Gene R13H9.6 (Nematode worm)
R13H9.6
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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R13H9.6.AA | Protein | Genbank | 380 | None | Fasta, JSON |
R13H9.6.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 256 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of R13H9.6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | R13H9.6.AA | Worm6 | 24-293 | 50 | 6.30000000001e-161 | 540.91 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 24-293 Range on HMM: 1-279/279 Sequence Identity: 50% (141 aa) YKVIALLGKGGYGAVYSVLRLSDME--KFAIKCEK--ATAGKKVLLMDCNVMKGATQIKSRHFSTVLDRANVKDR-FNFIVMKLIGKNLWDLRQDRGDGK .|| ...|.||.||||.|.. ||.. .||.|||| ... ...| |.|.|.| ....|.||| .. ||..|. | ||.|||.|.||||||||..| |.| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FTMGTSLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGR---KESNEHHVIFMLDFGLCREYVKRAEGKDLRAAR-TTAPFRGTTRYAPLASMLQQDQSR |.|||.|| |.||| .||.||..|..|||.|||||. || ||.|||| |.|||||.||..... .|..|| | |...||||.||||||.. .|.|.| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR KDDIESWLYMVVEWTSGGLPWRKLKAHDREKVLQYKQDLRTKPDILDDFLFLCPKKEFTRILKYLDTLGYYAVPDYKFI |||.|||.||.||...|.||||..|.||.......... ||.... .|.. |||.||..|..|.|.. |. |||||| KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | R13H9.6.AA | CK1 | 24-293 | 30 | 2.2e-114 | 386.3 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 24-293 Range on HMM: 1-339/339 Sequence Identity: 30% (105 aa) YKVIALLGKGGYG-AVYSV-----LRLSDM-----EKFAIKCEKA-TAGKKVLLMDCNVMKGATQIK---------SRHFST----------VLDRANVK .||. ..|.||.| ..| | .... |..|.|.|.. ..|.. .||.. .|. ..| . ..||.. . . ... WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED DRFNFIVMKLIGKNLWDLRQ-DRG-DGKFTMGTSLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGRKES-----------NEHHVIFMLDFGLCR-EYV |..|..|| | |.||.|||. .| ..||.|.|.|. | |.| ..|..|. |..||||||.||. ||.|| |||....|.|||..| |. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR KRAEGK----------DLRAART---TAPFRG-TTRYAPLASMLQQDQSRKDDIESWLYMVVEWTSGG--LPWRKLKAHDR----EKVLQYKQDLRTKPD .. ... .| .|. ...||| |.||......|...|.|.||..||.||..||. |. |||...|.... . | . |.. .... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEKK ILDDFLFLCPKK-------EFTRILKYLDTLGYYAVPDYKFI .. |. || | || |.||...| || |||..| MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | R13H9.6.AA | TTBKL | 24-297 | 30 | 1.8e-64 | 216.58 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 24-297 Range on HMM: 1-288/288 Sequence Identity: 30% (91 aa) YKVIALLGKGGYGAVYSVLRLSDMEK-FAIKCEKAT-AGK-KVLLMDCNVMKGATQIKSRHFSTVLDRANVKDRFNFIVMKLIGKNLWDLRQDRGDGK-F .... ..|.||.|.|| | ..| .. .| | || . .|. ... | .|.. .|.|| .... . ....||.|| | |.|| ||| . .| | WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGK-RKDYNFMVMTLCGPNLQDLRKMMPNKKRF TMGTSLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGRKESN--EHHVIFMLDFGLCREYVKRAE---------GKDLRAART---TAPFRGTTRYAPLA . ||.. . ||| .. .|. |..|||.||.|.. | .... . .... .|||..| |.. . .. .|..|. .|||||||||. .. SDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPN SMLQQDQSRKDDIESWLYMVVEWTSGGLPWRKLKAHDREKVLQYKQDLRTKPDILDDFLFLCPK-----KEFTRILKYLDTLGYYAVPDYKFIYFCV . ..|.|.||. ||.||..| | |||. .. |.... . |... ...|. .|. .||. . |.| .| || ||| || | MHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNME--DKMEIEHMKKNM-----KDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | R13H9.6.AA | TTBK | 93-293 | 43 | 1e-60 | 208.02 | In-house | 68-257 (257) | Show / Hide |
Range on Protein: 93-293 Range on HMM: 68-257/257 Sequence Identity: 43% (87 aa) DRFNFIVMKLIGKNLWDLRQDRGDGKFTMGTSLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGRKESNEHHVIFMLDFGLCREYVKRAEGKDLRAARTT |.||..||.| |||| ||| .|.|...| |. | | ||| || |.||||||| ||| || |. . .|||||| | |. |.| . |..| DKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKC-YMLDFGLARQYTN-ACG-EVRPPREV APFRGTTRYAPLASMLQQDQSRKDDIESWLYMVVEWTSGGLPWRKLKAHDREKVLQYKQDLRTKPDILDDFLFLCPKKEFTRILKYLDTLGYYAVPDYKF | |||| ||| . . .. |.|| | || || | |||||.| |...| . |. . ...|.. || .|| .. . |.| |||.. AGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRKIK--DKDQVGEMKEKYDH-RMLLKH----CP-HEFHQFMDHIKSLNYEDRPDYQL I | I |
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Kinase | R13H9.6.AA | Dual | 24-297 | 30 | 4.3e-48 | 159.77 | In-house | 1-282 (282) | Show / Hide |
Range on Protein: 24-297 Range on HMM: 1-282/282 Sequence Identity: 30% (89 aa) YKVIALLGKGGYGAVYSVLRLSD----MEKFAIKCEKATAGKKVLLMD--CNVMKGATQ----IK---SRHFSTVLDRANV-KDRFNFIVMKLIGKNLWD ||. ||| || . || | | | .....| | .| | . ||. . | ..| |. .. .|. ...|| . | | . WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE LRQDRGDGKFTMGTSLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGRKESNEHHVIFMLDFGLCREYVKRAEGKDLRAARTTAPFRGTTRYAPLASMLQ | . | ..| .| | | | .| ||| |||||.||| ||. | . . ..|.||.. | |. | | |.||.. . |. ||| | |.| IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGM--DETTVYMQDFRIVRKYID-PENKKHRTARKKVKMYGCGRYACRACMMQ QDQSRKDDIESWLYMVVEW--TSGGLPWRKLKAHDREKVLQYKQDLRTKPDILDDFLFLCPKKEFTRILKYLDTLGYYAVPDYKFIYFCV .|| ||||.|.| ||| . |..|||. |. .... |. . | . . ... .. | . . | ||| . | KDQGRKDDLECWIYMVFDLMDPEHGMSWRKEC--DCNMMIKQKDNFMYH---FDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL |
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Kinase | R13H9.6.AA | CK1-Unique | 24-236 | 28 | 9.2e-41 | 139.03 | In-house | 1-233 (337) | Show / Hide |
Range on Protein: 24-236 Range on HMM: 1-233/337 Sequence Identity: 28% (66 aa) YKVIALLGKGGYGAVYSVLRLSDM------EKFAIKCEKATAGKK--VLLMDCNVMKGATQIK-----SRHFSTVLDRANVKDRFNFIVMKLIGKNLWDL ..||...|.|||| |. | . . ... | | . | |. ||||. .|||. | | . . .||| ..|... . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHD-FHQHRDWWWIVMTMHGPSMEEC RQDRGDGKFTMG------TSLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGRKESNEHHVIFMLDFGLCREYVKRAEGKDLRAARTTAPFRGTTRYAPL . . .|| . . .. . ||| || | |..||..||.|. .. . |...|||.| || . .| | ..||||. .|.| CMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPC ASMLQQDQSRKDDIESWLYMVVEWTSG--GLPWR .. . ....|.|| |||.|| . . || |. SCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK |
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Kinase | R13H9.6.AA | CK1-A | 24-293 | 29 | 8.6e-34 | 116.71 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 24-293 Range on HMM: 1-261/261 Sequence Identity: 29% (80 aa) YKVIALLGKGGYGAVYSVLRLSDMEKFAIKCEKATAGKKVLLMDCNVMKGATQIKSRHFSTVLDRANVKDRFNFIVMKLIGKNLWDLRQDRGDGKFTMGT |... .| | .| .| . . . | ||| |.. | |. . | . . . ... . || .| .|| |.| | || . .||| | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYR--ILQGCVGIPHMRWYGCEKD-YNVMVMDLLGPSLEDL-FNFCKRRFTMKT SLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGRKESNEHHVIFMLDFGLCREYVKRAEGKDLRAARTTAPFRGTTRYAPLASMLQQDQSRKDDIESWLY | | | . || .| ...|||||| || | . .|..|||| . | . .. . |. || ||| . | .|||.||.|| | VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNK--LFLIDFGLAKKY-RDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGY MVVEWTSGGLPWRKLKAHDREKVLQYKQDLRTKPDILDDFLFLCPKKEFTRILKYLDTLGYYAVPDYKFI ... . | ||| .|| | .| . . | . . | ||. ...| |.. .||| .. VMMYFNRGKLPWQGMKAM--TKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | R13H9.6.AA | CK1-D | 24-293 | 28 | 3.3e-28 | 96.51 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 24-293 Range on HMM: 1-261/261 Sequence Identity: 28% (79 aa) YKVIALLGKGGYGAVYSVLRLSDMEKFAIKCEKATAGKKVLLMDCNV---MKGATQIKSRHFSTVLDRANVKDRFNFIVMKLIGKNLWDLRQDRGDGKFT |.. .| | .| .| .. | ||| | . . | .. . |.| | . .| .|| |.| | || . || YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGI------PEIRWCGQEGDYNVMVMDLLGPSLEDL-FNYCHRKFS MGTSLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGRKESNEHHVIFMLDFGLCREYVKRAEGKDLRAARTTAPFRGTTRYAPLASMLQQDQSRKDDIES . | | | | . ||..|. ..|||||| || | ......|||| . | . |. . . | || ||| . . .|||.||.|| LKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGL--GKRGNMVYIIDFGLAKRY-RDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLES WLYMVVEWTSGGLPWRKLKAHDREKVLQYKQDLRTKPDILDDFLFLCPKKEFTRILKYLDTLGYYAVPDYKFI |... . | ||| ||| | .| . | .. | | .||.. . | .| . ||| .. LGYVLMYFNRGSLPWQGLKAA--TKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | R13H9.6.AA | CK1-G | 95-293 | 32 | 4.8e-25 | 81.77 | In-house | 70-266 (266) | Show / Hide |
Range on Protein: 95-293 Range on HMM: 70-266/266 Sequence Identity: 32% (66 aa) FNFIVMKLIGKNLWDLRQDRGDGKFTMGTSLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGRKESNEHHVIFMLDFGLCREYVKRAEGKDLRAARTTAP .| .|| | | | || | | ||.. | . | | . .| .|| . ||.|| || ||. ....|||.. |||. ..|. .. . | YNIMVMDLLGPSLEDL-FDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHI-PYREHKS FRGTTRYAPLASMLQQDQSRKDDIESWLYMVVEWTSGGLPWRKLKAHDREKVLQYKQDLRTKPDILDDFLFLC--PKKEFTRILKYLDTLGYYAVPDYKF || || | . ||| ||.|. | | ||| ||| | | ..|. || . . | ..| . |.| | . ||| . LTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKA-DNNK-ERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDY I . L |
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Kinase | R13H9.6.AA | CK1 | 24-244 | 29 | 2.4e-23 | 77.37 | In-house | 1-225 (271) | Show / Hide |
Range on Protein: 24-244 Range on HMM: 1-225/271 Sequence Identity: 29% (70 aa) YKVIALLGKGGYGAVYSVLRLSDMEK--FAIKCEKATAGKKVLLMDCNVMKGATQIKS-------RHFSTVLDRANVKD-RFNFIVMKLIGKNLWDLRQD |.|. .| | | .| . .....|. ||| ||... |. ..| . . .. .. . . .|..|| | |..| || . YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYK---ILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FN RGDGKFTMGTSLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGRKESNEHHVIFMLDFGLCREYVKRAEGKDLR-----AARTTAPFRGTTRYAPLASML ..||.. | | | | . ||..|. ...|||||| || || ...|.... |||| .|. | . |. .. ||.||| . . | FCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYR------DDKTHQHIPYRENKNLTGTARYASINTHL QQDQSRKDDIESWLYMVVEWTSGGLPWRKLKAHDRE |||.|| || |. . | ||| ||| .. GIEQSRRDDMESLGYVLMYFLRGSLPWQGLKANTKK |
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Kinase | R13H9.6.AA | S_TKc | 24-279 | 17 | 2.4e-12 | 4.2 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 24-279 Range on HMM: 1-231/231 Sequence Identity: 17% (49 aa) YKVIALLGKGGYGAVYSVLRLSDMEKFAIKCEKATAGKKVLLMDCNVMKGATQIKSRHFSTVLDRANVKDRFNFIVMKLIGK---NLWDLRQDRGDGK-- |... ..|||..| || . .. ...|||. | . .. ...| . . . .| . ..|| ... .| |. ..|| .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --FTMGTSLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGRKESNEHHVIFMLDFGLCREYVKRAEGKDLRAARTTAPFRGTTRYAPLASMLQQDQSRKD |. . . . | . .|..|| | .|||.|| | . .| ||||.|.. | || | . . FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL---------------TTFCGTPWYMAPEVL--------- DIESWLY----------MVVEWTSGGLPWRKLKAHDREKVLQYKQDLRTKPDILDDFLFLCPKKE------FTRILK---------YL .. . .. | .| |.. . ..... .. . ||. | .|. .|. .. ---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | R13H9.6.AA | TTBK | 24-72 | 38 | 7.7e-09 | 27.41 | In-house | 1-50 (257) | Show / Hide |
Range on Protein: 24-72 Range on HMM: 1-50/257 Sequence Identity: 38% (19 aa) YKVIALLGKGGYGAVYSVLRLSDM-EKFAIKCEKATAGKKVLLMDCNVMK ||.. | ||.| .|. . . |. ||| |.| . | || | |.| WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLK |
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Kinase | R13H9.6.AA | Pkinase | 24-56 | 27 | 1e-05 | 21.26 | Pfam | 1-33 (293) | Show / Hide |
Range on Protein: 24-56 Range on HMM: 1-33/293 Sequence Identity: 27% (9 aa) YKVIALLGKGGYGAVYSVLRLSDMEKFAIKCEK |... .|.|..| || . .. ...|.|. | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK |
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Kinase | R13H9.6.AA | TyrKc | 24-279 | 17 | 0.000535 | -157.99 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 24-279 Range on HMM: 1-280/280 Sequence Identity: 17% (52 aa) YKVIALLGKGGYGAVYS-VLRLSDMEKFAIKCEKATAGKKVLLMDCNVMKGA-TQ----IKSRHFSTV-LDRANVKDRFNFIVMKLIGK-NLWDLRQDRG . . || | .| || ... .. |.|. |. | .. .. ..|. . .. | . . . .||| . . .| | .... ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKHR DGKFTMGTSLKAASQCLVSIEHLHSFGYLHRDIKPGNFAAGRKESNEHHVIFMLDFGLCREYVKR----AEGKDLRAA-RTTAPFRGTTRYAPLASMLQQ . ..| . |. . | |.||| .. |||. | |.. .. ||||.|. .... |.. . . . | .. .. PK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--- DQSRKDDIES--WLYMVVEW---TSGGLPWRK-----LKAHD-REKVLQY-KQDLRTK---------PDILDDFLFLCPKK------EFTRILKYL . .| ..| | . |. | | |. |. ... . .|.| | . || . . | . |. | ... -NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | R13H9.6.AA | Pkinase | 116-153 | 35 | 0.001137 | 14.06 | Pfam | 100-139 (293) | Show / Hide |
Range on Protein: 116-153 Range on HMM: 100-139/293 Sequence Identity: 35% (14 aa) DGKF--TMGTSLKAASQCLVSIEHLHSFGYLHRDIKPGNF .|.| .. . . . | | .|..|| | .|||.|| |. HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI |
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Kinase | R13H9.6.AA | CK1 | 270-291 | 36 | 0.004896 | 6.53 | In-house | 250-271 (271) | Show / Hide |
Range on Protein: 270-291 Range on HMM: 250-271/271 Sequence Identity: 36% (8 aa) KEFTRILKYLDTLGYYAVPDYK .||.. |.| |... |||. NEFAMYLNYCRQLHFEEKPDYM |