Gene MKK1 (Bakers Yeast)

MKK1

Species: Bakers Yeast
Alias: MKK1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MKK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
MKK1.AA Protein Refseq_NP 508 Mitogen-activated kinase-kinase involved in protein kinase C pathway; Mkk1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of MKK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MKK1.AA STE7-Unclassified 221-488 50 2.5e-172 578.79 In-house 1-301 (301) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-301/301
Sequence Identity: 50% (151 aa)

IETLGILGEGAGGSVSKCKLKN------GSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQ-SEYIVRYYGMFTDDENS-SIYIAMEYMGGRSLD---A
.|.|..||.|..|.|.||..||      ..||.|.|||.|...|.|..|||.|||......| ..|||.|||........ .|.|.||||...|||   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

IYKNLLE----RGGRISEKVLGKIAEAVLRGLSYLHEKK-VIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSL--ATTFTGTSFYMAPERIQGQ-----
|||...|    |||.|.|.||||||..|..||.|||||. .|||||||.|||.|..||||.|||||.|...|.|  |.|..|...||.|||||||     
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

PYSVTSDVWSLGLTILEVANGKFPCS----SEKMAANIAP-----FELLMWILTFT-PELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMIN-HP
.|||.||.|||||||.|.|.||.|..    ||....|..|     .|||..|..|. |.|.|.|| .||||..|..||..|.||..||||...|..| ||
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPE-DIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

WI
||
WI
Kinase MKK1.AA STE7 221-488 45 1.3e-152 513.31 In-house 1-288 (288) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-288/288
Sequence Identity: 45% (133 aa)

IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQ-SEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERG-
.|..| ||.|..|.| |. .|. .||.|.|.|.. |.|||.||||..||....... ..|||..||.| ..  ..|.|.||||.| .|| .||...... 
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GRISEKVLGKIAEAVLRGLSYLHE-KKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSL--ATTFTGTSFYMAPERIQG--QPYSVTSDVWSLG
    |||.|..||||| ||..||.||||  |.||||.||.|||.|..|||||||||..|. |.|.  ||||.|...|||||||.|  | |.| |||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LTI-LEVANGKFPCS-------SEKMAANI-----APFELLMWILTF-T-PELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMIN-HPWI
.|. .|.|.|..|.        ..|...|.     |.||.|..|... . |.|.       ..||.|..|...||.|| .|||...|. . ||.|
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP-------KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase MKK1.AA STE 221-488 31 1.9e-108 366.55 In-house 1-359 (359) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-359/359
Sequence Identity: 31% (115 aa)

IETLGILGEGAGGSVSKCKLKNGS---------------KIFALKVIN---------------TLNTDPEYQKQIFRELQFNRSFQ--SEYIVRYYGMFT
 | ....|.||.|.| |.. .. .               .|.| |..|               . |...| ..|| .|... . ..  ...||.|||.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DD-----ENSSIYIAMEYMGGRSLDAIYKNLLERG----------GRISEKVLGKIAEAVLRG-LSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSG
..     ......|.||||.| ||| |.|.  ..|          .|..|.....|. ..|.| |.|||....|||||||.||||     ||||||||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

EAVNSLA----------------T--TFTGTSFYMAPERIQG------QPYSVTSDVWSLGLTILEVANGKFPCSS-EKM-AANIAP--------FELLM
  ..|.|                   ||.||  .||||.||.      ..|.. .|.||||.||.| |.|| |..    | |   .|        ||.| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

WILT-FTPELKDEPESN-------------IIWSPSFKSFIDYCLKKDSRERPSPRQMIN--HPWI
.|.    | |.|. ..|               |||.|| ||. ||.|| ..||.. |...  ||.|
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MKK1.AA Pkinase 221-488 30 5.5e-98 336.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-293/293
Sequence Identity: 30% (93 aa)

IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFR--ELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGR----SLD----AI
.......|.|. |.| ||. |. .||.|.|.|.  ..... ... .|  |.|  .......|||.|..|.|  ...||. |||..|     .|     . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

YKNLLERGGRI--SEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQV----KLCDFGVSG---EAVNSLATTFTGTSFYMAPERIQ-GQPYS
     .|.|..  ||... ...  .|||| |.|....||||.||.|||...||..    |.||||..    .  || .|||.||..||||| |. ||.|.
-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

VTSDVWSLGLTILEVANGKFPCSSE----KMAANIAPFELLMWILTFTPELKDEP-------------ESNIIWSPSFKSFIDYCLKKDSRERPSPRQMI
  .|.||.|... |...|..|....    . .  .. ... |.  .  .. .. .             .  . ||...|.||..||.||  .||...|  
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQIL

NHPWI
.|||.
QHPWF
Kinase MKK1.AA S_TKc 221-488 30 2.7e-84 287.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-231/231
Sequence Identity: 30% (85 aa)

IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGG--RSLDAIYKNLLERG
 | | ..|.|| |.| ||. |.  .|.|.|.|.         ..| ||.|  .. . ..||..|..| |   ...|. |||..|   .|  . |.   .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

GR--ISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSFYMAPERIQGQPYSV-TSDVWSLGLTILEV
.|  ..| .  ...  ....| |.|....||||.||.||||.|  ..|.||||.. .      ||| || .||||| .   .|.   .|.||.| .. | 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMIN-------HPWI
. |. | .         .....  |.                ||..|.||. ||.|| ..||.  .  .       |||.
LCGYPPFP--------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MKK1.AA STE20 221-488 34 2.7e-81 276.39 In-house 1-288 (288) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-288/288
Sequence Identity: 34% (102 aa)

IETLGILGEGAGGSVSKCKLKNGSKI----FALKVINTLNTDP--EYQKQIFRELQFNRSFQSEYIVRYYGMFTDD-EN-SSIYIAMEYMGGRSLDAIYK
 | |  .|.|. |.| |.  |   ..     | |..|  . |.  . .. |. | .. . .....||.||| .  | .. ....|.|||.|| ||  |.|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

NLLERGG-----RISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVN----SLA---TTFTGTSFYMAPERIQG----
. ...|.     ...|.    |   ||.||.|||....|||||| .||||.|.|.|||.||||..   .    . .    || || ..|||| ||.    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-QPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWIL--TF-TPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWI
 ..|   .|.|||| |..| |.|. | .      .. |.  .. |.  .  .|.|||.      |||.|. |.| || ||  .||.. |. .||.|
DKGYDYKCDIWSLGITAIEMAEGEPPYF------DMHPMRAMFMIPKNQNPPPTLKDD-K-PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MKK1.AA MEK1 221-421 50 5.1e-71 241.92 In-house 1-195 (297) Show / Hide 
Range on Protein: 221-421
Range on HMM: 1-195/297
Sequence Identity: 50% (102 aa)

IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGR
.|..| ||.| || | ||. ..   | | |.|  |   |  ..|| ||||      | ||| .|| | .|..  | | |||| | ||| . |.     ||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIH-LEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGE--ISICMEYMDGGSLDQVLKKA----GR

ISEKVLGKIAEAVLRGLSYLHEK-KVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGK
| ||.|||.. ||||||.||..| |..|||.|| ||| | .| .|||||||||  . |.|  | ||  ||.|||.||  |.| ||.||.|| . |.| |.
IPEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGR

FP
.|
YP
Kinase MKK1.AA MEK5 221-488 41 5.9e-69 235.39 In-house 1-254 (254) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-254/254
Sequence Identity: 41% (111 aa)

IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGR
|     || | ||.| |       ||.|.|||  |.   | ||||  ||.      | ||. .|| |   ||  | |  |.| | ||| .|.       .
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVI-LLDITLELQKQIMSELEILYKCDSPYIIGFYGAFF-VEN-RISICTEFMDGGSLD-MYR-------C

ISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKF
| |..||... |. .|| || . |..|||.|| |.| | .||.||||||||   |||.. |. ||  ||||||| |. | . |||||||. ..|.| |.|
IPEHILGRMTVAIVKGLNYLWNLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRF

PCSSEKMAA-NIAPFELLMWILTFTPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWI
|    .    ...| .||  |    |      .    .|  |  ||  |..|  ..|| |.....||.|
PYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDK----FSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MKK1.AA Ciliate-E2 221-488 22 6.4e-61 207.86 In-house 1-365 (365) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-365/365
Sequence Identity: 22% (85 aa)

IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLN----------TDPEYQKQIF--RELQFNRSFQSEY-----------------------IVRYYG
.. . ..|.|. ||| ||| ..  | ||.|.|.  .          .  .| . |.  .....  . ....                       |...| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

MFTDDENSSIYIAMEYMGGRSLDA-IYKNLLERG------GRISEKVLGKIAEAVLR---------------GLSYLHEKK-VIHRDIKPQNILLNENGQ
 | .  ...||. |||  | .|   |..| . |.      ....||  ..| . .|.               .| |||.|. .|||||||.|||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKLCDFGVSGEAVNS---------------------------------LATTFTGTSFYMAPERIQGQP---------YSVTSDVWSLGLTILEVANGKF
.|..||| | .. ..                                 .. |. ||  ||||| ..|..         |.  .|.|||| .. |   ||.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PCSSEKMAANIAPFELLMW-ILTFTPELKDEPESN---------IIWSPSFKSFIDY----CLKKDSRERPS-PRQMINHPWI
|            ..  .   . | .. .... ..           ||.. | .|      .|.||  .|.. . | .||||.
PF-----------QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MKK1.AA MEK7 221-488 36 2.8e-57 192.88 In-house 1-269 (269) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-269/269
Sequence Identity: 36% (102 aa)

IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQ-FNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLER-G
.. .| .| |  | | |.. |    | | |     .   |  | | . |     .. . |||. .|.|    .|.. |.|| | .  .|   | . .   
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRR-TGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFM--TDSDVWICMECM-STCCDKLLKRIKHPKL

GRISEKVLGKIAEAVLRGLSYLHEK-KVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATT-FTGTSFYMAPERIQG-----QPYSVTSDVWSLGLT
  | |...||.  |.   |.|| ||  ..|||.|| |||| . |..||||||.||  | | | |   |   |||||||         | . .|||||| |
DFIPEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGIT

ILEVANGKFPCSSEKMAANIAPFELLMWILTF---TPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWI
. | | |..|    .|      || .  ||      | |. .   |   || | .|.| ||.|| |.||  |... || |
LVELATGQYPYPGCDME-----FEMMTKILNDNLEPPCLPEHMKYN--FSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MKK1.AA MEK4 221-421 42 6.2e-56 180.97 In-house 1-211 (275) Show / Hide 
Range on Protein: 221-421
Range on HMM: 1-211/275
Sequence Identity: 42% (90 aa)

IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTD-----PEYQKQIFRELQ-FNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNL
 . || .| || |.| |   |   || | | |   | |        ||.  .|.    .|    |||..||           | || |   |.|  ||  
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDC--WICMELM-DISMDKFYKYV

LE-RGGRISEKVLGKIAEAVLRGLSYLHEK-KVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTF-TGTSFYMAPERIQG----QPYSVTSDVWS
 . .  || | ..|.|. .. . | || |. |.||||.|| ||||.  | |||||||..|. |.| | |   |   |||||||.     . | . |||||
YMVQKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWS

LGLTILEVANGKFP
|| |. |||.||||
LGITMYEVATGKFP
Kinase MKK1.AA MEK3 221-421 42 1e-52 177.64 In-house 1-205 (264) Show / Hide 
Range on Protein: 221-421
Range on HMM: 1-205/264
Sequence Identity: 42% (89 aa)

IETLGILGEGAGGSVSKCKLKNGSKIFALKVIN-TLNTDPEYQKQIFRELQFN-RSFQSEYIVRYYG-MFTDDENSSIYIAMEYMGGRSLDAIYKNLLE-
....  || || | | | . .    | | | |  | |.    ||..  ..  . ||    | |..|| ||       . | || |   .||  |.. .. 
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNS--QEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGD---VWICMEVMDT-CLDKFYRHVYKP

RGGRISEKVLGKIAEAVLRGLSYLHEK-KVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTF-TGTSFYMAPERIQGQ--P--YSVTSDVWSLGL
.| .| | .|||||  . ..| |.||. ||||||.|| |.|.| .||||.||||.||  |.| | |   |   ||||||| ..  .  |.| ||||||| 
HGMHIPEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGI

TILEVANGKFP
|. |.| | .|
TMIEMAIGRYP
Kinase MKK1.AA Pkinase_Tyr 221-371 32 1.5e-21 73.64 Pfam 1-158 (270) Show / Hide 
Range on Protein: 221-371
Range on HMM: 1-158/270
Sequence Identity: 32% (52 aa)

IETLGILGEGAGGSVSKCKLK----NGSKIFALKVINTLNTDPE-YQKQIFRELQFNRSF-QSEYIVRYYGMFT-DDE-NSSIYIAMEYMGGRSLDAIYK
|. .  ||||| |.| |...|    |.    | |...   .... ...  .||..  ... . . |||.||  | ..| | .||| |||| . .|.    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDY--

NLLER---GGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVS
 | ..   ..... | | ...  . .|..||..|. ||||.   |.|..||..|| |||| .
-LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase MKK1.AA TyrKc 221-488 23 1.2e-15 30.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSF--QSEYIVRYYGMFTDD-EN----SSIYIAMEYMGGRSLDAIYKN
|. . .||||| | | |...|      | |...        .. . ||..  ...  . . ||| ||  |.. .|      ..| |||| . .|.   ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNS-------LATTFT---GTS-----FYMAPERIQGQP
  ..   .. | | ...  . .| .|||.|..||||.   |.|..||..|| .||| | .  .           . .   |.        |||| |.   
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YSVTSDVWSLGLTILEVA-NGKFPCSS-EKMAANIAPFELLMWILTF-TPELKDEPESNII----WSPSFKSFIDYCLKKDSRERPSPRQMINHPWI
..  ||||| | .. |.  .|. | .  ...   . ..|.. .. .   ..  ....   .     ..   . .  | . |  .||. ..   |  .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MKK1.AA MEK3 458-488 45 8.4e-09 26.05 In-house 234-264 (264) Show / Hide 
Range on Protein: 458-488
Range on HMM: 234-264/264
Sequence Identity: 45% (14 aa)

SPSFKSFIDYCLKKDSRERPSPRQMINHPWI
|| .. ||  ||||.. ||||  . . || .
SPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MKK1.AA MEK4 454-488 28 5.7e-07 18.6 In-house 241-275 (275) Show / Hide 
Range on Protein: 454-488
Range on HMM: 241-275/275
Sequence Identity: 28% (10 aa)

NIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWI
.. .|.....||  || || ..||.  .   .| .
DMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MKK1.AA MEK1 456-488 36 3e-06 16.97 In-house 265-297 (297) Show / Hide 
Range on Protein: 456-488
Range on HMM: 265-297/297
Sequence Identity: 36% (12 aa)

IWSPSFKSFIDYCLKKDSRERPSPRQMINHPWI
..|  |. |.| ||.|   ||   .|...|..|
VFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MKK1.AA Pkinase_Tyr 389-421 41 0.107078 6.37 Pfam 181-214 (270) Show / Hide 
Range on Protein: 389-421
Range on HMM: 181-214/270
Sequence Identity: 41% (14 aa)

MAPERIQGQPYSVTSDVWSLGLTILEVAN-GKFP
|||| |.   ... ||||| | .. |.   |. |
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQP