Gene Y106G6E.6 (Nematode worm)

Y106G6E.6

Species: Nematode worm
Alias: aSWK075, CE29604, Y106G6E.6
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: I:4.37, WormBase Physical Map location: I: 10239266-10235807

Classification

Group: CK1
Family: CK1
Subfamily: CK1-G

Sequence

Name Sequence Type Origin Length Description Download
Y106G6E.6.AA Protein Sugen 407 None Fasta, JSON
Y106G6E.6.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Y106G6E.6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y106G6E.6.AA CK1-G 28-290 75 2.7e-223 748.11 In-house 1-266 (266) Show / Hide 
Range on Protein: 28-290
Range on HMM: 1-266/266
Sequence Identity: 75% (202 aa)

FKVGKKIGCGNFGELRLGKNLYNNEHVAIKLEPMKSKAPQLHLEYRFYKLLGQA-EGLPQVHYFGPCGKYNALVMELLGHSLEDLFDLCDRHFSLKTVAM
..|||||||||||||..|||.|||||||||.|||||.|||||.||||||.|... ||.|||.|||.|||||..||.|||.|||||||.|||.||.|||.|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

VAMQLIRRFEYVHTKHLFYGDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDCDTGKHIAYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMY
||.|.|.|.||||..||.|.||||.||||||.|...|||.||||||.||.|||..|..||.|||||||||||||||||||||.|||||||.|||||||||
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

FLRGSLPWQGLKADTLKERYQKIGDTKRQTAVEVLCEG--FPDEFAQYLRYARRLDFFETPDYDFC
||||||||||||||..||||||||||||.|..|.||..  ||..||.||||.|||||||.||||. 
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase Y106G6E.6.AA CK1 28-288 57 1.5e-183 616.07 In-house 1-271 (271) Show / Hide 
Range on Protein: 28-288
Range on HMM: 1-271/271
Sequence Identity: 57% (156 aa)

FKVGKKIGCGNFGELRLGKNLYNNEH---VAIKLEPMKSKAPQLHLEYRFYKLLGQ------AEGLPQVHYFGPC--GKYNALVMELLGHSLEDLFDLCD
..||.|||.|.||...||.|. .|..   ||||||..|||.|||| |...|| |        ..|.|.....|..  |.||..||.||| ||||||..|.
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN

RHFSLKTVAMVAMQLIRRFEYVHTKHLFYGDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDCDTGKHIAYREHKSLTGTARYMSINTHLGKEQSRRDD
|.|||||| |.| |.|.| ||||.|.. . |.||.|||.|| . ...|...||||||||.|.| .|..|| |||.|.|||||||.|||||||.|||||||
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD

LEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRQTAVEVLCEG-FPDEFAQYLRYARRLDFFETPDYD
.|.||...|||||||||||||||.| |..|.||...|..| ||.||.| || |||.||.|.|.|.|.|.|||.
MESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase Y106G6E.6.AA CK1-Unclassified 28-262 53 4.2e-139 413.17 In-house 1-244 (244) Show / Hide 
Range on Protein: 28-262
Range on HMM: 1-244/244
Sequence Identity: 53% (131 aa)

FKVGKKIGCGNFGELRLGKNLYNNEHVAIKLEPMKSKAPQLHLEYRFYKLLGQAE-------GLPQVHYFGPC--GKYNALVMELLGHSLEDLFDLCDRH
..|..|||.| |||  ...|. .||.||||||  .|| |||  | .... |   .       |.| ....|    | || .||.||| |||||| .| | 
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

FSLKTVAMVAMQLIRRFEYVHTKHLFYGDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDC-DTGKHIAYREHKSLTGTARYMSINTHLGKEQSRRDDL
|||||| | | |.| | ||.| |.. . | ||.|||.|. . ...|...||||||.| |||   ||||| ||| |.||||||| |||.|||.||||||||
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGK-LGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL

EALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRQTAVEVLC
|.||  ..|||.||||||..||.. ||.|.|| . | .| || ||
ESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase Y106G6E.6.AA CK1-D 28-290 53 2.9e-130 439.08 In-house 1-261 (261) Show / Hide 
Range on Protein: 28-290
Range on HMM: 1-261/261
Sequence Identity: 53% (142 aa)

FKVGKKIGCGNFGELRLGKNLYNNEHVAIKLEPMKSKAPQLHLEYRFYKLLGQAEGLPQVHYFGPCGKYNALVMELLGHSLEDLFDLCDRHFSLKTVAMV
...|.||| | ||.. .|.|. .|| ||||||..|.| ||||.| .|||..    |.|.....|  | ||..||.||| ||||||  |.|.|||||| |.
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

AMQLIRRFEYVHTKHLFYGDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDCDTGKHIAYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYF
| |.|.| ||.|..     |.||.|||.|    .. .. .|||||||| | |  | .||.|||.|.||||||| |||||.| |||||||||.|| ..|||
ADQMICRIEYIHCRNFIHRDIKPDNFLMGL--GKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF

LRGSLPWQGLKADTLKERYQKIGDTKRQTAVEVLCEGFPDEFAQYLRYARRLDFFETPDYDFC
 ||||||||||| | ...|..| . | .| ...||.|.| ||.||. |.|.| | . ||| . 
NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase Y106G6E.6.AA CK1 28-290 33 1.5e-115 390.14 In-house 1-339 (339) Show / Hide 
Range on Protein: 28-290
Range on HMM: 1-339/339
Sequence Identity: 33% (113 aa)

FKVGKKIGCGNFG-ELRLG-----KNLYNN-----EHVAIKLEPMKSK--APQLHLEYRFYKLLGQA-------------------EGLPQVHYFGPCGK
.||.||||.| || .  ..     |.. ||     |..|.|.|| ||.   |||. ||..||.| .                    .. | ..... ...
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--YNALVMELLGHSLEDLFD---LCDRHFSLKTVAMVAMQLIRRFEYVHTKHLFYGDVKPENFLIGRYS-----------TRKQHVLHIIDFGLAK-EYI
  || .||.||| .||||..   .|.|.||.||. |.|.|.. . ||.| ..  . |.||.||..||..            .. .....||||.|.  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DC-----------DTGKHIAYRE---HKSLTG-TARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGS--LPWQGLKADTL-------KERYQKIGDTKR
|             |..|. .||   .|...| ||||.|||.||||||.|||||.....|....|.|.  ||||..|. .        |. |..| ..| 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

QTAVEVLCEG-----FPDEFAQYLRYARRLDFFETPDYDFC
.| .. ||..     .|.|| ... | | |.....|||.. 
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase Y106G6E.6.AA CK1-A 28-290 52 1.7e-113 383.35 In-house 1-261 (261) Show / Hide 
Range on Protein: 28-290
Range on HMM: 1-261/261
Sequence Identity: 52% (138 aa)

FKVGKKIGCGNFGELRLGKNLYNNEHVAIKLEPMKSKAPQLHLEYRFYKLLGQAEGLPQVHYFGPCGKYNALVMELLGHSLEDLFDLCDRHFSLKTVAMV
... .||| | ||.. || |. | | ||||.|  | . |||  | . |..|  . |.|.....|    ||..||.||| |||||| .|.|.|..||| |.
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

AMQLIRRFEYVHTKHLFYGDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDCDTGKHIAYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYF
| |.| | ||||.|     |.||.|||.|    |    |..||||||| | |  | .|| ||| | ||||||| ||| ||| |||||||.|..| ..|||
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF

LRGSLPWQGLKADTLKERYQKIGDTKRQTAVEVLCEGFPDEFAQYLRYARRLDFFETPDYDFC
 ||.|||||.|| | | .| || . |  |..|.|| ||| ||. |. |.| | | |.||| . 
NRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase Y106G6E.6.AA TTBK 28-290 34 2.9e-43 150.06 In-house 1-257 (257) Show / Hide 
Range on Protein: 28-290
Range on HMM: 1-257/257
Sequence Identity: 34% (92 aa)

FKVGKKIGCGNFGELRLGKNLYNN-EHVAIKLEPMKSKAPQLHLEYRFYKLLGQAEGLPQVHYFGPCG---KYNALVMELLGHSLEDL-FDLCDRHFSLK
 || |||| | |||   .|.. |. |.||||.|  . .   | .|    | |    | . |  |  ||   |.| .||.|.| .| ||     .  ||| 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKL---QGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLS

TVAMVAMQLIRRFEYVHTKHLFYGDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDCDTGKHIAYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH
|   . .|..   | .|       |.|| || .|| . . . .  ..|||||  |.   .|   . ||     ||.|| ||| |. .|  |.|||  |  
TTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKC-YMLDFGLARQYTNA-CGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFY

MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRQTAVEVLCEGFPDEFAQYLRYARRLDFFETPDYDFC
|   |. | |||  .|    |.   ..| .| .    .| .  | || |..   . |.....||| . 
MLVEFVQGQLPWRKIKD---KD---QVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase Y106G6E.6.AA Worm6 28-290 27 9.6e-40 138.36 In-house 1-279 (279) Show / Hide 
Range on Protein: 28-290
Range on HMM: 1-279/279
Sequence Identity: 27% (78 aa)

FKVGKKIGCGNFGELRLGKNLYNNE--HVAIKLEP--MKSKAPQLHLEYRFYKLLGQAE--GLPQVHYFGPCGK--YNALVMELLGHSLEDLFDLC-DRH
.||.|||| | ||   . ..  ...  ..|.|.|    ..| ..| .|.   |....    .....   |  ..  .| .||.|.| .|.||   . ||.
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLKTVAMVAMQLIRRFEYVHTKHLFYGDVKPENFLIGR---YSTRKQHVLHIIDFGLAKEYIDCDTGK-HIAYR-EHKSLTGTARYMSINTHLGKEQSR
||. |   .| | ... | .|  .    |||| || |||    . ...| . ..|||.....  |..|.  .  | ..    || ||.... | |.||.|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDLEALGHMFMYFLRGSLPWQGLKADTLKE-RYQKIGDTKRQTAVEVLCEGFPD-EFAQYLRYARRLDFFETPDYDFC
.||.|    |   ...| |||...|..  .| .. .. ...| .  . . ...|  ||   . |   ......|||.|.
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase Y106G6E.6.AA TTBKL 147-294 27 2e-32 106.85 In-house 127-288 (288) Show / Hide 
Range on Protein: 147-294
Range on HMM: 127-288/288
Sequence Identity: 27% (47 aa)

DVKPENFLIGRYS--TRKQHVLHIIDFGLAKEYIDCDTG----------KHIAYRE---HKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGS
|||| |. .| ..  .........||||.|. |.. | .          .. . |.   . .. || ||.|.| |..|||.| ||| ..  |..... | 
DVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-

LPWQGLK-ADTLKERYQKIGDTKRQTAVEVLCEG------FPDEFAQYLRYARRLDFFETPDYDFCYNLF
|||.... ..       .|. .|...  |.|. .      .|.||.   .. |.|.. ..|||.  |..|
LPWTNMEDKM-------EIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase Y106G6E.6.AA Pkinase 28-253 21 1e-25 92.02 Pfam 1-234 (293) Show / Hide 
Range on Protein: 28-253
Range on HMM: 1-234/293
Sequence Identity: 21% (53 aa)

FKVGKKIGCGNFGELRLGKNLYNNEHVAIKLEPMKSKAPQLH----L--EYRFYKLLGQAEGLPQVHYFGPCGKYNALVMELLGHSLEDLFDLC------
...|.||| |.||. .....  ... ||.|  . ... .. .    .  | .  | |.    .   ..|   ...  .|||.... |. ..||.      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYISTW

-DRHF--SLKTVAMVAMQLIRRFEYVHTKHLFYGDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDCDTGKHIAYREHKSLTGTARYMSINTHL-GKEQ
 .. |  | ... ... |..|  || | .   . |.||||.||          ..|.|||||| .       .  ..  ....|| .||.   .. |.. 
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

SRRDDLEALGHMFMYFLRGSLPWQGL----KADTLKERYQKIGDTK
... |  ..| .. ..| | .|..|     . .. ......|....
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPP
Kinase Y106G6E.6.AA VRK 99-249 33 3e-16 48.94 In-house 106-257 (284) Show / Hide 
Range on Protein: 99-249
Range on HMM: 106-257/284
Sequence Identity: 33% (53 aa)

LVMELLGHSLEDLFD-LCDRHFSLKTVAMVAMQLIRRFEYVHTKHLFYGDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDCDTGKHIAYREHKSLT--
.||. .| .|. . .  .   || |||  .| ...   || | .    ||.| .| | |   . . .|   .|.|||  |  |. ||| .| | .     
MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFE-KNPDQVY-LVDYGLAYRY--CPNGKHRQYKEDPRRCHN

GTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKA--DTLKERYQKI
||  . |.  |.|   ||| ||| ||   |. | |.|||  ..   |. | . .|.
GTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQ
Kinase Y106G6E.6.AA S_TKc 28-312 17 4.5e-16 58.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-312
Range on HMM: 1-231/231
Sequence Identity: 17% (54 aa)

FKVGKKIGCGNFGELRLGKNLYNNEHVAIKLEPMKSKAPQLHLEYRFYKLLGQAEGLPQVHYFGPCGKYNALVMELLGHSLEDLFDLCDRH--------F
.....||| | ||. .....   ...||||  .      ..  | .  |   . . . . ...    ..  .|||.....| ||||. ...        |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLKTVAMVAMQLIRRFEYVHTKHLFYGDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDCDTGKHIAYREHKSLTGTARYMSINTHLGKEQSR-RDDLE
.  ... .. |...  || | ..  . |.|||| |. .       .. |.|||||...              ... ||  ||.         .. . |  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWW

ALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRQTAVEVLCEGFPDEFAQYLRYARRLDFFETPDYDFCYNLFK-SVLDRLGATYDYE-------FD
..| ..  .| |  |..     .... ..|||                                  .  ||  ....    .|..|    .         
SCGCILYEMLCGYPPFP-----QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

WT
| 
WF
Kinase Y106G6E.6.AA TTBKL 28-132 24 1.9e-11 34.99 In-house 1-112 (288) Show / Hide 
Range on Protein: 28-132
Range on HMM: 1-112/288
Sequence Identity: 24% (27 aa)

FKVGKKIGCGNFGELRLGKNLYN-NEHVAIKLEPMK-SK-APQLHLEYRFYKLLG--QAEGLPQVHYFGPCGKYNALVMELLGHSLEDLF-DLCDRH-FS
... |.|| | ||.  ..... . ... | | |... ..    ...|    ..|    .   |..|. |  ..|| .||.|.| .| ||  ... .. ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LKTVAMVAMQLI
  |.. ...|..
DGTWSRIGIQCL
Kinase Y106G6E.6.AA VRK 28-42 46 5.6e-05 12.37 In-house 1-15 (284) Show / Hide 
Range on Protein: 28-42
Range on HMM: 1-15/284
Sequence Identity: 46% (7 aa)

FKVGKKIGCGNFGEL
...||.|| |.||..
WRLGKPIGQGGFGCI
Kinase Y106G6E.6.AA TyrKc 28-294 20 0.000143 -148.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 28-294
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

FKVGKKIGCGNFGELRLGKNLYNNEHVAIKLEPMKSKAPQLHLEYRFYKLLG-QAEGLPQVHYFGPCG---------KYNALVMELLGH-SLEDLFDLCD
 . |||.|.|.||| ..|.     . ||.|     .    .. | |  . || . . .  |  .| |          .   .|||.  | .| |    . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNI--VRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

RHFSLKTVAMVAMQLIRRFEYVHTKHLFYGDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDCDTG--KHIAYRE--HKSLT--GTARYMSINTHLGKE
.....|.    . |  .  || | |..   |    | |.|     ..|.  | ||||...  | |.    .  ||   ||.       | |..       
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVG-----ENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP-------

QSRRDDLEALGHM--------FMY-------FLRGSLPWQGLKA--DTLKERYQKIGDTKRQTAVEVLCEG-----FPDEFAQYLRYARRLDFFETPDYD
       |.. .         ...       | .|  |. |      . .| .... . .|    .  .        |||  |  .   . |  . |   
-------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

FCYNLF
 .. .|
EIHECF