Gene R10D12.10 (Nematode worm)
R10D12.10
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| R10D12.10.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 263 | Kinase domain by global Sugen HMM | Fasta, JSON |
| R10D12.10.AA | Protein | Genbank | 425 | None | Fasta, JSON |
Protein domains of R10D12.10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | R10D12.10.AA | TTBKL | 27-287 | 38 | 5.5e-128 | 431.48 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 27-287 Range on HMM: 1-288/288 Sequence Identity: 38% (112 aa) WFSIGEIAKGDLSTVSRVIDSEG-KIEAAMKVEKLSKD--SKKRSIEKDVLEALR--DSPHSAHIIEQLLIGDYRFTVMTLSGPTLGIIKHIMDNK--FS | ...|..| .| .|.|... | .||||.|| ... ... .| .|| .| .||| ...... ..||.| |||| || |. ... | || || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS DSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPYKS----SRNILLLDFGEARQFARNDNG--------KWMLRKPRD---KAPFRGSDQYCSPRM |.|..|.....|.|.|..|..||||||. | |... ... .|...|.||| |||.|..|.. |||.|.||. ||||||. .||||.| DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HNHEEQGRVDDLWSWLYVFVELRAFLPWTDSTSRFKYGPLKRELLDDLLASDP-----FITTFCPIVTLLREGKYADRPDYGKIYEIL |.. ||||.||||||.|...||.. ||||..... ... .|....|..|..|. . ||.... ||. .|.|||||..|||.. HDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | R10D12.10.AA | CK1 | 27-283 | 25 | 1.3e-83 | 284.06 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 27-283 Range on HMM: 1-339/339 Sequence Identity: 25% (88 aa) WFSIGEIAKGDLS-TVSRV-----IDSEGK-----IEAAMKVEKLSKD--SKKRSIEKDVLEALRDS----------------PHSAHIIEQLLIGD--- | . |..| .. .| .|.... |.|||||. . . .. .| ....|.. .. ... .. .. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED --YRFTVMTLSGPTLGIIKH---IMDNKFSDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPY-------------KSSRNILLLDFGEAR-QFA |.. |||| ||.|. .. ...|||..|.|.. ...|.|....|..||||||. | |.... . . .|.. ..||| || ... DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR RNDNG---------KWMLRKPRD---KAPFRG-SDQYCSPRMHNHEEQGRVDDLWSWLYVFVELR-AF--LPWTDSTSRFK-----YGPLKRELLDDLLA ..|.. .|..| ||. |..||| |||...|.. ||||.||||||.|...|. |||.. .. | . |.| |. . DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM SDP-----------FITTFCPIVTLLREGKYADRPDYGKI |.| . | .|.. .|. || ||||| .| STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | R10D12.10.AA | Worm6 | 28-283 | 30 | 2.6e-39 | 136.9 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 28-283 Range on HMM: 1-279/279 Sequence Identity: 30% (85 aa) FSIGE-IAKGDLSTVSRVIDSEGKI--EAAMKVEK--LSKDSKKRSIEKDVLEAL--RDSPHSAHIIEQLLIGD--YRFTVMTLSGPTLG-IIKHIMDNK ..... |..|. ..| | |...| . |||.|| . ... .| || |. . ..| |... .. ... |||| |. |. ..|. .|.| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPY-----KSSRNILLLDFGEAR-QFARNDNGKWMLRKPR-DKAPFRGSDQYCSPRMHNHEEQ || .| |... .| || ||| .||||||. | | . | . ...| .|||| .| ...|.... ||.|| ....||| .|.. |.. || FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNE--LRTPRWTACGFRGTVRYAPLACHKGQEQ GRVDDLWSWLYVFVELRAF-LPWTDSTSRFKYGPLKRELLDDL------LASDPFIT-TFCPIVTLLREGKYADRPDYGKI .| ||. ||.|. ||. . ||| .. .. ...|.. ... . |. . | | . . ...| ||||| .| CRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | R10D12.10.AA | TTBK | 94-232 | 39 | 3.4e-24 | 82.41 | In-house | 69-207 (257) | Show / Hide |
Range on Protein: 94-232 Range on HMM: 69-207/257 Sequence Identity: 39% (56 aa) DYRFTVMTLSGPTLG-IIKHIMDNKFSDSTILRLSMRTLMAIKDLHEHGFIHRDLEP--FNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDK .. . ||.| | | . . .|| || ||| . | .|. |. || ||| | | . . |.. |.. .|||| |||. |.. | || KFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPST-CRKCYMLDFGLARQYT---NACGEVRPPREV APFRGSDQYCSPRMHNHEEQGRVDDLWSWLYVFVE-LRAFLPW | ||| | | | | || ||||| |. || . ||| AGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPW |
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| Kinase | R10D12.10.AA | CK1-Unique | 27-226 | 26 | 1e-22 | 75.59 | In-house | 1-223 (337) | Show / Hide |
Range on Protein: 27-226 Range on HMM: 1-223/337 Sequence Identity: 26% (61 aa) WFSIGEIAKGDLSTVSRVIDS-EG-----KIEAAMK--VEKLSKDSKKRSIEKDVLEALR-------DSPHSAHIIEQLLIGDYRFTVMTLSGPTLGIIK | | .| .|. .| |||.. .| . . .|| . .| . .||. |. .. .. | .. . .|. . |||. || . .. WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC HIMDN-KFSDS------TILRLSMRTLMAIKDLHEHGFIHRDLEPFNIAL-SPY-KSSRNILLLDFGEARQ--FARNDNGKWMLRKPRDKAPFRGSDQYC | | .| . ...... .| .| |.|||.||.. | |. . .| . . ||.|. | | | . .|.|| ..|||| || MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNH---QIRQPRPITPFRGCKDYC SPRMHNHEEQGRVDDLWSWLYVFVEL . | .|.|| ||. ||.| .. | PCSCHQCREHGRRDDMESWFYMLYHL |
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| Kinase | R10D12.10.AA | CK1-A | 94-283 | 29 | 2.5e-13 | 43.27 | In-house | 68-261 (261) | Show / Hide |
Range on Protein: 94-283 Range on HMM: 68-261/261 Sequence Identity: 29% (57 aa) DYRFTVMTLSGPTLGIIKHIMDNKFSDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDKAPF || || | || | . . . .|. |.| | .| | .||..|||||. | | . . . |.||| |... | . . . || DYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY-RDSRTRQHIPYREDKN-L RGSDQYCSPRMHNHEEQGRVDDLWSWLYVFVEL-RAFLPW---TDSTSRFKYGPLKRELLDDLLAS--DPFITTFCPIVTLLREGKYADRPDYGKI | | | | || | ||. | ||.. |. ||| . | . || . . .. | . || ... |. .. . ||| . TGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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| Kinase | R10D12.10.AA | CK1-D | 93-283 | 29 | 8.1e-13 | 41.4 | In-house | 67-261 (261) | Show / Hide |
Range on Protein: 93-283 Range on HMM: 67-261/261 Sequence Identity: 29% (58 aa) GDYRFTVMTLSGPTLGIIKHIMDNKFSDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDKAP ||| || | || | . . ||| |.| |. . |. .| . |||||. | | . | . ..||| |... . . |.. GDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPY--RENKN FRGSDQYCSPRMHNHEEQGRVDDLWSWLYVFVEL-RAFLPWT---DSTSRFKYGPLKRELLDDLLAS--DPFITTFCPIVTLLREGKYADRPDYGKI | | | | || | ||| | ||.. | ||| | | || . .. . . . | . |. |. |.||| . LTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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| Kinase | R10D12.10.AA | S_TKc | 27-292 | 17 | 6.4e-11 | -16.73 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 27-292 Range on HMM: 1-231/231 Sequence Identity: 17% (50 aa) WFSIGEIAKGDLSTVSRVIDSEGKIEAAMKVEKLSKDSKKRSIEKDVLEALRDSPHSAHIIEQLLIGDYRFTVMTLSGPTLGIIKHIMDNK--------F . . .| || ..| .... . . . |.|. | .. | ..|. . |. .... |. . || . . || ....... | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF SDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDKAPFRGSDQYCSPRMHNHEEQGR-VDDLW . .. .. .. |.. .|.||.||||| | || |. .| . ||| |||. | |. |..| . |. | | PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------------TTFCGTPWYMAPEVL---GYGKCKCDWW SW---LYVFVELRAFLPWTDSTSRFKYGPLKRELLDDLLASDPFITTFCPIVTLLREGKYADRPDYGKIYE----ILAAKMT | || .. . | .... .. .. .. . . ..|| .. . | . SCGCILYEMLCGYPPFP------------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | R10D12.10.AA | MSK | 132-218 | 28 | 2.8e-09 | 27.49 | In-house | 112-195 (277) | Show / Hide |
Range on Protein: 132-218 Range on HMM: 112-195/277 Sequence Identity: 28% (26 aa) MAIKDLHEHGFIHRDLEPFNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDKAPFRGSDQYCSPRMHNH--EEQG---RVDDLWS ||.. .|. |.||||| | || . .... . | ||| || | .. . . .... .| .| | . ...| . |.|| MAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKS--------PCFTLHYMAPEMLRRGYAQDGGYDEACDWWS |
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| Kinase | R10D12.10.AA | Dual | 97-221 | 28 | 3.3e-09 | 26.97 | In-house | 88-211 (282) | Show / Hide |
Range on Protein: 97-221 Range on HMM: 88-211/282 Sequence Identity: 28% (36 aa) FTVMTLSGPTLG-IIKHIMDNKFSDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDKAPFRG . || . ||.| | . . . .| .. . .| ||.||| |..||. | | . . ..||. .| . |.| | .| | . | YWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKK--HRTARKKVKMYG SDQYCSPRMHNHEEQGRVDDLWSWLY | . . .||| ||| .| | CGRYACRACMMQKDQGRKDDLECWIY |
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| Kinase | R10D12.10.AA | RSK | 132-202 | 34 | 1.1e-08 | 28.18 | In-house | 115-177 (278) | Show / Hide |
Range on Protein: 132-202 Range on HMM: 115-177/278 Sequence Identity: 34% (25 aa) MAIKDLHEHGFIHRDLEPFNIALSPYKSS-RNILLLDFGEARQFARNDNGKWMLRKPRDKAPFRGSDQYCSP .|.. ||..|.||||| | || . . . . | | ||| ..|| |.|...|. |... .|. | LAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF-RCDHNQWTMT-------FCYTIEYMAP |
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| Kinase | R10D12.10.AA | TTBK | 273-283 | 63 | 0.078663 | 2.29 | In-house | 247-257 (257) | Show / Hide |
Range on Protein: 273-283 Range on HMM: 247-257/257 Sequence Identity: 63% (7 aa) KYADRPDYGKI .|.||||| | NYEDRPDYQLI |
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