Gene Y42A5A.4 (Nematode worm)

Y42A5A.4

Species: Nematode worm
Alias: aSWK171, CE20258, Y42A5A.4
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: V:2.97, WormBase Physical Map location: V: 11108095-11109872

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
Y42A5A.4.AA Protein Genbank 353 None Fasta, JSON
Y42A5A.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 283 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Y42A5A.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y42A5A.4.AA CDKL 4-286 64 1.5e-215 722.33 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-286/286
Sequence Identity: 64% (184 aa)

YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVNDELI
|..|.|.||||||||.||.|..||||||||||.|.||||..||||.|||.|||||||.|.|.|||||.|.|||||||| ||.|||||||..|.||.....
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

KKIIYQLLEALKFCHSHKCIHRDVKPENIFLT-RNDQVKLGDFGFARIIN-TTEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALW
.|...|.|.|..|||.|.|||||.|||||..| .|.||||.||||||... ..|.|||||||||||.|||||||.|||.||||||.|||.||...|..||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNAS-SAQLDFLQKCFEMSPDRRFSCSELMLHGIF
||.|||||||||.|.||...|||..||..|.||.|...||.||.|||....||.| ...|||..||..|.||.|..|..|| | .|
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase Y42A5A.4.AA CMGC 4-286 23 2.2e-124 410.93 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 23% (119 aa)

YDRLSKLGEGSYGVVYKCKN--------------RDTGQIVAIKKFVETEDDPHIKK----------IALREIRMLKQLK-----------------HQN
|. ..|.|||.|||||||..              ..|..||||||. . . ... .|          .|||||..||.|.                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVGLIEVFKRNR-----------------KLHLVFELCDRTVLHELEKNP--------HGVNDEL------------IKKII------YQLLEALK--FC
.|.|...|...                  .|.||||..| . .. ...|.        .. ..              ||...      ||.|..||  .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSHK--CIHRDVKPENIFLTRN--------------------DQVKLGDFGFARIINT----------------------TEMYTDYVATRWYRSPELLV
|||.   |||| ||||| .. |                    ...|..|||.||....                      ...||.||.|||||.||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GD---------VQYGPPVDIWAVGCVYAELLTG--------EALWPGRSD-----------IDQLYHIRKTLGEFL---------------PR-------
|.          .|..|.|.|.|||. ||..||        . |.||.|.           ||||..| |.|| .                ..       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------HISIFRTNQFFFGLSIPEPE--HLEPLPSKLPN--------------------------------ASSAQLDFLQKCFEMSP
                  |.|.|  |... ... |..   ....|  ..||                                ...  .|.|.|.... |
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DRRFSCSELMLHGIF
|.| .... . |  |
DKRITAEQALQHPYF
Kinase Y42A5A.4.AA Pkinase 4-286 29 8.5e-99 339.33 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 29% (89 aa)

YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALR--EIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRT----VLHELEK--NP
| ...|.|.||.|.||||....||.|||.|..   ....  .....|  ||...| |.| | | |...| .......|.|.|. .     |... .  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HGV--NDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQV----KLGDFGFARI--INTTEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAV
 ..   .. .|...||.|..|..|||...||||.|||||.. .|...    |..|||.|.   .   . .|... |.||..||.. |.  |||.||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVYAELLTGEALWPGR----SDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNASSAQLDFLQKCFEMSPDRRFSCSELMLH
||. .|.|.|. ..||.    . .||.. |....|  |.....  ...  || ... . .  . .  . .|.|.. .||. .|... | .| .. ... |
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

GIF
  |
PWF
Kinase Y42A5A.4.AA S_TKc 4-286 28 1.6e-97 331.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDR---TVLHELEKNPHG---
|. | |.|.|..|.||||....||.|||||.           . ..|||..||. .| |.| |..||    .|..|.|.||    .... ..|....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMYTDYVATRWYRSPELLVGDVQYGP-PVDIWAVGCVYAEL
   .   .....||...||..||||. ||||.|||||.|..  ..|..|||.||..      | .. |.||..||.|    .||. ..|.|..||. .|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

LTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNASSAQLDFLQKCFEMSPDRRFSCSELML-------HGIF
|.|. ..|   ........ .                                        |.  .||..||... |..| .. |..        |  |
LCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Y42A5A.4.AA CDK 4-218 37 8.7e-97 310.2 In-house 1-242 (284) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-242/284
Sequence Identity: 37% (95 aa)

YDRLSKLGEGSYGVVYKCKNRDTG-----QIVAIKKF-VETE----DDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRN-----------RKLHLVFEL
|..| |.|||.||||||.....||     ||||.||. .|.|    ..  .   |.||| .||.| |.| | |..|.  .           .|| .||| 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CDRTVLHELEKNPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQ-----VKLGDFGFARIIN-------TTEMYTDYVATRWYRSPE
.|    . ..          || ...|||..| .|||.. .||| || || ...| .     .|..|||.||. .        .  ||  | |.|||.||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLVGDVQYG--PPVDIWAVGCVYAELLT---GEALWPGRSDIDQLYHIRKTLG
|| |. .|.  .|.|.|.|||. ||..|   ...| ||.|.|||| .| ...|
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICG
Kinase Y42A5A.4.AA CDC2 4-218 41 2e-87 268.67 In-house 1-226 (301) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-226/301
Sequence Identity: 41% (95 aa)

YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKF-VETEDDP-HIKKIALREIRMLKQLK-HQNLVGLIEVFKRNRKLHLVFELCDRTVLHELE-KNP--HG
| .. |.|||.||||||||...|.||||.||. .|.||.   .   |.|||  || || |.|.| | .|..  .|| .||| .|.     .. ..|    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

VNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINT-TEMYT--DYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAEL
.  .|.|...||.|... |||... .||| || ||.. .. ..|..||| || ...    ||    | |.|||.||.| |. .|  |||.|..||. ||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---LTGEALWPGRSDIDQLYHIRKTLG
    | ..| .| | ||||. | ..||
FMDVTKKPLFHGDSEIDQLFKIFRILG
Kinase Y42A5A.4.AA RCK 4-218 40 5.1e-81 256.75 In-house 1-231 (298) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-231/298
Sequence Identity: 40% (97 aa)

YDRLSKLGEGSYGVVYKCKNRDTGQIVAIK----KFVETEDDPHIKKIALREIRMLKQLK-HQNLVGLIEVFKRNR--KLHLVFELCDRTVLHELEKN--
|  ...||.|.||.| | .| .||.|||||    ||   |.      . ||||. |. |. | |.. |.||.. |    |..|||..| . | .. |.  
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEE-----CMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMD-MNLYQMMKDFK

--PHGVNDEL--IKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTR---------NDQVKLGDFGFARIINTTEMYTDYVATRWYRSPELLVGDVQYGPP
   . .. .   ||.|.||.| .|...|.|   |||.||||| .|          .| .|..||| .| |     ||||| |||||.||.|  . .|  |
ERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSP

VDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLG
.|||||||. .|| .  .|.|| | |||.. | | .|
MDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMG
Kinase Y42A5A.4.AA CDK7 4-218 40 5.3e-81 215.37 In-house 1-220 (288) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-220/288
Sequence Identity: 40% (89 aa)

YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFV----ETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVN
|. ....||| ...|||     |||||||||        | .  |   |.||| .|. ..| | .||| .|     . |||.. |    .  . .     
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

DELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINT-TEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGE
   || .  ..|  | .|| .   ||| || |  .  | |.|..||| || .    ..||  | |||||.|||| |  .||. ||.|.|||. |||.   
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

ALWPGRSDIDQLYHIRKTLG
   || ||||||  | .|||
PYLPGDSDIDQLTRIFQTLG
Kinase Y42A5A.4.AA CDK5 4-218 41 1.2e-76 241.57 In-house 1-217 (287) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-217/287
Sequence Identity: 41% (89 aa)

YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVNDELI
|... |.||| ||.||| .|..|. |||.|.    ..|  .   |.||| .|| |||.| | |. |   ..|| |||| ||      ...   ... ..|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINT-TEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELL-TGEALW
| ..||||  | |||.|.  ||| || |    .| . ||.||| ||        |.  | | ||| |  | |  .|  ..|.| .||..||.  .|  | 
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGRSDIDQLYHIRKTLG
|| .. |||  | | .|
PGNDVEDQLKRIFKIMG
Kinase Y42A5A.4.AA MAPK 4-218 33 1.4e-69 237.48 In-house 1-252 (328) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-252/328
Sequence Identity: 33% (86 aa)

YDRLSKLGEGSYGVVYKCKNRD------TGQIVAIKKFVETEDDPHIKKIALREIRMLKQL-KHQNLVGLIEVFKRN-----------RKLHLVFELCDR
|. |...|.|.|||| ... .       .|..|||||..   ..|.  | ..|||..|. . .| | ..|...|.             . . .|.||.. 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

TVLHELEKNPHGVNDELIKKIIYQLLEA--LKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTE---------------MYTDYVATRWYRS
  || . | .   .|. |. ..||.| .  ||. ||   |||| ||.|| .. |...|..||| ||.| ...               . |.||||||||.
D-LHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLVGD--VQYGPPVDIWAVGCVYAELLT-GEALWPGRSDIDQLYHIRKTLG
||.. .     |   ||.|.|||  ||.|| .  | ||.. |||. .| ..||
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLG
Kinase Y42A5A.4.AA ERK7 4-286 33 8.3e-67 227.45 In-house 1-292 (292) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-292/292
Sequence Identity: 33% (97 aa)

YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLK-HQNLVGLIEVFK--RNRKLHLVFELCDRTVLHELEKNPHGVND
|. ...|| | ||.| |   . |.|.||.||      ..       ||| .|.... | |.. ||.|..   .| . ||||  . | ||   .  .   |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFME-TDLHAVIRKGNILKD

ELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTE-------MYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAE
   . |.|||| |.|. || . ||||.|| || |  .  ||. ||| || |  .|       | |.||||||||.|| |.|  .| . || | .||. .|
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

LLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNASSAQLDFLQKCFEMSPDRRFSCSELMLHGIF
.|.| .. || | ..|.  | .|...     |     .     |.  . .. ..|   .|... . .| |..   . |..| .  . . |   
MLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase Y42A5A.4.AA p38 4-218 39 3.5e-60 204.32 In-house 1-221 (289) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-221/289
Sequence Identity: 39% (89 aa)

YDRLSKLGEGSYGVVYKCKNRDTGQI---VAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKR-NRKLH------LVFELCDRTVLHELEK
| .|. .|.|.|| | |   |.|||    |||||. .   ...  | . ||.| || ..| | ..|..||   .. .       .| .. ..  |. . |
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGAD-LNNIMK

NPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAE
  .  .|. |. ..||.| .||. ||   |||| || || .. .  ..  ||| ||    .|| |.||||||||.|| .   ..|   |||| |||. ||
CQR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-HCDDEM-TGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAE

LLTGEALWPGRSDIDQLYHIRKTLG
|.||..| ||   ||||  | | .|
LITGRTLFPGDDHIDQLQRIMKVCG
Kinase Y42A5A.4.AA TyrKc 4-286 21 1e-16 47.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQL--KHQNLVGLIEVFKRN-------RKLHLVFELCDRTVLHE-LEK
   . ||||| .|.|||.. .   . ||.|.  |      .. . .||.|....|  .|.|.| |. |             | .|.|...   |.. | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTT-------EMYT------DY--VATRWYRSPELLVGDVQY
. . .. .   .. .|  .   . ||..|||||    |. ...| .|| .||| .| |          ..|.          .  ||. .|| .  .  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

GPPVDIWAVGCVYAELLT-GEALWPG-----RSDIDQLYHIRKTLGEFLPRH---ISIFRTNQFFFGLSIPEPEHLEPLPSKLPNASSAQLDFLQKCFEM
 .  |.|. | .  |..| |.  .||      |... . ....      | .   .|                       .  . ....  .  ..| . 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F--VCCPDEMYQIMKQCWHE

SPDRRFSCSELMLHGIF
 |. | . ||.  | .|
DPEDRPTFSEI--HECF
Kinase Y42A5A.4.AA Pkinase_Tyr 4-158 28 1.2e-16 57.04 Pfam 1-169 (270) Show / Hide 
Range on Protein: 4-158
Range on HMM: 1-169/270
Sequence Identity: 28% (48 aa)

YDRLSKLGEGSYGVVYKCKNR----DTGQIVAIKKFVETEDDPH--IKKIALREIRMLKQL-KHQNLVGLIEVFK-RNRK--LHLVFELCDR-TVLHELE
   . |||||..|.|||.. .    .|.. ||.|.  |. ....  ...  .||....||| .|.|.| |. |   . .   . .|.|..     |. | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF-MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KN---PHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMY-T
|.   .. .. . . .. .|  ... . .|..|||||.   |. .|.| .|| .||| || |  .. | .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYR
Kinase Y42A5A.4.AA CDK 250-286 29 1e-06 17.01 In-house 253-284 (284) Show / Hide 
Range on Protein: 250-286
Range on HMM: 253-284/284
Sequence Identity: 29% (11 aa)

SKLPNASSAQLDFLQKCFEMSPDRRFSCSELMLHGIF
.|||.      |.|.|.. . |..|.|... . |  |
TKLPDY-----DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Y42A5A.4.AA CDK7 255-286 28 0.000286 6.8 In-house 257-288 (288) Show / Hide 
Range on Protein: 255-286
Range on HMM: 257-288/288
Sequence Identity: 28% (9 aa)

ASSAQLDFLQKCFEMSPDRRFSCSELMLHGIF
||   ||.... . | | .| .|..   .  |
ASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase Y42A5A.4.AA CDK5 241-286 21 0.000716 7.58 In-house 241-287 (287) Show / Hide 
Range on Protein: 241-286
Range on HMM: 241-287/287
Sequence Identity: 21% (10 aa)

EPEHLEP-LPSKLPNASSAQLDFLQKCFEMSPDRRFSCSELMLHGIF
.. .... . .  |. ..  .|.|||  .. |. | |  . . |  |
PMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase Y42A5A.4.AA p38 252-286 34 0.000882 8.48 In-house 255-289 (289) Show / Hide 
Range on Protein: 252-286
Range on HMM: 255-289/289
Sequence Identity: 34% (12 aa)

LPNASSAQLDFLQKCFEMSPDRRFSCSELMLHGIF
...|.   .| | |  |. ||.| . .| | |  |
FMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase Y42A5A.4.AA MAPK 252-286 30 0.043179 2.76 In-house 290-328 (328) Show / Hide 
Range on Protein: 252-286
Range on HMM: 290-328/328
Sequence Identity: 30% (12 aa)

LPN----ASSAQLDFLQKCFEMSPDRRFSCSELMLHGIF
.||    |..  .|.|.|  ...||.| .  | . |  |
FPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Y42A5A.4.AA RCK 247-286 25 0.07866 1.26 In-house 259-298 (298) Show / Hide 
Range on Protein: 247-286
Range on HMM: 259-298/298
Sequence Identity: 25% (10 aa)

PLPSKLPNASSAQLDFLQKCFEMSPDRRFSCSELMLHGIF
||.. .||.|.  .. ..|.    |. | . ...  |  |
PLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF