Gene W06F12.3 (Nematode worm)
W06F12.3
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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W06F12.3.AA | Protein | Genbank | 318 | None | Fasta, JSON |
W06F12.3.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 263 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of W06F12.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | W06F12.3.AA | TTBKL | 38-295 | 38 | 3.5e-136 | 458.71 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 38-295 Range on HMM: 1-288/288 Sequence Identity: 38% (110 aa) FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSV-E--SGRIVLELHILVELA--HSPHIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQKGRC-FS ....||.|.|||||.....||..| .|...|.| . | . |. .|.|.|..|. .|||.||.|.||....|||.||.|.| |. |||| . .. || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS AETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEH----KRVLYIVDFGMARQIRFPSGAF-----------RPERP---YASFRGTTRYVSLAA ..|..|.|||||..|||.|. |.||||.||.|.|.|. .| |..|..|||||||.. ..| . |..|. .|.|||||||.|... DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HERKEQGFADDIWCLFFSLLELAEGLPWKNVVDQDQVYHAKQLLLRNFQSRK------MGQNFGTFPRALELIKRTETPNYENFIVIL |.||||| ||.|...... ||..||||.|..|.....|.|. .. . . . . . |. | ..|. . ..|.|| .. .. HDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | W06F12.3.AA | CK1 | 38-291 | 30 | 3.7e-103 | 349.02 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 38-291 Range on HMM: 1-339/339 Sequence Identity: 30% (102 aa) FQVEKMVGGGGFG-QIFRA-----VDMETK-----LVVAVKVEPKSVESGRIVLELHILVELA----------------------HSPHIPKVHYSGEIG ..|.|. |.|||| ||... .||... .|.|||||. . . .|. ... .. ..||.....|.|| . WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED G-YNFIVMQLLGSNITDLRK--FQKGRCFSAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEH-------------KRVLYIVDFGMAR-QIR . ||..||.||| |. |||| .. .|.|| |. ...||.||.|...|. |.|||||||.|.|.|..|. .|..|..|||||| . | DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR FPSG------------AFRPERP---YASFRG-TTRYVSLAAHERKEQGFADDIWCLFFSLLELAEG---LPWKNVVDQDQ-----VYHAKQLLLRNFQS ...| || |. ..||| |.||.|...|..|||| ||.|..|. |.|. | |||.|. |... | ..|. ... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM RK------------MGQNFGTFPRALELIKRTETPNYENF . | | .. .. |. ..|.||.. STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | W06F12.3.AA | TTBK | 38-291 | 38 | 1.2e-66 | 227.71 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 38-291 Range on HMM: 1-257/257 Sequence Identity: 38% (98 aa) FQVEKMVGGGGFGQIFRAVDMETK-LVVAVKVEPKSVESGRIVLELHILVELAHSPHIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQKGRCFSAETTA .| | .|||||| |. | || .. ||.||| .| .| | .|. . | .|..||||.| | ||| | ||| || WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL RVGIQCLEGLKQIHELGYIHRDIKPSNICVG-IGEHKRVLYIVDFGMARQIRFPSGAFRPERPYASFRGTTRYVSLAAHERKEQGFADDIWCLFFSLLEL |.|.| |.....||..|. |||||||| .| . | |..|||.||| .| || |. | |||| || | || .| | || | ||. | | RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF AEG-LPWKNVVDQDQVYHAKQLLLRNFQSRKMGQNFGTFPRALELIKRTETPNYENF ..| ||| . | ||| . |. . ..| .| .. .. ..|.| . VQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | W06F12.3.AA | Worm6 | 38-291 | 31 | 2e-66 | 227.01 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 38-291 Range on HMM: 1-279/279 Sequence Identity: 31% (87 aa) FQVEKMVGGGGFGQIFRAVDMETKL--VVAVKVEP--KSVESGRIVLELHILVELAHSP--HIPKVHYSGEIGG--YNFIVMQLLGSNITDLRKFQKGRC ..|.| .| |||| .. . | ..| .|.|.| .. ... .|. .| ...|.. | .|. | .. .|.|||.|.| | ||||.. .|. WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGI-----GEHKRVLYIVDFGMAR--QIRFPSGAFRPER-PYASFRGTTRYVSLAAHERKEQGF || |. ...|||||.. . | |.||||.||.| |.| . . .|..||||.| . . . |. | . . ||||.|| .||.| ..||. FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR ADDIWCLFFSLLELAEG-LPWKNVVDQDQVYHAKQLLLRNFQSRKMGQNFGTFPR--------ALELIKRTETPNYENF ||. . | ..|. | |||... | |.| | |. ... | . ||..|. . ... ..|.|.. KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | W06F12.3.AA | CK1-Unclassified | 38-220 | 31 | 1.8e-53 | 156.17 | In-house | 1-194 (244) | Show / Hide |
Range on Protein: 38-220 Range on HMM: 1-194/244 Sequence Identity: 31% (62 aa) FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVELAHSP-------HIPKVHYSGEI--GGYNFIVMQLLGSNITDLRKFQKGR ..|.. .| | ||.|. ...|.|. .||.|.| | ... .. | |. .| . .|||....| |.||..|| |||... || .. ... YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK CFSAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVG-IGEHKRVLYIVDFGMARQIRFP--SGAFRPERPYASFRGTTRYVSLAAHERKEQG || |. . | .. . ..|. ..||||||| |...| | .. ..||.||| . . . | | | .. ||.|| |. || .||. -FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQS |
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Kinase | W06F12.3.AA | CK1 | 38-220 | 31 | 4.3e-45 | 153.22 | In-house | 1-194 (271) | Show / Hide |
Range on Protein: 38-220 Range on HMM: 1-194/271 Sequence Identity: 31% (62 aa) FQVEKMVGGGGFGQIFRAVDMETKLV---VAVKVEPKSVESGRIVLELHILVELAH------SPHIPKVHYSGEI--GGYNFIVMQLLGSNITDLRKFQK ..|.. .| | ||.|. . .| |. . ||.|.|.. . .. | |. .| . ...||.....| | ||..|| ||| . || .| . YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN GRCFSAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGI-GEHKRVLYIVDFGMARQIR-FPSGAFRPERPYASFRGTTRYVSLAAHERKEQG .. || |. .. | .. . .|. ..||||||| |...|. | |. ..||.|||.| . | .. | | .. ||.|| |. .| .||. RK-FSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQS |
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Kinase | W06F12.3.AA | CK1-D | 38-242 | 31 | 1.2e-34 | 119.63 | In-house | 1-206 (261) | Show / Hide |
Range on Protein: 38-242 Range on HMM: 1-206/261 Sequence Identity: 31% (66 aa) FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVELAHSPHIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQKGRCFSAETTAR . . . .|.| ||.|. ...| ||.|.|. . . .| .. . ||.... |. | || .||.||| . || . . | || | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCH-RKFSLKTVLM VGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKRVLYIVDFGMARQIRFPS-GAFRPERPYASFRGTTRYVSLAAHERKEQGFADDIWCLFFSLLELA .. | . .. || .||||||| | .|.| . . ||.|||.|.. | . | | . || || |. | || ||. | . |. . LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN EG-LPWK | |||. RGSLPWQ |
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Kinase | W06F12.3.AA | CK1-A | 38-242 | 31 | 2.2e-32 | 111.68 | In-house | 1-206 (261) | Show / Hide |
Range on Protein: 38-242 Range on HMM: 1-206/261 Sequence Identity: 31% (66 aa) FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVELAHSPHIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQKGRCFSAETTAR ... . .| | || |. .. .. ||.|.| . . .. | . |. . ||.... |. || .||.||| . || | | | |. | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCK-RRFTMKTVLM VGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKRVLYIVDFGMARQIR-FPSGAFRPERPYASFRGTTRYVSLAAHERKEQGFADDIWCLFFSLLELA . | . . .|| ..||||||| | .||| | |...|||.|.. | . | | || || |. || || ||. . . .. LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN EG-LPWK | |||. RGKLPWQ |
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Kinase | W06F12.3.AA | CK1-G | 38-225 | 35 | 3.2e-31 | 103.0 | In-house | 1-191 (266) | Show / Hide |
Range on Protein: 38-225 Range on HMM: 1-191/266 Sequence Identity: 35% (69 aa) FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVELAHSP-HIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQKGRCFSAETTA ..| | .| | || .| | . . ||.| || . .| |. | ||.|.| | | || .|| ||| || . .| || |.. YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWC-DRKFSVKTVC RVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKR--VLYIVDFGMARQIRFPS-GAFRPERPYASFRGTTRYVSLAAHERKEQGFADDI | || .. ....|. | ||.|| | .| |. |..|.|||||.| . | . | | | || || | | .|| ||. MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDM |
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Kinase | W06F12.3.AA | CK1-Unique | 38-242 | 24 | 2e-28 | 95.7 | In-house | 1-233 (337) | Show / Hide |
Range on Protein: 38-242 Range on HMM: 1-233/337 Sequence Identity: 24% (56 aa) FQVEKMVGGGGFGQIFRAVDMETK------LVVAVKVEPKSVESG--RIVLELHILVELAHSP-------HIPKVHYSGEIGGYNFIVMQLLGSNITDLR ..| | |.||.| | . . . | | ... | |. .. .. | ..|| .. . . .|||...| .. .. WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC KFQKGRCFSAE------TTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGE--HKRVLYIVDFGMARQ--IRFPSGAFRPERPYASFRGTTRYVSLA |. | . . | |||... |. |..||..|| |.| . | ...|. |.| | . ... |. || ..|||. .| . . MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS AHERKEQGFADDIWCLFFSLLELAE---GLPWK |. .|.| || .|..|. | || || CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK |
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Kinase | W06F12.3.AA | Pkinase | 38-210 | 24 | 7.3e-19 | 67.78 | Pfam | 1-179 (293) | Show / Hide |
Range on Protein: 38-210 Range on HMM: 1-179/293 Sequence Identity: 24% (46 aa) FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESG----RIVL--ELHILVELAHSPHIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQ------ ..... .| |.||. ..... | .||||. .|. |. . .. |..|. .| ..|.| . ... | ... .|| ... . . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW KGRCF--SAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKRV---LYIVDFGMARQIRFPSGAFRPERPYASFRGTTRYVS ...|| | .. .. | |.||. .|. | ||||.||.|| . .. . . | ||| |.|.. . . . .| || .|.. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA |
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Kinase | W06F12.3.AA | S_TKc | 38-302 | 20 | 1.2e-18 | 69.24 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 38-302 Range on HMM: 1-231/231 Sequence Identity: 20% (57 aa) FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVELAHSPHIPKVHYSGEIGGYNFIVMQLLGS---NITDLRKFQKG----RCF ... . .| |.||. ..... .|. .||.|. . .| |. || . | |.| | ... . .. ..|| ... . |. | ... . | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF SAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKRVLYIVDFGMARQIRFPSGAFRPERPYASFRGTTRYVSLAAHERKEQGF-ADDIWCLF . ..... | ...|. .|..| ||||.||.|| . .. | |||.|||. .| || |.. |. . |.| . PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG FSLLELAEGLP-WKNVVDQDQVYHAKQLLLRNFQSRKMGQNFGTFPRALELIKRTETPNYE---NFIVILKSC-----SSRV | |.. | | . |.. .... | |...|.. . . | .|... . CILYEMLCGYPPFP------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | W06F12.3.AA | TyrKc | 38-239 | 16 | 1.2e-05 | -131.5 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 38-239 Range on HMM: 1-280/280 Sequence Identity: 16% (48 aa) FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVEL-AHSPHIPKVHYSGEIG-------GYNFIVMQLLGSNITDLRKF-QKGR . .|. | | ||...... . ||||. .. . |. |. .| | |.| . . . . .||| . ||... .| | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYLRKHR C-FSAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKRVLYIVDFGMARQI-----------RFPS----GAF------------------- .. .. .| .| .|. ..||||. |. || . . | |||..| | . |. PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT -----------------RPERPY-------ASFRGTTRYVSLAAHERKEQG--------FADDI-----WCLFF------SLLELAEGL . . || | . .|| .. . |.. .| . . |. | . TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |