Gene KIN3 (Bakers Yeast)

KIN3

Species: Bakers Yeast
Alias: KIN3
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK2

Sequence

Name Sequence Type Origin Length Description Download
KIN3.AA Protein Refseq_NP 435 protein kinase; Kin3p [Saccharomyces cerevisiae] Fasta, JSON
KIN3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 319 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of KIN3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase KIN3.AA NEK2 25-343 63 5.4e-262 876.67 In-house 1-319 (319) Show / Hide 
Range on Protein: 25-343
Range on HMM: 1-319/319
Sequence Identity: 63% (204 aa)

YQVLEEIGRGSFGSVRKVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSILSQLKHENIVEFYNWDFDEQKEVLYLYMEYCSRGDLSQMIKHYKQEHKY
|.||..||.||||..|||......|.||.|.|.||||..||.|.|..||.||.||||.|||..|.|..|.|...||..||||..||||||||....|..|
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IPEKIVWGILAQLLTALYKCHYGVELPTLTTIYDRMKPPVKGKNIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ
..|...|.|..||.|||..||.||||||||||||||||...||....|||.||.||||.||..|||||||||||||||||||||||||||||||||||||
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

VVVKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMDQPYSPLSDIWSLGCVIFEMCSLHPPFQAKNYLELQTKIKNGKCDTVPEYYSRGLNAIIHSMI
|||||||||||..|.....||.|.||||||||||....|.|...|||||.||.|.|||.|||||||.|...||.|||.|.....|..|||.||.|||.||
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

DVNLRTRPSTFELLQDIQI
.|....|||..|.||..||
NVDHYHRPSIEEILQHPQI
Kinase KIN3.AA NEK 25-343 35 2.6e-136 459.15 In-house 1-286 (286) Show / Hide 
Range on Protein: 25-343
Range on HMM: 1-286/286
Sequence Identity: 35% (121 aa)

YQVLEEIGRGSFGSVRKVIHIPTKKL-----LVRKDIKYGHMNSKERQQLI-AECSILSQLKHENIVEFYNWDFDEQKEVLYLYMEYCS-RGDLSQM---
|.....||.||||.| || .. ..|      .| | |..|.|..||.|...  |. ||.||||.|||..|.. ..||.. |.  ||||   |||.|.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKHYKQEHKYIPEKIVWGILAQLLTALYKCHYGVELPTLTTIYDRMKPPVKGKNIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDHRVNSG
||..||..||..|...| ...|.. ||. .|. . .|               .. ..|||.|| ||||. ...||                         
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GP---------------QRKILHRDIKPQNIFLTKNNNDY-------------------------

KRGSPMDYSQVVVKLGDFGLAKSLETSIQFATT-YVGTPYYMSPEVLMDQPYSPLSDIWSLGCVIFEMCSLHP--PFQAK--NYLELQTKIKNG-KCDTV
          ..||.||||..| |... ..|.| .|||||||||||. ..||.  |||||||||..|||.|.|  ||.|.  | ..| .||..| ... .
----------HNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPI

PEY--YSRGLNAIIHSMIDVNLRTRPSTFELLQDIQI
|..  ||. |. .|..|. ..   |||. ..|.. .|
PSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase KIN3.AA S_TKc 25-343 26 3.1e-66 227.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-343
Range on HMM: 1-231/231
Sequence Identity: 26% (89 aa)

YQVLEEIGRGSFGSVRKVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSILSQLKHENIVEFYNWDFDEQKEVLYLYMEYCSR--GDLSQMIKHYKQ--
|..|..||.|.||.|.|..|. |...   | ||         .... | .||.. .|.||| .| .  |   . ||. ||||.   ||| ..||...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

EHKYIPEKIVWGILAQLLTALYKCHYGVELPTLTTIYDRMKPPVKGKNIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPM
 ....||  .. ...|.. ||  ||                     .. .||||||| ||.|.                                     
LRFPFPE-HARFYMYQICCALEYCH---------------------SHGIIHRDLKPENILLDE------------------------------------

DYSQVVVKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMDQPYSP-LSDIWSLGCVIFEMCSLHPPFQAKNYLELQTKIKNGKCDTVPEYYSRGLNAI
     ..|..|||||. |       ||..|||.||.||||   .|..  .|.||.||...||..  |||.  .. ..  ||.           |. .  .
-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDF

IHSMIDVNLRTRPSTFELLQ-------DIQI
|  . ... . ||.  |.||       .  .
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KIN3.AA Pkinase 25-343 25 5.2e-66 230.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-343
Range on HMM: 1-293/293
Sequence Identity: 25% (92 aa)

YQVLEEIGRGSFGSVRKVIHIPTKKLLVRKDIKYGHMNSKERQQLIA--ECSILSQLKHENIVEFYNWDFDEQKEVLYLYMEYCSRG----DLSQMIKHY
|.... ||.||||.|.| .|. | |. . | ||. | .|...|...   |..|.  |.|.|||..| |  |  |  .|. ||||  |    ||. .|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

KQEHKYI--PEKIVWGILAQLLTALYKCHYGVELPTLTTIYDRMKPPVKGKNIVIHRDLKPGNIFLS--YDDSDYNINEQVDGHEEVNSNYYRDHRVNSG
 ..|. .  .|. .  .. |.| .|. ||                        .||||||| ||...  .. ..                          
-WRHGCFYFSEWECKFYMYQILRGLEYCHSM---------------------GIIHRDLKPENILIDNNGHIDA--------------------------

KRGSPMDYSQVVVKLGDFGLAKSL-ETSIQFATTYVGTPYYMSPEVLM-DQPYSPLSDIWSLGCVIFEMCSLHPPFQAK----NYLELQTKIKNGKCDTV
            ||..|||||| . . . . .||..|||.||.|||.. .|.|.| .|.||.||...||.. .|||. .    | .. . .|.. ..  .
-----------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPL

PEYYS-----------------------RGLNAIIHSMIDVNLRTRPSTFELLQDIQI
.. ..                       . .  .| ......   ||.  ..||.  .
HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase KIN3.AA Ciliate-E2 25-343 18 1.6e-46 157.72 In-house 1-365 (365) Show / Hide 
Range on Protein: 25-343
Range on HMM: 1-365/365
Sequence Identity: 18% (83 aa)

YQVLEEIGRGSFGSVRKVIHIPTKK----------LLVRK------DIKYGHMNSKERQQLIAECSILSQLK-------------------HENIVEFYN
| ... ||.|.||||.|. .. ..|          . .|       .||.  |.... .|...  .......                   | ||...| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

WDFDEQKEVLYLYMEYCSRGDLSQ-MIKHYKQEHKYIP------EKIVWGILAQLLTALYKCHYGVELPTLTTIYDRMKPPVKG----------------
.  ..... .|| ||||. ||| . .....|.... |.      || .  | .|.| .                         .                
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFK-----------------------TKAEFYIACIILALEYL

--KNIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLAKSLETSIQ---------------------
  || .||||.|| ||..                                            .|. ||||.| . .. |                     
HSKNNIIHRDIKPENILF--------------------------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTP

----------FATTYVGTPYYMSPEVLMDQP---------YSPLSDIWSLGCVIFEMCSLHPPFQAKNYLELQTKIKNGKCDTV----------------
           . |..|||.||.||.|. ..         |.  .||||||....||..  |||        | .||..|.|                  
GYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWK

-PEYYSRGLNAIIHS----MIDVNLRTRPS-TFELLQDIQI
 ... |     .|      |....   |..   ..|.   .
SWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase KIN3.AA NEK1 226-343 44 7.8e-38 128.87 In-house 159-276 (276) Show / Hide 
Range on Protein: 226-343
Range on HMM: 159-276/276
Sequence Identity: 44% (53 aa)

VVKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMDQPYSPLSDIWSLGCVIFEMCSLHPPFQAKNYLELQTKIKNGKCDTVPEYYSRGLNAIIHSMID
.||||||| |. |  .  .| |..||||| |||    .||   |||||||||  | | |  ||.|.|   |  ||  |    .|  ||. |   . .|  
LVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFK

VNLRTRPSTFELLQDIQI
.| | |||.  .|.   |
RNPRHRPSVNQILERPFI
Kinase KIN3.AA STE 167-343 21 1.2e-34 119.79 In-house 170-359 (359) Show / Hide 
Range on Protein: 167-343
Range on HMM: 170-359/359
Sequence Identity: 21% (50 aa)

KNIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLAKSLETSIQ----------------FATTYVG
.. .||||.||.||.|                                            ||| |||....|. |.                   .| ||
SHHIIHRDIKPANILL--------------------------------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVG

TPYYMSPEVLM------DQPYSPLSDIWSLGCVIFEMCSLHPPFQAKNYL-ELQTKIKN--------------GKCDTVPEY------------------
|| .|.|||..      |..|.  .|||||||.| ||.  .||.   ...  .  ...|              |.. . |.                   
TP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPH

-YSRGLNAIIHSMIDVNLRTRPSTFELLQ--DIQI
 .|  ..  |    . . . ||.. .||.     |
KWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase KIN3.AA ULK 170-302 29 1.4e-33 114.58 In-house 151-269 (329) Show / Hide 
Range on Protein: 170-302
Range on HMM: 151-269/329
Sequence Identity: 29% (45 aa)

VIHRDLKPGNIFLSYD----DSDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLAKSLETS---IQFATTYV------GTPYYMS
.||||.|| || .. .    ||                           |      . ..|.|..|||.||... .   .| ..|.|      |||.||.
IIHRDIKPQNILIHNGQPKTDSK--------------------------K----VHP-NGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMA

PEVLMDQ----PYSPL-SDIWSLGCVIFEMCSLHPPFQAKNYLELQTKIKN
|..|..|    ||.   .|||||||...||    |||.|  . ... .|..
PQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQ
Kinase KIN3.AA CAMK 170-343 22 6e-33 102.95 In-house 200-425 (425) Show / Hide 
Range on Protein: 170-343
Range on HMM: 200-425/425
Sequence Identity: 22% (56 aa)

VIHRDLKPGNIFLSYDD--SDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLAKSLETSI-----------------------QF
..|||||| || |....  ||  . |  |         . |              ..  .|. |||.|. .. .                        | 
IVHRDLKPENILLDDNNDDSDP-V-E-HD-------EIF-D-------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQK

ATTYVGTPYYMS-PEVLMD--------------QPYSPLSDIWSLGCVIFEMCSLHPPFQAK-------------NYLELQTKIKNGKCDTVPEYYSR--
 .|..|||.||. ||||                ..|.| .|.||.|.. . | . .|||...             |. ||  ||..||.|  |.| |   
MKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPIS

---------------------GLNAIIHSMIDVNLRTRPSTFELLQDIQI
                          | .|  |.   |..  . |..  .
CNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase KIN3.AA ULK 170-302 27 1.6e-32 112.69 In-house 147-279 (324) Show / Hide 
Range on Protein: 170-302
Range on HMM: 147-279/324
Sequence Identity: 27% (45 aa)

VIHRDLKPGNIFLSYD----DSDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLAKSLE---TSIQFATTYV------GTPYYMS
.||||.|| || .. .    ||                           |      . ..|.|..|||.||...    . |  .|.|      |||.||.
IIHRDIKPQNILIHNGQPKTDSK--------------------------K----VHP-NGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMA

PEVLMDQ----PYSPL-SDIWSLGCVIFEMCSLHPPFQAKNYLELQTK--------------IKN
|..|..|    ||.   .|||||||...||    .||..  . ... .              |||
PQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKN
Kinase KIN3.AA Ciliate-E2-Unclassified 170-343 19 2.5e-32 109.46 In-house 165-352 (352) Show / Hide 
Range on Protein: 170-343
Range on HMM: 165-352/352
Sequence Identity: 19% (44 aa)

VIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLAKSLETSIQF---------------ATTYVGTPYY
.||||.|| ||... . .                                       .|. |||..| .......               ..| .|||.|
IIHRDIKPENILFDNNGK------------------------------------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNY

M----SPEVLMDQPYSPL----SDIWSLGCVIFEMCSLHPPFQAKNYLE----------------LQTKIKNGKC-----------DTVPEYYSRGLNAI
|    .||||. | |.      .||||||....||.   .||...|. .                |. .||....           ..... .   .| .
MPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDL

IHSMIDVNLRTRPSTFELLQDIQI
...|...|.  |..  ..|.   .
LQKMLKKNPNKRITFEQILNHPWF
Kinase KIN3.AA NEK4 226-343 39 1.2e-31 111.01 In-house 140-257 (257) Show / Hide 
Range on Protein: 226-343
Range on HMM: 140-257/257
Sequence Identity: 39% (47 aa)

VVKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMDQPYSPLSDIWSLGCVIFEMCSLHPPFQAKNYLELQTKIKNGKCDTVPEYYSRGLNAIIHSMID
..|.||||... |. . ..| | .|||||||||.   .||   |||||||| ..||  |   |.||.   |  .| .|.   .|  ||  |  ..  |..
IIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLE

VNLRTRPSTFELLQDIQI
     ||| |...|   |
KQPTKRPSIFDIFQMPYI
Kinase KIN3.AA STE 25-142 23 1.9e-24 83.28 In-house 1-166 (359) Show / Hide 
Range on Protein: 25-142
Range on HMM: 1-166/359
Sequence Identity: 23% (39 aa)

YQVLEEIGRGSFGSVRKVIHI------PTKKL---------LVRKDIKYGHMNS---------------KERQQLIAECSILSQLK--HENIVEFYNWDF
.. .|.||.|.||.| | ...      .|...            | ... . |.               .|.||.. | .|.....  |.|||..|   |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE-----QKEVLYLYMEYCSRGDLSQMIKHYK---QEHK-------YIPEKIVWGILAQLLTA-LY
.|     ... |...|||.. | |...|||..   ....       ..||...  |. |.| . ||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLY
Kinase KIN3.AA ULK 25-141 27 1.6e-23 78.99 In-house 1-143 (329) Show / Hide 
Range on Protein: 25-141
Range on HMM: 1-143/329
Sequence Identity: 27% (40 aa)

YQVLEEIGRGSFGSVRKVIHIPT-----KKLLVRK-DIKYGHMNSKERQ------QLIAECSILSQLK--------HENIVEFYNWDFDEQKEVLYLYME
|.. ...| |||| | | ... |     .|  . . |...  ....|..      .|. |. |. .||        |.|||..| |  . .   .|. ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCSRGDLSQMIKHYKQ------EHKYIPEKIVWGILAQLLTAL
||  |||.| || .|       |.|...|...  .. |.| ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGF
Kinase KIN3.AA ULK 25-141 29 9.3e-23 77.61 In-house 1-139 (324) Show / Hide 
Range on Protein: 25-141
Range on HMM: 1-139/324
Sequence Identity: 29% (41 aa)

YQVLEEIGRGSFG-SVRKVIHIPT---KKLLVRKDIKYGHMNSKERQ--------QLIAECSILSQLK---HEN--IVEFYNWDFDEQKEVLYLYMEYCS
|.. ...| ||||  | | ... |   ...   | |    || |. .        .|. | .|. .||   |.|  ||..| |  . .   .|. |||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

RGDLSQMIKHYKQ-----EHKYIPEKIVWGILAQLLTAL
 |||.| || .|      |.|...|... ... |.. ..
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGF
Kinase KIN3.AA CAMK 30-145 19 8.2e-22 66.42 In-house 1-196 (425) Show / Hide 
Range on Protein: 30-145
Range on HMM: 1-196/425
Sequence Identity: 19% (38 aa)

EIGRGSFGSVRKVIHIPTK------------KLLVRKDIKYGHMN--------------------------SKERQQLIAECSILSQ-------LKHENI
..|||||| |...||. |.            .    | |.   .                            | |...  | .|...       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEFYNWDFDEQ-----------------KEVLYLYM---EYCSRG----DLSQMIKHY------------KQEHKYIPEKIVWGILAQLLTALYKCH
. .| .  |..                 .. .|. |   |||| |    || ..|.                |.....|. .  .  |.. |.  ||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCH
Kinase KIN3.AA Ciliate-E2-Unclassified 25-146 23 1.2e-19 64.87 In-house 1-161 (352) Show / Hide 
Range on Protein: 25-146
Range on HMM: 1-161/352
Sequence Identity: 23% (38 aa)

YQVLEEIGRGSFGSVRKVIHIPTK---------KLLVRKDIKYGHMNSKERQQLIAECS---------------ILSQLKHENIVEFYNWDFDEQKEVLY
| ... ||.|.||.|.|..|. .|         |  ..|. .. ...  . ........               ||....|..|| .. .. |.|.  .|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--IY

LYMEYCSRGDLSQMIKHYKQ------------EH-KYIPEKIVW-----GILAQLLTALYKCHY
. ||||  |||.|.||..|.            .. | ..|. .       ..||.| .| ..|.
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH
Kinase KIN3.AA NEK1 25-127 36 1.5e-19 64.64 In-house 1-103 (276) Show / Hide 
Range on Protein: 25-127
Range on HMM: 1-103/276
Sequence Identity: 36% (38 aa)

YQVLEEIGRGSFGSVRKVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSILSQLKHENIVEFYNWDFDEQKEVLYLYMEYCSRGDLSQMIKHYKQEHKY
| ..  || |||| . .| |    ...| | |.   | .|||..   |  ||. .||.|||....  . . . .||  ||||  ||| | |.  |   | 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IPE
..|
FSE
Kinase KIN3.AA NEK4 25-121 34 5e-14 46.91 In-house 1-97 (257) Show / Hide 
Range on Protein: 25-121
Range on HMM: 1-97/257
Sequence Identity: 34% (34 aa)

YQVLEEIGRGSFGSVRKVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSILSQLKHENIVEFYNWDFDEQKE-VLYLYMEYCSRGDLSQMIKHYKQE
|. .  .|.||.| |  | |   ||  | | ..     ..||.    |  .|||||| ||||. .  ..      ||  | .|  ||| .  |  | .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKE-SWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQ
Kinase KIN3.AA TyrKc 25-341 16 6e-14 2.79 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-341
Range on HMM: 1-280/280
Sequence Identity: 16% (59 aa)

YQVLEEIGRGSFGSVRKVIHIPTKKLLV-----RKDIKYGHMNSKERQQLIAECSILSQL--KHENIVEFYNWDFDEQK-----EVLYLYMEYCSRGDLS
 . ....|.| || |.| . .    . |     ..|          |. .. | .|...|  .|.||| .|    ...      | |.. |||.. ||| 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

QMIKHYKQEHKYIPEKIVWGILAQL---LTALYKCHYGVELPTLTTIYDRMKPPVKGKNIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDH
. .. .. .   .. |    .  |       | .                          .|||||   |. .. .                        
DYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK------------------------NCIHRDLAARNCLVGENH-----------------------

RVNSGKRGSPMDYSQVVVKLGDFGLAKSLETS--------IQFATTYVGTP-----YYMSPEVLMDQPYSPLSDIWSLGCVIFEMCSL-HPPFQA-----
                .|| .||||.. ..             ...  |.        |.||....  ... ||.|| | ...|....  .|        
----------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQM

KNYLELQTKIKNGKCDTVPEY--------YSRGLNAIIHSMIDVNLRTRPSTFELLQDI
..  |.  ..|.|.    |..         .  .  |. .  . .   ||.  |. ...
MSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase KIN3.AA Pkinase_Tyr 226-284 26 3.1e-07 25.12 Pfam 149-210 (270) Show / Hide 
Range on Protein: 226-284
Range on HMM: 149-210/270
Sequence Identity: 26% (17 aa)

VVKLGDFGLAKSLETSIQFATTYVGT-----PYYMSPEVLMDQPYSPLSDIWSLGCVIFEMCSL
||| .|||||. . ..     .....        |.||....  ..  ||.|| | ...|....
VVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase KIN3.AA NEK1 170-189 40 4e-05 13.93 In-house 125-144 (276) Show / Hide 
Range on Protein: 170-189
Range on HMM: 125-144/276
Sequence Identity: 40% (8 aa)

VIHRDLKPGNIFLSYDDSDY
..|||.|. ||||.  ....
ILHRDIKSQNIFLTISKNGM
Kinase KIN3.AA Pkinase_Tyr 63-111 33 0.000754 13.66 Pfam 42-94 (270) Show / Hide 
Range on Protein: 63-111
Range on HMM: 42-94/270
Sequence Identity: 33% (18 aa)

SKE--RQQLIAECSILSQL-KHENIVEFYNWDFDEQKE-VLYLYMEYCSRGDL
...  |. ...| .|..|| .|.||| .|    |...   .|. |||.  |||
HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase KIN3.AA NEK4 170-182 69 0.009787 5.87 In-house 123-135 (257) Show / Hide 
Range on Protein: 170-182
Range on HMM: 123-135/257
Sequence Identity: 69% (9 aa)

VIHRDLKPGNIFL
..|||||  ||||
ILHRDLKTQNIFL
Kinase KIN3.AA Pkinase_Tyr 25-41 35 0.098689 6.49 Pfam 1-17 (270) Show / Hide 
Range on Protein: 25-41
Range on HMM: 1-17/270
Sequence Identity: 35% (6 aa)

YQVLEEIGRGSFGSVRK
 . ....|.|.||.|.|
ITFGKKLGEGAFGEVYK