Gene R06A10.4 (Nematode worm)
R06A10.4
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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R06A10.4.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 252 | Kinase domain by global Sugen HMM | Fasta, JSON |
R06A10.4.AA | Protein | Genbank | 391 | None | Fasta, JSON |
Protein domains of R06A10.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | R06A10.4.AA | PSK | 71-322 | 60 | 1.5e-205 | 663.32 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-258/258 Sequence Identity: 60% (156 aa) YEVLAVVGKGSFSQVLRVQHRVTRKYFAVKVVNGDCGAVN----NELNILSRLSHPFVIRLEEVFKSSSKLFIVMQMASGGEMYDRVVAKGRYSEEEARN |...|..||||||.|.||.|||||...|.|.|...|.... ||||||.|..||..|.|.|||........||.||.||||.||.|||||..|..|.. YDIKALIGKGSFSRVVRVEHRVTRQPYAIKMVETKCREGREFCENELNILRRVRHPYIIQLMEVFETQDRVYMVMEMATGGEMFDRIVAKGRFTERDATR ALKMLLTGLTYLHSIRVTHRDLKPENLLYADSRPEARLLITDFGLAYQATKPNE-TMTETCGTPEYIAPELLLRVPYTQKVDMWAVGVIAYILMSGIMPF .|.|.|.|..|||..|.||||||||||||.....|....|||||||||..|.|. .|..|||||||||||.|||.||||.|||||||||||||||||||| VLQMVLDGMRYLHALRITHRDLKPENLLYYHPGNESKIMITDFGLAYQRKKSNDWMMKTTCGTPEYIAPEVLLRKPYTQSVDMWAVGVIAYILMSGIMPF DDDCRSRLYTHIITANYVYYPQFWSG-SELAKQFVDSLLETNSVERLSSSAAMKHEWL |||||.|||.||.|..|.||.|.|.. |.|||.|.|.|||.|..||...|.||||.|. DDDCRTRLYRHILTGKYNYYGQPWPSVSHLAKDFIDKLLEINQGERMTASQAMKHPWV |
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Kinase | R06A10.4.AA | CAMK | 76-322 | 21 | 1.1e-101 | 328.43 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 76-322 Range on HMM: 1-425/425 Sequence Identity: 21% (90 aa) VVGKGSFSQVLRVQHRVTR------------KYFAVKVVNG--------------------------------DCGAVNNELNILSRLS-------HPFV . |.|||..| ...|. | . .|.|... |. | .|..|...|. || . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IRLEEVFK------------SSSK--------LFIVM---QMASGGEM----YDRVVAK---------------GRYSEEEARNALKMLLTGLTYLHSIR |.| ||. . || ...|| ..||||. .|..|.. ||..|.||| . .. .. |.|| IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN VTHRDLKPENLLYADSRPE--------------ARLLITDFGLAYQATK-----------------------PNETMTETCGTPEYIA-PELLLR----- . ||||||||.|. |. .. . . |.|||.| . .. ... |.. ||||||.| ||.|.. IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN ---------VPYTQKVDMWAVGVIAYILMSGIMPFDDD-------------CRSRLYTHIITANYVYYPQFWSG-------------SEL--------AK .|..|.|||..||| ||. .| .||..| . ..|. |....| ..| ..|. |. .| MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK QFVDSLLETNSVERLSSSAAMKHEWL ... ..|... .|.. . ...|.|. DLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | R06A10.4.AA | CAMK1 | 71-322 | 34 | 2.3e-98 | 286.52 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-276/276 Sequence Identity: 34% (96 aa) YEVLAVVGKGSFSQVLRVQHRVT---RKYFAVKVVN------GDC----GAVNNELNILS---RLSHPFVIRLEEVFKSSSKLFIVMQMASGGEMYDRVV ||. . |.|.||.| ...|. | | .|.|. . .. |. ||..|. ...||..| ..|.. | ... .||. .||| ||.| YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV AKGRYSEEEARNALKMLLTGLTYLHSIRVTHRDLKPENLLYADSRPEARLL--ITDFGLAYQATKPNE-TMTETCGTPEYIAPELLLR---VPYTQKVDM || |.|..||. | .| . |.|| . |||||||||||.| ... . | ||||. . ....| .|. ||||.|.||| | . || ...|| EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLS-KIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM WAVGVIAYILMSGIMPFDDDC-RSRLYTHIITANYVYYPQFWSG-SEL-AKQFVDSLLETNSVERLSSSAAMKHEWL | .||| ||| | || |. . |. |. . | . .| |. ||.|. .|| . .|.. . . .| |. WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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Kinase | R06A10.4.AA | S_TKc | 71-322 | 30 | 1e-89 | 305.25 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-231/231 Sequence Identity: 30% (81 aa) YEVLAVVGKGSFSQVLRVQHRVTRKYFAVKVVNGDCGAVNNELNILSRLSHPFVIRLEEVFKSSSKLFIVMQMASG--GEMYDRVVAKGR------YSEE ||.| ..|||.|..| ...|. | ...|.|... . .|..||.. ||....| .|| . ..|..|| ...| |...|. . .|| ..| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE- EARNALKMLLTGLTYLHSIRVTHRDLKPENLLYADSRPEARLLITDFGLAYQATKPNETMTETCGTPEYIAPELLLRVPYTQ-KVDMWAVGVIAYILMSG .|| .. .. .| |.|| .. ||||||||.| . .. |.||||| | | ||||.|.|||.| .|. |.|.|..|.| |....| HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG IMPFDDDCRSRLYTHIITANYVYYPQFWSGSELAKQFVDSLLETNSVERLSSSAAMK-------HEWL ||. ... .| |. ||.|.. .|. . .|.. |.. |.|. YPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | R06A10.4.AA | Pkinase | 71-322 | 29 | 5.4e-81 | 280.19 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-293/293 Sequence Identity: 29% (87 aa) YEVLAVVGKGSFSQVLRVQHRVTRKYFAVKVVNGDCGAVN---------NELNILSRLSHPFVIRLEEVFKSSSKLFIVMQMASGG----EMYDRVV--A |... ..|.|||..| . .|. |.| .|||... . .. .|. |. ||.||...|| ..| ..... .|| . || . .|.. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR KGRY--SEEEARNALKMLLTGLTYLHSIRVTHRDLKPENLLYA-DSRPEARLLITDFGLAYQA-TKPNETMTETCGTPEYIAPELLL-RVPYTQKVDMWA .|.. ||.|... .. .| || |.|| .. ||||||||.|. . ..|.. |.||||| |. . .|. || ||||.|.|||... . .|..|||||. HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS VGVIAYILMSGIMPFDDD------CRSRLYTHIITANYVYYPQFW-SGS-----------------ELAKQFVDSLLETNSVERLSSSAAMKHEWL .|.| |....| ||... . .. | . . . . | |.| | .|.|....|. . .|.. ...|.|. CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | R06A10.4.AA | CAMKL | 71-322 | 28 | 2.7e-80 | 255.92 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-297/297 Sequence Identity: 28% (87 aa) YEVLAVVGKGSFSQVLRVQH-RVTRKYFAVKVVN-----GDCGAVNN--------------ELNILSRLS---HPFVIRLEEVFKSSSK------LFIVM |... . |||||..| .| | |.. |.|... |. . .| | .|...|. || .|.| ||. ... ...|| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM QMASGGE--MYDRVVAK----GRYSEEEARNALKMLLTGLTYLHSIRVTHRDLKPENLLYADSRPEARLLITDFGLA--YQA--TKPNETMTETCGTPEY .|||| ..|..|.. || .|.||| . .. .. |.|| .. |||.||||.| .. . . |.|||.. |. .|...... ||.|.| EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY IAPELLLR--VPYT-QKVDMWAVGVIAYILMSGIMPFDDDC-------RSRLYTHIITANYVYYPQFWSGSELAKQFVDSLLETNSVERLSSSAAMKHEW |||.... || .|||.|. ||| | .. | .|||||. .. ..| |.| . . | .... ..|..| .| . |.|.| MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW L . M |
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Kinase | R06A10.4.AA | CAMK-Unique | 71-322 | 21 | 1.3e-75 | 249.04 | In-house | 1-363 (363) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-363/363 Sequence Identity: 21% (79 aa) YEVLAVVGKGSFSQVLRVQHRVTRKYFAVKVVNG-----DCGAV-------------------NNELNILSRLSHPFVIRLEEV----FKSSS------- |. . ..|.|.|. |.... |.|.| .|.|.|. . . . .|..|. ...|| |.|... | . YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI --------KLFIVMQMASGGEMYDRVVA--------------------KGRYSE--EEARNALKMLLTGLTYLHSIRVTHRDLKPENLLYADSRP----- ...|||. . ||...| ... .|..|| .... || . |.||. . |||||.||... | . IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH --------EARLLITDFGLAYQATKPNET--MTETCGTPEYIAP--------------ELLLRVPYTQKV----DMWAVGVIAYILMSGIMPFDDDCRS- .. ..||||. . . | ..||||.|.|| |.. ...| |.. | |. |||.|.. .|..||| .| RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR -------RLYTHIITANY-VYYPQFWSG----SELAKQFVDSLLETNSVERLSSSAAMKHEWL ... | ..| . . |.| |. ||.||. .... . |.|.. . .|.|. DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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Kinase | R06A10.4.AA | MARK | 71-322 | 33 | 2.5e-69 | 225.83 | In-house | 1-262 (262) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-262/262 Sequence Identity: 33% (89 aa) YEVLAVVGKGSFSQVLRVQHRVTRKYFAVKVVN----GD---CGAVNNELNILSRLSHPFVIRLEEVFK--SSSK-LFIVMQMASGGEMYDRVVAK--GR |..| . |.||...| ..|. |.. .|.|... | . | |..|...|.|| .|.| .|. ... ....| |||||.||...|. || YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR YSEEEARNALKMLLTGLTYLHSIRVTHRDLKPENLLYADSRPEARLLITDFGLAYQATKPNETMTETCGTPEYIAPELLLRVPYT-QKVDMWAVGVIAYI .||||| . .. .. |.||... |||.||||.| . . |.|||.. . .|.. .. ||||.| |||..|. ||. .|||.|. ||. |. LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENG-NHNIKIIDFGFSICI-PPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYF LMSGIMPFDDDC--RSRLYTHIITANYVYYPQFWSGSELAKQFVDSLLETNSVERLSSSAAMKHEWL . .| |||.|. || | . .| ... | ..... .|| .| || . . |||.|. MVCGYFPFDGDTQDYKELYKKILRGKYDIPCH---VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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Kinase | R06A10.4.AA | RAD53 | 71-322 | 27 | 2.5e-69 | 205.51 | In-house | 1-305 (305) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-305/305 Sequence Identity: 27% (84 aa) YEVLAVVGKGSFSQVLRVQHRVTRKYFAVKVVNG------------DCGAVNNELNILSRLSHPFVIRLEEVFKS-SSKLFIVMQMASGGEMYDRVVAKG | . ..|.| |..|... . |.. .|.| .. . |.||..|| .|.|| .||....| . . ...|. ..||| ....|. . YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK R----YSEEEARNALKMLLTGLTYLHSIRVTHRDLKPENLLYADSRPEA---------------RLLITDFGLAYQATKPNETMTETCGTPEYIAPELLL | ..| ... .. ..... |||. .|||||||| |... . | . ||||||. .. . |. |||| | ||| .. RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLS-KFVGEGSFMKTMCGTPQYVAPEVIT ---R------------VPYTQKVDMWAVGVIAYILMSGIMPFDDD------CRSRLYTHIIT-ANYVYYPQFWSG-SELAKQFVDSLLETNSVERLSSSA . | || |||.| |.| ||. .| ||.|| |.. |. |.. ..| ... |. || || .....| . .|.. SKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQ-LFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDE AMKHEWL |. | |. ALNHPWM |
