Gene CDC28 (Bakers Yeast)

CDC28

Species: Bakers Yeast
Alias: CDC28
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK2

Sequence

Name Sequence Type Origin Length Description Download
CDC28.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 288 Kinase domain by global Sugen HMM Fasta, JSON
CDC28.AA Protein Refseq_NP 298 Catalytic subunit of the main cell cycle cyclin-dependent kinase; Cdc28p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of CDC28.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC28.AA CDC2 8-295 60 2.7e-222 690.79 In-house 1-301 (301) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-301/301
Sequence Identity: 60% (186 aa)

YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEG--VPSTAIREISLLKELK-DDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYME-GIP
|...||.||||||||||. |.. .|   .|||||||||.||||  ||||||||||.||||| ..|||.| |..|.  .|||.|||.|| |||.||.  ||
YQKIEKIGEGTYGVVYKCKDMQTNQ---IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ--NKLYMVFEYLDMDLKKYMDMSIP

KDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYT--HEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCI
|....  ..||..|.|...|...||..||.||||||||.||.|.||.|..|||||||||.|.|.||  ||.|||||||||.||| |.|||.|| ||||||
KNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCI

FAEM---CNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPS---------LDPRGIDLLDKLLAYDPINRISARRA
||||   ...||.|.|||||||.|||||.|||||| .||..  |||.|..||.|...|||...|.         |||.|||||...|.|||..||||..|
FAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEA

AIHPYF
  ||||
LQHPYF
Kinase CDC28.AA CDK 8-295 51 9.60000000001e-184 592.92 In-house 1-284 (284) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-284/284
Sequence Identity: 51% (166 aa)

YKRLEKVGEGTYGVVYKALDLRPGQ--GQRVVALKKIRLES-----EDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDA----------HKLYLVFEF
|..|||.||||||||||| |.. |.   ...|||||||.|.     |.||.|.||||||||||||  .|||.|.|..|...          .|||.|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGN-----LKLGDFGLARAFGV------PLRAYTHEIVTLWYRA
.| ||| ||.            .| .|.|| .|..||||..|.||||||||.|||..|.     ||..|||||||||.      |.|.||||.|||||||
MDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRA

PEVLLGGKQYS--TGVDTWSIGCIFAEMCN---RKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDK
||.||| |.||  |..| ||.||||||| .   |||.| |||||||.|||||..|||.| .||... |||.                        |||.|
PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNK

LLAYDPINRISARRAAIHPYF
.|.||| .||||  |  ||||
MLCYDPKKRISAEQALQHPYF
Kinase CDC28.AA CDK5 8-295 57 2.1e-174 555.92 In-house 1-287 (287) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-287/287
Sequence Identity: 57% (168 aa)

YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQP
|...||.||||||.||||..    . . .||||..||.||||||||||||||.||||||  |||||.|..||.  || |||||.| |||.||. .     
YEKMEKIGEGTYGTVYKARNK---ETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSE-KKLTLVFEFCDQDLKKYMDSCNG--E

LGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMC-
. ..|.| || || ||.|.||.|..|||||||||||||| |.|||.|||||||||.| | |.||.||||||.| ||.| |.||| .| ||.|||||||  
MDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMAN

NRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFK---PSFPQWRRKD-LSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYF
. .| | | .. || ..||...|||.|  || |  |||.|     .| .  .  ..|.||.|| .| ||| |.| ..|  ||||  |  ||||
AGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDC28.AA CMGC 8-295 29 2.1e-149 494.67 In-house 1-513 (513) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-513/513
Sequence Identity: 29% (154 aa)

YKRLEKVGEGTYGVVYKALDLRPG-----------QGQRVVALKKIRLES---------EDEGVPSTAIREISLLKELK----------------DDN-I
|. ..|.||||||||||. | | .           .....||.|||...          | .|.|..|.|||..||.|.                ..| |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VRLYDIVHSDA----------------HKLYLVFEFLDLDLKRYMEGIP------KDQPLGADI------------VKKFM------MQLCKGIA--YCH
|.||||....                  .||||||..| ||..|..  .      . .||                .|.||       |...|..  |||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SHR--ILHRDLKPQNLLINKD--------------------GNLKLGDFGLARAFGVP---------------------LRAYTHEIVTLWYRAPEVLLG
||.  |.||||||.|.|||..                    |.||..||||||.....                     .|.|||..||.||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

GKQYS---------TGVDTWSIGCIFAEMCNR--------KPIFSGDSE-----------IDQIFKIFRVLGTPN---------------EAIWPDIVYL
 |.|.         |..| ||.||||||| ..        ||.| |.||           |||.||||.|||||.               | .||... |
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PDFKP--------------S------------FPQWRRKDLSQVVPS-----------------------------------LDPRGIDLLDKLLAYDPI
|....              |            ||.|..|......|                                    .|| .||||.|.| ||| 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

NRISARRAAIHPYF
.||.|  |  ||||
KRITAEQALQHPYF
Kinase CDC28.AA CDK7 8-295 43 9.69999999999e-142 380.45 In-house 1-288 (288) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-288/288
Sequence Identity: 43% (129 aa)

YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIR----LESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIP
|. ....|||....||||.|.  |   ..|| |||.     .  . |.  |||||| .|.|.. ||.. | ||       ..|||.|.| ||    | . 
YEKIKHIGEGQFATVYKACDHQTG---QIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIF-MHKSNIQLVFDFMDWDL----EVVI

KDQPL---GADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGC
||. .    |.| | .||.. .|. ||| . |||||||| |||.|..| ||..||||||..| | |.||| .|| |||||| | | ..| |||| ||.||
KDKSIILTPAHI-KAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGC

IFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPD---FKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYF
||||   | |.. |||.|||. .||. ||||.|. ||..  ..|   || .||   |  | ..        .||. .... .|..|.... .  .|||
IFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFK-DFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDC28.AA PCTAIRE 8-295 51 8.49999999999e-123 414.25 In-house 1-291 (291) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-291/291
Sequence Identity: 51% (154 aa)

YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQP
|..|.| |||||  |||    |      .|||| |||| | || | |||||.||||.||  ||| | ||.| . | | ||||..| |||.||.     . 
YIKLDKLGEGTYATVYKC---RSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIIHTH-HQLTLVFEYMDMDLKQYMDDC--GNI

LGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCN
.    || |. ||  | ||||  .|||||||||||||| .| ||| |||||||  || . | ||.|||||| |.||.|  .||| .|.| .||||.||| 
MNMHNVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCT

RKPIFSGDS------EIDQIFKIFRVLGTPNEAIWPDIVYLPDFKP-SFPQWRRKDLSQVVPSLD---PRGIDLLDKLLAYDPINRISARRAAIHPYF
 .| | |          ||   |||.|||| |  ||..  ...|.. .||..| . |  . | ||     ..||| .|| | . ||.||  |  ||||
GRPLFPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase CDC28.AA PITSLRE 8-295 46 1.4e-121 410.24 In-house 1-295 (295) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-295/295
Sequence Identity: 46% (139 aa)

YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLE--SEDEGVPSTAIREIS-LLKELKDDNIVRLYDIVH-SDAHKLYLVFEFLDLDLKRYMEGIP
.. | ...||||||||.| | | .   ..||||.. .|   | || | |..|||. .|..|. .||| .  ||  |.  | |.|.|... |||  || . 
FQCLNRIHEGTYGVVYRAKDKRTD---EIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMK

-KDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIF
 ..||     .| .| || .|... |.. |.|||||  |||..  |.||..|||||| .| |...||  .|||||||||.||| | ||| || ||.||||
RRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIF

AEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKP--SFPQWRRKDLSQVVP---SLDPRGIDLLDKLLAYDPINRISARRAAIHPYF
||.   ||.| |.|||||| .||  .|||.| |||..  || .|   .||.     | . .|    .   | ||| ..| |.| |||.|  |  ||.|
AEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDC28.AA PFTAIRE 8-295 49 2.1e-120 406.28 In-house 1-287 (287) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-287/287
Sequence Identity: 49% (145 aa)

YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQP
|..||| |||.|  |||.     .|   .|||| |||. ..||.| ||||| ||||.||  ||| | ||.| .   | .|||... ||. ||.  |    
YEKLEKLGEGSYATVYKGISCINQQ---FVALKEIRLQ-QEEGTPFTAIREASLLKNLKHANIVCLHDIIHTK-ETLTFVFEYVHTDLCQYMDKHP--GG

LGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCN
.  . |. |. ||  | .|||  |.|||||||||||| . | ||| |||||||  || . | ||.|||||| | ||||   ||| .| | .|||| ||  
MHPNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMW

RKPIFSGD-SEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQ---WRRKDLSQVVPSLD--PRGIDLLDKLLAYDPINRISARRAAIHPYF
 .| | |     ||  |||.|||||.|  || .  || .||   .    . | | ...|...  | . ||. |.| . | .|.||  |  ||||
GQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDC28.AA CDK4 8-295 45 3.3e-108 365.77 In-house 1-290 (290) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-290/290
Sequence Identity: 45% (135 aa)

YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDE--GVPSTAIREISLLKELKDD---NIVRLYDIVH-SDAHK----LYLVFEFLDLDLKR
|. .  .||| || ||.| ||  |   . ||||..|  ...|  |.|   |||||... |.     |||.|.|. | .|       . .|||  | ||. 
YQCVAEIGEGAYGTVYRARDLHTG---HFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHT

YMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWS
|.. .|.   . .  .|. | ||  |. . ||||| ||||||||.|.. || .|| |||||| ..    | |  .||||||||||||    | | || ||
YLDKCPP-PGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQM-ALTPVVVTLWYRAPEVLL-QSYYNTPVDMWS

IGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYF
.||||||| .|.| | | || ||  ||| | |.| |  ||  | ||    .||| . . .  ..| ..  |.||| | | |..  |.||...  ||||
VGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP--WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDC28.AA Pkinase 8-295 33 1.4e-101 348.55 Pfam 1-293 (293) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-293/293
Sequence Identity: 33% (102 aa)

YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIR--EISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDL-----DLKRYME
|....|.|.|..|.|||. .   |.   .||.|.|....|..... |..|  ||...|.|. .|||||||..... | .|.|.|...      ||..|..
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDH-IYMVMEYCEGGLYVMDLFDYIS

GIPKDQPL--GADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNL----KLGDFGLARAF-GVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGV
.  .. ..    . .|..| |...|..||||..|.||||||.|.||...|..    |..|||||. |   . . .|.  .|.||.||||..||. |.. |
T-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DTWSIGCIFAEMCNRKPIFSGD----SEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRA
| ||.|||..||....|.|.|.    . .||...|.|..|.|..  ||     ..|.  .. | .. .. . . ... ..|.....|..||  |..|. .
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

AIHPYF
  ||.|
LQHPWF
Kinase CDC28.AA CRK7 8-295 35 2.9e-100 339.4 In-house 1-343 (343) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-343/343
Sequence Identity: 35% (122 aa)

YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESE---DEGVPSTAIREISLLKELKDDNIVRLYDIVHSD-------AHK--LYLVFEFLDLDL
|.... .|||||| |||| ... |.    |||||.|.. |    || | |||||| .|..|. .|||.| .|| ..        ||   |.|||  | ||
YEMIMQIGEGTYGQVYKAKNKHTGE---MVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDL

KRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPL--RAYTHEIVTLWYRAPEVLLGGKQY----
   .|  .  .    . .| || ||  |..|||   .||||.|  |.|.|  |..|. |||||| .      | ||  ..|||||.|| ||| ..|    
MGLLES-KEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQH

----------------------------------STGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQW--R
                                   . .| || |||..|  ..|||| |  |..|. ||... |.|| . ||..  || ..   |.   .
ILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYN

RKDLSQVVP-----SLDPRGIDLLDKLLAYDPINRISARRAAIHPYF
|. . ...       ...   |||||.|..||  |..|  .  |..|
RRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDC28.AA S_TKc 8-295 30 2.1e-96 327.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-231/231
Sequence Identity: 30% (93 aa)

YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDL---DLKRYMEGIPK
|. |.|.|.|..|.|||. . .    .|.||.|.|.          ...|||..||. . .|||.|||. ..  ..||.|.|..|    ||..|..  ..
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGR

---DQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYST-GVDTWSIGC
   ..|.    ....| |.|....|||||.|.||||||.|.|...  ..|..|||||| .       |. ..|.||.|||||    .|..  .| ||.||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

IFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAI-------HP
|..||. ..| |.      |....|...|                                   .| ..|...|.| .|| .|..|  |         ||
ILYEMLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

YF
.|
WF
Kinase CDC28.AA Pkinase_Tyr 8-160 30 2.6e-20 69.4 Pfam 1-160 (270) Show / Hide 
Range on Protein: 8-160
Range on HMM: 1-160/270
Sequence Identity: 30% (51 aa)

YKRLEKVGEGTYGVVYKALDL-RPGQGQRVVALKKIRLESEDEGVPSTA------IREISLLKEL-KDDNIVRLYDIVHSDAHK--LYLVFEFLDL-DLK
 . ..| ||| .|.|||.     |....  || |...     ||  . .      .||....|.| . .|||||| .. ..     .|.|.|.  . ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

RYMEGI-PKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARA
 |     . .|||      .. .| .|| .| .|... ||||   | |.....  | .||||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CDC28.AA TyrKc 8-257 23 1.3e-14 13.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-257
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKEL--KDDNIVRLYDIVHSDA------HKLYLVFEFLDL-DLKRY
 . ..| ||| .|.|||.         . || |... ..         .||......|  . .|||||| .. ..       . |..|.|. .. ||| |
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

MEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVP------LRAYT-----HEI--VTLWYRAPEVLLG
     ..  |  .   .|. | ..| .| ||... ||||   | |.....  | .||||.|. .           |.     ..   . .   |||..  
LRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

GKQYSTGVDTWSIGCIFAEMCNR----KPI-----FSGDSEIDQIFKIFRVLGTPN--EAI----WPDIVYL---------PDFKPSFPQWRRKDL
|| ..|  | || |    |.. .     |       | .  | .. . .|    ||  . .     || .|          |.  |.| .  ....
GK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF