ZC581.2

Species: Nematode worm
Alias: ZC581.2, CE15237, aSWK102
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: I:1.22, WormBase Physical Map location: I: 6663778-6666098

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
ZC581.2.AA Protein Genbank 350 None Fasta, JSON
ZC581.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 280 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of ZC581.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ZC581.2.AA TTBKL 48-311 33 1.6e-130 439.93 In-house 1-288 (288) Show / Hide
Range on Protein: 48-311
Range on HMM: 1-288/288
Sequence Identity: 33% (98 aa)

FMVKGLIGRGGFGQIYYGSDATFPEDVVIKIEPVVLKGRPRRRMILEQKVLYRLQ--GRPHVPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKR-LS
.|....||.|||||.|...| . ..|. ...|..  ...  .||..|..||..||  | ||.|....||.... ||.||.|.|||..||.|..|.|. .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

QTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQST---RHVLKLVDYGMVRRFKNVDGTR-----------RKQRY---KPGFRGTLRYSSVRV
..|..||.|| ..||...|. |.|||||||.|.|.|.....   .... |.|.||.|.... || .           |..|.   |..||||.|| |...
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HDGKEQTPVDDFVSMAYSGAELLLVNLPWKLVS-TDDIRQTKVDFNTPNSPYLLL----TGPYFSVFCGAIFNLRSEDEPDHSSLQNLL
||.|||...||..|. |. .||..  |||. .. ...| ..|.. .. .  . .       ..|  |. .. .||  |.||........
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF

Kinase ZC581.2.AA CK1 48-307 26 4.1e-93 315.64 In-house 1-339 (339) Show / Hide
Range on Protein: 48-307
Range on HMM: 1-339/339
Sequence Identity: 26% (91 aa)

FMVKGLIGRGGFG-QIYYG-----SDATFP-----EDVVIKIEPVVLKGRPRRRMILEQKVLYRLQG-------------------RPHVPIMCASGHTE
..|. .|| |||| ||| .     .| . .     |....|.||.  .|.....|...| ...  .|                   .||....  .|...
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

QLN-FIVMQLLGPNIGDLKK--RSPVKRLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQS------------TRHVLKLVDYGMVR-RFK
. . ..||.|||||..||.|  | . ...| .|. .|.|| . ||...|. |.||||.||.|.|.|. .|            ..... ..|.||.| ...
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

NVDGTR------------RKQRY---KPGFRG-TLRYSSVRVHDGKEQTPVDDFVSMAYSGAELLLVN--LPWKLVSTDD------IRQTKVDFNTPNSP
. ||..            | .|    | |||| |.|| |...|.||||...|| .|..|  .|.|  .  |||. ..  .      ... | .| . . .
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

YLLL----------TGPYFSVFCGAIFNLRSEDEPDHSSL
....            ..|  .   | .|. .|.||   .
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI

Kinase ZC581.2.AA Worm6 48-263 32 7.6e-47 161.95 In-house 1-228 (279) Show / Hide
Range on Protein: 48-263
Range on HMM: 1-228/279
Sequence Identity: 32% (75 aa)

FMVKGLIGRGGFGQIYYGSDATFPE--DVVIKIEPVVL--KGRPRRRMILEQKVLYRLQGRP--HVPIMCASGHTEQ--LNFIVMQLLGPNIGDLKKRSP
. |  .|| |||| .|  .|..  .   ...| |      ....|.   .|  || ..  ..  |.. .   | ...   |.|||.|.|.| .||.| .|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCE---KQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP

VKRLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGV----TQSTRHVLKLVDYGMVR--RFKNVDGTRRKQR-YKPGFRGTLRYSSVRVHDGKE
 ...| .|  .| || ..|..|.|. |.|||||||.| |.|.     .  .| . ..|.|| |  ...| ....|..|  . |||||.|| ..  |.|.|
DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQE

QTPVDDFVSMAYSGAELLLVNLPWKLVSTDD
| . ||  |  |  .|... .|||. .. .|
QCRKDDCESWFYMMVEMIVGCLPWRHMKDHD

Kinase ZC581.2.AA TTBK 48-307 34 1.7e-46 160.83 In-house 1-257 (257) Show / Hide
Range on Protein: 48-307
Range on HMM: 1-257/257
Sequence Identity: 34% (90 aa)

FMVKGLIGRGGFGQIYYGSDATFP-EDVVIKIEPVVLKGRPRRRMILEQKVLYRLQGRPHVPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKRLSQT
  |.  || |||| || . |     | | ||.| .     |.  . .|  || .|||..||      |  .. |..||||.| |  ||    |    |  
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQ---QPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLS

TVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNVDGTRRKQRYKPGFRGTLRYSSVRVHDGKEQTPVDDFVSMAYSG
|  |. .| . ... .||.|. |||.|| |   | . ||.    ..|.|. |.. |  |  |  |   ||||| || |.  |  .|    ||  |. |  
TTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML

AELLLVNLPW-KLVSTDDIRQTKVDFNTPNSPYLLLTGPY-FSVFCGAIFNLRSEDEPDHSSL
 | .   ||| |.   |.. ..|  ...   . ||   |  |..|   |  |  || ||   .
VEFVQGQLPWRKIKDKDQVGEMKEKYDH---RMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI

Kinase ZC581.2.AA CK1-Unclassified 48-244 31 1e-31 90.89 In-house 1-204 (244) Show / Hide
Range on Protein: 48-244
Range on HMM: 1-204/244
Sequence Identity: 31% (66 aa)

FMVKGLIGRGGFGQIYYGSDATFPEDVVIKIEPVVLKGRPRRRMILEQKVLYRLQGRP-------HVPIMCASGHTEQ--LNFIVMQLLGPNIGDLKKRS
..|.  || | ||.|| . .    | | ||.|    |    .    | |....||..        ..| |  .|  ||   |..|| ||||.. ||..  
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK---HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNM-

PVK-RLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNV--DGTRRKQRYKPGFRGTLRYSSVRVHDGKEQTP
  . ..|  ||  |. | |  .  .|. ..|||| || | . | ..  .|.. ..|.|   |..    .|.   .| . .. || ||.|.. | |.||  
-CNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSR

VDDFVSMAY
 ||  |..|
RDDLESLGY

Kinase ZC581.2.AA CK1 48-244 33 2.2e-29 98.4 In-house 1-204 (271) Show / Hide
Range on Protein: 48-244
Range on HMM: 1-204/271
Sequence Identity: 33% (70 aa)

FMVKGLIGRGGFGQIYYGSDATFPED--VVIKIEPVVLKGRPRRRMILEQKVLYRLQG------RPHVPIMCASGHTEQ--LNFIVMQLLGPNIGDLKKR
..|   || | ||.|| | . |  |   | ||.|.   |  |      | |....|||       ...| |  .|  ||   |..|| ||||.  ||.. 
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSK-HP--QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNF

SPVKRLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFK-NVDGTRRKQRYKPGFRGTLRYSSVRVHDGKEQTPV
   ...|  ||  |. | |  .  ||. ..||||.|| | . |...   |.. ..|.|.  |..   ...   .| . .. || || |.  | |.||   
C-NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRR

DDFVSMAY
||  |..|
DDMESLGY

Kinase ZC581.2.AA CK1-D 48-257 29 1.6e-27 94.06 In-house 1-206 (261) Show / Hide
Range on Protein: 48-257
Range on HMM: 1-206/261
Sequence Identity: 29% (63 aa)

FMVKGLIGRGGFGQIYYGSDATFPEDVVIKIEPVVLKGRPRRRMILEQKVLYRLQGRPHVPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKRLSQTT
. .   || | ||.||.| . .  |.| ||.|..  |      . .| |.   .||   .| .   |.  . | .||.|||| . ||      .. |  |
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTK---HPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKT

VARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNVDGTRR-KQRYKPGFRGTLRYSSVRVHDGKEQTPVDDFVSMAYSG
|  .  | |. .  .|.  .||||.|| |   |. .   ..  ..|.|. .|..     .    | .    || || |.  | | ||   ||. |. |  
VLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRG-NMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL

AELLLVNLPWK
    .  |||.
MYFNRGSLPWQ

Kinase ZC581.2.AA CK1-A 48-257 33 1.7e-27 94.11 In-house 1-206 (261) Show / Hide
Range on Protein: 48-257
Range on HMM: 1-206/261
Sequence Identity: 33% (71 aa)

FMVKGLIGRGGFGQIYYGSDATFPEDVVIKIEPVVLKGRPRRRMILEQKVLYRLQGRPHVPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKRLSQTT
. .   || | || || |   |  |.| ||.|    .      .| | ||   ||| . .| |   |.  . | .||.|||| . ||      .| .  |
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKAR---HPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKT

VARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNVDGTRRKQRYKP--GFRGTLRYSSVRVHDGKEQTPVDDFVSMAYS
|  .  | |. .  ||  ..||||.|| |   |.     ..  |.|.|. ....    ||.   |.      || || |.  | | ||.  ||. ||.| 
VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLF-LIDFGLAKKYRDSR-TRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYV

GAELLLVNLPWK
     .  |||.
MMYFNRGKLPWQ

Kinase ZC581.2.AA Worm8 107-207 34 4e-20 54.86 In-house 60-159 (261) Show / Hide
Range on Protein: 107-207
Range on HMM: 60-159/261
Sequence Identity: 34% (35 aa)

VPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKRLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNVDGT
|| | . | |.  |.||| .|         |   |. |  |  .|| | .  |.|.|| | .| |.|. |.       ..  | |||.|. ..|| . | 
VPRMFDYGSTDYHNWIVMEQLSDDLINIICRNENKMFSKPTGYQIMWQLVKILQDIHSFGIVHGDIKADNLMVSHSNRMFM-LVLVDFGCSCWFKDHNGN

R
|
R

Kinase ZC581.2.AA Dual 116-224 28 6e-17 53.4 In-house 83-191 (282) Show / Hide
Range on Protein: 116-224
Range on HMM: 83-191/282
Sequence Identity: 28% (31 aa)

TEQLNFIVMQLLGPNIGDLKKRSPVKRLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKN-VDGTRRKQRYKP
.  ....|| . || . .  .   .. ||  .   . || . |..| ||.||.||..||||   |.      |  . |...|| .     .  |  | | 
QDKCKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVY-MQDFRIVRKYIDPENKKHRTARKKV

GFRGTLRYSS
 . |..|| .
KMYGCGRYAC

Kinase ZC581.2.AA S_TKc 48-334 16 6.4e-12 -2.06 SMART 1-231 (231) Show / Hide
Range on Protein: 48-334
Range on HMM: 1-231/231
Sequence Identity: 16% (51 aa)

FMVKGLIGRGGFGQIYYGSDATFPEDVVIKIEPVVLKGRPRRRMILEQKVLYRLQGRPHVPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKR-----
. .  .||.|.||. | . .    . | ||| .        .... | ..| .  . |..  .  . .. .  ..|| ... . |||...   ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNVDGTRRKQRYKPGFRGTLRYSSVRVHDGKEQTPVDDFV
  ..  .....| | . ||   ||.| ||||.||.|  .        ..|. | |. |..               | ||. | .  |             
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------

SMAYSG------------AELLLVNLPWKLVSTDDIRQTKVDFNTPNSPYLLLTGPYFSVFCGAIFNLRSEDEPDHSSLQNLLC-DMTRGKSLREAYD--
   |..            .|.|    |.     . . .  .                              ...  . ....|. | ..  .  ||    
--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

WDENYRDAL
|| .    .
WDIKCHPWF