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Kinase | R06A10.4.AA | DCAMKL | 71-322 | 29 | 8.7e-66 | 203.44 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-279/279 Sequence Identity: 29% (83 aa) YEVLAVVGKGSFSQVLRVQHRVTR-KYFAVKV----------------------VNGDCGAVNNELNILSRLSHPFVIRLEEVFKSSSKLFIVMQMASGG |.. ...|.| |. | . || |. . .| |. . | . . ||. |.....||..|.| |.. ....|| ..|| YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQGG EMYDRVVAKGRYSEEEARNALKMLLTGLTYLHSIRVTHRDLKPENLLYAD--SRPEARLLITDFGLAYQATKPNETMTETCGTPEYIAPELLLRVPYTQK .| .. ....| .|. . | |.|||. . |||.|||||| . . | | ||||| .. . |||| |.||| | . | | DLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDG-EKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCK VDMWAVGVIAYILMSGIMPF--DDDCRSRLYTHIITANYVYYPQFWSG-SELAKQFVDSLLETNSVERLSSSAAMKHEWL ||.||.||| ||| | || |. .| |. . . . |.. | || . .|. . | ... |.| | VDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV |
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Kinase | R06A10.4.AA | Ciliate-E2 | 71-322 | 19 | 2.9e-64 | 219.49 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-365/365 Sequence Identity: 19% (76 aa) YEVLAVVGKGSFS-----QVLRVQHR------------------VTRKYFAVKVVNGD-CGAVNNELNIL----------------SRLSHPFVIRLEEV |... . |.|.|. .| .||.. |. |..|.|... . ....|..|. ..|.||..|.. |. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FK--SSSKLFIVMQMASGGEMYDRVV------------AKGRYSEEEARNALKMLLT---------------GLTYLHSIR-VTHRDLKPENLLYADSRP |. . .....|| ..||...|. . ....|.|... | .| .| |||| . |||.||||.|. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- EARLLITDFGLAYQATKPNE-------------------------------TMTETCGTPEYIAPELLLRVP---------YTQKVDMWAVGVIAYILMS . |.||||. .....|. . .||||.| ||| | . . |. |.|.|..||| |.... ---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF GIMPFDDDCRSRLYTHIITANYVYYPQF---------------W-SGSELAKQFVDS----LLETNSVERLS-SSAAMKHEWL | || .| . . .|.. | . |. .|.. .|. . .|.. . ...|.|. GKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | R06A10.4.AA | RSK | 71-322 | 27 | 6.6e-63 | 215.31 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-278/278 Sequence Identity: 27% (76 aa) YEVLAVVGKGSFSQVLRVQHRVTRKYFAVKVVNGDCGAVN--------NELNILSRLS-HPFVIRLEEVFKSSSKLFIVMQMASGGEMYDRVVAKGR--- .|| |.|..... ...|. |....|.||.. ... | |||.| |||...| ..|. .||...|. .|||.... ... LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC YSEEEARNALKMLLTGLTYLHSIRVTHRDLKPENLLYADSRPE-ARLLITDFGLAYQATKPNETMTET-CGTPEYIAPELLL----RVPYTQKVDMWAVG ||.||. . . . .||. . |||||||| ||.| . . ... .||||.. |. .. .| | |.| ||.|||.| .. ... .| | | FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG VIAYILMSGIMPFDD---DCRSRLYTHIITAN-YVYYPQFWSGSELAKQFVDSLLETNSVERLS-----SSAAMKHEWL |. | . .| || . |. . . | ... . | . |. || .. .|. . ||. . .|.|. VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | R06A10.4.AA | TyrKc | 71-322 | 19 | 5.4e-11 | -44.88 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-280/280 Sequence Identity: 19% (57 aa) YEVLAVVGKGSFSQVLRVQHRVTRKYFAVKVVNGDCGAVN---NELNILSRL--SHPFVIRLEEVFKSS-------SKLFIVMQMASGGEMYDRVVAKGR . . . | | | .| . . . |||... |. . .|..|...| .|| ..|| | .. |.||| ...| |. .... ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP -YSEEEARNALKMLLTGLTYLHSIRVTHRDLKPENLLYADSRPEARLLITDFGLAYQATKP------NETMTETC--GTPE-----YIAPELLLRVPYTQ . .. . | |||| .. |||| | |... . . |.||||. . .. . . |. ||| . .| KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT KVDMWAVGVIAY-ILMSGIMPFDD-----DCRSRLYTHIITANYVYYPQF-------WSGSELAKQFVDSLLETNSVERLSSSAAMKHEWL | | |. || . |. | .| . .... .. . .. |. .|. . . . . .| . |. || . KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF |