Gene vab-1 (Nematode worm)

vab-1

Species: Nematode worm
Alias: M03A1.1a, M03A1.1A, M03A1.1x=(spaaa..yese), M03A1.1, aSWK335, CE25060, vab-1
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: II:-2.86116, WormBase Physical Map location: II: 4572074-4590896

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
vab-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 280 Kinase domain by global Sugen HMM Fasta, JSON
vab-1.AA Protein Genbank 1117 None Fasta, JSON

Protein domain

Protein domains of vab-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd vab-1.AA Ephrin_lbd 31-212 30 8.6e-85 264.51 Pfam 1-190 (190) Show / Hide 
Range on Protein: 31-212
Range on HMM: 1-190/190
Sequence Identity: 30% (60 aa)

QEVLFDLSKVGSDLKWDQVSLRHDRDDVWMEETWRNPAATDEKHANQRAYVTC-NYDMINPSNWLFSHFIEVKTARRIYIELLFNTRDCDAYLNPK-SCK
..||.| ....|||.|.. . . .|||.|||..|.. . .||.....| |. | |... |..|||....||...|.|||.|| |..|||... . . .||
EVVLMDTKTATSDLGWTTYPYN-GRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCK

ETFSVYLKQFKTSRPGSTKIEKERFSEDIDNWKNIGRLARSNS------------NMTTETLGMEIDSDTKTIRIAFEEQGICLSLLNVKIYYRIC
|||..|. .. .    .....||... . .....|...|. .|            ...||.. ... |. .....|| .|| |..|..|..||. |
ETFNLYYYESDH----YDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSK-RGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd vab-1.AA EPH_lbd 31-212 27 4.9e-71 243.23 SMART 1-184 (184) Show / Hide 
Range on Protein: 31-212
Range on HMM: 1-184/184
Sequence Identity: 27% (54 aa)

QEVLFDLSKVGSDLKWDQVSLRHDRDDVWMEETWRNPAATDEKHANQRAYVTCNYDM---INPSNWLFSHFIEVKTARRIYIELLFNTRDCDAYLNPK--
..||.| ... ..|.|.. .         ...||......||.|...|.|..||...    |..|||..|.|. ..|.|||.|| |..|||... ...  
EVVLMDTKTETGELGWTTYPP--------HGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGV

SCKETFSVYLKQFKTSRP-GSTKIEKERFSEDIDNWKNIGRLARSN-----SNMTTETLGMEIDSDTKTIRIAFEEQGICLSLLNVKIYYRIC
||||||..| ........ ..|....|.. ..||..... ......     ..|.||.. ...  ..|....||..||.|..|..|...|..|
SCKETFNLYYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGP-LSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 vab-1.AA GCC2_GCC3 279-320 25 1e-06 24.33 Pfam 2-49 (49) Show / Hide 
Range on Protein: 279-320
Range on HMM: 2-49/49
Sequence Identity: 25% (12 aa)

QIADSNGARCESCPTNTYKPKGQSL-CKSCPSN-----SISSEAASSC
.  ......||.|| .||....... |..||..     .. | ..|.|
TYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGSTSESDC
FN3 vab-1.AA FN3 342-427 18 1.9e-10 41.94 SMART 1-69 (69) Show / Hide 
Range on Protein: 342-427
Range on HMM: 1-69/69
Sequence Identity: 18% (19 aa)

PSRPIK---LVANAITAT------STRLSWNEPSSLGGRPEIWYEVKCSGRGECGTVVMTPGDKKLSTRSVQINGLRPS----SDYTFLVFAKNK--VSA
|. |     |.. ..|.|      | .|||..|       .. |.                         . . ||.|     . |.| | |.|.  .  
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGE

Q
 
G
FN3 vab-1.AA FN3 449-527 20 2.8e-07 31.43 SMART 1-69 (69) Show / Hide 
Range on Protein: 449-527
Range on HMM: 1-69/69
Sequence Identity: 20% (19 aa)

VPPVSH---LRVDASQSD------GITIAWSVSDSDVSDFEVEVRPAIVKKRTFETRHVNMTYTTFIGLNPE----TVYQFRVRIRDD--LRWS
 .|...   ||| .  |.       .|. |.         .|. |                   |. || |     | |.|||| ...    ..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase vab-1.AA Eph 692-979 54 1.4e-188 632.75 In-house 1-264 (264) Show / Hide 
Range on Protein: 692-979
Range on HMM: 1-264/264
Sequence Identity: 54% (157 aa)

VFITQVIGGGEFGDVCLGGLSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYETVAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVM
..|..|||.||||.|| | |...|.....| |.                   .|||||||.|...|....||.||.|||||.|||.||| ||||...|||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVW-VD-------------------PVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVM

IVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRDLAARNVLLDMELRCKIADFGLSRGVRSEGSSVEPEYTTNGGKIPVRW
||.|||.|||||.|||..|.   .... ....||.|||||||||.||.||||||||||.|....|.||..||||||......| ||..|||.|||||.||
IVTEYMENGSLDSFLRQHDG---QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPS-VEATYTTRGGKIPIRW

TAPEAITHRKFTPSSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMIGYRLPPPMDCPMGLYRIAQWCWKMERHERPTFTQLLATF
||||||..||||..|||||.|.|.|||.|.|||||||..||.||.... |||||||||||..|......||...|..||.|.|. ...
TAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase vab-1.AA TyrKc 692-979 33 4.8e-128 432.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 692-979
Range on HMM: 1-280/280
Sequence Identity: 33% (108 aa)

VFITQVIGGGEFGDVCLGGLSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYETVAIKTLKSGSSAKAKAEFLTEATIMGQF--SHPNVIRLIGVVTSA--
.   ...| |.|| |..| ..                              ..||.|.||...    ...|. || || ..  .|||..||.||.|.   
ITLGKKLGEGAFGEVYKGTWK------------------------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGR

-----EPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRDLAARNVLLDMELRCKIADFGLSRGVRSE---GSSVEPE
     ||.||| |||..|.|...||..  .   . ...  .. . ||.|| || .....||||||||.|.. ....||.|||||| . ..   |  .. .
NFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--ESKD

YTTN----GGK--IPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCSFGERPYWD-----WTNQKVISEVMIGYRLPPPMD--------CPMGLYRIAQW
| .     |||  .|.||.|||.| ..|||. ||||||||..||....|. ||..      .|| ||  |. |||.|.| .        ||  .|.| ..
YYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQ

CWKMERHERPTFTQLLATF
||. . ..||||...   |
CWHEDPEDRPTFSEIHECF
Kinase vab-1.AA Pkinase_Tyr 692-979 34 6.8e-113 382.97 Pfam 1-270 (270) Show / Hide 
Range on Protein: 692-979
Range on HMM: 1-270/270
Sequence Identity: 34% (102 aa)

VFITQVIGGGEFGDVCLGGLSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYETVAIKTLKSGSSAKA--KAEFLTEATIMGQF-SHPNVIRLIGVVT-SA
. . ...| |.||.|..| .                          ....  .||.|.|| |.. ..  ...|. || || |. .|||..||.||.|   
ITFGKKLGEGAFGEVYKGTWKG-----------------------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQG

EP--VMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRDLAARNVLLDMELRCKIADFGLSRGVRSEGSSVEPEYTTNGG
||  ..|| |||..|.|. .||.    ....  . . .| . ||.|| || .....||||||||.|.. .. .||.||||.| .  .  .    ... ||
EPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYY-YRKRGGG

KIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCSFGERP-YWDWTNQKVISEV-MIGYRLPPPMDCPMGLYRIAQWCWKMERHERPTFTQLLATF
|.|..|.|||.| ..|||  ||||||||..||....|| | |....|. |.  .   |||.|.|..||  .|.. . ||. .  .||||....  .
KLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase vab-1.AA TK 692-979 23 7.6e-113 379.78 In-house 1-486 (486) Show / Hide 
Range on Protein: 692-979
Range on HMM: 1-486/486
Sequence Identity: 23% (113 aa)

VFITQVIGGGEFG---DVCLGGLSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYETVAIKTLKSGSSAKAKA-------------EFLTEATIMGQFS--
. . ...| |.||   .|..| .   .|  .| . ...| .     .. ...  ..||.|.||.|... ...             .|| || .| ...  
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMT-V-TLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHS

---HPNVIRLIGVVTSA------------EPVMIVAEYMANGS----LDQFLRNTDQRGEK---------------------------------------
   |||..||.||.|              ||.||| |||..|.    |...||. . .. .                                       
LGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQ

---------------------------------VHWEKITEMLYGIASGMKYLTDM------GYVHRDLAARNVLLDMELR-----------CKIADFG-
                                 .. .    | . ||.|| || ..      ..|||||||||.|.. ...           ||||||| 
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

-------LSRGVRS--EGSSVEPEYTTN------------------GGKIPVRWTAPEAIT---------HRKFTPSSDVWSFGVVIWEVCSFG-ERPYW
       |.| . |  .  ......|.                   |||.|.||.|||...         ..|||. ||||||||..||....| | .|.
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYG

DWTNQKVIS-----------------------EVMIGYRLPPPMDCP--------------MGLYRIAQWCWKMERHERPTFTQLLATF
...||.|..                       ||  ..|.|.|..||                .|.. | ||. .  .||||.||.  .
GMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase vab-1.AA UTK 692-979 35 2.7e-104 352.78 In-house 1-296 (296) Show / Hide 
Range on Protein: 692-979
Range on HMM: 1-296/296
Sequence Identity: 35% (112 aa)

VFITQVIGGGEFGDVCLGGLSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYETVAIKTLKSGSSAKAKA---EFLTEAT---IMGQFS-HPNVIRLIGVV
| . . .| |.||.|... . . |. . .  |....                       ..... ....   .|. ||.   .|.||. ||||.||.||.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---------------------HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVC

TSAEPVMIVAEYMANGSLDQFLR----NTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRDLAARNVLLDME-------LRCKIADFG---LSRGVR
|. || ||| |||.||.|...||    ....... .  .. ..| . ||.|| ||  .|.|||||||||.|..|        . |||||||   .||.| 
TQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVN

S------EGSSVEPEYTTNG-GKIPVRWTAPEAITHR-KFTPSSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMIG--YRLPPPMDCPMGLYRIAQW
.      ...|  ..|. .. ...|.||.||||.||. .|| .||||||||| ||....| .|| ...|..|. .|. |  ||.|.| |||. .||. . 
TFHFSNRYWES--YYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHR

CWKMERHERPTFTQLLATF
||...  |||.| .|....
CWHYDPQERPDFEDLVQQM
Kinase vab-1.AA Src 745-979 43 3e-92 312.8 In-house 26-255 (255) Show / Hide 
Range on Protein: 745-979
Range on HMM: 26-255/255
Sequence Identity: 43% (103 aa)

VAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRD
||.||||.|.   . . || || || ...|.....|  |..  ||. || |||..||| ..|.. |..| ..| ..  .|   .|.||.||  | |.|||
VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRD

LAARNVLLDMELRCKIADFGLSRGVRSEGSSVEPEY-TTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMIGYR
||||||| . .. ||.||||| | .  |.   . ||    | |.|..|||||||....||  |||||||. ..|. ..|  ||  .||. |. .|. |||
LAARNVLVGENNVCKVADFGLAR-LIKED---DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYR

LPPPMDCPMGLYR-IAQWCWKMERHERPTFTQLLATF
.| |. ||  ||  | . ||. .  .||||  |   .
MPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase vab-1.AA RTKC 745-979 44 1.2e-84 279.22 In-house 31-261 (261) Show / Hide 
Range on Protein: 745-979
Range on HMM: 31-261/261
Sequence Identity: 44% (105 aa)

VAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNT-D-QRGEKVHWEKITEMLYGIASGMKYLTDMGYVH
|| | |.  .....  | | || .| || ||||..||||||  .|. .| |.. .|||  .| |  |     ||..       | .||||      | .|
VACKSLHHTAMDNDRQELLEEAAVMAQFEHPNVVHLIGVVTVGKPILVVLEFCERGSLKSYLMNNPDCTEHQKVRF------CYQCASGMEHIHSFGFIH

RDLAARNVLLDMELRCKIADFGLSRGVRSEGSSVEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMIGY
||.|||||||.  |.||.||||| |   ... | |  |   .| .|||||||||   |||. .||||.||.   |.   .| || .| || |  ||  ||
RDVAARNVLLSSDLTCKVADFGLARESPCNDDSHEAYYRSRSGNLPVRWTAPEALDDRKFSEKSDVWAFGILMYEIYTKAEMPYDGWSNQRVWVEVCAGY

RLPPPMDCPMGLYRIAQWCWKMERHERPTFTQLLATF
|||.| ||.  .| . . ||.. .|.|||| .. . .
RLPCPEDCHKEVYDMMMDCWMHTPHDRPTFSEVVHWL
Kinase vab-1.AA Fer 692-980 28 2.5e-77 262.86 In-house 1-283 (283) Show / Hide 
Range on Protein: 692-980
Range on HMM: 1-283/283
Sequence Identity: 28% (87 aa)

VFITQVIGGGEFGDVCLGGLSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYETVAIKTL-KSGSSAKAKAEFLTEATIMGQ-FSHPNVIRLIGVVTSAEP
| .. ..| | ||.|..|              . .....|..  ..       |. |..  ...... ..||. || || . ..||||....|| .. .|
VTLGKKLGEGAFGEVYKGR-------------RTLKCKKGKWHVVNK----VAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQP

VMIVAEYMANGSLDQFLRNTDQRGEKVHWE-KITEMLYGIASGMKYLTDMGYVHRDLAARNVLLDM-ELRCK--IADFGLSRGVRSEGSSVE--PEYTTN
.||| |.. .|||| .|. ....   . .. .. .|.|..|.||.||  .. .|||.||||.|..  .. .|  |.|||.||  . .|.. .  .     
IMIVMEFCNGGSLDSYLKKNKNK---TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKE----K

GGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCSFGERPYWD----WTNQKV----ISE-VMIGYRLPPPMDCPMGLYRIAQ-WCWKMERHERPTFT
  |.|.||.|||... . ..| .|||||||..||... |. || .     ..  |    .   .  ||..|.|  .|  ...|    ||...  .|||..
ACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMK

QLLATFH
..  ...
EICQKLK
Kinase vab-1.AA Frk 745-983 41 7.5e-77 261.62 In-house 26-260 (260) Show / Hide 
Range on Protein: 745-983
Range on HMM: 26-260/260
Sequence Identity: 41% (99 aa)

VAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRD
||.||||.|.      .|| || || .  || .|.|  | |  ||..|..| | .||| ..|.  ...|.... ... .|   .|.|| || .. |.|||
VAVKTLKPGTM--DPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRD

LAARNVLLDMELRCKIADFGLSRGVRSEGSSVEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMIGYRL
|||||||.. .. |||||||| | .  .   .    .  | ..|..||||||.   |||  |||||||... |.  .|  ||   ||..|.  |  |||.
LAARNVLVGEHNICKIADFGLARVLMKDNEDI--YESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRM

PPPMDCPMGLYRIAQWCWKMERHERPTFTQLLATFHKYI
| | .||  || | . ||. . ..||||  |   . .|.
PQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase vab-1.AA TK-Unique 692-979 30 1.1e-76 261.13 In-house 1-294 (294) Show / Hide 
Range on Protein: 692-979
Range on HMM: 1-294/294
Sequence Identity: 30% (99 aa)

VFITQVIGGGEFGDVCLGGLSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYE-TVAIKTLKSGSSAKAKAEFLTEATIMGQFS-HPNVIRLIGVVTSA-E
... .||| |.|| |. |......                      ...     ||.|.|| ...   |..|| |. .| .   |||.....|. |.  |
LEVGDVIGEGAFGQVWRGEVWGIW----------------------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDE

PVMIVAEYMANGSLDQFLR----------------------NTDQRGEKVHWEKITEMLYGIASGMKYLTD--MGYVHRDLAARNVLLDMELRCKIADFG
|.||. ||...|.|. .||                      . ..| | .  .     ...||.||.||    .. |||||.||||||   ..|||.|||
PWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFG

LSRGVRSEGSSVEPEYTTNG--GKIPVRWTAPEAIT--HRKF-TPSSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMIGYRLPPPMDC-PMGLYRIA
..| |.      . .| ...  |.||.|| |||..   |. . |. ||||||||..||....|..|| .  . ... ..  |||.| |  | .  .| . 
MARDVYT-----NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLM

QWCWKMERHERPTFTQLLATF
. ||. |..|||.|.|..  .
KSCWQWEPEERPSFRQIKHRL
Kinase vab-1.AA RTKD 745-981 40 6.9e-74 250.28 In-house 33-262 (262) Show / Hide 
Range on Protein: 745-981
Range on HMM: 33-262/262
Sequence Identity: 40% (96 aa)

VAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRD
||.|..| . |  .  |.. || .| || |.|..|| ||||  .|...| ||   |||. .||   ..|| .   .   |   .| |  || . | .|||
VAVKIMKNQ-SQEQVMEMTREAAFMAQFNHDNIVRLHGVVTTNQPHIMVMEYCEHGSLQAYLR---ENGEDMDNQHRFRMARDVAMGLAYLHFRGCCHRD

LAARNVLLDMELRCKIADFGLSRGVRSEGSSVEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMIGYRL
 ||||.||| ..| ||.||||.|    .  .. . |.  |. ||||| |||.    ||   ||||| .|...|. . .. || |  ||||   |. ||||
IAARNILLDSNYRAKIGDFGLTR---QQANGDSEYYISHGQAIPVRWCAPEVLEEHKFSQASDVWSWAVFVYEIWTQAQLPYRDMHNQKVWHYVIQGYRL

PPPMDCPMGLYRIAQWCWKMERHERPTFTQLLATFHK
. || ||  ....   ||  .  |||...|.     |
TRPMQCPRDIWALMMDCWAEDPKERPRMCQVVDQMTK
Kinase vab-1.AA Syk 744-973 39 1.7e-72 247.14 In-house 33-257 (257) Show / Hide 
Range on Protein: 744-973
Range on HMM: 33-257/257
Sequence Identity: 39% (92 aa)

TVAIKTLKSGSSAKA-KAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLY-GIASGMKYLTDMGYV
.||||.||   . .| | ||. || .| |  || ..|.|| .  ||. | | |    |.. ..|    | .. .    . |...  .|.||.||     |
KVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIG-ICHAEMMMMVMEMAELGPMHKYLQ---QHRHEITANNVLELWHTQVAMGMCYLEEKHFV

HRDLAARNVLLDMELRCKIADFGLSRGVRSEGSSVEPEYT-TNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMI
|||||||||||  .   || |||.|.  .      . .|. | .|| ||.| ||| |  .||  .|||||||| .||  | | .||   ..| |.  .  
HRDLAARNVLLVNRHYAKISDFGMSKALGAD----SQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYGQKPYGEMKGQEVMKFIEN

GYRLPPPMDCPMGLYRIAQWCWKMERHERPTFT
| |.. |  ||  .| . . ||. .   |||| 
GHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase vab-1.AA S_TKc 692-983 20 7e-42 146.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 692-983
Range on HMM: 1-231/231
Sequence Identity: 20% (61 aa)

VFITQVIGGGEFGDVCLGGLSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYETVAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVM
  | ..|| | || |...   |                             . |||| .|          .. |  |. .  |||...|..|  . . . 
YEILRKIGKGAFGKVYKCRHKK---------------------------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLY

IVAEYMAN--GSLDQFLRNTDQRG--EKVHWEKITEMLYGIASGMKYLTDMGYVHRDLAARNVLLDMELRCKIADFGLSRGVRSEGSSVEPEYTTNGGKI
.| ||. .  |.| .....   .|   . .   .  ..| |.....|. ..| .||||   |.|||   . ||.||||.| .             .    
MVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCG

PVRWTAPEAITHRKFTP-SSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMIGYRLPPPMDCPMGLYRIAQWCWKMERHERPTFTQLLATF-----HK
   . ||| .   .... ..|.||.|....| .. |. |..   ..... ...           .  .  . . |....  .|||  ..|.       | 
TPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

YI
..
WF
Kinase vab-1.AA Pkinase 692-979 20 5.7e-33 117.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 692-979
Range on HMM: 1-293/293
Sequence Identity: 20% (68 aa)

VFITQVIGGGEFGDVCLGGLSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYETVAIKTLKSGSSAK--AKAEFL-TEATIMGQFSHPNVIRLIGVVTSAE
  | ..|| | || |...   ...                            .||.|..|  .  .   .. .. .|. ||  ..|||..||......  
YHIGRKIGSGSFGCVYKCHHKGTGK---------------------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKD

PVMIVAEYMANG----SLDQFLRNTDQRGEKV--HWEKITEMLYGIASGMKYLTDMGYVHRDLAARNVLLDMELRC----KIADFGLSRGVRSEGSSVEP
 . .| ||. .|    .|  ...   .|. ..   .. .  ..| |..|..|. .|| .||||   |.|.| .  .    ||.||||.. ..       .
HIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-N

EYTTNGGKIPVRWTAPEAIT-HRKFTPSSDVWSFGVVIWEVCSFGERPYW------DWTNQKVISEVMIG--YRLPPPMDCP------------------
   ...     .. ||| |  ... .|..|.||.|....|... |. |..      .  .|... .   |  .. . | .|.                  
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNW

-MGLYRIAQWCWKMERHERPTFTQLLAT--F
   .  .  ||...  ..|||..|.|    |
SEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase vab-1.AA Frk 692-720 31 0.040232 2.74 In-house 1-29 (260) Show / Hide 
Range on Protein: 692-720
Range on HMM: 1-29/260
Sequence Identity: 31% (9 aa)

VFITQVIGGGEFGDVCLGGLSKNSPAAAK
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IQLIRRLGSGQFGEVWEGLWNNTTPVAVK