Gene plk-1 (Nematode worm)

plk-1

Species: Nematode worm
Alias: CE26649, plk-1, K06H7.1PLK-1, K06H7.1, C14B9.4a, aSWK238
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: n/a, WormBase Physical Map location: III: 8096804-8099534,

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
plk-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 249 Kinase domain by global Sugen HMM Fasta, JSON
plk-1.AA Protein Genbank 648 None Fasta, JSON

Protein domain

Protein domains of plk-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase plk-1.AA PLK 38-289 61 5.69999999999e-189 620.37 In-house 1-258 (258) Show / Hide 
Range on Protein: 38-289
Range on HMM: 1-258/258
Sequence Identity: 61% (158 aa)

YEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMTQEVQIHRELGHINIVKLFNFFEDNLNVYITLELCARRSLMELHKRR-KAVTEP
||.|.||||||||.|||.|. .|..|.|.||||||...|..||.||.||..|||.| | ||||. .||||. ||||.||.| .||||..|||| |..|||
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

EARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDLVVKIGDFGLATTVNGD-ERKKTLCGTPNYIAPEVL--NKAGHSFEVDIWAVGCILYILLFGQP
|.||...||| |..|||. .|||||.|||||||||...||||||||||....| |||||.||||||||||||  || |||.|||.|..|||.|.||.|.|
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFESKSLEETYSRIRHNNYTIPSI--ATQPAASLIRKMLDPEPTRRPTAKQVQRDGFF
|||.|...|||.||.||.|..|.   . ..|..||.|||.. |..|||..|. .. ||
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase plk-1.AA PLK1 38-289 75 7.4e-178 589.5 In-house 1-253 (253) Show / Hide 
Range on Protein: 38-289
Range on HMM: 1-253/253
Sequence Identity: 75% (191 aa)

YEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMTQEVQIHRELGHINIVKLFNFFEDNLNVYITLELCARRSLMELHKRRKAVTEPE
|||||||||||||||||.....|.||.||||||||.|.||.||||||||.||||.| | .|||...||||. ||||.||||.|||||||||||||.||||
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

ARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDLVVKIGDFGLATTVNGD-ERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVGCILYILLFGQPPFE
.||...|||.|..|||...|||||.|||||||||.| ||||||||||... | ||||||||||||||||||||.|||||||||..|||.|||||||||||
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFE

SKSLEETYSRIRHNNYTIPSIATQPAASLIRKMLDPEPTRRPTAKQVQRDGFF
.|.|.||||||..|.|.|||...||||.||||||||.||||||..|| .| ||
TKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase plk-1.AA PLK2 38-289 52 5.4e-131 424.2 In-house 1-257 (257) Show / Hide 
Range on Protein: 38-289
Range on HMM: 1-257/257
Sequence Identity: 52% (135 aa)

YEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMTQEVQIHRELGHINIVKLFNFFEDNLNVYITLELCAR----RSLMELHKRRKAV
| .|. ||||||| |||.|   |  | |.|.||.|   |  || || .|. .||.| | .||. . .|||  |.|| ||.| |    .|.    | |.  
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

TEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDLVVKIGDFGLATTVNGDE-RKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVGCILYILLFGQ
|||| ||.  ||| |. |||.  ||||| ||||.|.||   |||||||||  .   | ...|.|||||||||||||. |||.| |||| ||| | .| | 
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQGHSCESDIWALGCIMYTMLCGR

PPFESKSLEETYSRIRHNNYTIPSIATQPAASLIRKMLDPEPTRRPTAKQVQRDGFF
||||  .| ||| .|||| |..|.    || .|| .|| |.|  ||   .. |. ||
PPFETANLKETYRCIRHNHYHMPTHLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase plk-1.AA PLK-Unclassified 38-289 50 2.5e-129 435.98 In-house 1-264 (264) Show / Hide 
Range on Protein: 38-289
Range on HMM: 1-264/264
Sequence Identity: 50% (133 aa)

YEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMTQEVQIHRELGHINIVKLFNFFEDNLNVYITLELCARRSLMELHKRR-------
|..|.|||||||| ||. .|  | .. | |..||| | |. .| |  .| .||  | | ||||   .|||. |||| ||.|   .|||..|||       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KAVTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDLVVKIGDFGLATTVNG-DERKKTLCGTPNYIAPEVL-NKA-GHSFEVDIWAVGCILYI
|  ||.|....| ||| .. |||. .||||| ||||.||||. .|||.|||||| ...  |.||| ||||||||||.| .|  |||.|||.|. ||||| 
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLFGQPPFESKSLEETYSRIRHNNYTIPSIAT--QPAASLIRKMLDPEPTRRPTAKQVQRDGFF
|| | |||| |. . || .|. |.|  |  ..    | .||.. |.. | .|||  |   . |.
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase plk-1.AA S_TKc 38-289 32 5.5e-94 319.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-289
Range on HMM: 1-231/231
Sequence Identity: 32% (87 aa)

YEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMTQEVQIHRELGHINIVKLFNFFEDNLNVYITLELCAR--RSLMELHKRRKA---
||..| .|||.|. .|  ... | ..|| |...          ... .|.||... .| |||||. .|.|  ..|. .|.|     .|... |.|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDLVVKIGDFGLATTVNGDERKKTLCGTPNYIAPEVLNKAGHSF-EVDIWAVGCILYIL
    .| .||....||.... |.|...||||| |  |..|..  ..||.|||||. .      .|.||||.|.|||||   |... ..|.|..|||||..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LFGQPPFESKSLEETYSRIRHNNYTIPSIATQPAASLIRKMLDPEPTRRPTAKQVQR-------DGFF
| |.|||.   ..... .|.          ...| ..|||.|. .|..|||| .. .       . .|
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase plk-1.AA CAMK 43-289 21 6e-91 293.24 In-house 1-425 (425) Show / Hide 
Range on Protein: 43-289
Range on HMM: 1-425/425
Sequence Identity: 21% (90 aa)

FLGKGGFAHCYELTNRATR------------EVVAGKVVPKSMLVK-------------------------QYQRDKMTQEVQIHRELG-------HINI
 ||.|.|.  .. ... |             . || |...|. | .                         .. |... .|..|.. |        | ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLFNFFED-------------------NLNVYITL---ELCARR----SLMELHKRR---------------KAVTEPEARYFTHQIVDGVLYLHDLNI
.||. ..||                   . ..|. .   |.|        | .  ...               . .|| |||.. .||...| |.|..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDMKLGNLFLNDD-----------------LVVKIGDFGLATTVNG------------------------DERKKTLCGTPNYIA-PEVLNK------
.||| |. |. |.|.                   .|| |||.|. ...                        ..  || |||| |.| |||||.      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------AGHSFEVDIWAVGCILYILLFGQPPFESK-------------SLEETYSRIRHNNYT-IPSI-----------------------ATQPAAS
         ......|.|..|.||||.| | |||...             ...|.. .|.  .|. .|.                         .| . .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIRKMLDPEPTRRPTAKQVQRDGFF
|||||| ..|..|.|..|. .. ..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase plk-1.AA AGC 38-289 20 9.4e-87 223.57 In-house 1-395 (395) Show / Hide 
Range on Protein: 38-289
Range on HMM: 1-395/395
Sequence Identity: 20% (80 aa)

YEKGRFLGKGGFAHCYELTNR------ATREVVAGKVVPKSM-LVKQY--QRDKMTQE------------VQIHRELG----------HINIVK-LFNFF
.|  . .|||.|  .|    .      .| .. | ||. |.   |.    . ..   |             .|  ..           | .||| |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDNLN--VYITLELCA----------R-RSLMELHK--RRKAVTEPEARYFTHQ-------IVDGVLYLHD-LNIIHRD-MKLGNLFLNDDLVVKIGDFG
.|. .  .|. .|..              ... |..  ...  .|..||... .       || .. |||. ..||||| .|. |. |..|  .|. |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LATTVNGDE---------------------------------------------------RKKTLCG--TPNYIAPEVLNKAGHSFEVDIWA--VGCILY
|.. ...|.                                                   | .|.||  ||.|.|||.|    .....|.|.  .||..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ILLFGQPPFESKSLE----------ETYSRIR------HNNYTIPSI----------ATQPAASLIRKMLDPEPTRRPT----------AKQVQRDGFF
 .|.|.||| ... .          |.. .|.      ... ..|.            .. | .||.|.| ..|..|..          |.....  .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase plk-1.AA Pkinase 38-289 28 2e-85 294.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 38-289
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

YEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMT-QEVQIHRELGHINIVKLFNFFEDNLNVYITLELCARR----SLMELHK--RR
|..|| .|.|.|. .|. ... |...|| |...|.   .. .. .   .|.||...|.| |||.|. .|||. ..|. .|.|       .|... .  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KAV--TEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDLVV----KIGDFGLATT--VNGDERKKTLCGTPNYIAPEVLN-KAGHSFEVDIWAV
...  .| |.. .  ||. |. |.|. .|||||.|. |...... ..    ||.|||||       ..  .|.||||.|.||||..   ... .||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYILLFGQPPFESK------SLEETYSRIRHNNYTIPSIAT---------------------QPAASLIRKMLDPEPTRRPTAKQVQRDGFF
|||||..|.|.||| ..      .  . . ||..  .  ..  .                     ... ..|...|.. |..||||.|.  . .|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase plk-1.AA CAMKL 38-289 28 2.7e-76 242.97 In-house 1-297 (297) Show / Hide 
Range on Protein: 38-289
Range on HMM: 1-297/297
Sequence Identity: 28% (84 aa)

YEKGRFLGKGGFAHCYELTN-RATREVVAGKVVPKSMLVKQYQRDKM------------TQEVQIHRELG---HINIVKLFNFFEDNLN------VYITL
|. |. ||||.|.     |. | |.| || |.. |. . .  . .|.            ..|.||.. |    | ||.||.  .|.  .      .|. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCARRS--LMELHKRR----KAVTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDL--VVKIGDFGLATTVN-G----DERKKTLCGTPNYI
|.|   .  |..  ...    .  .|.||| .  |||..| |.|...|.||| |. |. | ..   ..|| |||...    .    ..  || ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLNK--AGHS-FEVDIWAVGCILYILLFGQPPFE----------SKSLEETYSRIRHNNYTIPSIATQPAASLIRKMLDPEPTRRPTAKQVQRDGFF
|||....    .  ..||||. | ||| ...|. ||.           . ...   ..   ...|..    .. .|||||| . |..|||..|. .. ..
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase plk-1.AA SAK 38-289 40 2e-75 256.28 In-house 1-254 (254) Show / Hide 
Range on Protein: 38-289
Range on HMM: 1-254/254
Sequence Identity: 40% (103 aa)

YEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMTQEVQIHRELGHINIVKLFNFFEDNLNVYITLELCARRSLME-LHKRRKAVTEP
|. .  |||||||  |      |   || |.. | .. |    ... .||.||  | |  |..|.|.||||  ||. ||.|    .   ...| .  || 
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

EARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDLVVKIGDFGLATTVN-GDERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVGCILYILLFGQPPF
||| | |||| |.||||  .|.|||. | |. |  |. .|| |||||| ..  .|.  |.|||||||.||.  .. |  . |.|..||.|| || |.|||
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPF

ESKSLEETYSRIRHNNYTIPSIATQPAASLIRKMLDPEPTRRPTAKQVQRDGFF
.  . ..|  ..   .| .|.     |  || |||  .|. | | . |    | 
DTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase plk-1.AA ULK 38-277 28 3.3e-66 226.27 In-house 1-312 (324) Show / Hide 
Range on Protein: 38-277
Range on HMM: 1-312/324
Sequence Identity: 28% (90 aa)

YEKGRFLGKGGFA-HCYELTNRAT---REVVAGKVVPKSMLVK-------QYQRDKMTQEVQIHRELG---HIN--IVKLFNFFEDN--LNVYITLELCA
|.. . |||| |.   |. .|  |    ..|| |...|. . |       ||. ..  .|.|| ..|    | |  ||||. .||.    |.|| .|.| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

RRSLMELHKRRKA---------VTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDL------------VVKIGDFGLATTVNGDERKKTLC--
   | .. |..|           .|.||. | .||. |  .||. ||||||.|. |. ....             |.||.|||.| .|. ..  ...|  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

--------GTPNYIAPEVLN----KAGHS-FEVDIWAVGCILYILLFGQPPFESKSLEETYSR--------------IRHNNYTIP-----SIATQPAAS
        ||| | ||..|.    .  .. ...||| .|||.| .|.|..||.|   ...| .              |. ..  .|      .  .   .
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIRKMLDPEPTRR
|||.||  ... |
LIRRMLQYDEKDR
Kinase plk-1.AA ULK 38-277 28 3.9e-66 226.03 In-house 1-317 (329) Show / Hide 
Range on Protein: 38-277
Range on HMM: 1-317/329
Sequence Identity: 28% (91 aa)

YEKGRFLGKGGFAHCYELTNRATR----EVVAGKVVPKS--MLVK-----QYQRDKMTQEVQIHREL----GHIN----IVKLFNFFEDN--LNVYITLE
|.. . |||| |.  |. .|  |     |.|| |...|.     .     ||. .  ..|..| ..|    .|.|    ||||. .||.    |.|| .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCARRSLMELHKRRKA----------VTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDL------------VVKIGDFGLATTVNGD-----
.|    |... |..|            .|.||. | .||. |  .||. ||||||.|. |  ....             |.||.|||.| .|. |     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-ERKKT----LCGTPNYIAPEVLN----KAGHS-FEVDIWAVGCILYILLFGQPPFESKSLEETYSRIRHNNYTIP--------------------SIAT
 .   .    ||||| | ||..|.    .  .. ...||| .|||.| .|.|.|||..   ...| .|  ... .|                     .  
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

QPAASLIRKMLDPEPTRR
.   .|||.||  ... |
PECKDLIRRMLQYDEKDR
Kinase plk-1.AA TyrKc 38-288 23 3.8e-17 54.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 38-288
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

YEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMTQEVQIHREL--GHINIVKLFNFFEDN-------LNVYITLELCARRSLME-LH
 ..|. || | |   |. | .   . || |.. ..       |  . .| .| ..|   | |||.|.    .          ..| .|...  .| . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KRRKAVTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDLVVKIGDFGLATTVNGD----ERKKTLC-----GTP-----NYIAPEVLNKAGHS
|.|. .. ..  .| .|| .|  |||. |.||||    |  ......|||.||||.  .  |    |.|..       |.         |||..|.   .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

FEVDIWAVGCILY-ILLFGQPPFES-----KSLEETYSRIRHNNY-TIPSI--------ATQPAASLIRKMLDPEPTRRPTAKQVQRDGF
.. |.|. |  .. |. .||.| .      .| .| . .... ..  .|          ...   .....  . .|  ||| ... .. |
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase plk-1.AA Pkinase_Tyr 79-251 28 2e-12 42.74 Pfam 44-233 (270) Show / Hide 
Range on Protein: 79-251
Range on HMM: 44-233/270
Sequence Identity: 28% (55 aa)

Q--RDKMTQEVQIHREL-GHINIVKLFNFFE-DNLN--VYITLELCARRSLME-LHKR---RKAVTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLF
|  |... .|..| ..|  | |||.|      .     .|| .|...  .| . |.|.   ....| ..   . .|| .|  ||.. |.||||    |  
QNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCL

LNDDLVVKIGDFGLATTV--NGDE-RKKTLCGTP-NYIAPEVLNKAGHSFEVDIWAVGCILY-ILLFGQPP-FESKSLEETYSRI-RHNN
.....||||.||||| ..   .   ||.. .  |    |||..|    . . |.|. |  .. |. .|. | ..  | || | .| ....
VTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGY
POLO_box plk-1.AA POLO_box 419-484 35 4.7e-25 94.36 Pfam 1-74 (74) Show / Hide 
Range on Protein: 419-484
Range on HMM: 1-74/74
Sequence Identity: 35% (26 aa)

YSDKYGIGYQLCDNSVGVL-FNDNSRIMLDQAGN-ELTYIE--KSNKEHYFSMHS----GEMPGLLNKKVTLLK
|..||||.|||....|.|. ||| ..|.|.. .  ..|||.  ............    |..|  |.||.|.||
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box plk-1.AA POLO_box 519-588 50 5.1e-31 114.16 Pfam 1-74 (74) Show / Hide 
Range on Protein: 519-588
Range on HMM: 1-74/74
Sequence Identity: 50% (37 aa)

FRTKSAIVLHLSNGTVQINFFNDHVKMMMCPLMQ-AVTFID--QNKRMLTYKLNNLQRNGC-PEKFLHRLKYAK
.|||..|. .|||||||.|||||| |...|| |. |||.||  .|..  ||.|......|| || . ..|.|.|
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK