Gene R09D1.12 (Nematode worm)

R09D1.12

Species: Nematode worm
Alias: aSWK391, CE28068, R09D1.12
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: II:1.27, WormBase Physical Map location: II: 9452342-9450027,

Classification

Group: TK
Family: KIN16

Sequence

Name Sequence Type Origin Length Description Download
R09D1.12.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 301 Kinase domain by global Sugen HMM Fasta, JSON
R09D1.12.AA Protein Genbank 473 None Fasta, JSON

Protein domain

Protein domains of R09D1.12.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase R09D1.12.AA KIN16 160-460 48 6.1e-232 688.03 In-house 1-332 (332) Show / Hide 
Range on Protein: 160-460
Range on HMM: 1-332/332
Sequence Identity: 48% (160 aa)

DTFNRKLGKGKFGIINKGLLTLRICKT--NEVVQVNVAVKKMVDPTDEKQDKLIYDEIKLMCAIGKHPNVLAIVGAITKKEKVSGREYNQAVSEFIEGGD
..|...||.|.||...||||... .|.  .......||||....|.|..|.|.||||.|.||||||||||||.|||.||.....||.... |.|..|.||
LEFEEPLGSGHFGVVRKGLLHMKNPKNEKEHKNRLEVAVKSPANPHDICQQKMIYDELKVMCAIGKHPNVLALVGAVTKNMRQGGRHMLMIVTEYVECGD

LRSVLRNSP--YTFQDEITSRERTGGQNVD--------------------AEVFDTISTSDLFSFAYQIANGMEYLASLPC-VHRDLALRNVFVKKNKII
||..||. .  ..........||..|.|..                    ...||...||||.|||||||||||.||. || ||||||.||||.|.||||
LRKFLRQHRNNFQNHQVCWDNERQSGYNINNKERKHYVFKNFCENEQLVIKDIFDSLCTSDLLSFAYQIANGMEWLAHVPCCVHRDLACRNVFIKRNKII

RIGDFGLARHNGDKDYYKVKYSPETPLPIFWLAPECFDDG----TSFTEMTDVWSYGVCLFELFSLGASPYLEEFQNF--FDPIYYVVAFLESGKRLSSP
||.||||||.. .||||..|.|..||||..|.|||||...    . |||..|||||||||.|.|||| .|| .  .|.  .|...||...|..|.||..|
RIADFGLARWHENKDYYRMKSSMDTPLPMRWMAPECFEEEQERKMKFTEKSDVWSYGVCLYEIFSLGETPYPNCPNNNCRDDYFQYVMEYLRKGNRLPQP

KYCRSDIYNFMLECWNSDAKQRPRFTKCKEFF
..|...||.||. ||| |...||.|..|.|||
EHCHPEIYDFMKMCWNFDPEKRPTFSECVEFF
Kinase R09D1.12.AA TyrKc 160-460 32 3.9e-114 386.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 160-460
Range on HMM: 1-280/280
Sequence Identity: 32% (104 aa)

DTFNRKLGKGKFGIINKGLLTLRICKTNEVVQVNVAVKKMVDPTDEKQDKLIYDEIKLMCAIG-KHPNVLAIVGAITKKEKVSGR---EYNQAVSEFIEG
 |...||| | ||.. || ..           ..||||.. . .     . ...|...|| .| .|||.....|..|...        |    | |. ..
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPH

GDLRSVLRNSPYTFQDEITSRERTGGQNVDAEVFDTISTSDLFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKNKIIRIGDFGLARHNGDK-------
|||.. ||..  .                       ....|| ||..|||.|||||.| .|.||||| ||. |..|....|.||||.|  .|.       
GDLKDYLRKHRPK-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESK

DYYKVKY--SPETPLPIFWLAPECFDDGTSFTEMTDVWSYGVCLFELFSLGASPYLEEFQNFFDPIYYVVAFLESGKRLSSPKY--------CRSDIYNF
|||..|   .  |.||| |.||||...|. ||. .||||.|||..|.|..|..|| .. |. . . . |......|.|.  |..        | ...|. 
DYYRKKEHKGGKTMLPIRWMAPECINYGK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQI

MLECWNSDAKQRPRFTKCKEFF
|..||. |...||.|. ..|.|
MKQCWHEDPEDRPTFSEIHECF
Kinase R09D1.12.AA TK 160-460 22 2e-98 330.62 In-house 1-486 (486) Show / Hide 
Range on Protein: 160-460
Range on HMM: 1-486/486
Sequence Identity: 22% (112 aa)

DTFNRKLGKGKFG---IINKGLLTLRIC-------------------KTNEVVQVNVAVKKMVDPTDEKQDKL--------------IYDEIKLMCA-IG
 |. .|||.| ||    . ||..  |.                    |......| |...|  |...... ..                 |.|.||. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHPNVLAIVGAITKKEKV------SGREYNQAVSEFIEGGD----LRSVLRNSPYTFQD-------------------------EITSRERTGGQNVD--
.|||.. ..|..|..| .      ...|    | |. ..||    ||. ||... .||.                          . |.|..... ..  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY-SHESNSPC-PEEQ

-------AEVFDTISTSDLFS-------------------FAYQIANGMEYLASLPC------VHRDLALRNVFVKKNKI-----------IRIGDFG--
       ........|.|| .                   ...|||.|||||.|..|      |||||| ||. | .|..           ..|.|||  
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARHNGDKDYYKVKYSPET----------------------PLPIFWLAPECFDDGT--------SFTEMTDVWSYGVCLFELFSLGASPYLEE
      |||  ...|.| .| |. |                       ||| |.||||..|..         ||. .||||.||...|.|..|. || ..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

FQNFFDPI----YYVVAFLESG--------------KRLSSPKYCR--------------SDIYNFMLECWNSDAKQRPRFTKCKEFF
  |.   .      |. .|..|               |.  |..|                ..| .|..||. |...||.|. ..|..
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase R09D1.12.AA Pkinase_Tyr 161-460 33 1.9e-93 317.14 Pfam 2-270 (270) Show / Hide 
Range on Protein: 161-460
Range on HMM: 2-270/270
Sequence Identity: 33% (103 aa)

TFNRKLGKGKFGIINKGLLTLRICKTNEVVQVNVAVKKMVDPTDEKQ--DKLIYDEIKLMCAIGKHPNVLAIVGAIT-KKE-KVSGREYNQAVSEFIEGG
||..|||.| || . || ..       .  .. ||||.. . ....|   .    |.|.|. .|.|||..  .|..| ..| .     .   | |. ..|
TFGKKLGEGAFGEVYKGTWKG----DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHG

DLRSVLRNSPYTFQDEITSRERTGGQNVDAEVFDTISTSDLFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKNKIIRIGDFGLARHNGDKDYYKVKYS
||.. ||.                      |  . ....|| ....|||.|||||.| .|.||||| ||. |..|....|.||||||   ..||| .. .
DLLDYLRKHR--------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKR

PETPLPIFWLAPECFDDGTSFTEMTDVWSYGVCLFELFSLGASP-YLEEFQNFFDPIYYVVAFL-ESGKRLSSPKYCRSDIYNFMLECWNSDAKQRPRFT
 ...|||.|.||||. .|  ||. .||||.||...|.|..|..| | .   |.      |.... |.| |.  |..|  .||. |..||. |...||.|.
GGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEE-----VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFS

KCKEFF
 . |..
EIHEQL
Kinase R09D1.12.AA TK-Unique 161-460 30 3e-67 229.74 In-house 2-294 (294) Show / Hide 
Range on Protein: 161-460
Range on HMM: 2-294/294
Sequence Identity: 30% (97 aa)

TFNRKLGKGKFGIINKGLLTLRICKTNEVVQVNVAVKKMVDPTDEKQDKLIYDEIKLMCAIGKHPNVLAIVGAITKKEKVSGREYNQAVSEFIEGGDLRS
......|.|.|| . .| .. ..  ...  |..||||.  |. .. ...   .||..| ..|.|||.. ..|. ||..     |  . . |....|.|..
EVGDVIGEGAFGQVWRGEVWGIW--KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-----EPWMIIMEYCPCGNLQH

VLRNSP-YTFQDEITSRERTGGQNVD-------AEVFDT-ISTSDLFSFAYQIANGMEYLASLPC--VHRDLALRNVFVKKNKIIRIGDFGLARHNGDKD
 ||..  ...|   |      . |..       ...... ||  ||..||.|||.|||||||...  |||||. |||..  .|.. |.|||.||.  .  
YLRTCRPAMRQHQ-T------YGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--

YYKVKYSPET---PLPIFWLAPECFD--DGTSFTEMTDVWSYGVCLFELFSLGASPYLEEFQNFFDPIYYVVAFLESGKRLSSPKYC-RSDIYNFMLECW
    .|| ..   ..|| |.||| .   .|. .|. .||||.|| ..|.|.||| ||     .  ..   ..  .. |.|.  |..| . ..||.| .||
--NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPY----PGMPWKD--IMECIRDGYRMPQPEHCCSHEMYNLMKSCW

NSDAKQRPRFTKCKEFF
......|| |...|  .
QWEPEERPSFRQIKHRL
Kinase R09D1.12.AA Met 296-454 38 1.1e-52 170.87 In-house 105-271 (271) Show / Hide 
Range on Protein: 296-454
Range on HMM: 105-271/271
Sequence Identity: 38% (66 aa)

DLFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKNKIIRIGDFGLARHN-GDKDYYKVKYSPE-TPLPIFWLAPECFD--------DGTSFTEMTDVWS
||..|. |.| ||.|.||.  |||||| ||    .  .. ..||||.|    || || ..       ||. |.||||          .   ||  .||||
DLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKSDVWS

YGVCLFELFSLGASPYLEEFQNFFDPIYYVVAFLESG--KRLSSPKYCRSDIY-NFMLECWNSDAKQRPRFT
 || . ||.  ||.||  .  |.||    .  .|. |  .||. | ||   .|   ||.|| ... .|| | 
FGVVMWELMTRGAPPY-PHVDNWFD----ITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase R09D1.12.AA UTK 161-401 28 2.4e-48 163.5 In-house 2-241 (296) Show / Hide 
Range on Protein: 161-401
Range on HMM: 2-241/296
Sequence Identity: 28% (77 aa)

TFNRKLGKGKFGIINKGLLTLRICKTNEVVQVNVAVKKMV-DPTDEKQDK---LIYDEIK---LMCAIGKHPNVLAIVGAITKKEKVSGREYNQAVSEFI
 . |.||.| ||...|. .|     .. . .. ||||. . . .....      .  | .   .| .   |||||  ||  |. |          |.|. 
QLGRQLGQGAFGEVHKARFTQ---CSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP------WMIVTEYM

EGGDLRSVLRNSPYTFQDEITSRERTGGQNVDAEVFDTISTSD-LFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKN-------KIIRIGDFG---LA
|.|||||.||... |.                   .... |.. . ..|..||.||.||.|  .|||||| ||..| ..        ...|.|||   ..
ENGDLRSYLRRHRPTPP-----------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMS

RHNG-------DKDYYKVKYSPETPLPIFWLAPECFDDGTSFTEMTDVWSYGVCLFELFSLGASPY
|  .       ....| .. .. ...|| | |||.....| ||. .||||.|| ..|... |. ||
RRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPY
Kinase R09D1.12.AA KIN6 289-460 40 6.8e-48 156.26 In-house 135-305 (305) Show / Hide 
Range on Protein: 289-460
Range on HMM: 135-305/305
Sequence Identity: 40% (74 aa)

FDT---ISTSDLFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKNK---IIRIGDFGLAR-HNGDKDYYKVK---YSPETPLPIFWLAPECFDDGTSFT
.|.   |.  || .||.||..|||||.|  |.||||| ||| | .        |.||||.|    |.  |. |   |     ||| |.||||.  .  | 
YDDMMCIRHKDLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRY-----LPIKWMAPECL-KHYEFS

EMTDVWSYGVCLFELFSLGASPYLEEFQNFFDPIYYVVAFLESGKRLSSPKYCRSDIYNFMLECWNSDAKQRPRFTKCKEFF
  .||||.|| .||.|||| .|| .| |   .    . ....||.|.. ||.|   ||. |  ||...   || |.  .  |
YKSDVWSFGVLMFEMFSLGDVPY-PEMQRPTE----MIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase R09D1.12.AA EGFR 290-461 39 5.3e-47 154.0 In-house 96-258 (258) Show / Hide 
Range on Protein: 290-461
Range on HMM: 96-258/258
Sequence Identity: 39% (68 aa)

DTISTSDLFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKNKIIRIGDFGLARH-NGDKDYYKVKYSPETPLPIFWLAPECFDDGTSFTEMTDVWSYGV
|.|   .|  ...||| ||.||     |||||| ||| ||. . ..| |||||.  . |.. |...   .  .|| |.| ||.  .  .|   |||||||
DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQ---GGKMPIKWMALECIHHRC-YTHQSDVWSYGV

CLFELFSLGASPYLEEFQNFFDPIYYVVAFLESGKRLSSPKYCRSDIYNFMLECWNSDAKQRPRFTKCKEFFK
 . ||   |..||    ..   |   .  .|| |.||. |. |  |.|  |. ||  |.. ||.| .  | ||
TCWELMTFGQKPY----DGI--PAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase R09D1.12.AA Fer 291-461 31 6.9e-46 154.3 In-house 107-283 (283) Show / Hide 
Range on Protein: 291-461
Range on HMM: 107-283/283
Sequence Identity: 31% (58 aa)

TISTSDLFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKNKIIR---IGDFGLARHNGDKDYYKVKYS---PETPLPIFWLAPECFDDGTSFTEMTDVW
|.|. ... ..||.|.||||| |  |.|||.| ||. . |.|.     | |||..|.   .. |...|.   ... .|| |||||....|. ....||||
TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQ---CSDYGYDYKMKEKACKVPIRWLAPETWQTGI-YSPKTDVW

SYGVCLFELFSLGASPYLE---EFQNFFDPIYYV---VAF-LESGKRLSSPKYCRSDIYNFML-ECWNSDAKQRPRFTKCKEFFK
|.|| ..| |. || ||..   .    . .       ..   ..|...  |. . ..|...|.  ||. | ..|| ... .. .|
SFGVMCWEIFTNGAEPYPGQPHG----MKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase R09D1.12.AA FGFR 191-401 38 4e-39 130.98 In-house 31-239 (293) Show / Hide 
Range on Protein: 191-401
Range on HMM: 31-239/293
Sequence Identity: 38% (83 aa)

QVNVAVKKMVDPTDEKQDKLIYDEIKLMCAIGKHPNVLAIVGAITKKEKVSGREYNQAVSEFIEGGDLRSVLRNSPYTFQDEITSRE-------RTGGQN
.. ||||.. .   .|       |.  |  ||||.|..   |. |      |  |   . |. . | ||  ||      .|   . .       |.  | 
EITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQE----GPLY--VIVEYCHHGNLRDFLRARRPPGMDYKKDSQEYTDYKPRKPEQQ

VDAEVFDTISTSDLFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKNKIIRIGDFGLARHNGDKDYYKVKYSPETPLPIFWLAPECFDDGTSFTEMTDV
 | |.   ..  || |.|||.| |||||||  |.||||| ||| |  . .. | ||||||   . |||. | . .  ||| | |||  .|   .|   ||
DDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYR-KTT-NGRLPIKWMAPEALFD-RVYTHQSDV

WSYGVCLFELFSLGASPY
||||| | | . .| .||
WSYGVLLWEIMTYGGQPY
Kinase R09D1.12.AA VEGFR 290-401 50 8.1e-37 128.63 In-house 168-278 (332) Show / Hide 
Range on Protein: 290-401
Range on HMM: 168-278/332
Sequence Identity: 50% (57 aa)

DTISTSDLFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKNKIIRIGDFGLARH--NGDKDYYKVKYSPETPLPIFWLAPECFDDGTSFTEMTDVWSYG
| . . || ....|.|.|||.|||  |.||||| ||. .  |... | |||||||    | ||  |.    . ||| |.|||   |   .|   ||||||
DPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDY--VRKGDQGRLPIKWMAPESIFDKV-YTTYSDVWSYG

VCLFELFSLGASPY
| | | ||||.|||
VFLWEIFSLGGSPY
Kinase R09D1.12.AA S_TKc 160-460 19 1.6e-24 88.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 160-460
Range on HMM: 1-231/231
Sequence Identity: 19% (63 aa)

DTFNRKLGKGKFGIINKGLLTLRICKTNEVVQVNVAVKKMVDPTDEKQDKLIYDEIKLMCAIGKHPNVLAIVGAITKKEKVSGREYNQAVSEFIEG--GD
 .. ||.||| ||   |.  .          .  ||.|..         . |. ||...    .|||.  . ...         ..   | |...|  ||
YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGD

LRSVLRNSPY-----TFQDEITSRERTGGQNVDAEVFDTISTSDLFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKNKIIRIGDFGLARHNGDKDYYK
|...... ..      |    . .                       ..|||....||. |.  .||||   |... .   | |.||||||.        
LFDYIKKRGRHGLRFPFPE-HARF-----------------------YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------

VKYSPETPLPIFWLAPECFDDGTSFTE-MTDVWSYGVCLFELFSLGASPYLEEFQNFFDPIYYVVAFLESGKRLSSPKYCRSDIYNFMLECWNSDAKQRP
           ...||| .    ...    |.|| |..|.|... |  |.  . |  |. |                    ..  .|.  |.. | ..||
----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLC-GYPPFP-QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRP

RFTKCKE---------FF
   .. .         .|
TA-EALQDEWDIKCHPWF
Kinase R09D1.12.AA Pkinase 161-460 21 3e-21 76.22 Pfam 2-293 (293) Show / Hide 
Range on Protein: 161-460
Range on HMM: 2-293/293
Sequence Identity: 21% (72 aa)

TFNRKLGKGKFGIINKGLLTLRICKTNEVVQVNVAVKKMVDPTDEKQDKLIYD----EIKLMCAIGKHPNVLAIVGAITKKEKVSGREYNQAVSEFIEGG
.. ||.|.| ||   |.      .         ||||..  . .|| .|....    ||..|  . .|||.. . .. .      ....   | |. |||
HIGRKIGSGSFGCVYKCHHKGTGK--------IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-----KDHIY-MVMEYCEGG

----DLRSVLRNSPYTFQDEITSRERTGGQNVDAEVFDTI--STSDLFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKNKII----RIGDFGLAR---
    || ....                       .   ..  |  .. ...|||. |.||. |  ..|||| . |.....|  |    .|.|||||.   
LYVMDLFDYIST----------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD

HNGDKDYYKVKYSPETPLPIFWLAPECFDDGTSFTEMTDVWSYGVCLFELFSLGASPYLEE--FQNFFDPIYYVVAFLESGKRLSSPKYCR---------
.  .  .. .  .|.      ..|||   .|.  .   |.||.|. |.|... |  |. ..    |  |... ..  ..   . ..|. |.         
Y-NNS-MTTFCGTPW------YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW

----------SDIYNFMLECWNSDAKQRPRFTKCKEF--F
          ..   |.  |.. | |.|| .. ...   |
HFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase R09D1.12.AA FGFR 417-460 34 1e-10 32.66 In-house 250-293 (293) Show / Hide 
Range on Protein: 417-460
Range on HMM: 250-293/293
Sequence Identity: 34% (15 aa)

AFLESGKRLSSPKYCRSDIYNFMLECWNSDAKQRPRFTKCKEFF
..| .|.|.  |. | ..||  | .||   ..||| |..  | .
KYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase R09D1.12.AA VEGFR 418-460 37 1.1e-10 36.68 In-house 290-332 (332) Show / Hide 
Range on Protein: 418-460
Range on HMM: 290-332/332
Sequence Identity: 37% (16 aa)

FLESGKRLSSPKYCRSDIYNFMLECWNSDAKQRPRFTKCKEFF
.| .| |.  |.||   ||  ||.||  . ..||.|    | .
RLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase R09D1.12.AA UTK 415-460 27 2.7e-07 20.99 In-house 249-296 (296) Show / Hide 
Range on Protein: 415-460
Range on HMM: 249-296/296
Sequence Identity: 27% (13 aa)

VVAFLESG--KRLSSPKYCRSDIYNFMLECWNSDAKQRPRFTKCKEFF
|..... |   |. .|. |  ..|. |..||..|   ||.|    ...
VWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase R09D1.12.AA EGFR 163-232 30 4e-06 16.27 In-house 4-68 (258) Show / Hide 
Range on Protein: 163-232
Range on HMM: 4-68/258
Sequence Identity: 30% (21 aa)

NRKLGKGKFGIINKGLLTLRICKTNEVVQVNVAVKKMVDPTDEKQDKLIYDEIKLMCAIGKHPNVLAIVG
 ..|| | || . ||.    | .  | |.. ||.| . . |..|. . . || . |  . .||... ..|
VKVLGSGAFGTVYKGIW---IPE-GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASV-DHPHLVRLLG
Kinase R09D1.12.AA Fer 161-238 32 3.7e-05 13.62 In-house 2-82 (283) Show / Hide 
Range on Protein: 161-238
Range on HMM: 2-82/283
Sequence Identity: 32% (27 aa)

TFNRKLGKGKFGIINKG-LLTLRICK-TNEV-VQVNVAVKKM-VDPTDEKQDKLIYDEIKLMCAIGKHPNVLAIVGAITKKE
|.. |||.| ||.  ||   ||...| .. | ..| |.|||.  . ....| | .  | ..|    .|||| .. | .. ..
TLGKKLGEGAFGEVYKGRR-TLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQ
Kinase R09D1.12.AA VEGFR 214-236 43 0.011905 6.06 In-house 52-74 (332) Show / Hide 
Range on Protein: 214-236
Range on HMM: 52-74/332
Sequence Identity: 43% (10 aa)

EIKLMCAIGKHPNVLAIVGAITK
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ELKMLIHIGHHLNVVNFLGCCTK