    ||| .||| |.      ||.||||  | |   |..||.. . .|.   |          .|.  
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

ILTFSPQLKDEPE--LDISWSKTFRSFID----YCLKKDARERPSPRQMLKHPWI
|.   .| . .|.   .  ||..   ||      .|||.  .|... | |.|||.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MKK2.AA Pkinase_Tyr 214-364 30 1.9e-17 59.75 Pfam 1-158 (270) Show / Hide 
Range on Protein: 214-364
Range on HMM: 1-158/270
Sequence Identity: 30% (49 aa)

ITTLGILGEGAGGSVAKCRLK----NGKKVFALKTINTMNTDPEY--QKQIFRELQFNKSF-KSDYIVQYYGMFTDEQSS-SIYIAMEYMGGKSLEATYK
|| .  ||||| |.| |...|    |.|   | |..   ....|   ..  .||..  |.. . . ||..||  ||.. . .||| |||| . .|    .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL----L

NLLKR----GGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVS
. |..    .....   . ...  . .|..||.... ||||.   |.|..|.. .| |||| .
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase MKK2.AA TyrKc 214-481 21 1.8e-14 11.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 214-481
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSF--KSDYIVQYYGMFTDE-----QSSSIYIAMEYMGGKSLEATYKN
|| . .||||| | | |...|      | |...        .. . ||..  ...  . . ||. ||  |..      .  ..| |||| . .|    |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL----KD

LLKRGGR-ISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNS-------LAMTFT---GTS-----FYMAPERIQGQ
 |.. .. .. .   ...  . .| .|||....||||.   |.|..|.. .| .||| | .  .           . .   |.        |||| |.  
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYSVTCDVWSLGLTLLEVA-GGRFPFESDKITQNVAPIELLTMILTF-SPQLKDEPELDI----SWSKTFRSFIDYCLKKDARERPSPRQMLKHPWI
 ..   |||| | .. |.   |  | . .     . ..|..  . .   .   ....  .      .. ..  .  | . |. .||. ..   |  .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase MKK2.AA MEK1 450-481 37 1.1e-05 14.85 In-house 266-297 (297) Show / Hide 
Range on Protein: 450-481
Range on HMM: 266-297/297
Sequence Identity: 37% (12 aa)

WSKTFRSFIDYCLKKDARERPSPRQMLKHPWI
.|. |. |.| ||.|   ||   .|.. |..|
FSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MKK2.AA Pkinase_Tyr 382-408 40 0.801085 3.41 Pfam 181-207 (270) Show / Hide 
Range on Protein: 382-408
Range on HMM: 181-207/270
Sequence Identity: 40% (11 aa)

MAPERIQGQPYSVTCDVWSLGLTLLEV
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MAPECINYGKFTTKSDVWSFGVLMWEI