Gene R05H5.4 (Nematode worm)

R05H5.4

Species: Nematode worm
Alias: R05H5.4, CE02291, aSWK350
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 10199671-10198235, WormBase Genetic Map location: II:2.17,

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
R05H5.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
R05H5.4.AA Protein Genbank 414 None Fasta, JSON

Protein domain

Protein domains of R05H5.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 R05H5.4.AA SH2 14-96 26 6.1e-11 43.59 SMART 1-87 (87) Show / Hide 
Range on Protein: 14-96
Range on HMM: 1-87/87
Sequence Identity: 26% (24 aa)

LPYFHGALMNIDADQLLVNE----GDFMVTMKKQLDINKLQLFLAVRLKKGIRRYEIKRTS-KTAKIGG---KTSQNIVKLINMLKADPIE
 |..|| .   .|.||| |.    |||.|    .   |. .. | || |.... | |.|.  .   |..   .. ...  |.|  .  |. 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES---NPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase R05H5.4.AA Fer 120-372 41 3.1e-133 448.92 In-house 1-283 (283) Show / Hide 
Range on Protein: 120-372
Range on HMM: 1-283/283
Sequence Identity: 41% (117 aa)

VIFQKKIGAGAYGTVYRGK----------LVKTDEVIAVKKLDPEGADEDGLAEMMKEARVMQL-YDHPNIVKFHGFILDDLPYLLVLEYCNGGAVEDRL
|...||.| ||.|.||.|.          .|...  ..|||.. |.|... ..|.|.|||.|.  |||||.|||.|.. |. |...|.|.||||.....|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RDKGEK-IKVPTRVKYTYMAACGMDYLHKKNCIHRDIASRNCLIHKGVVK----MADFGMCRAQSVYKVDLKKP-----CNIRWLAPEVWDNGETRFNTD
. ...| ... ......|.|||||.|||.|||||||||.||||.||..||    ..||||.|..|.|..| |..     ..|||||||.|..|.....||
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VYAFGIMMWEFFETPFKSPYV---EMKAAQV-----KRKTRAGYRLPPPPSMPSRMVEIMS-ECWQVDAEKRPTAEELKEKLE
|..||.|.||.|. . ....    .||...|     |.....||..|.|..||.....||   |||.| |.|||. |...||.
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase R05H5.4.AA TyrKc 120-371 33 1.7e-103 351.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 120-371
Range on HMM: 1-280/280
Sequence Identity: 33% (96 aa)

VIFQKKIGAGAYGTVYRGKLVKTDEVIAVKKLDPEGADEDGLAEMMKEARVMQLY--DHPNIVKFHGFILDD-------LPYLLVLEYCNGGAVEDRLRD
. . ||.| ||.|.||.|..    .  |||.| ..      ....|.|||.|  .  .|||||...| ....        |...|.||. .|.  |.||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KGEKIKVPTRVKYTYMAACGMDYLHKKNCIHRDIASRNCLIHKGV-VKMADFGMCRAQ----------SVYKV----DLKKPCNIRWLAPEVWDNGETRF
...|..... ... . .||||.|||.|||||||.| ||||....  || .|||..|.           ..|..    . | .  |||.|||... |.  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

NTDVYAFGIMMWEFFETPFKSPYVE----MKAAQVKRKTRAGYRLPPPPS--------MPSRMVEIMSECWQVDAEKRPTAEELKEKL
 .||..||..||| |    . .. .    |....| .. ..|||.|.||.        .|. | .||..||. |.|.||| .|..|..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase R05H5.4.AA Pkinase_Tyr 120-371 35 1.5e-102 347.98 Pfam 1-270 (270) Show / Hide 
Range on Protein: 120-371
Range on HMM: 1-270/270
Sequence Identity: 35% (96 aa)

VIFQKKIGAGAYGTVYRGKLV----KTDEVIAVKKLDPEGADEDG--LAEMMKEARVMQLY-DHPNIVKFHGFIL-DDLP--YLLVLEYCNGGAVEDRLR
..| ||.|.||.|.||.|..     .|.   |||.| .|||...   ....|.||..|  . .|||||...| .. .. |  ...|.||. .|   | ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

DK---GEKIKVPTRVKYTYMAACGMDYLHKKNCIHRDIASRNCLIH-KGVVKMADFGMCRAQ---SVY-KVDLKKPCNIRWLAPEVWDNGETRFNTDVYA
..   ........ ... .  |.||.||. |||||||.| ||||.. ..||| .|||..|.    . | ..  . .. |.|.|||.. .|.    .||..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGIMMWEFFETPFKSP-YVEMKAAQVKRKT-RAGYRLPPPPSMPSRMVEIMSECWQVDAEKRPTAEELKEKL
||. ||| |     .| | .|. ..|...  . |||.|.|.  |  . ..| .||. |.|.||| .|. |.|
FGVLMWEIFTYGE-QPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase R05H5.4.AA TK 120-371 19 1.3e-83 280.07 In-house 1-486 (486) Show / Hide 
Range on Protein: 120-371
Range on HMM: 1-486/486
Sequence Identity: 19% (93 aa)

VIFQKKIGAGAYG---TVYRGKLVK---------------------------TDEVIAVKKLDPEGADEDGLAEMMK----------EARVMQLYD----
... ||.|.|..|   .||.|..                             |.  ....|.. . ..|. ..|.|.          ||..|.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVKFHG-------------FILDDLPYLLVLEYCNGGA----VEDRLRDKGEK-------------------------------------------
 |||||...|             . ... |...|.||...|       | ||.. .|                                           
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------IKVPTRVKYTYMAACGMDYLHKK------NCIHRDIASRNCLIHKG------------VVKMADFGMC
                                . ..... . . .|||| |||.|      |..|||.| ||||....            |.| ||||..
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

R-----------------------------------AQSVYKVDLKKPCNIRWLAPEVWD---------NGETRFNTDVYAFGIMMWEFFETPFKSPYVE
|                                   .|. |. . .    |||.|||...         .|     .||..||..||| |    . .| .
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

MKA---------AQVKRKTRAG--------------YRLPPPPSMP--------------SRMVEIMSECWQVDAEKRPTAEELKEKL
|           ..| .. |.|              .|.|.|| .|                . ..| .||. |.|.||| ..|.|.|
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase R05H5.4.AA UTK 120-371 27 6e-67 228.05 In-house 1-296 (296) Show / Hide 
Range on Protein: 120-371
Range on HMM: 1-296/296
Sequence Identity: 27% (81 aa)

VIFQKKIGAGAYGTVYRGKLVK-----TDEVIAVKKLDPEGADEDGLA---EMMKEAR---VMQLYD-HPNIVKFHGFILDDLPYLLVLEYCNGGAVEDR
|.. ...|.||.|.|.......     .. . |||..........  .   . |.|||   .|.  . |||.... |  ... | ..|.||. .|   . 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRDKGEKIK-----VP--TRVKYTYMAACGMDYLHKKNCIHRDIASRNCLIHKG--------VVKMADFG---MCRAQS------------VYKVDLKKP
||. ...       .   .|... .  |.|| ||| ....|||.| ||||.|.         |.| ||||   |.|. .             |. .  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

CNIRWLAPEVWDNG-ETRFNTDVYAFGIMMWEFFETPFKSPYVEMKAAQVKRKTRAG--YRLPPPPSMPSRMVEIMSECWQVDAEKRPTAEELKEKL
  ||| |||. ...    . .||..||. .|| .    . || .| ..||    ..|  ||.|.|...| .. ..| .||. | ..||..|.| ...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW-GRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase R05H5.4.AA TKL 126-371 22 9.7e-59 201.46 In-house 1-364 (364) Show / Hide 
Range on Protein: 126-371
Range on HMM: 1-364/364
Sequence Identity: 22% (83 aa)

IGAGAYGTVYRGKLVKTD--------EVIAVKKLDPEGADEDGL-----------------------AEMMKEARVMQLYD--HPNIVKFHGFILDDLP-
|| |..|.||.||.  ..        ...||||.  .  ||. .                       ..  .|  .|..    |||||.| |. ..  . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YLLVLEYCNGGAVEDRLRDKGEKIKVPTRVKYTYMAACGMDYLHK--------KNCIHRDIASRNCLIHK-GV--------------V
            . .| ||| ||  ...|         . |..  . .|.||.|||         .. ||||. |.|.|... .               .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KMADFGMCR--------------------AQSVYKVDLKKPC-NIRWLAPEVWDNGETRFNT----------------DVYAFGIMMWEFFE--TPFKSP
| .||| .|                    .| ...  . ..| ..||.|||| .. .   .                 |||.|||..|| .   .|.. .
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

YVEMKA------AQVKRKTRAGYRLPPP------------PSMPSRMVEIMSECWQVDAEKRPTAEELKEKL
  ..        .  .     |.|.|.|            |..| .| ..| .||. |.||||...|....|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase R05H5.4.AA SFK-Src 120-375 34 6.9e-55 160.79 In-house 1-259 (259) Show / Hide 
Range on Protein: 120-375
Range on HMM: 1-259/259
Sequence Identity: 34% (90 aa)

VIFQKKIGAGAYGTVYRGKLVKTDEVIAVKKLDPEGADEDGLAEMMKEARVMQLYDHPNIVKFHGFILDDLPYLLVLEYCNGGAVEDRLRD-KGEKIKVP
.  .|| |.| .| |..|.  .| || ||| | |    ..   | ..|| ||    ||| .. .    |  |   . | .  |   | |.. .|.  ..|
IRLEKKLGSGQFGDVWKGRWNNTTEV-AVKTLKPGAMSAE---EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMP

TRVKYTYMAACGMDYLHKKNCIHRDIASRNCLI-HKGVVKMADFGMCR---AQSV-YKVDLKKPCNIRWLAPEVWDNGETRFNTDVYAFGIMMWEFFETP
. |  .   | || ||  .| .||| | || |.    |.| .|||| |   ...  |         |.| |||           || .|||.| |   | 
QLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIV-TY

FKSPYVEMKAAQVKRKTRA--GYRLPPPPSMPSRMVEIMSECWQVDAEKRPTAEELKEKLEEFK
   ||  |  . | ..     |||.| ||  | .. .|| .|||  .. ||| | || ..|.| 
GRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase R05H5.4.AA S_TKc 120-375 24 1.6e-54 188.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 120-375
Range on HMM: 1-231/231
Sequence Identity: 24% (65 aa)

VIFQKKIGAGAYGTVYRGKLVKTDEVIAVKKLDPEGADEDGLAEMMKEARVMQLYDHPNIVKFHGFILDDLPYLLVLEYCNG--GAVEDRLRDKGEK---
  . .||| ||.|.||... .||... |.|...           ...| ....  .||||||..... |   . .|.|||.|  | . |.....| .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IKVPTRVKYTYMAACGMDYLHKKNCIHRDIASRNCLIHKGVVKMADFGMCRAQSVYKVDLKKPCNIRWLAPEVWDNGETRFNTDVYAFGIMMWEFFE-
  .   .  .|.|  .|...|.|... ||||.   | |. . ..| .|||..|                ..||||   | ...  |....|....|..  
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCG

-TPFKSPYVEMKAAQVKRKTRAGYRLPPPPSMPSRMVEIMSECWQVDAEKRPTAEELKE-----KLEEFK
 .||     ...  .. .              .. . .... |.|.| |||||| |. .     |. .. 
YPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase R05H5.4.AA Frk 120-375 32 1.1e-52 180.89 In-house 1-260 (260) Show / Hide 
Range on Protein: 120-375
Range on HMM: 1-260/260
Sequence Identity: 32% (87 aa)

VIFQKKIGAGAYGTVYRGKLVKTDEVIAVKKLDPEGADEDGLAEMMKEARVMQLYDHPNIVKFHGFILDDLPYLLVLEYCNGGAVEDRLR---DKGEKIK
. . ...|.| .| |. |.   |  | |||.| |  .|     ....||..|.   || ... .     . | ... |    |.. . |.   |||....
IQLIRRLGSGQFGEVWEGLWNNTTPV-AVKTLKPGTMDP---NDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQ

VPTRVKYTYMAACGMDYLHKKNCIHRDIASRNCLIHKG-VVKMADFGMCR-----AQSVYKVDLKKPCNIRWLAPEVWDNGETRFNTDVYAFGIMMWEFF
... |  .   | || || ..| ||||.| || |. .. ..|.||||. |      . .|         |.| |||     .     ||..|||.. |  
MQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEII

ETPFKSPYVEMKAAQVKRKTRAGYRLPPPPSMPSRMVEIMSECWQVDAEKRPTAEELKEKLEEFK
 |  . ||  |  |.|     .|||.| ||  | .. ||| |||..|..|||| | |. |||.. 
-TYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase R05H5.4.AA TK-Unique 120-371 29 7.2e-52 177.12 In-house 1-294 (294) Show / Hide 
Range on Protein: 120-371
Range on HMM: 1-294/294
Sequence Identity: 29% (87 aa)

VIFQKKIGAGAYGTVYRGKLVKTD------EVIAVKKLDPEGADEDGLAEMMKEARVMQLYD-HPNIVKFHGFILDDL-PYLLVLEYCNGGAVEDRLRDK
. ....|| ||.|.|.||......       ..|||.|  .  |.|  ....||...|.  . |||||.. |   ..  | ....||| .|  .. || .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTD-KQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

G-------------------EKIKVPTRVKYTYMA------ACGMDYLHK--KNCIHRDIASRNCLI-HKGVVKMADFGMCR---AQSVYKVD-LKKPCN
.                   .... .. ...  ..      |||| ||..  |...|||...||.|. ...|.| .|||| |   .  ||     ...  
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

IRWLAPEVWD--NGET-RFNTDVYAFGIMMWEFFETPFKSPYVEMKAAQVKRKTRAGYRLPPPPSM-PSRMVEIMSECWQVDAEKRPTAEELKEKL
|||.|||.     |   .  .||..||. ||| | |  . || .|..... .. |.|||.| |..  . .| ..|..||| ..|.||. ...| .|
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIF-TLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase R05H5.4.AA Abl 120-371 34 6.2e-49 161.11 In-house 1-252 (252) Show / Hide 
Range on Protein: 120-371
Range on HMM: 1-252/252
Sequence Identity: 34% (88 aa)

VIFQKKIGAGAYGTVYRGKLVKTDEVIAVKKLDPEGADEDGLAEMMKEARVMQLYDHPNIVKFHGFILDDLPYLLVLEYCNGGAVEDRLRDKGEKIKVPT
.. ..|.| | || || |   . | ..||| |     |   . | .||| .|.   |||.|.  |    . |. .. |.   | . | ||. ...   . 
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLK---EDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPA-

RVKYTYMA---ACGMDYLHKKNCIHRDIASRNCLI-HKGVVKMADFGMCR--AQSVYKVDLKKPCNIRWLAPEVWDNGETRFNTDVYAFGIMMWEFFETP
 |   |||   | ||.|| |.. ||||.| ||||.  . .||.||||. |   . .|         |.| |||     .     ||.|||...||   | 
-VVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWE-IATY

FKSPYVEMKAAQVKRKTRAGYRLPPPPSMPSRMVEIMSECWQVDAEKRPTAEELKEKL
  |||  .   .|  |   |||.  |.  |  . |.| .||| ..  ||. .|. ...
GMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase R05H5.4.AA Src 120-371 32 6.1e-47 157.49 In-house 1-255 (255) Show / Hide 
Range on Protein: 120-371
Range on HMM: 1-255/255
Sequence Identity: 32% (86 aa)

VIFQKKIGAGAYGTVYRGKLVKTDEVIAVKKLDPEGADEDGLAEMMKEARVMQLYDHPNIVKFHGFILDDLPYLLVLEYCNGGAVEDRLR--DKGEKIKV
. . .|.|.| .| |. |.  .. .| ||| | |   . . .    .|| .|   .|...|. .    .. |.. | || . |   | |.  ..| ....
IKLCRKLGQGQFGEVWMGYWNGNTKV-AVKTLKPGTMSPEAFL---QEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHL

PTRVKYTYMAACGMDYLHKKNCIHRDIASRNCLIHKG-VVKMADFGMCRAQS----VY--KVDLKKPCNIRWLAPEVWDNGETRFNTDVYAFGIMMWEFF
|. .  .   | ||.|| ..| |||| | || |. .. |.| ||||  |       .|  . . | |  |.| |||  . |     .||  ||| ..| .
PQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFP--IKWTAPEAINYGRFTIKSDVWSFGILLTEIV

ETPFKSPYVEMKAAQVKRKTRAGYRLPPPPSMPSRMVE-IMSECWQVDAEKRPTAEELKEKL
 |  . ||  |. ..| ..  .|||.| |.  | .. | || .||. |.|.||| | | ..|
-TYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase R05H5.4.AA Pkinase 120-371 21 1.5e-45 162.16 Pfam 1-293 (293) Show / Hide 
Range on Protein: 120-371
Range on HMM: 1-293/293
Sequence Identity: 21% (64 aa)

VIFQKKIGAGAYGTVYRGKLVKTDEVIAVKKLDPEGADEDGLAEMMK--EARVMQLYDHPNIVKFHGFILDDLPYLLVLEYCNGG----AVEDRLR-DKG
  . .|||.|..|.||... ..| .. |||... ...... . .  .  |...|.  .|||||.....  |.  . .|.|||.||       |... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EKI--KVPTRVKYTYMAACGMDYLHKKNCIHRDIASRNCLIH-KGVV----KMADFGMCRA--QSVYKVDLKKPC-NIRWLAPEVWD-NGETRFNTDVYA
 ..     .  .| |  ..|..|.|....||||. . |.||. .|..    | .||| ..      .   .. .|  ....||||   . .     |...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGIMMWEFFE--TPFKSP-----YVEMKAAQVKRKTRAGYRLPPPPSMP-----------------SRMVEIMSECWQVDAEKRPTAEELKEK--L
.|....|..   .||..      . .|.  . .....  .  | . |..                 . . .... |...| .||||||....   .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase R05H5.4.AA TKL-Unique 122-371 29 2.3e-44 153.69 In-house 1-290 (290) Show / Hide 
Range on Protein: 122-371
Range on HMM: 1-290/290
Sequence Identity: 29% (86 aa)

FQKKIGAGAYGTVYRGKLVKTDEVIAVKKLDP-EGADEDGLAEMMKEARVMQLYD-HPNIVKFHGFIL----DDLPYLLVLEYCNGGAVEDRLR------
| .|||.|.||.||.||  ...  .|.|.. | |.   . . |  .| ..|   . |||||.. |.      .   . .|.|||.||   | |       
FWNKIGEGGYGQVYKGKWRGYP--VAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---DKGEKIKVPTRVKYTYMAACGMDYLHKKN--CIHRDIASRNCLIHKG------VVKMADFGMCRAQSVY---KVDLK------KPC-NIRWLAPEVW
    .  |.    |||    .| ||.||| ..   ||||. |.| |.  .       .| .||| .. .|     ..  .       .| ..||.|||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

DNGETRFNT--DVYAFGIMMWEFFETPF----KSPYVEMKAAQVKRKTRA---GYRLPPPPSMPSRMVEIMSECWQVDAEKRPTAEELKEKL
 . .. ...  |||.|||..|| ...      | || .|   |.. . .    .||.| |...| .  ... .||  | ..||. .|  ..|
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL