Gene ZC373.3 (Nematode worm)

ZC373.3

Species: Nematode worm
Alias: aSWK151, ZC373.3, CE02376
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: X:1.64, WormBase Physical Map location: X: 10064310-10065419

Classification

Group: CK1
Family: Worm7

Sequence

Name Sequence Type Origin Length Description Download
ZC373.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 246 Kinase domain by global Sugen HMM Fasta, JSON
ZC373.3.AA Protein Genbank 321 None Fasta, JSON

Protein domain

Protein domains of ZC373.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ZC373.3.AA Worm7 36-296 67 2.6e-213 714.93 In-house 1-263 (263) Show / Hide 
Range on Protein: 36-296
Range on HMM: 1-263/263
Sequence Identity: 67% (181 aa)

YKLIHKVGSGSFGEVWQATDKLEGNVAKIVKIINKYVGGSGPRDILYDNEIEFFKYCHDAPNIPTLFHHFSHVGFNVLVMSEEGQNLREVAKRSPG-SFS
||||||.|.|.||||||..||..|||..||||||||..||..|||.||.|||||||||..||||.|||||.|||.|..||||||||||.|.||... .||
YKLIHKIGNGQFGEVWQVIDKQDGNVPMIVKIINKYKNGSMKRDISYDREIEFFKYCHHVPNIPKLFHHFTHVGWNCIVMSEEGQNLRDVVKRNNNKPFS

LNNLIRIAYQIGSTLCFIHDKSFIHRDLKAENVLVSLKNKVCKMVLIDFGNAVRFKDVNGNELPEFNDGFDYTHCTHKSINVLLGISHTQNDDWASLVYL
.||.||||.||||||||||.|||||||....||||.||||||||||||||||||||||||||||.||||..|.||.||||||..|..||..|||.||.||
TNNVIRIAWQIGSTLCFIHNKSFIHRDVHSQNVLVTLKNKVCKMVLIDFGNAVRFKDVNGNELPQFNDGYQYHHCVHKSINVMKGNPHTCRDDWISLIYL

LLEMHGVTWGSRTGEMFMNKVEFEANPTEILVDKMLWIHKMY--------QDSVELNMGRENNKQIMDNL
..||||..|||||.||.|||.||..|...|..|.|.||||||        ||.|.       |. |.  |
CVEMHGKNWGSRTTEMYMNKMEFHSNRDWIYIDNMKWIHKMYNVIMNWMTQDTVD-------NQEILRFL
Kinase ZC373.3.AA CK1 36-261 20 1.8e-48 167.17 In-house 1-298 (339) Show / Hide 
Range on Protein: 36-261
Range on HMM: 1-298/339
Sequence Identity: 20% (60 aa)

YKLIHKVGSGSFG-EVWQA-----TDKLEG-------NVAKIVKIINKYVGGSGPRDILYDNEIEFF---------------KYCHDAPNIPTLFHHFSH
.|...| |.|.|| ... .     .|.  .        . |. .. ..  . .  ....  .. ..                | |.    ..  .|.. .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

VGFNVLVMSEEGQNLREVAK--RSPG-SFSLNNLIRIAYQIGSTLCFIHDKSFIHRDLKAENVLVSLK-------------NKVCKMVLIDFGNAV-RFK
 ..|..||.  | || .. |  | ..  ||..  ..||.|. . | ..||. |||||.|..|......             |.  ....|||| |  ...
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DVNGN-----------ELPEFNDG------FDYTHCTHKSINVLLGISHTQNDDWASLVYLLLEMHGVT----WGSRTGEMF-------MNKVEFEANP
| .|.           .. .. ..        .  . . |||. ||. ..  ||. |. |.|.|..  |    |   . ||        . | || ...
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGC-TARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEK
Kinase ZC373.3.AA CK1-A 36-236 26 2.7e-24 82.67 In-house 1-196 (261) Show / Hide 
Range on Protein: 36-236
Range on HMM: 1-196/261
Sequence Identity: 26% (55 aa)

YKLIHKVGSGSFGEVWQATDKLEG-NVA-KIVKIINKYVGGSGPRDILYDNEIEFFKYCHDAPNIPTLFHHFSHVGFNVLVMSEEGQNLREVAKRSPGSF
|.|..|.||||||... .    .| .|| |. .   ..        ..|  |   ..  . .. ||.. .. .   .||.||   |  | ..       |
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHP------QLIY--EAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRF

SLNNLIRIAYQIGSTLCFIHDKSFIHRDLKAENVLVSLKNKVCKMVLIDFGNAVRFKDVNGNELPEFNDGFDYTHCT-HKSINVLLGISHTQNDDWASLV
..   . .| |. . . ..| |.|||||.| .| |. .     |. ||||| | ...| .  .  .. .  . |      |||  |||  .  ||  |. 
TMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMG

YLLL
| ..
YVMM
Kinase ZC373.3.AA Ciliate-E2-Unclassified 36-196 21 1.4e-22 75.17 In-house 1-204 (352) Show / Hide 
Range on Protein: 36-196
Range on HMM: 1-204/352
Sequence Identity: 21% (45 aa)

YKLIHKVGSGSFGEVWQATDKLEGNVA------KIVKIIN-KYVGGSGPRDILYDNEIEFFK---------------YCHDAPNIPTLFHHFSHVGFNVL
||.|.. |.|.||.|... .| ..  .      | ..|.. |..  .  . ..  .|..  |               . |. |.|  .|..|       .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMSE-EGQNLREVAKRSPG----------------SFSLNNLI-----RIAYQIGSTLCFIHDKS-FIHRDLKAENVLVSLKNKVCKMVLIDFGNAVRFK
||   ||..|..  | ...                 |. .. .     ....|| . |...| |  .||||.| ||.|.. ..|  .  .||||.. . .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

DVNGNE
. |...
QNNNCD
Kinase ZC373.3.AA CMGC 36-186 18 4.2e-22 68.61 In-house 1-251 (513) Show / Hide 
Range on Protein: 36-186
Range on HMM: 1-251/513
Sequence Identity: 18% (48 aa)

YKLIHKVGSGSFGEVWQATDKL-------------EGN--VA-KIVKIINKYVGG--SGPRDILYD-----------NEIEFFKYCH-------------
|. | |.|.|..|.|....||.             |.|  || |..|    |  .  |                    ||.. |. .             
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKS-------TIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDP

---DAPNIPTLFHHFSHVGFN-----------------VLVMSEEGQNLREVAKRSP---------------------------GSFSLNNLIRIAYQIG
   . .|| .|. .| | . .                  ||.   ...| .. |. .                            .|.. .   ..||| 
DNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQIL

STLC--FIHDKS--FIHRDLKAENVLVSLKNKV-----------------CKMVLIDFGNA
  |   ..| .   .|||||| ||.|.. ....                  .  ..|||.|
RGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase ZC373.3.AA Worm5 113-261 30 1.1e-21 62.0 In-house 82-235 (260) Show / Hide 
Range on Protein: 113-261
Range on HMM: 82-235/260
Sequence Identity: 30% (47 aa)

LVMSEEGQNLREVAKR-SPGSFSLNNLIRIAYQIGSTLCFIHDKSFIHRDLKAENVLVSLK-NKVCKMVLIDFGNAVRFKDVNGNELPE-FNDGFDYTHC
.||. || .| .| .|  .. ||  |  .|   ..  |  .|   |||||. ..|...  .  ..    |||||   |||   |.  ..      .   |
FVMHKEGDCLNDVWMRNKNKRFSRKNVLKIMCCMSHSLQTLHSIGFIHRDCHWQNIMFAKRITPINPCKLIDFGIGKRFKNRRGHYCKDRPQRDVNFKDC

THKSINVLLGISHTQNDDWASLVYLLLEMHGVTWGSR--TGEMFMNKVEFEANP
 | | ||  |      ||  |..||.| | |.   .     . |. |  |. ||
RHCSWNVHCGGIPRKKDDFESMMYLALRMSGIHCYRYENKEQRFCQKMKFHFNP
Kinase ZC373.3.AA CK1-D 36-236 28 1.9e-18 61.57 In-house 1-196 (261) Show / Hide 
Range on Protein: 36-236
Range on HMM: 1-196/261
Sequence Identity: 28% (58 aa)

YKLIHKVGSGSFGEVWQATDKLEGNVAKIVKIINKYVGGSGPRDILYDNEIEFFKYCHDAPNIPTLFHHFSHVGFNVLVMSEEGQNLREVAKRSPGSFSL
|..  |.||||||...  |.   .     | |    .    |     . |  |.|. .    ||..    .   .||.||   |  | ..       |||
YRIGRKIGSGSFGDIYHGTNIQTNEE---VAIKLECIKTKHPQ---LHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSL

NNLIRIAYQIGSTLCFIHDKSFIHRDLKAENVLVSLKNKVCKMVLIDFGNAVRFKDVNGNELPEFNDGFDYTHCT-HKSINVLLGISHTQNDDWASLVYL
   . .| |. . . .|| ..|||||.| .| |. |  .   . .|||| | |..| .  .   . .  . |      |||  .||     ||  || |.
KTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYV

LL
|.
LM
Kinase ZC373.3.AA CAMK 41-196 18 3.1e-18 54.71 In-house 1-262 (425) Show / Hide 
Range on Protein: 41-196
Range on HMM: 1-262/425
Sequence Identity: 18% (48 aa)

KVGSGSFGEVWQATDKLEGN-----------VAKIVKIINKY---------------VGGSGPRD----------ILYDNEIEFFKYCH------DAPNI
. |.||||.|  ...|. ..           .   .|||.|                .  |....              .|||  | ..      | |||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

PTLFHHFSHVGF-------------------NVLVM-----SEEG---QN-LREVAKRSP-------------GSFSLNNLIRIAYQIGSTLCFIHDKSF
  |....    .                    ..||      . |   .  .  . ....             | |.     |.  || | . ..|..  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKAENVLVSLKN--------------KVCKMVLIDFGNAVRFKD---------VNGNE
.||||| ||.|.. .|              ....  .|||| | .|..         ..|.|
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE
Kinase ZC373.3.AA Worm8 152-195 47 8.7e-17 45.03 In-house 115-158 (261) Show / Hide 
Range on Protein: 152-195
Range on HMM: 115-158/261
Sequence Identity: 47% (21 aa)

IHDKSFIHRDLKAENVLVSLKNKVCKMVLIDFGNAVRFKDVNGN
|| .  .| | ||.| .|| .|.. ..||.||| . .|||.|||
IHSFGIVHGDIKADNLMVSHSNRMFMLVLVDFGCSCWFKDHNGN
Kinase ZC373.3.AA S_TKc 36-270 19 4.2e-13 15.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-270
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

YKLIHKVGSGSFGEVWQATDKLEGNVAKIVKIINKYVGGSGPRDILYDNEIEFFKYCHDAPNIPTLFHHFSHVGFNVLVMSEEGQ---NLREVAKRSPGS
|... |.|.|.||.|.....|   .    .|||.          .   .||.  |   . ||| .|. .| . ..  .||   ..   .|... |. .. 
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FSLNNLIRIAYQIGSTLCFIHDKSFIHRDLKAENVLVSLKNKVCKMVLIDFGNAVRFKDVNGNELPEFNDGFDYT---------HCTH-K----S
     |.     ...||| . | ..|.. .|||||| ||.|..         ..||| | ..            . |  |         . .. |    |
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------------TTFCGTPWYMAPEVLGYGKCKCDWWS

INVLLGISHT-----QNDDWASLVYLLLEMHGVTWGSRTGEMFMNKVEFEANPT-----EILV-------DKML
. ..| .  .     .       ....... |    |. .  |..|  .. .|.     |.|        .  .
CGCILYEMLCGYPPFP------QMQMMFKKIG----SPEAKDFIRKC-LQKDPEKRPTAEALQDEWDIKCHPWF
Kinase ZC373.3.AA Ciliate-E2 127-197 26 4.6e-11 34.2 In-house 138-214 (365) Show / Hide 
Range on Protein: 127-197
Range on HMM: 138-214/365
Sequence Identity: 26% (23 aa)

KRSPGSFSLNNLIRIAYQIGS---------------TLCFIHDKS-FIHRDLKAENVLVSLKNKVCKMVLIDFGNAVRFKDVNGNEL
|   ..|...  ..| .|| .                | ..| |   ||||.| ||.|.          .||||.. ...| | |..
K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRT
Kinase ZC373.3.AA Pkinase 131-207 30 5.9e-11 39.82 Pfam 101-174 (293) Show / Hide 
Range on Protein: 131-207
Range on HMM: 101-174/293
Sequence Identity: 30% (25 aa)

GSF--SLNNLIRIAYQIGSTLCFIHDKSFIHRDLKAENVLVSLKNKVC--KMVLIDFGNAVRFKDVNGNELPEFNDGFDYT
|.|  | . .....||| . | ..|....|||||| ||.|.. .| ..  .  ..||| |  |.    .   . ...|  |
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGT
Kinase ZC373.3.AA TyrKc 36-269 16 7.9e-08 -96.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-269
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)

YKLIHKVGSGSFGEVWQATDKLEGNVAKIVKIINKYVGGSGPRDILYDNEIEFFKYC-HDAPNIPTLFHHFSHVG------FNVLVMSE--EGQNLREVA
 .|..| |.| ||||...| |   .||  || ....            .|..  .    . |||  |.   .. |        ...  |  .. .|..  
ITLGKKLGEGAFGEVYKGTWK--IQVA--VKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KRSPGSFSLNNLIRIAYQIGSTLCFIHDKSFIHRDLKAENVLVSLKN--KVCKMVLIDFGNAV-------RFKDV----NGNEL-------PEFNDGFDY
... . ...  |. ...|| .   ..|.| .||||| | |.||. ..  |..   |  ..            ...    .|. .       ||     .|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NY

THCTHKS------INVL-----LGISHTQN-----DDWASLVYLLLEMHGVTWGSR---------TGEMFMNKVE--FEANPTE-----ILVDKM
  .|.||      . ..     .| .   .      ... .. .. . .                . ||..   .   ...| .      .....
GKFTTKSDVWSFGV-CMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase ZC373.3.AA Ciliate-E2 36-71 22 1e-06 18.75 In-house 1-58 (365) Show / Hide 
Range on Protein: 36-71
Range on HMM: 1-58/365
Sequence Identity: 22% (13 aa)

YKLIHKVGSGSFGEVWQATDKLEGN-------------------VA---KIVKIINKY
||.| | |.|.|| |..........                   |.   . .||..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKN
Kinase ZC373.3.AA Pkinase_Tyr 127-177 29 6e-06 20.88 Pfam 99-151 (270) Show / Hide 
Range on Protein: 127-177
Range on HMM: 99-151/270
Sequence Identity: 29% (16 aa)

KRS---PGSFSLNNLIRIAYQIGSTLCFIHDKSFIHRDLKAENVLVSLKNKVCK
..    ......  |. ...|| . . . ..| .||||| | |.||. .| |.|
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVK
Kinase ZC373.3.AA Pkinase 36-70 50 1.3e-05 20.9 Pfam 1-34 (293) Show / Hide 
Range on Protein: 36-70
Range on HMM: 1-34/293
Sequence Identity: 50% (18 aa)

YKLIHKVGSGSFGEVWQATDKLEGN-VAKIVKIINK
|... |.||||||.|.....| .|  ||  ||||.|
YHIGRKIGSGSFGCVYKCHHKGTGKIVA--VKIIKK
Kinase ZC373.3.AA Worm8 36-70 31 2.7e-05 11.21 In-house 1-34 (261) Show / Hide 
Range on Protein: 36-70
Range on HMM: 1-34/261
Sequence Identity: 31% (11 aa)

YKLIHKVGSGSFGEVWQATDKLEGNVAKIVKIINK
| |  . | |..|.|  . |.   | ....| | |
YTLEKVLGRGMYGDVHLCQDDRN-NEWRVMKLIHK
Kinase ZC373.3.AA Pkinase_Tyr 36-54 42 0.000632 13.92 Pfam 1-19 (270) Show / Hide 
Range on Protein: 36-54
Range on HMM: 1-19/270
Sequence Identity: 42% (8 aa)

YKLIHKVGSGSFGEVWQAT
 ....| |.|.||||...|
ITFGKKLGEGAFGEVYKGT
Kinase ZC373.3.AA Worm5 36-69 23 0.025871 2.87 In-house 1-34 (260) Show / Hide 
Range on Protein: 36-69
Range on HMM: 1-34/260
Sequence Identity: 23% (8 aa)

YKLIHKVGSGSFGEVWQATDKLEGNVAKIVKIIN
|. |  .|.|..| ..   |  . .  . .| .|
YYIIYVLGEGEYGTIYACVDMDDRHNQLAIKAMN