Gene T27C10.5 (Nematode worm)

T27C10.5

Species: Nematode worm
Alias: aSWK415, T27C10.5, CE28494
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: I:5.48, WormBase Physical Map location: I: 10893543-10887826

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
T27C10.5.AA Protein Genbank 2454 None Fasta, JSON
T27C10.5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 293 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of T27C10.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank T27C10.5.AA Ank 90-122 36 2e-06 27.88 Pfam 1-33 (33) Show / Hide 
Range on Protein: 90-122
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

RGKTALHMAAESGETSIVLELVELGSDPMKSDN
 | |.||.|...| |..| .|.. | |.   |.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank T27C10.5.AA Ank 56-89 29 5.9e-05 22.13 Pfam 1-33 (33) Show / Hide 
Range on Protein: 56-89
Range on HMM: 1-33/33
Sequence Identity: 29% (10 aa)

HGRTPLMLAAHNGKLDSLRTILMLSPNSLNLVND
.|.|||.||...| .. ..  |     ..|...|
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank T27C10.5.AA Ank 325-347 47 0.00083 17.99 Pfam 1-23 (33) Show / Hide 
Range on Protein: 325-347
Range on HMM: 1-23/33
Sequence Identity: 47% (11 aa)

EGSTCLHWAARCGSSECVSTILN
.| |.||.|.|||. |.|.  |.
DGFTPLHLACRCGHTEVVKMLLQ
Ank T27C10.5.AA Ank 378-396 47 0.763897 7.3 Pfam 1-19 (33) Show / Hide 
Range on Protein: 378-396
Range on HMM: 1-19/33
Sequence Identity: 47% (9 aa)

ECRTAMYLAVAEGHLEVVK
. .|.  ||.  ||.||||
DGFTPLHLACRCGHTEVVK
Ank T27C10.5.AA Ank 422-454 36 7.6e-07 28.95 Pfam 1-33 (33) Show / Hide 
Range on Protein: 422-454
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

RGRTPFMLAAFNQNLPLMTLLLDAGADVNLPLA
 |.|| .||... ..  ...||..|||||.   
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank T27C10.5.AA Ank 468-493 34 1.751696 6.0 Pfam 1-26 (33) Show / Hide 
Range on Protein: 468-493
Range on HMM: 1-26/33
Sequence Identity: 34% (9 aa)

IGSGALVEAVRSDGLHIVHFLLDRGA
 |  .|  |.|.... .| .||..||
DGFTPLHLACRCGHTEVVKMLLQHGA
LRR_TYP T27C10.5.AA LRR_TYP 591-614 37 0.022408 13.37 SMART 1-24 (24) Show / Hide 
Range on Protein: 591-614
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LAAITRVDLSDNRLNTFPSILFQM
| . .. |||.|.| . |. .|| 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC T27C10.5.AA LRR_BAC 591-610 20 0.435584 3.98 SMART 1-20 (20) Show / Hide 
Range on Protein: 591-610
Range on HMM: 1-20/20
Sequence Identity: 20% (4 aa)

LAAITRVDLSDNRLNTFPSI
 ..... . |.|.| ..|  
PPHLKWLNVSNNQLTELPEL
LRR_1 T27C10.5.AA LRR_1 593-614 22 0.589402 7.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 593-614
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

AITRVDLSD-N--RLN-TFPSI-LFQM
 ... |||. |  .|  ..|.  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 T27C10.5.AA LRR_1 616-630 26 5.609857 4.09 Pfam 1-19 (26) Show / Hide 
Range on Protein: 616-630
Range on HMM: 1-19/26
Sequence Identity: 26% (5 aa)

SLRSLNLAD-N--SI-RKI
.|..|.| . |  .. ..|
NLQHLDLSGCNCCNLTGHI
LRR_TYP T27C10.5.AA LRR_TYP 663-686 41 2.7e-05 24.84 SMART 1-24 (24) Show / Hide 
Range on Protein: 663-686
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LPQLQQLDVSKNELSQLPEYIWLC
||.|. || | | |..||. .. .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC T27C10.5.AA LRR_BAC 686-705 50 0.000523 20.56 SMART 1-20 (20) Show / Hide 
Range on Protein: 686-705
Range on HMM: 1-20/20
Sequence Identity: 50% (10 aa)

CPALKELNASYNRLSTLPMV
 |.||.||.|.|.|..||  
PPHLKWLNVSNNQLTELPEL
LRR_BAC T27C10.5.AA LRR_BAC 663-682 50 0.004613 17.42 SMART 1-20 (20) Show / Hide 
Range on Protein: 663-682
Range on HMM: 1-20/20
Sequence Identity: 50% (10 aa)

LPQLQQLDVSKNELSQLPEY
 |.|. |.|| |.|. ||| 
PPHLKWLNVSNNQLTELPEL
LRR_1 T27C10.5.AA LRR_1 641-663 25 0.008433 14.1 Pfam 1-26 (26) Show / Hide 
Range on Protein: 641-663
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLEILNLRN-N--QLE-CIAIQFLSSL
.|..|.|.. |  .|. .|    . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 T27C10.5.AA LRR_1 665-686 29 0.081858 10.6 Pfam 1-26 (26) Show / Hide 
Range on Protein: 665-686
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

QLQQLDVSK-N--ELS-QLPEY-IWLC
.|| ||.|  |   |. ..|.  .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP T27C10.5.AA LRR_TYP 640-662 30 0.143996 6.75 SMART 2-24 (24) Show / Hide 
Range on Protein: 640-662
Range on HMM: 2-24/24
Sequence Identity: 30% (7 aa)

TSLEILNLRNNQLECIAIQFLSS
..|. |.| ||||. .  . ...
PNLRELDLSNNQLTHLPPGAFQG
LRR_TYP T27C10.5.AA LRR_TYP 687-711 44 0.293157 4.22 SMART 2-24 (24) Show / Hide 
Range on Protein: 687-711
Range on HMM: 2-24/24
Sequence Identity: 44% (11 aa)

PALKELNASYNRLSTLPMVARASRG
|.|.||. |.|.|..||  ..| .|
PNLRELDLSNNQLTHLP--PGAFQG
LRR_BAC T27C10.5.AA LRR_BAC 639-658 35 0.712102 2.35 SMART 1-20 (20) Show / Hide 
Range on Protein: 639-658
Range on HMM: 1-20/20
Sequence Identity: 35% (7 aa)

STSLEILNLRNNQLECIAIQ
  .|..|| .||||..    
PPHLKWLNVSNNQLTELPEL
LRR_1 T27C10.5.AA LRR_1 688-703 30 0.910675 6.89 Pfam 1-20 (26) Show / Hide 
Range on Protein: 688-703
Range on HMM: 1-20/26
Sequence Identity: 30% (6 aa)

ALKELNASY-N--RLS-TLP
 |..|. |. |  .|. ..|
NLQHLDLSGCNCCNLTGHIP
LRR_1 T27C10.5.AA LRR_1 779-799 18 0.243703 8.92 Pfam 1-26 (26) Show / Hide 
Range on Protein: 779-799
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

TLTTINLSF-N--KFH-TFPF--CLAC
.|....||  |  ..  ..|   . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC T27C10.5.AA LRR_BAC 777-796 25 0.705689 2.38 SMART 1-20 (20) Show / Hide 
Range on Protein: 777-796
Range on HMM: 1-20/20
Sequence Identity: 25% (5 aa)

SNTLTTINLSFNKFHTFPFC
 ..|...| |.|.  ..|  
PPHLKWLNVSNNQLTELPEL
LRR_BAC T27C10.5.AA LRR_BAC 801-820 50 0.063967 10.34 SMART 1-20 (20) Show / Hide 
Range on Protein: 801-820
Range on HMM: 1-20/20
Sequence Identity: 50% (10 aa)

CPRLLILNMSNNSMTSLPPM
 |.| .|| |||. |.|| .
PPHLKWLNVSNNQLTELPEL
LRR_1 T27C10.5.AA LRR_1 826-850 27 0.128967 9.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 826-850
Range on HMM: 1-26/26
Sequence Identity: 27% (8 aa)

HLRTLDLSY-N--KIQ-ESFIEASPLHVV
.|..||||. |  ... .  |  | .   
NLQHLDLSGCNCCNLTGH--IPPSCF-NL
LRR_TYP T27C10.5.AA LRR_TYP 801-824 45 0.152749 6.54 SMART 1-24 (24) Show / Hide 
Range on Protein: 801-824
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

CPRLLILNMSNNSMTSLPPMACVP
 | |  |. |||  |.||| |. .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 T27C10.5.AA LRR_1 803-823 25 0.29805 8.61 Pfam 1-26 (26) Show / Hide 
Range on Protein: 803-823
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

RLLILNMSN-N--SMT-SLPP--MACV
.| .|..|. |  ..| ..||      
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC T27C10.5.AA LRR_BAC 824-841 35 0.876787 1.66 SMART 1-20 (20) Show / Hide 
Range on Protein: 824-841
Range on HMM: 1-20/20
Sequence Identity: 35% (7 aa)

PAHLRTLDLSYNKIQE--SF
|.||..|. |.|.. |   .
PPHLKWLNVSNNQLTELPEL
LRR_TYP T27C10.5.AA LRR_TYP 915-939 28 0.354878 3.54 SMART 1-24 (24) Show / Hide 
Range on Protein: 915-939
Range on HMM: 1-24/24
Sequence Identity: 28% (7 aa)

LEWLKTLQLAGNRLRSISVTNAASK
|  |..| | .|.|...   .| . 
LPNLRELDLSNNQLTHLP-PGAFQG
LRR_BAC T27C10.5.AA LRR_BAC 915-934 25 0.980256 1.29 SMART 1-20 (20) Show / Hide 
Range on Protein: 915-934
Range on HMM: 1-20/20
Sequence Identity: 25% (5 aa)

LEWLKTLQLAGNRLRSISVT
 . ||.|   .|.|.. .  
PPHLKWLNVSNNQLTELPEL
LRR_1 T27C10.5.AA LRR_1 917-932 35 47.123826 0.81 Pfam 1-20 (26) Show / Hide 
Range on Protein: 917-932
Range on HMM: 1-20/26
Sequence Identity: 35% (7 aa)

WLKTLQLAG-N--RL-RSIS
 |..| | | |  .| ..|.
NLQHLDLSGCNCCNLTGHIP
LRR_TYP T27C10.5.AA LRR_TYP 942-965 37 0.182332 5.91 SMART 1-24 (24) Show / Hide 
Range on Protein: 942-965
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LPALNVMDISDNKLLQAPPDVARL
||.| . | |.|.| . ||.. . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 T27C10.5.AA LRR_1 944-965 29 4.354962 4.48 Pfam 1-26 (26) Show / Hide 
Range on Protein: 944-965
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

ALNVMDISD-N--KLL-QAPPD-VARL
 | . |.|. |  .|  . ||.    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 T27C10.5.AA LRR_1 967-989 33 3.515046 4.81 Pfam 1-26 (26) Show / Hide 
Range on Protein: 967-989
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

LLSMLNLSG-N-TAI-KELPPD-YGML
 |  |.||| | . . ...||.    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
ROC T27C10.5.AA ROC 1034-1220 24 1.3e-31 103.38 In-house 1-215 (215) Show / Hide 
Range on Protein: 1034-1220
Range on HMM: 1-215/215
Sequence Identity: 24% (54 aa)

YHHLRLMILGSDGVGKSVIWDALCKEAVQKRQ------PIHSETGVIR-QAEWKFEAKRSKGDKNLGPVGFSVIDFGGQREYHSTHQYFLSK-RSLNLVL
.....||..|  ||||.    .|...    .       . |. |  |    .|..  |  .  |  . . |.| ||||| .||.|||.||.. ||. |. 
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYLLV

WKITD-----GDE----ALA-QLDTWLVNIHARAPN--------STVILVGTNLDQVASNSSK-FGPGYIDIMEQKVRTRYMVADADKSGLPRI------
|.. .     ..|      .  |. || .|..|.|.        | ||.||| .|.|  .  | ..  ... |.||.          .  .|.|      
WDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCCRMWQKL----------RNKFPNICHSWMQ

----VDVILINSTSR-NDVKALLNT
    .... ...... .... | ..
IEHYQGFFHVDCETGCKGIDKLRHH
COR T27C10.5.AA COR 1221-1398 17 2.8e-16 48.97 In-house 1-211 (434) Show / Hide 
Range on Protein: 1221-1398
Range on HMM: 1-211/434
Sequence Identity: 17% (37 aa)

IYRTAWEVRMGKERA--MEQQIPSSYIALMKVTKELGVEFRKEGQPAVMTVEAYRERVKKRM----ISKFGRPFRDDIEFYAACTFLHDCGELVRFE---
|..|| .. ......  |.|..| |. .. .  .|..   .      .|. ..... ....     . .    . |. |. .. ..||| |... |.   
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRL-RHQNIIIDEDELHTVAMYLHDLGHIIHFKIWD

-DATLRDLIFVDPLWLAEFLTSVVILRSPN-----LPAGL-LSTDAINPHTRSFKSGA--------LLMLKTQLLDLLHKFELALATQP----------R
 |. |.|....|| |... . .... .  .      . |. .... .  . .  ...          . ....|. |..||||..   |          .
HDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETT

QLLIPSLLPDEY
..|||.||||..
TYLIPQLLPDDR
Miro T27C10.5.AA Miro 1038-1162 16 2e-06 25.52 Pfam 1-140 (140) Show / Hide 
Range on Protein: 1038-1162
Range on HMM: 1-140/140
Sequence Identity: 16% (24 aa)

RLMILGSDGVGKSVIWDALCKEAVQ------------KRQPIHSETGVIRQAEWKFEAKRSKGD---KNLGPVGFSVIDFGGQREYHSTHQYF--LSKRS
.....|. |.||| .  ..|.|  .            .|  ......|      ... .  ..      .    |.. |.||. . ...|. |  . ...
KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVD-----TMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWAD

LNLVLWKITDGD--EALAQLDTWLVNIHARAPN-STVILVGTNLD
  ...   ||..  . .  . .|| .. ... . . ||.||. .|
AICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
COR T27C10.5.AA COR 1462-1654 14 1e-06 17.22 In-house 233-369 (434) Show / Hide 
Range on Protein: 1462-1654
Range on HMM: 233-369/434
Sequence Identity: 14% (30 aa)

LRRIYAL------AYIPSGFWSRLVTRIVGDKNVCAAIESIFMTTSADRAKIADIATKHAKAEWVVWQTGIELHVKGH--SLFTLKQFLPLAEVRDIDYS
|||.| .       ..|.|||.|.  |.  .    . .                   . .  ||. |..|. |. .||   .. .|.          . .
LRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKC----------------FYERSC-CEWMYWRNGMVLKWEGHNKNEALVKCDN--------HDN

AIDMRAKDEQKRWRTWNQPSHRPIVEMVVNSLSISAASQHGRKLSMKTDVEGRSRLLAMISDLLDTLLEDWYPALGTR----FVHSSEGDLLVSRYVLCP
.|. .   .|. |.                                      ...|...| .... ....|.|  | .     .       ..  ...||
KIYITVRGCQDCWID------------------------------------MCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHW-------VCREWIPCP

QCVRD
.|..|
HCIQD
Kinase T27C10.5.AA LRRK 1755-2050 36 2.5e-153 515.67 In-house 1-351 (351) Show / Hide 
Range on Protein: 1755-2050
Range on HMM: 1-351/351
Sequence Identity: 36% (127 aa)

LKRSRMLGRGAFG-FVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDS------------------------------MEFACR
||. ...|||.|| ||.||..|......|...||||.|. ...|.|.|.......|..||.||.                              .|..||
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPY-MYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCR

AYCTSRQELSLLSRMKHPNVIGLVGVCTFPLSLVVELAPLGALNQLLGSHRKAG-----TKLSLGVIKESAVQVARALEYLHSAH--IIYRDLKSENVLG
|... |.|....|...|||.. |.|.|  || .| |.||.|.|...| .... |     ...| ... . |.|.|...|||||..  ||.|||||.|.| 
AFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

WRFPAPFS---PQTDVLLKLGDYGISR--SVLPSGGAKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTLK-FPFES---------EEHVK
|..|...|   |...|  |..|.||||  .....|.|||..|..|.|||||.|.|||||||.||||.||||.|.||||.. .||.          .|...
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE

ERMLDGARPVLL---PHELLLPTPMLDLLVHCWSAHPESRPSSSQLVGFCAA
.....| ||..     .. .... ..||..|||...|..||..|| | .   
DKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase T27C10.5.AA TKL 1761-2048 22 1.2e-67 231.11 In-house 1-364 (364) Show / Hide 
Range on Protein: 1761-2048
Range on HMM: 1-364/364
Sequence Identity: 22% (87 aa)

LGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDS-----------------------MEFACRAYCTSRQELSLLSR
.|.|.|| |.... |. .|  |                 || ....  |  |.|...                       ...|...  . ..|. ..||
IGSGGFGEVYKGKWRGWGG-KC-----------------PS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSR

MKHPNVIGLVGVCTFP---------------LSLVVELAPLGA-LNQLLGSHRKAGTKLSLGVIKESAVQVARALEYLHSAH--------IIYRDLKSEN
 .|||.. ..|.|. |               | .| |..| |  |..|.           . ..   | ..||...|||| .        ||.|||||.|
LRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

VLGWRFPAPF-----SPQTDVLLKLGDYGISRSVLPSGG--------------------AKGFGGTEGFMAPEIVRFN-------------GEEEYTQKV
.| ..   .      .|. |. .|..|.|.||.. .||.                        .|| ..||||. | .             ...||..|.
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKC

DCFSFGMFLYELLTLKFPFE---SEEHV---------KERMLDGARPVLL---------PHELLLPTPMLDLLVHCWSAHPESRPSSSQLVGFC
|..|||. |.|.|| . |..   .....         . . ..| || .          ...   |..| .|. .||.. ||.||| ....   
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase T27C10.5.AA S_TKc 1755-2047 22 6.8e-46 159.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 1755-2047
Range on HMM: 1-231/231
Sequence Identity: 22% (70 aa)

LKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSMEFACRAYCTSRQELSLLSRMKHPNVIGLVGVCT-FP
 .  | .|.|||| |.... .       .|| |..                                    .. |.|...|.. .|||.. | .|.    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----------------------------------EHIRREIQILKK-HHPNIVKLYDVFQDDH

LSLVVELAPL--GALNQLLGSHRKAGTK--LSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPSGGAK
| .| |...   | | ... .... |..  ..  ...  . |...||||.|| .||.|||| ||.|  .            .|..| |..| .      .
LYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------HIKICDFGLARQL------T

GFGGTEGFMAPEIVRFNGEEEYTQ-KVDCFSFGMFLYELLTLKFPFESEEHVKERMLDGARPVLLPHELLLPTPMLDLLVHCWSAHPESRPSSSQLVG--
 | ||  .||||..       |.  |.|  |.|  |||.|. . ||.      ..|..  .          . ...|.. .|.   || ||.  ..    
TFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

--------F
        |
WDIKCHPWF
Kinase T27C10.5.AA Pkinase 1755-2045 20 1.5e-36 130.28 Pfam 1-288 (293) Show / Hide 
Range on Protein: 1755-2045
Range on HMM: 1-288/293
Sequence Identity: 20% (69 aa)

LKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSMEFACRAYCTSRQELSLLSRMKHPNVIGLVGVCT---
... | .|.|.|| |... ... .|.  .|| | .. ..  .. . ... .                        .|.... |..|||.. | ....   
YHIGRKIGSGSFGCVYKC-HHKGTGK--IVAVKIIKKRHEKSWKDQTHRRL------------------------SEIQIMKRLNHPNIVRLYDWFEDKD

FPLSLVVELAPLG----ALNQLLGSHRKAGTKL--SLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVL---LKLGDYGISRS-
 .  .| |... |     |  ..    ......  |  ..|  . |..|.|||.||  ||.||||.||.|       .. .....   .|..| |...  
HIY-MVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL-------ID-NNGHIDACVKICDFGLAKQF

-VLPSGGAKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTLKFPFESE------EHVKERMLDGARPVLLPHELLLP--------------
   ... ...| || ..||||..|  | ..|..||| .|.|  |||.|. ..|| ..      .. .   ... .|.  . . . .              
DY-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWT

-----TPMLDLLVHCWSAHPESRPSSSQLV
      ...|..  |.   |..||.  |..
FHNWSEECKDFIKWCLCKDPKKRPTAEQIL
Kinase T27C10.5.AA Ciliate-E2 1830-1994 23 1e-30 102.63 In-house 81-296 (365) Show / Hide 
Range on Protein: 1830-1994
Range on HMM: 81-296/365
Sequence Identity: 23% (54 aa)

QELSLLSRMKHPNVIGLVGVC----TFPLSLVVELAPLGALNQLLGSHRK--------AGTKLSLGVIKESAVQVAR---------------ALEYLHSA
.|...|....|||.| .. .     .  . || |..  | | ... ...|        .  ....  ||.   |...               ||||||| 
NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK

H-IIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPS----------GGAKGFG-----------------------GTEGFMAPEIVRFNG-
. ||.||.| ||.|               .|. | |.|. . ..          .  .  .                       || |.|||||..  . 
NNIIHRDIKPENILF--------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKY

-----EEEYTQKVDCFSFGMFLYELLTLKFPF
     ...|. |.| .|.|. |||.|. |.||
DNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase T27C10.5.AA TK 1830-2048 16 1.1e-28 92.72 In-house 87-486 (486) Show / Hide 
Range on Protein: 1830-2048
Range on HMM: 87-486/486
Sequence Identity: 16% (68 aa)

QELSLLSRMK-----HPNVIGLVGVCT--------------FPLSLVVELAPLGA----LNQLLGSHRKAGTK---------------------------
.|.. .. |.     |||.. |.||||               |. .|.|..|.|     | . | ..|. ...                           
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

---------------------------------------------LSLGVIKESAVQVARALEYLHSA------HIIYRDLKSENVLGWRFPAPFSPQTD
                                             |..      ..|.|...|||||       ... |||   |.|       ..  ..
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCL------VGENNVC

V--------LLKLGDYGISR-------SVLPSGGAKGFGGTEGF----------------------------MAPEIVRFNG------EEEYTQKVDCFS
           |..|.| ||         ..|..     ...|                             |||| .. .       .  .| | | .|
KWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWS

FGMFLYELLTLK-FPFESE------------EHVKERMLDGARP-----------VLLPHELLLP--------------TPMLDLLVHCWSAHPESRPSS
|| ...|..|.   |.  .            . | |.  .| |.             .|   . |              . . ||.  ||.. || ||. 
FGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTF

SQLVGFC
|||. . 
SQLHEQL
Kinase T27C10.5.AA UTK 1755-1915 28 1e-26 88.41 In-house 1-150 (296) Show / Hide 
Range on Protein: 1755-1915
Range on HMM: 1-150/296
Sequence Identity: 28% (50 aa)

LKRSRMLGRGAFGFVFRATVRQPN--GELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSME----FACRAYCTSRQELSLLSRMK-HPNVIGLV
....| ||.|||| |..|...|..  ...  ||.| .                    ... .....|    |   |      || .... . ||||..||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-------------------HHADAQQEPEPYPDFMEEAR-----ELQMMKQFHWHPNVLRLV

GVCT--FPLSLVVELAPLGALNQLLGSHRK----AGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVL
||||   |. .|.|... | | ..| .||.    ... |.|    . |...||...|||| ... |||   |.|
GVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCL
Kinase T27C10.5.AA STE 1830-2050 20 4.6e-25 85.51 In-house 77-359 (359) Show / Hide 
Range on Protein: 1830-2050
Range on HMM: 77-359/359
Sequence Identity: 20% (60 aa)

QELSLLSRMK--HPNVIGLVGVCTFP---------LSLVVELAPLGALNQLLGSHRKAGTKLS----------LGVIKESAVQVARA-LEYLHSAHIIYR
.|........  |||..   | .            | .. |. . | | ... .  . |  |.            .|.  ..|. .. |.|||| ||| |
KEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHR

DLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPSGG-----------------AKGFGGTEGFMAPEIVRFNG---EEEYTQKVDCFSFGMFLYEL
|.|. |.|                || | |.. .. .|.                   . | ||  .||||... ||   . .|. |.|  |.|  . |.
DIKPANILL--------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM

LTLKFPFESEEHVKERMLDG-----------------ARPVLLPHEL----------------LLPTPMLDLLVHCWSAHPESRPSSSQLVG--FCAA
.| | |.  . . .  ..                     | | .|                   .  .. | . .|    |. ||..|||        
ATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase T27C10.5.AA TKL-Unique 1829-2040 25 7.4e-25 84.69 In-house 43-282 (290) Show / Hide 
Range on Protein: 1829-2040
Range on HMM: 43-282/290
Sequence Identity: 25% (64 aa)

RQELSLLSRMK-HPNVIGLVGVCT----FPL--SLVVELAPLGALNQLLGSHR--------KAGTKLSLGVIKESAVQVARALEYLHSAH--IIYRDLKS
. |...... . |||.  ..|.|.     |   ..|.|  |.| |. .|  |.        .  .||.. ..   | ..|....|||.    || |||||
ENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVL--HQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKS

ENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPS--GGAK--------GFGGTEGFMAPEIVRFNGE-EEYTQKVDCFSFGMFLYELLTLKF------PF
 |.|  ..    |.   .  |. | |.|..   .  . ..        .. |.   ||||.  .... . |..|.| .|||. |.|..| |       |.
SNFLVDNN----SNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV--LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPY

ESEEHVKER-----MLDGARPVLLPHELLLPTPMLDLLVHCWSAHPESRPS
.. .. . .     |... || . .|   .|    ||.  ||   |. |||
QGMDQEQWCEMVHYMEENYRPPIPNH---CPKEYRDLIQQCWHHDPSQRPS
Kinase T27C10.5.AA TyrKc 1755-2048 23 1.2e-23 85.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 1755-2048
Range on HMM: 1-280/280
Sequence Identity: 23% (80 aa)

LKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSMEFACRAYCTSRQELSLLSRM--KHPNVIGLVGVCTF
..  ..||.|||| |...| .       .|| ||| .                          ..|        ..|......   .|||.. |.|||| 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----------------------REDF--------MREARIMCKLGGHHPNIVRLYGVCTQ

---------PLSLVVELAPLGALNQLLGSHRKAGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVL-GWRFPAPFSPQTDVLLKLGDYGISRSV
         || .|.|..|.|.|.. | .||.    |..    . ..|.|.  ||||| ..| |||   |.| | ..            | .| | || .
QGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------TVKISDFGLSRDI

LPS------GGAKGFG---GTEG-----FMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTLKFPFESE--------EHVKERMLDGARPVLLPH--ELL
         .  .      |. .      ||||  ...   ..| | | .|||  ..|..|.  .  ..        ..| |.  .| |.   |.  . .
YDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG---KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-M

----LPTPMLDLLVHCWSAHPESRPSSSQLVGFC
     |. | ..   || . ||.||. |... . 
SFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase T27C10.5.AA Dicty4-Unclassified 1829-1989 28 1.7e-22 73.79 In-house 46-203 (263) Show / Hide 
Range on Protein: 1829-1989
Range on HMM: 46-203/263
Sequence Identity: 28% (49 aa)

RQELSLLSRMKHPNVIGLVGVCTFP------LSLVVELAPLGALNQLLG---SHRKAGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRF
. |  .|  . ||| . . | |  |      .  | |. . | |  .     | ..   ||   .|   |  .|. . .||.  .| ||.|| |.|  . 
KKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDK-

PAPFSPQTDVLLKLGDYGISRSVLPSGGAKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLT
        .   | .| |||| .         .||    .||. .    | |.|| | .|..| ||||.|
--------HFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLM---HESYNQKSDVYSYAMMLYELAT
Kinase T27C10.5.AA MLK 1829-1915 31 1.8e-18 60.76 In-house 53-159 (291) Show / Hide 
Range on Protein: 1829-1915
Range on HMM: 53-159/291
Sequence Identity: 31% (34 aa)

RQELSLLSRMKHPN----VIGLVGVCTFP---LSLVVELAPLGALNQLLGSHRKAGT----------KLSLGVIKESAVQVARALEYLHS-AH--IIYRD
..|  .|....|||    .| ..|||. |   . .| | .. | |. .| . |. .             .....   |.|.||...|||| |   || ||
EMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRD

LKSENVL
||| |.|
LKSHNIL
Kinase T27C10.5.AA MLK 1950-2048 28 7.7e-15 48.02 In-house 192-291 (291) Show / Hide 
Range on Protein: 1950-2048
Range on HMM: 192-291/291
Sequence Identity: 28% (28 aa)

GFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTLKFPFE-SEEHVKERMLDGARPVLLPHELLLPTPMLDLLVHCWSAHPESRPSSSQLVGFC
.. ||  .||||.     .| |. |.| .|.|. |.|.|| . |..   .     .  ..    .|..   | ..  |.  ||.. |..|||..| | . 
SNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase T27C10.5.AA Pkinase_Tyr 1830-1909 33 2.5e-14 49.15 Pfam 52-137 (270) Show / Hide 
Range on Protein: 1830-1909
Range on HMM: 52-137/270
Sequence Identity: 33% (29 aa)

QELSLLSRM-KHPNVIGLVGVCT---FP--LSLVVELAPLGALNQLLGSHRKAGTKLSLGVIKESAVQVARALEYLHSAHIIYRDL
.|..... . .|||.. |.||||    |  . .|.|..|.| |   | .||  . .|..  . . ..|.|...|||.| ..| |||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase T27C10.5.AA Dicty4 1829-1915 33 3.3e-12 37.2 In-house 46-146 (277) Show / Hide 
Range on Protein: 1829-1915
Range on HMM: 46-146/277
Sequence Identity: 33% (34 aa)

RQELSLLSRMKHPNVIGLVGVCT----FP--LSLVVELAPLGALNQLLGS---HRKAGTKLSLGVIKE---SAVQVARALEYLHS--AHIIYRDLKSENV
|.| ....   |||.. . | ||     |  .. | |. | | |  || .     .  .||... ||     |  .|| . .||.    || ||||| | 
RKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNL

L
|
L
Kinase T27C10.5.AA Dicty4 1932-1989 32 7.7e-12 35.95 In-house 154-212 (277) Show / Hide 
Range on Protein: 1932-1989
Range on HMM: 154-212/277
Sequence Identity: 32% (20 aa)

KLGDYGISR---SVLPSGG-AKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLT
| .| |.|.    .   .  ...  || . ||||. ..   ..|..|.| .|||. |.|.||
KVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMH---QPYNEKADVYSFGIVLWEILT
Kinase T27C10.5.AA TK 1755-1789 23 2.1e-07 20.07 In-house 1-60 (486) Show / Hide 
Range on Protein: 1755-1789
Range on HMM: 1-60/486
Sequence Identity: 23% (14 aa)

LKRSRMLGRGAFG---FVFRATVRQPN----------------------GELCEVAQKML
..  . ||.|.||    |.....|..|                      |. ..|| |||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKML
Kinase T27C10.5.AA UTK 1958-2048 30 2.6e-07 21.05 In-house 206-296 (296) Show / Hide 
Range on Protein: 1958-2048
Range on HMM: 206-296/296
Sequence Identity: 30% (29 aa)

MAPEIVRFNGEEEYTQKVDCFSFGMFLYELLT---LKFPFESEEHVKERMLDGARPVLLPHELLLPTPMLDLLVHCWSAHPESRPSSSQLVGFC
||||..  .    .|.| | .||| ...|..|   | .|  |.. | .. ..| |  ..|     | |. .|.. || . |. ||.  .|| . 
MAPEALTHHT--RFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGR-YRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase T27C10.5.AA Pkinase_Tyr 1755-1791 36 1.1e-05 19.86 Pfam 1-38 (270) Show / Hide 
Range on Protein: 1755-1791
Range on HMM: 1-38/270
Sequence Identity: 36% (14 aa)

LKRSRMLGRGAFGFVFRATVR-QPNGELCEVAQKMLEP
..  ..||.|||| |...| . .| .. ..|| ||| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE
Kinase T27C10.5.AA Dicty4 1755-1776 31 3.8e-05 13.29 In-house 1-22 (277) Show / Hide 
Range on Protein: 1755-1776
Range on HMM: 1-22/277
Sequence Identity: 31% (7 aa)

LKRSRMLGRGAFGFVFRATVRQ
...   .|.|.|| |...|.|.
INIEQRIGKGSFGEVYKGTWRG
Kinase T27C10.5.AA Pkinase_Tyr 1958-1990 36 0.000359 14.75 Pfam 181-210 (270) Show / Hide 
Range on Protein: 1958-1990
Range on HMM: 181-210/270
Sequence Identity: 36% (12 aa)

MAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTL
||||  ...    .| | |  |||  ..|..|.
MAPECINYGK---FTTKSDVWSFGVLMWEIFTY
Kinase T27C10.5.AA STE 1755-1785 23 0.005295 6.59 In-house 1-43 (359) Show / Hide 
Range on Protein: 1755-1785
Range on HMM: 1-43/359
Sequence Identity: 23% (10 aa)

LKRSRMLGRGAFGFVFRATVRQ-----PNGEL-------CEVA
... ...|.|||| |..|  .      ..||.       . .|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMA
Kinase T27C10.5.AA Dicty4 2020-2040 38 0.014907 4.53 In-house 245-265 (277) Show / Hide 
Range on Protein: 2020-2040
Range on HMM: 245-265/277
Sequence Identity: 38% (8 aa)

PTPMLDLLVHCWSAHPESRPS
|..  .|.. ||.  |..|||
PPSWKHLIQWCWDHDPQHRPS
Kinase T27C10.5.AA Ciliate-E2 1755-1776 31 0.015317 4.52 In-house 1-22 (365) Show / Hide 
Range on Protein: 1755-1776
Range on HMM: 1-22/365
Sequence Identity: 31% (7 aa)

LKRSRMLGRGAFGFVFRATVRQ
 |  ...|.|.|| |....|..
YKFIKKIGQGNFGSVYKCKVWK
Kinase T27C10.5.AA MLK 1755-1773 26 0.029478 3.79 In-house 1-19 (291) Show / Hide 
Range on Protein: 1755-1773
Range on HMM: 1-19/291
Sequence Identity: 26% (5 aa)

LKRSRMLGRGAFGFVFRAT
.. .. .| |.|| |....
IQFHEWIGSGSFGKVWKGR
Kinase T27C10.5.AA Dicty4-Unclassified 2026-2048 30 0.029877 3.47 In-house 241-263 (263) Show / Hide 
Range on Protein: 2026-2048
Range on HMM: 241-263/263
Sequence Identity: 30% (7 aa)

LLVHCWSAHPESRPSSSQLVGFC
| . ||.  |  ||.  | .   
LIKWCWHNDPNKRPTMNQIIQYL
Kinase T27C10.5.AA Pkinase_Tyr 2025-2048 37 0.452544 4.25 Pfam 247-270 (270) Show / Hide 
Range on Protein: 2025-2048
Range on HMM: 247-270/270
Sequence Identity: 37% (9 aa)

DLLVHCWSAHPESRPSSSQLVGFC
||. .|| . || ||. |... . 
DLMKQCWHYDPEDRPTFSEIHEQL