Gene Y106G6D.4 (Nematode worm)

Y106G6D.4

Species: Nematode worm
Alias: Y106G6D.4, CE19302, aSWK182
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: I:4.27, WormBase Physical Map location: I: 10122842-10126190

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
Y106G6D.4.AA Protein Genbank 512 None Fasta, JSON
Y106G6D.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 290 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Y106G6D.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y106G6D.4.AA GSK 27-316 32 3e-166 512.25 In-house 1-328 (328) Show / Hide 
Range on Protein: 27-316
Range on HMM: 1-328/328
Sequence Identity: 32% (107 aa)

MANLRLHARGVFSNVYRGTILSPG-TEQEI-----AIKKTWPKTPYR-NFELLFLSGLRRKPHKNIVQMLFAFSRNTTSGEGLEMKHSFCESYVFGFMPY
. . .....|.|..||.... ||. ...||     ||||.|... |. |.|| .. .|... |.|||.....|...... ...   | .|...|. .||.
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDEN---HVYCNCLVMEYMPQ

TLQNILK-----KTRLAEVDMKLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGTLKIADFGSAKVVLR--GSSSTSYQVTRFYRPPELLLDAKEYY
||.....     |........|||..|.| |..||. |.|.||||||.||||| |.|.|||.|||||| . .  .....||...|.||.|||......|.
TLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYT

WMVDVWSAGCCVGEMMKGKVLFPGASIKIMLKLIVQAIGLPSARDLDYMKVSS--MIDQ-QSAVKVIG------------------------LKEVLGTE
...||||.||...||.||..|||| | . .|..|....| |.......|..|.  . .. .|.... .                        . ....|.
CQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTD

NQEWADFLGAILRYRPRERLHGPKLLSHPFF
.|.| |.. ..|.|.|..||.. ....||||
MQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase Y106G6D.4.AA CMGC 27-316 18 1.8e-79 260.6 In-house 1-513 (513) Show / Hide 
Range on Protein: 27-316
Range on HMM: 1-513/513
Sequence Identity: 18% (94 aa)

MANLRLHARGVFSNVYRGTILSPG------------TEQEIAIKKTWPKTPYRN----------------FELLFLSGLRRKP--------------HKN
  ...   .| ...||...    .            |....|||| . .  | .                 |. .|  |...               |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVQMLFAFSRNTTSGEGLEMKHS-----FCESYVFGFMPYTLQNILKKTR----------LAEVD------------MKLYT------WQLFEGIR--YL
||...  | .. . |.. |.||.      .   || .|...| ...|...          | |               | ..      .|...|.   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

QAHM--IVHRDIKPVNILVDVDK-------------------GTLKIADFGSAKVVLRGSS----------------------STSYQVTRFYRPPELLL
  |   |.|||.|| |||.. ..                   |.|||.|||.|. .   |.                       |.| |||.||.||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

DAKEYY---------WMVDVWSAGCCVGEMMKG--------KVLFPGASI-----------KIMLKLIVQAIGLPS---------------ARDLDYMKV
 .|.|            .|.||.||  .||. |        | |||| |              .|..|.. .| |.                ..  .|. 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

SSMIDQ---------------------------QSAVKVIGLKEVLGT-----------------------------------ENQEWADFLGAILRYRP
    ..                              .. . .|..                                      ....  |.|  .|.| |
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

RERLHGPKLLSHPFF
 .|.     |.||.|
DKRITAEQALQHPYF
Kinase Y106G6D.4.AA CDK 113-316 31 8.4e-47 147.67 In-house 96-284 (284) Show / Hide 
Range on Protein: 113-316
Range on HMM: 96-284/284
Sequence Identity: 31% (70 aa)

VFGFMPYTLQNILKKTRLAEVDMKLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGT-----LKIADFGSAKVVL-------RGSSSTSYQVTRFYR
|| .|.. |  ...         | |.||| .|. |.  . |.|||.|| |||.. ..|.     ||||||| |.               |.  ||. ||
VFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILIN-NNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

PPELLLDAKEYY--WMVDVWSAGCCVGEMMK---GKVLFPGASIKIMLKLIVQAIGLPSARDLDYMKVSSMIDQQSAVKVIGLKEVLGTENQEWADFLGA
.||||| .|.|     .|.||.||  .||.    .| |||| |    |..| . .| |.  . .   |... |                      |.|  
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPT--EDNWPGVTKLPDY---------------------DLLNK

ILRYRPRERLHGPKLLSHPFF
 | | |  |.     |.||.|
MLCYDPKKRISAEQALQHPYF
Kinase Y106G6D.4.AA S_TKc 27-316 23 8.8e-47 162.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-316
Range on HMM: 1-231/231
Sequence Identity: 23% (72 aa)

MANLRLHARGVFSNVYRGTILSPGTEQEIAIKKTWPKTPYRNFELLFLSGLRRKPHKNIVQMLFAFSRNTTSGEGLEMKHSFCESYVFGFMPY---TLQN
   ||.  .| |. ||...  .  | .. |||.          |.  |.      |.|||... .|             ....   |. ...    .|  
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---EHIRREIQILKK----HHPNIVKLYDVFQD-----------DHLY--MVMEYCDGDLGDLFD

ILKKTR-------LAEVDMKLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGTLKIADFGSAKVVLRGSSSTSYQVTRFYRPPELLLDAKEYYW-MV
..|| .       . | . . |..|..... |.  | |.|||.|| |||.|    ..||.|||.|...      |.. .|..|..||.|     |    .
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKC

DVWSAGCCVGEMMKGKVLFPGASIKIMLKLIVQAIGLPSARDLDYMKVSSMIDQQSAVKVIGLKEVLGTENQEWADFLGAILRYRPRERLHGPKLLS---
|.|| ||.. ||. |. .||   .. |.|.|.                                       .|  ||.  .|.. |..|.   ..|    
DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

----HPFF
    ||.|
DIKCHPWF
Kinase Y106G6D.4.AA Pkinase 35-316 23 2e-46 165.2 Pfam 9-293 (293) Show / Hide 
Range on Protein: 35-316
Range on HMM: 9-293/293
Sequence Identity: 23% (74 aa)

RGVFSNVYRGTILSPGTEQEIAIKKTWPKTPYRNF--------ELLFLSGLRRKPHKNIVQMLFAFSRNTTSGEGLEMKHSFCESYVFGFMPY-----TL
.| |. ||...    ||... |.|. . ..   ..        |.  .  |.   |.|||... .| .          | . .   |. ...       |
SGSFGCVYKCH--HKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED----------KDHIY--MVMEYCEGGLYVMDL

QNILK---KTRL--AEVDMKLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGTL----KIADFGSAKV--VLRGSSSTSYQVTRFYRPPELLLDAKE
  ...   ....   | . | | .|...|. |. .. |.|||.|| |||.| ..|..    ||.|||.||.    ..|  |.. .|..|..||.......
FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

YYWMVDVWSAGCCVGEMMKGKVLFPGA----SIKIMLKLIVQAIG--LPSARDLDYMKVSSMIDQQSAVKVIGLKEVLGTENQEWADFLGAILRYRPRER
|   ||.||.|| . ||. |. .|||.    .   ....|..  |  |.. .. .. .  .. ...   . . ....    ..|  ||.  .|.. | .|
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKR

LHGPKLLSHPFF
.  . .| ||.|
PTAEQILQHPWF
Kinase Y106G6D.4.AA ERK7 113-316 31 6.5e-40 133.99 In-house 79-292 (292) Show / Hide 
Range on Protein: 113-316
Range on HMM: 79-292/292
Sequence Identity: 31% (68 aa)

VFGFMPYTLQNILKKTR-LAEVDMKLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGTLKIADFGSAKVVLRGS-------SSTSYQVTRFYRPPEL
|| ||   | .. .| . | ..  .   .||.  |.|.    ..|||.|| |||.| .  ..|..||| |  .             | |  || || || 
VFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSE-CMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEI

LLDAKEYYWMVDVWSAGCCVGEMMKGKVLFPGASIKIMLKLIVQAIGLPSARDLDYMKVS---SMIDQQSAVKVIGLKEVLGTENQEWADFLGAILRYRP
|| ...|   || || || .|||..|| .||| |    . .|.. |. |.. |.  .. .   .|..|    |   |....    ..  | | ..| . |
LLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNP

RERLHGPKLLSHPFF
..||   . |.||. 
KKRLTAEQALQHPYV
Kinase Y106G6D.4.AA CDC2 113-238 37 9.7e-35 103.81 In-house 78-213 (301) Show / Hide 
Range on Protein: 113-238
Range on HMM: 78-213/301
Sequence Identity: 37% (52 aa)

VFGFMPYTLQNILK----K-TRLAEVDMKLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGTLKIADFGSAKVVLRGSSSTSYQ-----VTRFYRPP
|| .. . | . ..    | . . .   | |..|. .|. .. .. |.|||.|| |||.| .||..|||||| |. .  |  .  |      ||. ||.|
VFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAP

ELLLDAKEYYWMVDVWSAGCCVGEM---MKGKVLFPGAS
|.|| .| |   ||.|| ||   ||   .  | ||.| |
EILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDS
Kinase Y106G6D.4.AA CDKL 113-238 37 1.9e-33 111.7 In-house 76-204 (286) Show / Hide 
Range on Protein: 113-238
Range on HMM: 76-204/286
Sequence Identity: 37% (49 aa)

VFGFMPYTLQNILKKTR--LAEVDMKLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGTLKIADFGSAKVVLRGSS--STSYQVTRFYRPPELLLDA
|| .. .|. ..|..    . | . . |.||. ..| ..  | ..|||||| |||.   .|..|. ||| |.  | ...   | |  || || ||||.. 
VFEYCDHTVLHELEEYPNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGD

KEYYWMVDVWSAGCCVGEMMKGKVLFPGAS
 .|   ||.|..|| ..||. |  |.|| |
TQYGKPVDIWAIGCVMAEMIDGQPLWPGQS
Kinase Y106G6D.4.AA ERK3 121-316 33 2.2e-33 104.51 In-house 98-300 (300) Show / Hide 
Range on Protein: 121-316
Range on HMM: 98-300/300
Sequence Identity: 33% (67 aa)

LQNILKKTRLAEVDMKLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGTLKIADFGSAKVVLRGSSSTSY----QVTRFYRPPELLLDAKEYYWMVD
| ...   ||.|   .|. .||  | .|.    . ||| || ||..      ||| ||| | .|    |   |     ||. || |.|||   .|   .|
LACVMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAID

VWSAGCCVGEMMKGKVLFPGASIKIMLKLIVQAIGLPSARDLDYMKV---SSMIDQQSAVKVIGLKEVLGTENQEWADFLGAILRYRPRERLHGPKLLSH
 |.|||   ||. || ||.||     . ||   | .   .|.. .     |. |  .       ||..|   . .  ||| ..| . | .||     |.|
MWAAGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQH

PFF
|..
PYM
Kinase Y106G6D.4.AA MAPK 113-316 27 3.1e-32 108.63 In-house 94-328 (328) Show / Hide 
Range on Protein: 113-316
Range on HMM: 94-328/328
Sequence Identity: 27% (64 aa)

VFGFMPYTLQNILKKTR-LAEVDMKLYTWQLFEGIR--YLQAHMIVHRDIKPVNILVDVDKGTLKIADFGSAKVVLRGSSS---------------TSYQ
|. .|   |..|.|  . | .  ..  ..|.  |..  |.    ..|||.|| ||||. . ..|||.||| | ..   ..                | | 
VMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNEN-CDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYV

VTRFYRPPELLLD--AKEYYWMVDVWSAGCCVGEMMK-GKVLFPGASIKIMLKLIVQAIGLPSARDLDYMK----VSSMIDQQ---SAVKVIGLKEVLGT
.||.|| ||..|   ...|   ||.||.||  .||.. .|.|||| .    ..||.. .| ||  .. ...    . ..| .       . . .....  
ATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPN

----ENQEWADFLGAILRYRPRERLHGPKLLSHPFF
     | .  |.|   |   | .|.     |.||.|
ANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Y106G6D.4.AA CDK-Unclassified 117-238 37 6.9e-31 98.75 In-house 103-243 (324) Show / Hide 
Range on Protein: 117-238
Range on HMM: 103-243/324
Sequence Identity: 37% (53 aa)

MPYTLQNILKKTR--LAEVDMKLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKG-----TLKIADFGSAKVVL----------RGSSSTSYQ---VT
||||. | |.  |  |   . . .  |..||| ||    | |||||| ||... ...      |||||||.|                 .. .|    .|
MPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMIT-NNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVST

RFYRPPELLLDAKEYYWMVDVWSAGCCVGEMMKGKVLFPGAS
| || ||||.  |.|   ||.||.|| . |. .|| .|.| .
RWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRT
Kinase Y106G6D.4.AA ERK5 140-316 32 1.1e-30 108.31 In-house 110-295 (295) Show / Hide 
Range on Protein: 140-316
Range on HMM: 110-295/295
Sequence Identity: 32% (60 aa)

WQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGTLKIADFGSAKVVLRGSSS------TSYQVTRFYRPPELLLDAKEYYWMVDVWSAGCCVGEMMKGKVL
.|.  |..|. .  ..|||.|| |.||  .   ||| ||| |. .   |.       |.|  ||.|| |||..  ..|   .|||| || .|||.  . .
YQILRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQM

FPGASIKIMLKLIVQAIGLPSARDLDYM---KVSSMIDQ-QSAVKVIGLKEVLGTENQEWADFLGAILRYRPRERLHGPKLLSHPFF
|||      |.||.. .|.|..  .  .   .|   . .  .  .   ...|     .   | |. .||. | ||.   | | ||| 
FPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase Y106G6D.4.AA TyrKc 27-316 19 7e-10 -62.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-316
Range on HMM: 1-280/280
Sequence Identity: 19% (64 aa)

MANLRLHARGVFSNVYRGTILSPGTEQEIAIKKTWPKTPYRNF--ELLFLSGL--RRKPHKNIVQMLFAFSRNTTSGEGLEMK------HSFCESYVFGF
   ..   .| |  ||.||       .. |.|.  . .  . |  |.  .. |  .   |.|||...         |  .. .      .  .   |. .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGH---HPNIVRLY---------GVCTQQGRNFMYIEPLMI--VMEY

MPY-TLQNILKKTR--LAEVDMKLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGTLKIADFGSAKVVLRG----SSSTSYQV-----TR-----FY
||.  |.. |.|.|  |   |.  . ||  .| .||  . ..|||.   |.||. .. | ||.||| .. .  .     |.  | .     ..       
MPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

RPPELLLDAKEYYWMVDVWSAGCCVGEMM-KGKVLFPG-----ASIKIMLKLIVQAIGLPSARD----LDYMKVSSMIDQQSAVKVIGLKEVLGTENQEW
 .|| . . ...    |||| | |  |..  |.   ||      | . ..... |   .|   .                              .  .| 
MAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F-VCCPDEM

ADFLGAILRYRPRERLHGPKLLSHPFF
 .      .. | .|     .  | .|
YQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Y106G6D.4.AA CDKL 281-316 30 5.8e-05 12.91 In-house 251-286 (286) Show / Hide 
Range on Protein: 281-316
Range on HMM: 251-286/286
Sequence Identity: 30% (11 aa)

VLGTENQEWADFLGAILRYRPRERLHGPKLLSHPFF
...  |.. .||. . |   |.||.   .|..||.|
YPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase Y106G6D.4.AA CDC2 291-316 38 0.000145 9.37 In-house 276-301 (301) Show / Hide 
Range on Protein: 291-316
Range on HMM: 276-301/301
Sequence Identity: 38% (10 aa)

DFLGAILRYRPRERLHGPKLLSHPFF
| |  .|.| |  |.   . |.||.|
DLLMQMLQYDPQKRISAKEALQHPYF
Kinase Y106G6D.4.AA CDK-Unclassified 291-316 26 0.015971 3.96 In-house 299-324 (324) Show / Hide 
Range on Protein: 291-316
Range on HMM: 299-324/324
Sequence Identity: 26% (7 aa)

DFLGAILRYRPRERLHGPKLLSHPFF
....  . | | .|.   ..|.|| |
NCEFQMVMYQPYNRWKCMEILQHPWF