Gene unc-43 (Nematode worm)

unc-43

Species: Nematode worm
Alias: 8-Dec, aSWK032, dec-8, K11E8.1A, CE28051, unc-43, K11E8.1a
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:4.58114, WormBase Physical Map location: IV: 10340534-10324299

Classification

Group: CAMK
Family: CAMK2

Sequence

Name Sequence Type Origin Length Description Download
unc-43.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
unc-43.AA Protein Genbank 559 None Fasta, JSON

Protein domain

Protein domains of unc-43.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase unc-43.AA CAMK2 12-269 88 5.1e-217 727.25 In-house 1-259 (259) Show / Hide 
Range on Protein: 12-269
Range on HMM: 1-259/259
Sequence Identity: 88% (229 aa)

YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADA
|...|||||||||||||||.|.||.|.||||||||||||||.|||||||||||||.||||||||||||||.||||||||||||||||||||||.||||||
YQLFEELGKGAFSVVRRCVKKCTGQEYAAKIINTKKLSARDHQKLEREARICRKLKHPNIVRLHDSIQEEGFHYLVFDLVTGGELFEDIVAREYYSEADA

SHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPP
||||||||||...||.||||||||||||||||||.||||||||||||||||. |..||.||||||||||||||.||||.|||||||||||||||||||||
SHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPP

FWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI
||||||||||.||||||||||||||||||||||.||..|||.|||||||||.|||.|||
FWDEDQHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPWI
Kinase unc-43.AA CAMK1 12-269 45 2.4e-152 446.22 In-house 1-276 (276) Show / Hide 
Range on Protein: 12-269
Range on HMM: 1-276/276
Sequence Identity: 45% (125 aa)

YDVKEELGKGAFSVVRRCVHKTT---GLEFAAKIIN-TKKLSARDF---QKLEREARICRK---LQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIV
| ...|.|.||||.|..|.|| |   | ..| |.|.  | ..  |    ..||.|  | .|   ..||||. ...  ..... ||| .||||||||. ||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

AREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVK--LADFGLAIEVNDSE-AWHGFAGTPGYLSPEVLKK---DPYSKPVDIW
 ...|.| ||.|...|||. . |.||.|||||||||||||...|  .. .|  .|||||.  ... |       |||||  ||||.    .||.|..|.|
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMW

ACGVILYILLVGYPPFWDED-QHRLYAQIKAGAYDYPSPEWDTVTPE-AKSLIDSMLTVNPKKRITADQALKVPWI
 .|||.||||.|||||.||. .. |...|| . |..|||.|| .  . || .|  ||.|.||||.|..|.|. |||
SIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase unc-43.AA CAMK 17-269 27 1.3e-135 439.82 In-house 1-425 (425) Show / Hide 
Range on Protein: 17-269
Range on HMM: 1-425/425
Sequence Identity: 27% (115 aa)

ELGKGAFSVVRRCVHK-TTGLE-----------FAAKIINTKKLS--------------------------ARDFQKLEREARICRKLQ-------HPNI
.||.|.|..|..|.|| |||.|           .|.|||..|||.                          ..| ....|| .|..|||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLHDSIQE-------------------ESFHYLVF---DLVTGGEL----FEDIVAREF---------------YSEADASHCIQQILESIAYCHSNGI
..|.. ..                    ... |.|.   ....||||    |. ||...                ..|..|.....||.. ..||||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENLLLASKAKG--------------AAVKLADFGLAIEVNDSE------------------------AWHGFAGTPGYLS-PEVLKK------
|||||||||.|| .. ..              . .|..|||.|......|                          . | |||.| . ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------DPYSKPVDIWACGVILYILLVGYPPFWDE-------------DQHRLYAQIKAGAYDYPSPE------------WDTVTPE--------AKS
        ..|....|.|.|||||||.|.|||||...             ....|. .|..| ||.|.|.            || .. |        .|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIDSMLTVNPKKRITADQALKVPWI
|| .||.|.|.||.|..|.|. ||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase unc-43.AA RAD53 12-269 36 9.69999999999e-119 355.44 In-house 1-305 (305) Show / Hide 
Range on Protein: 12-269
Range on HMM: 1-305/305
Sequence Identity: 36% (110 aa)

YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLS---ARDFQK---LEREARICRKLQHPNIVRLHDSIQE-ESFHYLVFDLVTGGELFEDIVARE
|.. .|||.|.|..|.... |.|.  .| |||..||..    ... |   ...|..| .||.||.|.|..|.... .   |.|  |.||||||..||...
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

F----YSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGA---------------AVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK
     ..|...     |..... | |.|||.|||||||| |.......                ..|..||||.  | ...    . ||| |. |||. .
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS

D---------------PYSKPVDIWACGVILYILLVGYPPFWDE-DQ----HRLYAQIKA-GAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQAL
                 |.| ||.|  |.||||.| ||||| |. .|      |. |||  | | .|.|.|| .. |||.||..||.|.|.||.|.|.||
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEAL

KVPWI
  ||.
NHPWM
Kinase unc-43.AA CDPK 12-269 41 1.3e-118 365.3 In-house 1-271 (271) Show / Hide 
Range on Protein: 12-269
Range on HMM: 1-271/271
Sequence Identity: 41% (113 aa)

YDVKEELGKGAFSVVRRCVHK-TTGLEF-AAKIINTKKLSARDF-QKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFD--LVTGGELFEDIVAREFY
|. |..||||.|..||...||  |. |  | |||. ....  .  |.. .|  | ..| ||||...    | | ..|.|.   ..||||||. |...  .
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

SEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGA----AVKLADFGLAIEVNDS-----EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWAC
.| .|.  ..|||  ..|||||.||||||||||.|. || ...     .|. |.|.. . . .     .    ..||| |..||||.|  | . .||| |
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSC

GVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI
||||||||.|||||. . .   ....| | |..  |||| .. ||| ||  ||...||||..|.|||. ||.
GVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase unc-43.AA S_TKc 12-269 37 2.7e-110 373.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-269
Range on HMM: 1-231/231
Sequence Identity: 37% (102 aa)

YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTG--GELFEDIVAREF----
|.. ...|||||..|..|.|| || ..| |||.         ....|| .|..| .|||||.|.|..|. .. |.|.... |  |.||. |. |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--YSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSK-PVDIWACGVILY
  ..| .| . ..||.. ..||||.||.||||||||.|| .      .|..||||| ..      . | ||| |..||||   .|.| ..|.|.||.|||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALK-------VPWI
..|.|||||.  ...... .|.              .||||..|. .|...|.||.|| .||.        ||.
EMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase unc-43.AA Pkinase 12-269 34 1.7e-102 351.57 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-269
Range on HMM: 1-293/293
Sequence Identity: 34% (103 aa)

YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLER--EARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGG----ELFEDIV--AR
| ... .|.|.|..|..|.|| || ..| |||. .. .    | . |  |..| ..|.|||||||.|. ....  |.|.... ||    .||. |   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EFY--SEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLA-SKAKGAAVKLADFGLAIE--VNDSEAWHGFAGTPGYLSPEVLK-KDPYSKPVDIWAC
  .  || .. ... |||. ..||||.||.||||||||.|.      .| ||..|||||       ..  ..|.|||.|..|||..   .|...||.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYILLVGYPPFWDE------DQHRLYAQIKAGAYDYPSPEWDTVT-----------------PEAKSLIDSMLTVNPKKRITADQALKVPWI
|.|||..| |.|||...      ||  ....|. . .....|.|...                  .|.|..|...|...||||.||.|.|. ||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase unc-43.AA CAMKL 12-269 34 9.1e-101 322.31 In-house 1-297 (297) Show / Hide 
Range on Protein: 12-269
Range on HMM: 1-297/297
Sequence Identity: 34% (106 aa)

YDVKEELGKGAFSVVRRCVH-KTTGLEFAAKIINTKKLSARDFQK-------------LEREARICRKLQ---HPNIVRLHDSIQEESF------HYLVF
|.. ..||||.|..|. ..| .||| . | |||. ||.. ... |             ..||..| ..|.   ||||..|.. |. ...       ||| 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

DLVTGGE--LFEDIVAREF----YSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVND-----SEAWHGFAGTPGY
 .. |||  ||. ||...      .| .| .  .||.. ..||||.||||||.||||.|| .. .   .|..|||....  .      .  . | |.| |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

LSPEVLKK--DPYS-KPVDIWACGVILYILLVGYPPFWDE--------DQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKV
 .||....  .||  ..||||.|||||| ...|| || |.        .. .|| .|. | | .|   |  |  ....|| .||.|||.||.|..| .. 
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWI
|| 
PWM
Kinase unc-43.AA DCAMKL 12-269 38 8.9e-99 307.95 In-house 1-279 (279) Show / Hide 
Range on Protein: 12-269
Range on HMM: 1-279/279
Sequence Identity: 38% (107 aa)

YDVKEELGKGAFSVVRRCVHKTTG-LEFAAKI-----------------INTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTG
|..    |.| |.||  |.|..||  ..| ||                 |. .|.    .   . | .| .|..||.|..|...   |   |||. .|.|
YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHM-IDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQG

GELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLAS-KAKGAAVKLADFGLAIEVND-SEAWHGFAGTPGYLSPEVLKKDPYSKP
| ||. |.    ..| ||.  . .. . . | |. .|||||.||||||.     .   .||.||||| .||.         ||| |  ||.|..  |.  
GDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCK

VDIWACGVILYILLVGYPPFWDE--DQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI
||||| ||||||||.|.|||  .  || .|  || .|....|.|.|| ..  || ||  || |.|.|| || | .. ||.
VDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV
Kinase unc-43.AA MARK 12-269 37 2.7e-94 308.63 In-house 1-262 (262) Show / Hide 
Range on Protein: 12-269
Range on HMM: 1-262/262
Sequence Identity: 37% (100 aa)

YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSA-RDFQKLEREARICRKLQHPNIVRLHDSIQ--EESF-HYLVFDLVTGGELFEDIVAR--EF
| .. ..|.|....|. ..|| || ..| ||.. .||.    .....||..| .||.||||..|.. |.  .|.   ||. ... ||||.. |.|.    
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

YSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYS-KPVDIWACGVILYIL
 .| .| .  .||.. . ||||..|||||.||||.|. .. .   .|..|||..|...  .    | ||| | .||...| ||  ..||||..||.||..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGN-HNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

LVGYPPFW--DEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI
..|| ||   . |.  || .| .| ||.|.     | .|...|| ..|||||..|.|... .| ||.
VCGYFPFDGDTQDYKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase unc-43.AA CAMK-Unique 12-269 25 1.2e-93 309.47 In-house 1-363 (363) Show / Hide 
Range on Protein: 12-269
Range on HMM: 1-363/363
Sequence Identity: 25% (92 aa)

YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLS-ARDFQ-----------------KLEREARICRKLQHPNIVRLHDS----IQEES-------
|.  . .|.|.|..|..|  ..|| ..| |... .. .  .  |                 ||.||..| ... ||||..| |      . .        
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------FHYLVFDLVTGGELFEDIVA--------------------REFYSE--ADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAK-----
          |.| ....||.||. |..                    .  .||  .|..  .|..|. .|| ||..|||||||.||... .  |     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------GAAVKLADFGLAIEVNDSEAWH---GFAGTPGYLSP--------------EVLKKDPYSKPV----DIWACGVILYILLVGYPPFWDEDQH-
           .||.||||. ..| ... |    . ||| |..|              ||.. ..|. ..    |||..|||.|..|.|.|||  |.   
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------RLYAQIKAGAY-DYPSPEWDT---VTPEAKSLIDSMLTVNPKKRITADQALKVPWI
       .... |..| | ..... |.    ...|||....  .|| |..|..| ..|...||
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase unc-43.AA RSK 14-269 31 8.9e-89 301.24 In-house 1-278 (278) Show / Hide 
Range on Protein: 14-269
Range on HMM: 1-278/278
Sequence Identity: 31% (88 aa)

VKEE--LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSAR--DFQKLEREARICRKLQ-HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREF---
.|.   .|.|.....|.|.|. || ..| |... .|. .|  |     .| .|    | ||.||.||.. |.|.  ||. ... |||||. .  ...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

YSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKG-AAVKLADFGLAIE-VND-SEAWHGFAGTPGYLSPEVLK---KDP-YSKPVDIWACG
 || .|.  . .|   . . |. ||.|||||||| |....  . . .|| |||.. . ..| ..  . | .|  |. ||.||   ..  ..| .|.|  |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VILYILLVGYPPFWD---EDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRIT-----ADQALKVPWI
|..| .|.|.|||     .... . ..|. | .. ..|.|.....|||.||  ||...|.||..     |.. .. ||.
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase unc-43.AA TyrKc 12-269 21 1.4e-15 29.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-269
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL--QHPNIVRLHDSIQEE-------SFHYLVFDLVTGGELFEDI-V
   ...|| ||| .|.... |   .. | | ..  .      . . ||||| .||  .|||||||.  . ..         ...|. .. .| | . .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

AREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVNDS------EAWHGFA---GTPG-----YLSPEVLKKDP
 |.  . .|  .   || .  .| ||....||||   | |....     || .||||. .. |       .     .   |. .      ..||....  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YSKPVDIWACGVILY-ILLVGYPPFWD-----EDQHRLYAQIKAGAYDYPSPE-----WDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI
..   |.|. || .. |.  | .| ..      .  ......|.| .  . |.       . ..|  ... .    .|..| |  .   .  .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase unc-43.AA Pkinase_Tyr 12-75 30 2e-09 32.56 Pfam 1-70 (270) Show / Hide 
Range on Protein: 12-75
Range on HMM: 1-70/270
Sequence Identity: 30% (22 aa)

YDVKEELGKGAFSVVRRCVHK----TTGLEFAAKIINTKKLSARD--FQKLEREARICRKL-QHPNIVRLH
    ..||.||| .|.... |     |... | |..   . . ..   ... |||.| ..| .|||||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase unc-43.AA Pkinase_Tyr 126-166 38 0.014707 9.29 Pfam 128-166 (270) Show / Hide 
Range on Protein: 126-166
Range on HMM: 128-166/270
Sequence Identity: 38% (16 aa)

HSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEV-NDSE
.|....||||   | |...   .  || .|||||  . ||..
ESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDY
CaMKII_AD unc-43.AA CaMKII_AD 426-550 60 8.1e-88 302.86 Pfam 1-128 (128) Show / Hide 
Range on Protein: 426-550
Range on HMM: 1-128/128
Sequence Identity: 60% (78 aa)

QKQDIVRVTQTLLDAISCKDFETYTRLCDTSMTCFEPEALGNLIEGIEFHRFYFD---GNRKNQVHTTMLNPNVHIIGEDAACVAYVKLTQFLDRNGEAH
.||.|..||.....||.|.|..|||.||...|||||.||.|||.||.|||||||.   ..|...||||||||.||..|.||||.|||.|||..|.||.||
EKQEIWKVTERWIEAIYCGDWHTYTKLCHPDMTCFEWEACGNLVEGMEFHRFYFEMHWTKRCKAVHTTMLNPHVHMYGDDAACCAYVRLTQYMDKNGMAH

TRQSQESRVWSKKQGRWVCVHVHRSTQP
||||.|.|||.|..|.|.|||.|||..|
TRQSEETRVWHKRDGKWQCVHHHRSAMP