Gene ZK930.1 (Nematode worm)

ZK930.1

Species: Nematode worm
Alias: ZK930.1, CE06671, aSWK257
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: II:4.19, WormBase Physical Map location: II: 11915740-11908624

Classification

Group: Other
Family: VPS15

Sequence

Name Sequence Type Origin Length Description Download
ZK930.1.AA Protein Genbank 1354 None Fasta, JSON
ZK930.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of ZK930.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ZK930.1.AA VPS15 27-290 48 9.20000000001e-183 613.45 In-house 1-296 (296) Show / Hide 
Range on Protein: 27-290
Range on HMM: 1-296/296
Sequence Identity: 48% (143 aa)

CDAVENLGSTRFMKVARGRTHEGVFVYKVFVR-QDLASLDPFPQRIIDIRKALMKSP--NCCPIKKVLVKQKYAVMVRAFQKHTLFDRLSTRPFVVEAEK
|..|.||||||||||.....|||..|.||||. .|..||.|..|||..|.|.||..|  ||||..||....|.|.|.|...||.|.||.|||||....||
CHYVKNLGSTRFMKVCKAKHHEGYIVVKVFVKHDDTYSLEPYKQRIEEIKKNLMQHPAFNCCPYQKVIETDKAAYMMRQYVKHNLYDRISTRPFLQMIEK

MWYIFLLFKALSQCETAG-VCHGDLKSQNVLISSTNWLQITDFAPFKPCFLTHDNPSSFTFFFDTSRRQSCYIAPERFISATEYDEKLRD----------
.|..|....||.||...| |||||.||.|.|..|.||...||||.||||.|..|||..||||||||||..||||||||.|.||.|.....          
KWIAFQTLCALEQCHKQGNVCHGDIKSENILVTSWNWCYLTDFACFKPCYLPEDNPADFTFFFDTSRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHTDS

---GQDEWLFGSLTPKMDMFSAGCIVFELLCDR--PPFTYSSLCEYRS-------------MNDADAGNMLLRLIQDVPAPYRPLLRLLLNRDPSF
   .|..||||.|||.||.|||||...||.|..  |||.||.||.|||             ..|....|.....||......|......||....|
IDRQQNPWLFGELTPAMDIFSAGCVIAELFCEGDQPPFDYSQLCKYRSGEYHPNREQIMEKIQDEHIRNLCHHMIQKDNPMKRMSCEEYLNKWRGF
Kinase ZK930.1.AA S_TKc 27-308 19 2e-12 5.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-308
Range on HMM: 1-231/231
Sequence Identity: 19% (59 aa)

CDAVENLGSTRFMKVARGRTHE--GVFVYKVFVRQDLASLDPFPQRIIDIRKALM-KSPNCCPIKKVLVKQKYAVMVRAFQKH---TLFDRLSTRPF---
 . .. .|.  | || ..| ..   ..  |.             ..|.  .. |. . || . .. | .  ..  ||  .  .   .|||..  |.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VVEAEKMWYIFLLFKALSQCETAGVCHGDLKSQNVLISSTNWLQITDF---APFKPCFLTHDNPSSFTFFFDTSRRQS-CYIAPERFISATEYDEKL
     | .   |.  ...||  |   |..| ||| .|.|...   . |.||   . .                  |.   .  |.||| .          
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------TTFCGTPWYMAPEVL----------

RDGQDEWLFGSLTP-KMDMFSAGCIVFELLCDRPPFTYSSLCEYRSMNDADAGNMLLRLIQDVPAPYRPLLRLLLNRDPSFRISANAVLT--GAALKFPH
          . .. | |. | |||..|.|| .|||                 .|....|   . . . ..| .|..||. |..|  .|.   .. . | 
----------GYGKCKCDWWSCGCILYEMLCGYPPFP--------------QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

I
.
F
Kinase ZK930.1.AA Ciliate-E2 223-303 16 1.1e-09 29.44 In-house 274-365 (365) Show / Hide 
Range on Protein: 223-303
Range on HMM: 274-365/365
Sequence Identity: 16% (18 aa)

TPKMDMFSAGCIVFELLCDRPPFTYSSLCEYRSMNDADAGNMLLRLIQDVPAPYR--------------------------PLLRL----LLNRDPSFRI
. | |..|.|.| .|.|. .|||                    .. |.. .  ..                           |..     .|..||. ||
DYKCDIWSLGVILYEMLFGKPPF--------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI

S-ANAVLTGAAL
. .. .|    .
TGWEQILNHPWF
Kinase ZK930.1.AA CK2 125-158 38 2.3e-07 17.25 In-house 99-132 (288) Show / Hide 
Range on Protein: 125-158
Range on HMM: 99-132/288
Sequence Identity: 38% (13 aa)

WYIFLLFKALSQCETAGVCHGDLKSQNVLISSTN
.|.| | ||| .|   |. | | |..|..|  ..
YYMFELLKALDYCHSMGIMHRDVKPHNIMIDHEK
Kinase ZK930.1.AA CMGC 130-165 21 1e-06 17.06 In-house 189-248 (513) Show / Hide 
Range on Protein: 130-165
Range on HMM: 189-248/513
Sequence Identity: 21% (13 aa)

LFKALS--QCETAG--VCHGDLKSQNVLISSTNWL--------------------QITDF
....|    |  ..  ..| ||| .|.||.... |                     | ||
ILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF
Kinase ZK930.1.AA Ciliate-E1 120-166 31 2e-06 17.33 In-house 108-154 (202) Show / Hide 
Range on Protein: 120-166
Range on HMM: 108-154/202
Sequence Identity: 31% (15 aa)

EAEKMWYIFLLFKALSQCETAGVCHGDLKSQNVLISSTNWLQITDFA
. .||  || |...|.. .  ...|.|.| ||.||.. . ....||.
FQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFG
Kinase ZK930.1.AA CCRK 111-165 38 4e-06 16.85 In-house 90-143 (285) Show / Hide 
Range on Protein: 111-165
Range on HMM: 90-143/285
Sequence Identity: 38% (21 aa)

RLSTRPFVVEAEKMWYIFLLFKALSQCETAGVCHGDLKSQNVLISSTNWLQITDF
| . || . ||    |. .| | .. |    . | |||  |.||| .  |.| ||
RHAQRP-LAEAQVKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADF
Kinase ZK930.1.AA STE-Unique 225-303 23 4e-06 17.29 In-house 533-616 (616) Show / Hide 
Range on Protein: 225-303
Range on HMM: 533-616/616
Sequence Identity: 23% (20 aa)

KMDMFSAGCIVFELLCDRPPFTYSSLC----EYRSMNDADAGNMLLRLIQDVPAP-YRPLLRLLLNRDPSFRISANAVLTGAAL
| |..| ||..|...|  ||..  .      |..  .   ... ....|..  .|  . .....|.|.|. | ||   |   .|
KVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase ZK930.1.AA Ciliate-E2-Unclassified 225-303 16 5e-06 17.07 In-house 250-352 (352) Show / Hide 
Range on Protein: 225-303
Range on HMM: 250-352/352
Sequence Identity: 16% (17 aa)

KMDMFSAGCIVFELLCDRPPFTYSSLCEYRSMNDADAGN-----MLLRLIQ----------------DVPAPYRPLLR----LLLNRDPSFRISANAVLT
| |..| |.| .|.|  ..|| . .  ... .. .   |     .|.. |.                ...  .  ...     .|. .|. ||... .| 
KCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN

GAAL
   .
HPWF
Kinase ZK930.1.AA Pkinase 223-245 65 2.7e-05 19.83 Pfam 190-212 (293) Show / Hide 
Range on Protein: 223-245
Range on HMM: 190-212/293
Sequence Identity: 65% (15 aa)

TPKMDMFSAGCIVFELLCDRPPF
.|| ||.|.|||..|.|| ||||
GPKVDMWSCGCILYEMLCGRPPF
Kinase ZK930.1.AA CMGC 218-245 25 5.1e-05 11.43 In-house 297-343 (513) Show / Hide 
Range on Protein: 218-245
Range on HMM: 297-343/513
Sequence Identity: 25% (12 aa)

LFGSL-----------TPKMDMFSAGCIVFELLCD--------RPPF
|.|.            |...|| |.||| .|..          .| |
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLF
Kinase ZK930.1.AA CDK4 142-165 41 0.000974 8.46 In-house 131-154 (290) Show / Hide 
Range on Protein: 142-165
Range on HMM: 131-154/290
Sequence Identity: 41% (10 aa)

VCHGDLKSQNVLISSTNWLQITDF
. | ||| ||.|..|   . ..||
IIHRDLKPQNILVTSDGHVKLADF
Kinase ZK930.1.AA CAMK 141-165 23 0.001167 6.87 In-house 199-240 (425) Show / Hide 
Range on Protein: 141-165
Range on HMM: 199-240/425
Sequence Identity: 23% (10 aa)

GVCHGDLKSQNVLISSTN----------------W-LQITDF
...| |||  |.|... |                . . |.||
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF
Kinase ZK930.1.AA CAMK 227-245 52 0.001895 6.18 In-house 316-334 (425) Show / Hide 
Range on Protein: 227-245
Range on HMM: 316-334/425
Sequence Identity: 52% (10 aa)

DMFSAGCIVFELLCDRPPF
|| |.|.| . .|| .|||
DMWSCGVILYIMLCGYPPF
Kinase ZK930.1.AA CDK4 227-245 57 0.002001 7.37 In-house 191-209 (290) Show / Hide 
Range on Protein: 227-245
Range on HMM: 191-209/290
Sequence Identity: 57% (11 aa)

DMFSAGCIVFELLCDRPPF
|| |.|||..|. | || |
DMWSVGCIFAEMYCRRPLF
Kinase ZK930.1.AA Ciliate-E2-Unclassified 141-165 28 0.002026 7.75 In-house 164-191 (352) Show / Hide 
Range on Protein: 141-165
Range on HMM: 164-191/352
Sequence Identity: 28% (8 aa)

GVCHGDLKSQNVLISSTN---WLQITDF
...| |.| .|.|... .    . |.||
NIIHRDIKPENILFDNNGKNYYIKIIDF
Kinase ZK930.1.AA Ciliate-E2 141-165 30 0.002973 7.0 In-house 180-200 (365) Show / Hide 
Range on Protein: 141-165
Range on HMM: 180-200/365
Sequence Identity: 30% (8 aa)

G-VCHGDLKSQNVLISSTNWLQITDF
. ..| |.| .|.|.     . |.||
NNIIHRDIKPENILF-----IKIIDF
Kinase ZK930.1.AA Pkinase 141-165 37 0.018954 9.74 Pfam 128-156 (293) Show / Hide 
Range on Protein: 141-165
Range on HMM: 128-156/293
Sequence Identity: 37% (11 aa)

GVCHGDLKSQNVLISSTNWL----QITDF
|..| |||..|.||.... .     |.||
GIIHRDLKPENILIDNNGHIDACVKICDF
Kinase ZK930.1.AA STE-Unique 141-166 24 0.022992 3.53 In-house 423-455 (616) Show / Hide 
Range on Protein: 141-166
Range on HMM: 423-455/616
Sequence Identity: 24% (8 aa)

G--VCHGDLKSQNVLISSTN-----WLQITDFA
.  . |.|||. |.....          | ||.
HNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFG
Kinase ZK930.1.AA CK2 226-245 35 0.051494 0.95 In-house 177-196 (288) Show / Hide 
Range on Protein: 226-245
Range on HMM: 177-196/288
Sequence Identity: 35% (7 aa)

MDMFSAGCIVFELLCDRPPF
.|| | ||... .. .. ||
LDMWSLGCMFASMIFKKEPF
HEAT ZK930.1.AA HEAT 419-449 29 0.000356 18.32 Pfam 1-31 (31) Show / Hide 
Range on Protein: 419-449
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

ILPYFVHLWMDPETQVRATAVTAVAELLAPI
|||.....  ||. .||..|. ....|.  .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT ZK930.1.AA HEAT 576-607 25 10.572291 2.83 Pfam 1-31 (31) Show / Hide 
Range on Protein: 576-607
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

LLRFLCTFLNAKTEWRLRAAFFDSLPVCVQKR
.| .|.. || . .|. |.| . .| . ... 
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC
HEAT ZK930.1.AA HEAT 611-641 25 0.11965 9.57 Pfam 1-31 (31) Show / Hide 
Range on Protein: 611-641
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

MVPLLQLGLQDGEEHVVVRALGCIHILIKNE
..|.|  .|.| ...|   |. |.  |... 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT ZK930.1.AA HEAT 651-677 25 6.253214 3.62 Pfam 1-27 (31) Show / Hide 
Range on Protein: 651-677
Range on HMM: 1-27/31
Sequence Identity: 25% (7 aa)

LLDDVLPFLVHPNDWIRSTVCDILLAI
.|. .|  | .|.. .|...|  | ..
ILPHLLKCLNDPDWEVREAACWCLGQL
WD40 ZK930.1.AA WD40 958-996 22 8.6e-11 33.67 Pfam 1-39 (39) Show / Hide 
Range on Protein: 958-996
Range on HMM: 1-39/39
Sequence Identity: 22% (9 aa)

GIIITHLHEHSGKITKLCANRE-SDLFLSGSTDGTVKVWK
.  .. . .|....| .. . . . ...||| |||...|.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 ZK930.1.AA WD40 957-996 22 9.8e-09 36.26 SMART 1-46 (46) Show / Hide 
Range on Protein: 957-996
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

KGIIITHLHEHSG--KITKLCANRES------DLFLSGSTDGTVKVWK
.   .  .. |.|   .| .| .  .      ....||| |||...|.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 ZK930.1.AA WD40 1013-1047 20 0.794759 0.99 SMART 1-46 (46) Show / Hide 
Range on Protein: 1013-1047
Range on HMM: 1-46/46
Sequence Identity: 20% (10 aa)

TWIPTETSR---E--KVNSVGWNDQ--------FACSATNDGFVRWAD
|  .. | .       |..| |..         . .|.  || .|  |
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 ZK930.1.AA WD40 1326-1354 29 0.000217 15.25 Pfam 9-39 (39) Show / Hide 
Range on Protein: 1326-1354
Range on HMM: 9-39/39
Sequence Identity: 29% (9 aa)

HRTPITDMMLLNS--ELLVSSGYDGVIKIWK
|  ..|..    .   .|.|.. || |.||.
HTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 ZK930.1.AA WD40 1311-1354 18 0.001803 17.68 SMART 1-46 (46) Show / Hide 
Range on Protein: 1311-1354
Range on HMM: 1-46/46
Sequence Identity: 18% (10 aa)

ENQKVVPLDSKPSTYHRT--PITDMMLLNS-------ELLVSSGYDGVIKIWK
. . |  ..      |.   ..|..    .       ..|.|.. || |.||.
T-KCVHTFK-----GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD