Gene MEK1 (Bakers Yeast)
MEK1
Group:
CAMK
Family:
CAMK-Unique
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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MEK1.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 284 | Kinase domain by global Sugen HMM | Fasta, JSON |
MEK1.AA | Protein | Refseq_NP | 497 | `Disp. for chr. pairing & chr. condensation seen by in situ hybrid. Required for full double strand breaks, normal length synaptonemal complexes, meiotic recomb. & spore viability. mek1 is rescued by spo13 & in early recomb. function; Mek1p [Saccharomyces cerevisiae]` | Fasta, JSON |
Protein domains of MEK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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FHA | MEK1.AA | FHA | 47-119 | 30 | 4.3e-21 | 81.18 | Pfam | 1-73 (73) | Show / Hide |
Range on Protein: 47-119 Range on HMM: 1-73/73 Sequence Identity: 30% (24 aa) VKVGRNDKECQLVLT-NPS-ISSVHCVFWCVFFDEDSIPMFYVKD--CSLNGTYL--NGLLLKRDKTYLLKHCDVIELS ...||. ..| .|| .|| .| .||.. . ..|.. .|..| || |||.. || ....... |.| |.| . WTIGRD-PDCDIVLDNDPSFVSRHHCEI-R-RYDNG---RWYIRDLGCSTNGTFVTGNGQRIQPGEPHRLHHGDRIRFG |
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FHA | MEK1.AA | FHA | 46-102 | 33 | 1.6e-14 | 55.49 | SMART | 1-49 (49) | Show / Hide |
Range on Protein: 46-102 Range on HMM: 1-49/49 Sequence Identity: 33% (20 aa) LVKVGRNDKECQLVLTNPSISSVHCVFWCVFFDEDSIPMFYVKDCS---LNGTYLNGLLL ...||. |...|..|||| .||... |.| |..|.. ||||.|| . TWTIGRHS--CDIQLPHPSISRHHCQIR----DGD-----YIIDLGEHSTNGTYVNGRRV |
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Kinase | MEK1.AA | CAMK-Unique | 162-444 | 30 | 7e-155 | 514.88 | In-house | 1-363 (363) | Show / Hide |
Range on Protein: 162-444 Range on HMM: 1-363/363 Sequence Identity: 30% (112 aa) EITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKP----------------NKFDKEARILLRLDHPNIIKVYHT----FCDRNN------ ....||.|.|.||||.............|...........|.|. .|...|..|....|||||||.|.. ||||.. YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI --------HLYIFQDLIPGGDLFSYLAKG-----------------DCLTSMSE--TESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEP----- ..||......|||||....|. .| ...|| .....|....|.|..|.|.||||||||||.||..|.... IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH --------CTRIVLADFGIAKDLNSNKER--MHTVVGTPEYCAPEVGFRANRKAYQSFSRAATLEQRGYDSKC----DLWSLGVITHIMLTGISPFYGDG ...|.|.|||.....|.||.. |.|..|||.|.|||..|..| ||...|........||..| |.||||||...||.|..||.... RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKN---YQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCEC SER-------SIIQNAKIGKL-NFKLKQWDI---VSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWI ..| .|......|.. ||. |.|.. .|..||.|||.....|...|...|..|.|.|| EDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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Kinase | MEK1.AA | CAMK | 167-444 | 23 | 1.9e-94 | 304.76 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 167-444 Range on HMM: 1-425/425 Sequence Identity: 23% (105 aa) IVGNGTFGHVLITHNSKERDEDVCYHPEN---------------YAVKIIKLK--------------------------------PNKFDKEARILLR-- . | |.|| | |.| .. .|.|||. | .. .| .|. . TLGRGSFGKVK-----------LCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQ -----LDHPNIIKVYHTFCDRNN------------------HLYIFQ---DLIPGG----DLFSYLAKGDCL------------TSMSETESLLIVFQIL |||||||| |... |... |.|.. ....|| |||.|. . | ..| | .. ||. GIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQIC QALNYLHDQDIVHRDLKLDNILLCTPEPCT--------------RIVLADFGIAKDLNSNK-----------------------ERMHTVVGTPEYCA-P .|..|.|...|||||||..||||.. .. . | ..||| |. ..... . |.|..|||||.| | SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP EVGFRANRKAYQSFSRAATLEQRGYDSKCDLWSLGVITHIMLTGISPFYGDG------------SERSIIQNAKIGKLNFKLKQ------------WDIV || . ....| . | |...|. ||| ||.|||. |||.| .||||| ... . .. . || .| .. || . EVLNGKGHCNMQ--N-ATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDI SDN--------AKSFVKDLLQTDVVKRLNSKQGLKHIWI ||. .|.... .||.| ||.. .| |.| |. SDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | MEK1.AA | Pkinase | 162-444 | 30 | 3.9e-94 | 323.83 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 162-444 Range on HMM: 1-293/293 Sequence Identity: 30% (98 aa) EITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKPNKFDK--------EARILLRLDHPNIIKVYHTFCDRNNHLYIFQDLIPGG----DL . |..| |.|| | . |. .... .||||||.. .| .| |..|..||.||||.. |..| | ..|.|. ... .|| || YHIGRKIGSGSFGCVYKCHHKGTGK--------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDL FSYLA--KGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLC-TPEPCTRIVLADFGIAKDL-NSNKERMHTVVGTPEYCAPEVGFRANR |.|. .. |.. .|| | .. |||..|.|.|.. |.|||||..|||. ........ ..|||.|| . . |.. |.|..|||.|.|||| FDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV------ KAYQSFSRAATLE-QRGYDSKCDLWSLGVITHIMLTGISPFYGD-----GSERSIIQNAKIGKLNFKLKQWDIVS-----------------DNAKSFVK . ...|..|.| ||.|.| ..||.| ||.|. ... .|.. . ..| | .|. .| ...|.|.| -----------IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK DLLQTDVVKRLNSKQGLKHIWI ..|. | ||.. .| |.| |. WCLCKDPKKRPTAEQILQHPWF |
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Kinase | MEK1.AA | S_TKc | 162-444 | 30 | 5.5e-84 | 286.23 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 162-444 Range on HMM: 1-231/231 Sequence Identity: 30% (91 aa) EITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKPNKFDKEARILLRLDHPNIIKVYHTFCDRNNHLYIFQDLIPG--GDLFSYLAKGDCL |..| |.|| | .. | . .|.|||| ... .| .|| . .||||.| | .| | .|||.. ....| ||||.|. | . YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH TS---MSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIAKDLNSNKERMHTVVGTPEYCAPEVGFRANRKAYQSFSRAAT ..| . .. ||..||.|.|.. |.||||| .||||.. .| ..|||.|. | .|..|||.|.|||| GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---------------- LEQRGYDS-KCDLWSLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLK-------HIWI ||. ||| ||.|.| .||.| ||. . .... . |. ||.|.. .|| | ||. . |. | |. ----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | MEK1.AA | Ciliate-E2 | 162-444 | 26 | 2.9e-67 | 229.76 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 162-444 Range on HMM: 1-365/365 Sequence Identity: 26% (103 aa) EITNRIVGNGTFG-----HVLITHN---SKERDEDVCYHPE---------NYAVKIIKLKPNKFDKEARILL-----------------RLDHPNIIKVY . ... |.|.|| | . . | | . . ||.||.| . .. | .. .|.|||||| | YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY HTFCD-RNNHLYIFQDLIPGGDLFSYLA-----KGDCLT---SMSETESLLIVFQILQ---------------ALNYLHDQD-IVHRDLKLDNILLCTPE .| . .|..|. ... |||||.|. .. ... ...| | . | |||| ||.||| . |.|||.|..|||. ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- PCTRIVLADFGIAKDLNSN----------K---------------------ERMHTVVGTPEYCAPEVGFRANRKAY--QSFSRAATLEQRGYDSKCDLW | ..|||..|... . | . .|..|||.| |||. |.| | | .| ||| |||.| ----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI---LNGKKYDNQ-------QKQKGYDYKCDIW SLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLK--------------QWDIVSDNAKSFVKD----LLQTDVVKRLN-SKQGLKHIWI ||||| ..||.| || .|. | .|..| . |. .|...| . | .|| | ||.. .| |.| |. SLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | MEK1.AA | RSK | 196-444 | 30 | 1.2e-64 | 221.13 | In-house | 27-278 (278) | Show / Hide |
Range on Protein: 196-444 Range on HMM: 27-278/278 Sequence Identity: 30% (84 aa) YAVKIIKL---KPNKFD-----KEARILLRLD-HPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLAKGDCLTSMSETESLLIVFQILQALNYLHDQDI ||.|..| .... | .| .||.| ||.|.. ...| . . .||. ....||.|| | | .. .||.| . .| |. .||.|.| YAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQT-EGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGI VHRDLKLDNILLCTPEPC-TRIVLADFGIAKD-LNSNKERMHTVVGTPEYCAPEVGFRANRKAYQSFSRAATLE----QRGYDSKCDLWSLGVITHIMLT .|||||..|||. . .|.| ||| .| ........| ..| ||.|||. | |.|.| ||.|||||. . ||| IHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEM-----------------LKRANQQGGHDKACDWWSLGVLMYEMLT GISPFYG--DGSERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLN-----SKQGLKHIWI | .||.| | . |... . ||...... |. .|..||.... .|. | |||. .. ..| |. GCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | MEK1.AA | RAD53 | 196-444 | 28 | 3.5e-59 | 174.69 | In-house | 27-305 (305) | Show / Hide |
Range on Protein: 196-444 Range on HMM: 27-305/305 Sequence Identity: 28% (84 aa) YAVKIIKL------------KPNKFDKEARILLRLDHPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLA-KGDCLTSMSETESLLIVFQILQALNYLH .|.|||.. |. . .|..|| .| ||.||. | | . .|. |. ||.||. .. . | .| .. .. .|.. |..||| VAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLH DQDIVHRDLKLDNILLCTPE-PC--------------TRIVLADFGIAKDLNSNKERMHTVVGTPEYCAPEVGF-------------RANRKAYQSFSRA |. |.||||| .|||. ... .| | ..||| .| . .... | | ||| |.|||| . DNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFV-GEGSFMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQ---------- ATLEQRGYDSKCDLWSLGVITHIMLTGISPFY-GDG---SERSIIQNAKI-GKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWI || .|.|.||.|.|. |.|.| || ... ..... . | ||..| ..|| .|..||...| .|. |. ||.. .. | | |. -----VGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM |
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Kinase | MEK1.AA | RSK | 161-444 | 32 | 8.7e-54 | 185.01 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 161-444 Range on HMM: 1-271/271 Sequence Identity: 32% (98 aa) WEITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKPNKFD-----KEARILLRL-DHPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLA |. | |.|.|. | . . . .| . ||.|||| . .. .| ||.|| .||.|.| . | . ..|. |. ||||| | YELHECI-GQGSFSKVYVCKKCQHKDTN-----QHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVF-QDEGKVYMIMDFMRGGDLFDRLL KGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTP-EPCTRIVLADFGIAKDLNSNKERMHTVVGTPEYCAPEVGFRANRKAYQSFSR | .. || | . . |. |..||| |.||||||| .|||. | ..||| || | . . | .| .| |||| KQKMF---SEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEV-------------- AATLEQRGYDSKCDLWSLGVITHIMLTGISPFYGDGSERS--IIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNS-----KQGLKHIWI | ..|.| || ||.||. ..|||| ||.. .. |||..| |.. . || .|| ||. . .| | .|| . .| ..| |. ---LKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF |
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Kinase | MEK1.AA | CAMKL | 161-339 | 27 | 2.2e-46 | 145.94 | In-house | 1-204 (297) | Show / Hide |
Range on Protein: 161-339 Range on HMM: 1-204/297 Sequence Identity: 27% (60 aa) WEITNRIVGNGTFGHVLITHNSKERDEDVCYH----PENYAVKIIK-----LKPNKFDK--------------EARILLRLD---HPNIIKVYHTFCDRN ..| | |.|| | . | | .|.|||. ..|.. .. |..|. .|. |||||| |... ... YRIGK-TLGKGSFGKVK-----------LATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPE N-----HLYIFQDLIPGGD--LFSYL-AKGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIA---KDL-NSNK . ..|.. ...||. || |. ..|.. .|.| | . ||. |.||.|...|||||.|..|||| . | ..||| . .. . . HDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPG ERMHTVVGTPEYCAPEV . ..| |.|.|.|||. QKLKTFCGSPPYMAPEI |
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Kinase | MEK1.AA | CAMK1 | 161-339 | 31 | 1e-45 | 130.81 | In-house | 1-184 (276) | Show / Hide |
Range on Protein: 161-339 Range on HMM: 1-184/276 Sequence Identity: 31% (62 aa) WEITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIK----LKP------NKFDKEARILL---RLDHPNIIKVYHTFCDRNNHLYIFQDLIPGG |....| |.|.|. | . . ..||.|.|. .| .....| |. ..||||||| | . . .||.|. ..|. || YEFGKEI-GRGAFSEVYLCTHKETQ----T-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWY-ESDNHFYLVMELVTGG DLFSYLAKGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIV--LADFGIAKDLNSNKERMHTVVGTPEYCAPEV .|| . . . .| . .|. |||.|..|.|...||||||| |.|. .... |. .||||..| .... . | |..|||.|.|||| ELFDRIVEKG---NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEV |
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Kinase | MEK1.AA | Ciliate-E2a | 163-339 | 31 | 1.9e-40 | 116.76 | In-house | 2-181 (275) | Show / Hide |
Range on Protein: 163-339 Range on HMM: 2-181/275 Sequence Identity: 31% (57 aa) ITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKPNKFDKEARILLRLDHPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLAKGDCLTSM .... |.|.||.| . .. .. . .. . ..| . .| .| |. .|||||||| | .. | .|..|. ... ||.|.... . ..... KFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYED-ENNYYLVMEYCEGGELYDKIKQCKRFFEE SETESLLIVFQIL-QALNYLHDQDIVHRDLKLDNILL--CTPE--PCTRIVLADFGIAKDLNSN-KERMHTVVGTPEYCAPEV . | | |.| |.|.|.| . |.|||||..|||. | .. . . |...||| |.. ... |..|.. .||| | |||| -IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEV |
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Kinase | MEK1.AA | CDPK | 162-339 | 35 | 3.3e-38 | 114.92 | In-house | 1-185 (271) | Show / Hide |
Range on Protein: 162-339 Range on HMM: 1-185/271 Sequence Identity: 35% (70 aa) EITNRIVGNGTFGHV-LITHN---SKERDEDVCYHPENYAVKII---KLKPNK----FDKEARILLRLDHPNIIKVYHTFCDRNNHLYIF--QDLIPGGD . ... | |.|| | ...| . || |.||| ..| .. | .| || ||||||||.| .. |..|. || . ||. YKIKKVLGKGHFGQVRKVKHKQKTNQER----------VAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNY-YIVMETEYCTGGE LFSYLAKGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCT----RIVLADFGIAKDLNSN----KERMHTVVGTPEYCAPEV || | . ..| |.|. .|. |||.|.|| |.. ||||||| |||... .. . |.. |.|..|. ..| .. | . .||| | |||| LFDYIIEKGHFT---EKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEV |
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Kinase | MEK1.AA | CAMK1 | 357-444 | 40 | 2.1e-32 | 91.48 | In-house | 185-276 (276) | Show / Hide |
Range on Protein: 357-444 Range on HMM: 185-276/276 Sequence Identity: 40% (37 aa) LEQ---RGYDSKCDLWSLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLKQWDIVSDN-AKSFVKDLLQTDVVKRLNSKQGLKHIWI ||. .|| .||.|| |||| |.|.| .|||.. . . . | ....| ..|| .|| || |.| .| | ||.. .| |.| || LECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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Kinase | MEK1.AA | CDPK | 357-444 | 40 | 5.1e-30 | 89.44 | In-house | 186-271 (271) | Show / Hide |
Range on Protein: 357-444 Range on HMM: 186-271/271 Sequence Identity: 40% (36 aa) LEQRGYDSKCDLWSLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWI |... |. |||.||.||| |.| | ||||. .. |... | || .|. ..||..||.|| .. .|..| ||. . | |.| |. LQKK-YNEKCDIWSCGVILYILLCGYPPFYGK-NDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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Kinase | MEK1.AA | Ciliate-E2a | 357-444 | 38 | 7.5e-26 | 73.1 | In-house | 188-275 (275) | Show / Hide |
Range on Protein: 357-444 Range on HMM: 188-275/275 Sequence Identity: 38% (34 aa) LEQRGYDSKCDLWSLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLKQ-WDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWI |... || |||.||.||| .|.|.| .||.| ... |.|. | |..| .. | .|...| ..| .|. | ||.. .| |.| | LKHKQYDTKCDMWSCGVIFYILLCGKPPFKGK-TYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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Kinase | MEK1.AA | CAMKL | 359-444 | 29 | 8.6e-14 | 40.24 | In-house | 209-297 (297) | Show / Hide |
Range on Protein: 359-444 Range on HMM: 209-297/297 Sequence Identity: 29% (27 aa) QRGYD-SKCDLWSLGVITHIMLTGISPFYGD-----GSERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWI .. || | | ||.||| |..| || .| | . || .. .. | || .... . .||.. || . .| ..| | NKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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Kinase | MEK1.AA | TyrKc | 162-442 | 20 | 8.7e-14 | 0.19 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 162-442 Range on HMM: 1-280/280 Sequence Identity: 20% (65 aa) EITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIK--LKPNKFDKEARILLRL--DHPNIIKVYHTFCDRN------NHLYIFQDLIPGGDLFS ... |.| || | . . .. ||| .| | .||||. .| .||||.. | . |.| . |.||| . ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD YLAKGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIAKDLNSN-----KERMHTV---VGTPE-----YCAPE || | . . | . .|| . .|||.. ..|||| |.|. . .. .||| ..|. . . . .. |. .||| YLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE VGFRANRKAYQSFSRAATLEQRGYDSKCDLWSLGVITHIMLTGISPFYGD-----GSERSIIQNAKIGKLNFKLKQ--WDI----VSDNAKSFVKDLLQT . . . . .| | || || ..| . | . | . .|.. | |. . . . .| . |. . C-----------------INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHE DVVKRLNSKQGLKHI | .| . .. . . DPEDRPTFSEIHECF |
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Kinase | MEK1.AA | Pkinase_Tyr | 210-327 | 29 | 7.5e-12 | 40.77 | Pfam | 52-172 (270) | Show / Hide |
Range on Protein: 210-327 Range on HMM: 52-172/270 Sequence Identity: 29% (37 aa) KEARILLRL-DHPNIIKVYHTFCDRNNH--LYIFQDLIPGGDLFSYLAKG-DCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCT .||.|. | .||||.. | |. . .|| . |.||| .|| | . . . . | . .|| ....||... ..|||| |.|. . REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--NN- RIVLADFGIAKDL-NSNKE-RMHT . .||| |.|. | |... VVKICDFGLARDIYNDDYYYRKRG |