Gene ZK596.2 (Nematode worm)
ZK596.2
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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ZK596.2.AA | Protein | Genbank | 305 | None | Fasta, JSON |
ZK596.2.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 285 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of ZK596.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | ZK596.2.AA | Worm6 | 19-284 | 51 | 4.7e-169 | 567.93 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 19-284 Range on HMM: 1-279/279 Sequence Identity: 51% (144 aa) WTILKKLGEGAFGAVYLVSQKEKPK-VEYALKVEA--ESDPLGLLKMEVAVLLEVKKQKIVGRHFLELADRGNLPQK-FNYMVMTLVGKSLQDLRKTAPF |...||.|||.|||||.|..|.. | ...|.|.|. |. . . ||||..||..||..| .|||... |||. ... |||.|||||||.|.||||..| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHK--CRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPD NKFSMGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGR---KEMHELRKVYMLDFGMAR-KFAREDGT-LRNPR-ARAGFRGTVKYAPLACHIQREQ .||||||....|.|.|||.|||||.||.|||.||||..||| ||..|....|||||||.| |.....|. ||.|| ...||||||.||||||| ..|| RKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQ CRKDDIESWLYMVVEMTCGRLPWRNLTESDDVG-VFKKECKTTR---LRCLFGGCPR-EFTEVFPILDKGKFFDAPEYTTI |||||.|||.||.|||..|.||||.....|.|. ..|. ...|| |..||.||. ||.... ..|.....|.|.|..| CRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | ZK596.2.AA | CK1 | 19-284 | 32 | 4e-118 | 398.74 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 19-284 Range on HMM: 1-339/339 Sequence Identity: 32% (112 aa) WTILKKLGEGAFG-AVYLV-----SQKEKPK----VEYALKVEAESDPLG-LLKMEVAVLLEVKKQKIV-------GRHFLE----------LADRGNLP |.. ||.|||.|| ..|.| . .. .| |||.||| .. . ..||...... .... ..||.. . . |. . WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED QKFNYMVMTLVGKSLQDLRK--TAPFNKFSMGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGRKEM-----------HELRKVYMLDFGMAR-KFA ...|||||||.|..|.|||| . . .||||.|.. .| | |||.|..|..||.||||||.|. .||.|. |.|.|||.|||||| |.. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR REDGTL------------RNPRA---RAGFRG-TVKYAPLACHIQREQCRKDDIESWLYMVVEMTCGR--LPWRNLTESDD-----VGVFKKECKTT--R . ||. | || ..|||| |..|....|| ..||.|.||..||.||..|.. | |||.|... . |.. |.|.... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM LRCLFGG--------CPREFTEVFPILDKGKFFDAPEYTTI ....| . ||.|| ........ |..|.|.| | STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | ZK596.2.AA | TTBKL | 19-288 | 37 | 1.8e-91 | 309.05 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 19-288 Range on HMM: 1-288/288 Sequence Identity: 37% (110 aa) WTILKKLGEGAFGAVYLVSQKEKPKVEYALKVEAES-DPLG-LLKMEVAVLLEVK--KQKIVGRHFLELADRGNLPQKFNYMVMTLVGKSLQDLRKTAPF |.| |..|||.||.||.|. .. .| ..|.|.| . . . .|||| ||.. ... ||... . |. .. .|.|||||.|..||||||. | WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSP----HFPKCHCSGKRKD-YNFMVMTLCGPNLQDLRKMMPN NK-FSMGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGRKE--MHELRKVYMLDFGMARKFAREDG-----------TLRNPRA---RAGFRGTVKY .| || ||. .. | |.|. ..| .||.|||.||.|. .| .. . | || .||||||..|..|| ..| || .|.||||..| KKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRY APLACHIQREQCRKDDIESWLYMVVEMTCGRLPWRNLTESDDVGVFKKECKTTRLRCLFGG------CPREFTEVFPILDKGKFFDAPEYTTIYELL . .. | .|| |.||. ||.||..|. || |||.|... .... ||..|... ||.. ||.||..... | .. | | |. |||.. CSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDED---LFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | ZK596.2.AA | TTBK | 19-284 | 41 | 7.3e-77 | 261.66 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 19-284 Range on HMM: 1-257/257 Sequence Identity: 41% (111 aa) WTILKKLGEGAFGAVYLVSQKEKPKVEYALKVEAESDPLGLLKMEVAVLLEVKKQKIVGRHFLELADRGNLPQKFNYMVMTLVGKSLQDLRKTAPFNKFS |...|| | |.|| .| . . |.||| | |||||||| .. | | . | . |||||||.| ||.| ||| .| .|| WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFI--GCGRND---KFNYMVMQLQGKNLADLRRKQPRGCFS MGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGRKEMHELRKVYMLDFGMARKFAREDGTLRNPRARAGFRGTVKYAPLACHIQREQCRKDDIESWL ..|.. . | |...| |..||||||||| |. .|| . ||.||||||.||.. | | ||. ||||||| || | || |.|| | LSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGR-NPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLF YMVVEMTCGRLPWRNLTESDDVGVFKKECKTTRLRCLFGGCPREFTEVFPILDKGKFFDAPEYTTI || || | |||| . |.|| |.. . | | || || . ...| |.| | YMLVEFVQGQLPWRKIKDKDQVGEMKEKYDH---RMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | ZK596.2.AA | Dual | 19-288 | 30 | 8.5e-56 | 186.06 | In-house | 1-282 (282) | Show / Hide |
Range on Protein: 19-288 Range on HMM: 1-282/282 Sequence Identity: 30% (86 aa) WTILKKLGEGAFGAVYLVSQKEK---PKVEYALKVEAESDPLGLLKMEVAVLLEVKKQK-------IVGRHFLELADRGNLP-QKFNYMVMTLVGKSLQD | . . || | |. || | . . .. |.||.|.| | | . ...| . ..| |. |.|. .| .|.|| ..| |||. WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE LRKTAPFNKFSMGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGRKEMHELRKVYMLDFGMARKFAR-EDGTLRNPRARAGFRGTVKYAPLACHIQR |. . . .|| .. || | |.|. |||.||.|||.||| |. .| .| | .|||.||...||. | . | .| . |. || || |. IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGL-GMDE-TTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQK EQCRKDDIESWLYMVVE-MTCGR-LPWRNLTESDDVGVFKKECKTTRLRCLFGGCPREFTEVFPILDKGKFFDAPEYTTIYELL .| ||||.|.| ||| | . ..||.. .. . | . ... . . ||.. . . .|.| . | DQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL |
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Kinase | ZK596.2.AA | CK1-Unique | 19-222 | 30 | 3.4e-43 | 147.58 | In-house | 1-221 (337) | Show / Hide |
Range on Protein: 19-222 Range on HMM: 1-221/337 Sequence Identity: 30% (67 aa) WTILKKLGEGAFGAVYLVSQKEKP-----KVEYALKVEAESDPLG--LLKMEVAVLLEVKKQK---IVGRHFLELADRGNLPQKFNYMVMTLVGKSLQDL | . |..| | .| |. | . . . .|. | | . .|. | .|... | .|||.|. | . . . ..|||..|.|. . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFH-QHRDWWWIVMTMHGPSMEEC RKTAPFN-KFSMG------TAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGRKEMHELRKVYMLDFGMARK--FAREDGTLRNPRARAGFRGTVKYAP . .. | .| . .|| . | |...| | ||.||..||.|| . .... ||||.| |. | . .|.|| .. |||. .|.| C-MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCP LACHIQREQCRKDDIESWLYMVV .|| ||. |.|| |||.|| . CSCHQCREHGRRDDMESWFYMLY |
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Kinase | ZK596.2.AA | CK1-Unclassified | 19-235 | 30 | 2.1e-31 | 89.96 | In-house | 1-220 (244) | Show / Hide |
Range on Protein: 19-235 Range on HMM: 1-220/244 Sequence Identity: 30% (70 aa) WTILKKLGEGAFGAVYLVSQKEKPKVEYALKVEAESDPLGLLKMEVAVLLEVKKQKIVGR----HFLELADRGNLPQ-KFNYMVMTLVGKSLQDLRKTAP ...|.| |.|| .|.. .. |.|.|.| . . .|. |. .. .... ... .. . | | .|.|||.| |.|| || . YRVIEKIGQGSFGEIYKCINMQTN-EEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNC-DNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNM-- FN-KFSMGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIG-RKEMHELRKVYMLDFGMARKFAR--EDGTLRNPRARAGFRGTVKYAPLACHIQREQC | |||. | | | .. .| ||| .|.|||||| |. .| . .| .||. ||| . .. . ..|. | .. || || . |. || CNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHH--QVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQS RKDDIESWLYMVVEMTCGRLPWRNLT |.|| || | . |.||| |.. RRDDLESLGYVLIYFLKGSLPWQNIK |
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Kinase | ZK596.2.AA | CK1 | 19-235 | 31 | 4.6e-29 | 97.29 | In-house | 1-220 (271) | Show / Hide |
Range on Protein: 19-235 Range on HMM: 1-220/271 Sequence Identity: 31% (70 aa) WTILKKLGEGAFGAVYLVSQKEKPKVE--YALKVEAESDPLGLLKMEVAVLLEVKKQKIV---GRHFLELADRGNLPQ-KFNYMVMTLVGKSLQDLRKTA . .|.|.|.|| .||. . ..| .| |.| . .|. |. .. . ... .. . .. . | | ..|.|||.| |.|| || . YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGH-NCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC PFN-KFSMGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGRKEMHELRKVYMLDFGMARKFA-REDGTLRNPRARAGFRGTVKYAPLACHIQREQCR | |||. | . .| | .. .| .|| .|.|||||| |. .|| . .||. |||.| .. .... | .. ||. || . |. .|| | --NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSR KDDIESWLYMVVEMTCGRLPWRNLT .|| || |. . | ||| .|. RDDMESLGYVLMYFLRGSLPWQGLK |
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Kinase | ZK596.2.AA | CK1-A | 19-284 | 30 | 5.8e-29 | 99.4 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 19-284 Range on HMM: 1-261/261 Sequence Identity: 30% (82 aa) WTILKKLGEGAFGAVYLVSQKEKPKVEYALKVEAESDPLGLLKMEVAVLLEVKKQKIVGRHFLELADRGNLPQKFNYMVMTLVGKSLQDLRKTAPFNKFS . ...|.| |.|| .|| . .. . | |.|.| . | | | . |. || . .. |. . .| ||| |.| || || .|. YRLVRKIGSGSFGDIYLGINITNGE-EVAIKMESNKARHPQLIYEAKVYRIL--QGCVG--IPHMRWYGCE-KDYNVMVMDLLGPSLEDLFNFC-KRRFT MGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGRKEMHELRKVYMLDFGMARKFAREDGTLRNP-RARAGFRGTVKYAPLACHIQREQCRKDDIESW | | . .| | . .| .|. .|.|||||| |. .| . | |....|||.|.|. . | | ||..|| . |. || |.||.|| MKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI-GRH-CNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESM LYMVVEMTCGRLPWRNLTESDDVGVFKK--ECKT-TRLRCLFGGCPREFTEVFPILDKGKFFDAPEYTTI |... |.||| .. . | | |. | . | | | ||. . . .| ..|.|. . GYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | ZK596.2.AA | CK1-D | 93-284 | 33 | 4.6e-27 | 92.44 | In-house | 69-261 (261) | Show / Hide |
Range on Protein: 93-284 Range on HMM: 69-261/261 Sequence Identity: 33% (65 aa) FNYMVMTLVGKSLQDLRKTAPFNKFSMGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGRKEMHELRKVYMLDFGMARKFAREDGTLRNP-RARAGF .| ||| |.| || || |||. | . .| | . .| .| |.|||||| |. .| .. ||..|||.|... | | YNVMVMDLLGPSLEDLFNYC-HRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM--VYIIDFGLAKRYRDARTHQHIPYRENKNL RGTVKYAPLACHIQREQCRKDDIESWLYMVVEMTCGRLPWRNLTESDDVGVFKKECK---TTRLRCLFGGCPREFTEVFPILDKGKFFDAPEYTTI || .|| . | || |.||.|| |... | ||| | . . | |.. | | | ||.. . . || | |.|. . TGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | ZK596.2.AA | Pkinase | 19-233 | 24 | 5.7e-15 | 54.02 | Pfam | 1-214 (293) | Show / Hide |
Range on Protein: 19-233 Range on HMM: 1-214/293 Sequence Identity: 24% (57 aa) WTILKKLGEGAFGAVYLVSQKEKPKVEYALKVEAESDPLGLLKM------EVAVLLEVKKQKIVGRHFLELADRGNLPQKFNYMVMTLVGKS--LQDLR- ..|..|.|.|.|| ||. | .| ..|.|. .. .. |........ || ... . . |||| .... ..|| YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIV--RLYDWFED----KDHIYMVMEYCEGGLYVMDLFD -----KTAPFNKFSMGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGRKEMHELRKVYMLDFGMARKFAREDGTLRNPRARAGFRGTVKYAPLACHI . .| ||. .......| |...| .|. |..|||.|| | | ...| .| ||| |..| . | . .| || |.. . YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIR -QREQCRKDDIESWLYMVVEMTCGRLPWRN ... .| |. | .. || |||.|... GGQYYGPKVDMWSCGCILYEMLCGRPPFPG |
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Kinase | ZK596.2.AA | S_TKc | 19-293 | 20 | 6e-15 | 42.25 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 19-293 Range on HMM: 1-231/231 Sequence Identity: 20% (60 aa) WTILKKLGEGAFGAVYLVSQKEKPKVEYALKVEAESDPLGLLKMEVAVLLEVKKQKIVGRHFLELADRGNLPQKFNYMVMTLVGK---SLQDLRKTAPFN ..||.|.|.|||| ||.. |. . ..|.|. .. |...| . . || . .. |||| ... .| |. | . . YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRH K----FSMGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGRKEMHELRKVYMLDFGMARKFAREDGTLRNPRARAGFRGTVKYAPLACHIQREQCRK . |. .| ....| ..|.| .|. |..|||.|| | . . . |||.||.. | || | . GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL-------- DDIESWLY----------MVVEMTCGRLPWRNLTESDDVGVFKKECKTTRLRCLFGGCPREFTEVFPILDKGKFFDAPEYTTIYELLE-------KAMV .. . .. || ||. |.. .. .||| . |. ...| .| . |. |.|. . ----GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | ZK596.2.AA | TyrKc | 19-288 | 20 | 3.8e-05 | -139.42 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 19-288 Range on HMM: 1-280/280 Sequence Identity: 20% (65 aa) WTILKKLGEGAFGAVYLVSQKEKPKVEYALKVEAESDPLGLLKMEVAVLLEV--KKQKIVGRHFLELADRGN----LPQKFNYMVMTLVGK-SLQD-LRK | .||||||||| ||. | .. | |. |. . . | .. .. . . || . . . .| | ..|| .. . .|.| ||| ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL---MIVMEYMPHGDLKDYLRK TAPFNKFSMGTAISVARQSLEAVEDLHNIGFLHRDIKPGNYTIGRKEMHELRKVYMLDFGMARKFARED--GTLRNPRARA----GFR--GTVKYAPLAC . | ..| . .| . | . | || .. |||. | .|.. | |||..|. .| | . |. | . .. . HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMA--- HIQREQCRKDDIESWLYM------------VV--EM-TCGRLPWRNLTE--SDDVGVFKKECKTTRLRCLFGG-------CPREFTEVFPILDKGKFFDA .|.. | |. |. | | |. . .. .. |... . |... . || .|.. | . .. -----------PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP---DEMYQIMK--QCWHE -----PEYTTIYELL | ..|.|.. DPEDRPTFSEIHECF |
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Kinase | ZK596.2.AA | CK1 | 249-282 | 25 | 0.016499 | 4.69 | In-house | 237-271 (271) | Show / Hide |
Range on Protein: 249-282 Range on HMM: 237-271/271 Sequence Identity: 25% (9 aa) TTRLRCLFGG-CPREFTEVFPILDKGKFFDAPEYT .| . |. | .| ||.. . . . .|...| |. STPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | ZK596.2.AA | CK1-D | 19-35 | 41 | 0.044807 | 2.92 | In-house | 1-17 (261) | Show / Hide |
Range on Protein: 19-35 Range on HMM: 1-17/261 Sequence Identity: 41% (7 aa) WTILKKLGEGAFGAVYL . | .|.| |.|| .|. YRIGRKIGSGSFGDIYH |