Gene Y38H8A.3 (Nematode worm)
Y38H8A.3
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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Y38H8A.3.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 260 | Kinase domain by global Sugen HMM | Fasta, JSON |
Y38H8A.3.AA | Protein | Genbank | 308 | None | Fasta, JSON |
Protein domains of Y38H8A.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | Y38H8A.3.AA | Worm6 | 17-276 | 49 | 2.1e-162 | 545.85 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 17-276 Range on HMM: 1-279/279 Sequence Identity: 49% (138 aa) WSIEKKLGEGGFGAVYRVFDATGK----YAMKVEG--ANEQIQVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGN--FNYVVMTLVGKSLQDLNKAGVGGH |...||.||||||||| | |...| .|||.|. .|...|.||.|..||... ....||||||||.|...| |||.|||||||.|.|| |. ... WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK MSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGR---PELNEIRKVYILDFGMCR-KFTGNDGT-IRKPR-QAAGFRGTVKYAPISCHLQRELCR .|||....|.||.|||.|||||.|..||||||||..||| |.||....|.||||||| |.. |.|. .|.|| .|.||||||.|||..|| ..|.|| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR KDDLETWMYMQVELSHGTIPWQYISDMNQVG-QAKQAIRNN---LGSLFPPPCPH-QFQDIMRMVDAMKYYDAPNYQAI |||.|.|.||.||. .|..||. ..|...|. ..|...|.. . ..| |||. .|.||| ..| ..|.|.|.|. | KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | Y38H8A.3.AA | CK1 | 17-276 | 33 | 4.4e-117 | 395.26 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 17-276 Range on HMM: 1-339/339 Sequence Identity: 33% (115 aa) WSIEKKLGEGGFG-AVYRV-----FDATGK-------YAMKVEGANEQIQ-VLKLEVSVLNKLSKRG---------NRHFCK----------IEDKGRFG | ..||.|||||| ..|.| | ... |||||| ... | ...|.... |. ..| ..|||| ....|. . WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED N-FNYVVMTLVGKSLQDLNK--AGVGGHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPE-----------LNEIRKVYILDFGMCR-KFT . .||.||||.|..|.|| | . ....||.... |.|| |||||..|..|..|||.||.|. .|| | || |.||..||||.| |.. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR GNDGT------------IRKPRQ---AAGFRG-TVKYAPISCHLQRELCRKDDLETWMYMQVELSHGT--IPWQYISDMNQ-----VGQAKQAIRNN--- .||. .| || ..|||| |..|..|.|||..|..|.|||..|.|| .|. || ||| ..| .. |...|...... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM LGSLFPPPCPH-------QFQDIMRMVDAMKYYDAPNYQAI . ..| .|| .| .|| .....||||.|.|..| STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | Y38H8A.3.AA | TTBKL | 17-280 | 37 | 1e-87 | 296.2 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 17-280 Range on HMM: 1-288/288 Sequence Identity: 37% (110 aa) WSIEKKLGEGGFGAVYRVFDAT--GK-YAMKVEGAN-EQI-QVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGH-MS | |.|..||||||.||.| | . .. .|||.| | . ...|.|| ||.||...| .||.|. . |. ...|..||||.|..|||| | .. .| WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS MGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELN--EIRKVYILDFGMCRKFTGNDG-----------TIRKPRQ---AAGFRGTVKYAPISC | . |||| |.|| ..| .|..||||||.|. .| . . . | ||..||||.|.. .|| ..|.|| |.||||..|. . DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HLQRELCRKDDLETWMYMQVELSHGTIPWQYISDMNQVGQAKQAIRNNLGSLFP-PP----CPHQFQDIMRMVDAMKYYDAPNYQAIYGMM |. .|. |.||| |||| .|| | ||....| .....|.. .. || .| || .| ..|... ...||| |.|. || . HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDED--LFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | Y38H8A.3.AA | TTBK | 17-276 | 42 | 6e-87 | 295.16 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 17-276 Range on HMM: 1-257/257 Sequence Identity: 42% (113 aa) WSIEKKLGEGGFGAVYRVFDATGK---YAMKVEGANEQIQVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGHMSMGC | . || | |||| .| | . |.||| |. . ||||.|| || || | | |. || .|||.||.| ||.| || . | |.. WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKL--QGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST SIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKDDLETWMYMQ . .|.| |...| |..|.||||.|| |. .|| ..||.|.||||. |..| | .| ||..||||||| || | |. ||. |.||| || TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGR-NPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML VELSHGTIPWQYISDMNQVGQAKQAIRNNLGSLFPPPCPHQFQDIMRMVDAMKYYDAPNYQAI || .| || | | .|||. |. . .. | |||.|. | . ..| | |.|| | VEFVQGQLPWRKIKDKDQVGEMKE--KYDHRMLL-KHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | Y38H8A.3.AA | Dual | 17-280 | 28 | 2.1e-47 | 157.44 | In-house | 1-282 (282) | Show / Hide |
Range on Protein: 17-280 Range on HMM: 1-282/282 Sequence Identity: 28% (80 aa) WSIEKKLGEGGFGAVYRVFDATG------KYAMKVEGANEQ--------IQVLKLEVSVLNKLSK-RGNRHFCKIEDKGRFGN--FNYVVMTLVGKSLQD | . . || |||. ||.|.. .|..|.| ... .. .. ... . |..| |...| | | .|.|| ..| |||. WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE LNKAGVGGHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEI-RKVYILDFGMCRKFTG-NDGTIRKPRQAAGFRGTVKYAPISCHLQ . . | .|| || ..|| |.|. |||.||||||..|| |. .| |.. .|| .||.. ||. . | .| . |. || . | .| IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCG---LGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQ RELCRKDDLETWMYMQVELS-HGT-IPWQYISDMNQVGQAKQAIRNNLGSLFPPPCPHQFQDIMRMVDAMKYYDAPNYQAIYGMM .. ||||||.| || | .. ..| | | . ..|.. . .. . | .. .. .|. . | .| | .. .. KDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL |
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Kinase | Y38H8A.3.AA | CK1-Unique | 17-224 | 32 | 4.7e-46 | 157.64 | In-house | 1-233 (337) | Show / Hide |
Range on Protein: 17-224 Range on HMM: 1-233/337 Sequence Identity: 32% (76 aa) WSIEKKLGEGGFGAVYRVFD-ATG-------KYAMK--VEGANEQIQVLKLEVSVLNKLSKRG-----NRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLN | . |..| ||.| |.|| . ..| .|.|| . .. | |. | .|. ..| ||||...| . . . |||..|.|. . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC KAGVGGHMSMG------CSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRK--FTGNDGTIRKPRQAAGFRGTVKYAPIS . . . . | | | | |...| | |..||. ||.|| . | . . |.||.| ||. | | . ||.|| . |||. .|.|.| MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS CHLQRELCRKDDLETWMYMQVELSHGT--IPWQ ||. ||. |.||.|.| || . | |.| . |. CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK |
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Kinase | Y38H8A.3.AA | CK1-Unclassified | 17-224 | 30 | 1.2e-25 | 72.7 | In-house | 1-217 (244) | Show / Hide |
Range on Protein: 17-224 Range on HMM: 1-217/244 Sequence Identity: 30% (66 aa) WSIEKKLGEGGFGAVYRVFDA--TGKYAMKVEGANEQIQVLKLEVSVLNKLSKRGNR-----HFCKIEDKGRF--GNFNYVVMTLVGKSLQDLNKAGVGG ...|.| | || .| . . ..|.|.| .| . |. |. ... | .. | .. |. |. |..|..||.| |.|| || . .. YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNM-CNR HMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIG-RPELNEIRKVYILDFGMCRKFT--GNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKD |. |. | .. .| ||| ...||| || |. .| . .. .||| ||| .. ..|. | .. || || | || | |.| KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLG--KNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRD DLETWMYMQVELSHGTIPWQ ||| .| . . |. ||| DLESLGYVLIYFLKGSLPWQ |
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Kinase | Y38H8A.3.AA | CK1 | 17-224 | 28 | 1.2e-24 | 81.87 | In-house | 1-217 (271) | Show / Hide |
Range on Protein: 17-224 Range on HMM: 1-217/271 Sequence Identity: 28% (62 aa) WSIEKKLGEGGFGAVYRVFDATGK----YAMKVEGANEQIQVLKLEVSVLNKLSK---RG-NRHFCKIEDKGRF--GNFNYVVMTLVGKSLQDLNKAGVG ...|.|.| || .| . . | . .|.|.| .. . |. |. ... | . . .. .. |. |..|..||.| |.|| || . . YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNFCN GHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFT-GNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKDD .. |. . |. | .. .| .|| ...|||.|| |. .|| .. .||| |||. .. .... | .. ||. || | || .| |.|| RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD LETWMYMQVELSHGTIPWQ .| .|. . . |. ||| MESLGYVLMYFLRGSLPWQ |
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Kinase | Y38H8A.3.AA | CK1-D | 17-276 | 26 | 6.8e-24 | 81.07 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 17-276 Range on HMM: 1-261/261 Sequence Identity: 26% (70 aa) WSIEKKLGEGGFGAVY--RVFDATGKYAMKVEGANEQIQVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGHMSMGCS . | .|.| | || .| . |.|.| . . |..| . .. | .| |. |..| .|| |.| || || . . |. YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQ--GGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNY-CHRKFSLKTV IGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKP-RQAAGFRGTVKYAPISCHLQRELCRKDDLETWMYMQ . .. | . .| .| ..|||.|| |. .| .. |||.|||. ... | | || .|| | |. | |.|||| |. LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM--VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL VELSHGTIPWQYISDMNQVGQAKQAIRNNLGSLFPPPC---PHQFQDIMRMVDAMKYYDAPNYQAI . .|..||| . ... . . . . | |..||. | . .|. | |.| . MYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | Y38H8A.3.AA | CK1-A | 17-231 | 27 | 5.5e-23 | 77.94 | In-house | 1-213 (261) | Show / Hide |
Range on Protein: 17-231 Range on HMM: 1-213/261 Sequence Identity: 27% (61 aa) WSIEKKLGEGGFGAVYRVFDATG--KYAMKVEGANEQIQVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGHMSMGCS . . .|.| | || .| | |.|.| .. . | | | . |. | . ... |. ..| .|| |.| || || . .| YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQ--GCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNF-CKRRFTMKTV IGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKP-RQAAGFRGTVKYAPISCHLQRELCRKDDLETWMYMQ . . | . .| .|. ...|||.|| |. .| |....|||. .|. . . | |. ||..|| | || | |.||.| |. LMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGR--HCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVM VELSHGTIPWQYISDMNQ . |..||| . |.. MYFNRGKLPWQGMKAMTK |
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Kinase | Y38H8A.3.AA | S_TKc | 17-268 | 17 | 2.4e-12 | 4.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 17-268 Range on HMM: 1-231/231 Sequence Identity: 17% (50 aa) WSIEKKLGEGGFGAVYRVFDAT--GKYAMKVEGANEQIQVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGNFNYVVMTLVGK---SLQDLNKAGVGGH--- . | .|.|.|.|| ||.. . ..|.|. . .. |...| | . . .|. | . .. |.|| ... .| |. | .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -MSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKDDLE .. . | ..||| .|. | .|||.|| | . . . | |||..|.. | || | . PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------ TWMYMQ------------VELSHGTIPWQYISDMNQVGQAKQAIRNNLGSLFPPPCPHQFQDIMRMVD------------A-------MKYY | |. | |.. |. . . |. | . |... . . . . --GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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Kinase | Y38H8A.3.AA | TyrKc | 17-280 | 17 | 3e-05 | -137.75 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 17-280 Range on HMM: 1-280/280 Sequence Identity: 17% (55 aa) WSIEKKLGEGGFGAVYR-VFDATGKYAMKVEGANEQIQVLKLEVSVLNKL--SKRGNRHFCK-----IEDKGRF---GNFNYVVMTLVGK-SLQDLNKAG . .|||||| || ||. . . . | |. .. .. . | ... || . . . . ......| . ..|| .. . .|.| .. ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGH---HPNIVRLYGVCTQQGRNFMYIEPL-MIVMEYMPHGDLKDYLRKH VGGHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGND--GTIRKPRQAA----GFR--GTVKYAPISCHL . .| . . .| . | || .. ||| | .|.. | | |||..|. . | | .| . | . .. .. RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAP---- QRELCRKDDLETWMYMQVE---------------LSHGTIPWQY-ISDMNQVGQAKQAIRNNLGSLFPPP--------CPHQFQDIMRMVDAMKYYDAPN |...| .. | |. | | .. . ... || || .||.. . . | |. ----------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT YQAIYGMM ..|. . FSEIHECF |
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Kinase | Y38H8A.3.AA | Pkinase | 17-45 | 32 | 4.2e-05 | 19.12 | Pfam | 1-31 (293) | Show / Hide |
Range on Protein: 17-45 Range on HMM: 1-31/293 Sequence Identity: 32% (10 aa) WSIEKKLGEGGFGAVYRVFDATGK--YAMKV . |..|.|.|.|| ||. . .|.|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI |
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Kinase | Y38H8A.3.AA | CK1 | 251-274 | 16 | 0.001956 | 7.92 | In-house | 248-271 (271) | Show / Hide |
Range on Protein: 251-274 Range on HMM: 248-271/271 Sequence Identity: 16% (4 aa) CPHQFQDIMRMVDAMKYYDAPNYQ .| .|.. .. . ......|.|. FPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | Y38H8A.3.AA | Pkinase | 122-191 | 30 | 0.011555 | 10.5 | Pfam | 118-179 (293) | Show / Hide |
Range on Protein: 122-191 Range on HMM: 118-179/293 Sequence Identity: 30% (22 aa) LEALEDLHNIGYLHRDVKPGNYTIG-RPELNEIRKVYILDFGMCRKFTGNDGTIRKPRQAAGFRGTVKYAP |..|| .|. | .|||.|| | | ...... .| | ||| ...| . . . . .| || |.. LRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA |