Gene pak-1 (Nematode worm)

pak-1

Species: Nematode worm
Alias: CE27670, C09B8.7, CePAK, C09B8.7a, pak-1, aSWK308
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 6017704-6013408, WormBase Genetic Map location: n/a,

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
pak-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
pak-1.AA Protein Genbank 572 None Fasta, JSON

Protein domain

Protein domains of pak-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD pak-1.AA PBD 66-124 56 8.7e-30 106.27 Pfam 1-60 (60) Show / Hide 
Range on Protein: 66-124
Range on HMM: 1-60/60
Sequence Identity: 56% (34 aa)

VISRP-SNFEHTIHVGYDPKTGEFTGMPEAWARLLTDSQISKQEQQQNPQAVLDALKYYT
.|| | .||.||.|||.|..||.|||||. |..||..| |||.||..|||||.|....| 
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD pak-1.AA PBD 67-102 52 5.7e-15 56.99 SMART 1-38 (38) Show / Hide 
Range on Protein: 67-102
Range on HMM: 1-38/38
Sequence Identity: 52% (20 aa)

ISRPS-NFEHTIHVG-YDPKTGEFTGMPEAWARLLTDS
|| |. ||.|..|||  |..||||||.|. |..||. .
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase pak-1.AA PAKA 295-546 70 7.50000000001e-195 653.61 In-house 1-260 (260) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-260/260
Sequence Identity: 70% (184 aa)

YRKVDKIGSGASGSVYTAIEISTEAE--VAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQ------M
|....||| ||||.||.|..|.|. |  |||||||.|.||||||||||||||.|.|| |||||.|||||.|||||||||..||.||||.|.|.      |
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

EDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGE
..|.||.||||.||.|||.||.|.|||||||||||||||||||.|||||||||..||.||.|||||||||||||..||||..|||.||||||||||.|||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL
||||||.||||.||||||||||.  .|...  |.||.|  |.|.|..|.||..||.||||
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase pak-1.AA STE20 295-546 48 2.5e-157 528.99 In-house 1-288 (288) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-288/288
Sequence Identity: 48% (139 aa)

YRKVDKIGSGASGSVYTAIEISTEAE----VAIKQMNLKDQ----PKKELIINEILVMRENKHANIVNYLDSYLVC----DELWVVMEYLAGGSLTDVVT
| ...|||.|..|.||.|....|  .    ||||.|||...    ...|.|..||..|.. || |||.|..|||.     ||||.||||..||||||...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---ECQ-------MEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSP-----EQRKRTTMVGTPYWMAPEVVTR----
   .|.       |.   ||..||||||.|..|||.|.||||||.|||||..||.|||.|||.||||..     .|.|| |.|||||||||||. .    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIA--TNGKPDFPG--RDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL
 |.|. |.|.|||||.||||.||||||....|.||...|.  .|..|.. .   .. .  |.||||. |.. .|.|..|||||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase pak-1.AA STE 295-546 32 6.5e-126 424.6 In-house 1-359 (359) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-359/359
Sequence Identity: 32% (117 aa)

YRKVDKIGSGASGSVYTAIEI------STEAE---------VAIKQMNLKDQ-----------------PKKELIINEILVMRENK--HANIVNYLDSYL
.....|||.||.|.||.|. .      .|  .         .|||||||...                  ... |..|| .|.. .  | |||.|...|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

V-------CDELWVVMEYLAGGSLTDVVT---ECQME------------DGIIAAVCREVLQA-LEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCA
.       .||||..|||..||||.|..    .|...              .||..||..|.. |..||| |.||||||..||||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLSPEQR----------------KRTTMVGTPYWMAPEVVTR------KQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATN-----------
||... .                ||.|.|||| ||||||...      |.|. |.|.||||...|||..|.||. ...|.||...|..|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GKPDFPGR-----------------DSMTLLFKDFVDSALEVQVENRWSASQLLT--HPFL
    . | .| .                 ....  ||||..  |.   ..|..|||||   |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase pak-1.AA PAKB 296-546 53 1.9e-124 419.72 In-house 2-252 (252) Show / Hide 
Range on Protein: 296-546
Range on HMM: 2-252/252
Sequence Identity: 53% (135 aa)

RKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVC
 .  ||| |  | |  | |..|   ||.|.|.|  |   ||  ||. .||. .| |||.  .|||| ||||||||.. ||.|||.||.  |.   ||.||
DNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATVC

REVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPL
| |||||..||.. ||||||||| |||  || |||.|||||||.| |  ||  .|||||||||||. |  ||..||.|||||| ||||.||||| || ||
RQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPL

RAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL
.|   |  .  | .          ..|.|  |   .. ||.|  || ||||
QAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase pak-1.AA S_TKc 295-546 31 4.9e-99 336.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAG--GSLTDVVTECQ-------
|....|||.|| |.|| .....|  .||||...       | |..|| .... .| |||...|..   |.|..||||. |  |.| |.  ...       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGP-KVDVWSLGIMAIEMVE
.    .. .......|||..||...||||.| .||||     .|..|||...||       ||..|||..|||||.   .||. |.|.||.|.. .||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLT-------HPFL
|.||.   .. . . .|              .  .|||..  |..  |.|..| ..|.       ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase pak-1.AA YSK 295-546 43 3.6e-98 296.18 In-house 1-257 (257) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-257/257
Sequence Identity: 43% (111 aa)

YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKK-ELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTE---CQMEDGI
. | ..|| |  | || .|.  |.  ||||  .| .     |.|  || .  . .  .| .|. |||    ||..|||..|||. |        |..   
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTR--KQYGPKVDVWSLGIMAIEMVEGEPP
|| . ||.|..|..|||  .||||||. |.||  .| ||| |||  .|.   | || |.|||||||||||.     .|  |.|.||||| |.||  ||||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL
|    |.|.  ||  |  |   ||.. .  ||.||.  |.   |.| ||..|| | | 
YCDYHPMRVMFLIPKNNPPKLEGRSYSK-MFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase pak-1.AA Pkinase 295-546 29 2e-92 318.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIIN----EILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGG----SLTDVVT---E
|... |||||..|.|| .....|. .||.|....... .......    || .|.. .| ||| ..|..   |....||||. ||    .| |...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

CQM--EDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSV----KLTDFGFCAQL-SPEQRKRTTMVGTPYWMAPEVVT-RKQYGPKVDVWSL
. .  ..  .  .....|..||..||. .||||.|..|||.  .| .    |..|||...|.    ..  || .|||..|||||.  .. ||||||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMAIEMVEGEPPYLNE----NPLRAIYLIATNGKPDFPGRDSMT---------------------LLFKDFVDSALEVQVENRWSASQLLTHPFL
|.. .||. |.||. ..    | .. ...|. ...|...   . .                       .|||... |..  . |..| |.| ||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase pak-1.AA MST 295-546 43 2.4e-86 274.48 In-house 1-254 (254) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-254/254
Sequence Identity: 43% (112 aa)

YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYL--VCDELWVVMEYLAGGSLTDVV--TECQMEDGI
. .|.|.| |. |||| || ..|  .||||...  .    | ||.||  | . |  .|| | .||.     ..| |||| ..||. |..  |  .     
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV-NEDLQE-IIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYL
||.... .|| |. ||... ||||||. ||||  .|  || |||  .||.  ..|| | .|||||||||| .   |  |.| ||||| |||| ||.||| 
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYS

NENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL
.  | ||. .| ..  | |   .     | ||| . |    | ||.| ||| ||| 
DIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase pak-1.AA FRAY 295-546 35 4e-77 239.03 In-house 1-277 (277) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-277/277
Sequence Identity: 35% (100 aa)

YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNL-KDQ-PKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGI--
|   . ||.||.. |..|. |  . ..|||  || | |    . .| || .|  ..| |.| |  |..| .|||.|| || .||. |..    |..|.  
YELQEVIGEGATAVVHKAYCIPRQENCAIKRINLEKCQNTSMDELIKEIQAMCQCHHPNVVHYHTSFVVNEELWLVMRYLECGSCLDIM-KFKMPQGEPH

---------IAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSP-----EQRKRTTMVGTPYWMAPEVVTRKQ-YGPKVDVWSL
         || . .|||..|...|.   ||||||..|||.| ||.. . |||  | |        .  |.|.|||| ||||||.   . |  |.|.||.
KQGVFDEHVIATILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIADFGVSAWLATGGDLSRCCVRHTFVGTPCWMAPEVMEQVHGYDFKADIWSF

GIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMT-------LLFKDFVDSALEVQVENRWSASQLLTHPFL
|| |||.. | .||    |     |.  |  |   .             .||. ... |    ..|  || || | | 
GITAIELATGKAPYHKYPPMKVLMLTLQNDPPSLETDEDDKDMYKKYGHSFKKMIEKCLQKDPSKRPTASELLKHKFF
Kinase pak-1.AA KHS 295-546 41 3.7e-76 255.65 In-house 1-258 (258) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-258/258
Sequence Identity: 41% (107 aa)

YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTEC-QMEDGIIAA
|  . ..|||  | || | .| ..  .|.| . .  .   ..|  ||..|.. .|.||| |  |||  | ||..|||  |||| |.     ....  || 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEV--VTRK-QYGPKVDVWSLGIMAIEMVEGEPPYL
||||.||.|..|||.  .|||||  ||||  .| ||| |||  ||..    ||   .||||||||||  | ||  |.   |.|..|| |||. |  ||  
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

NENPLRAIYLIATNG--KPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL
.  |.||..|..  .   |    ..  .  | .||  ||      | .|..||.|||.
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase pak-1.AA STE11 295-546 32 9.3e-72 244.7 In-house 1-303 (303) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-303/303
Sequence Identity: 32% (98 aa)

YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPK----------K----ELIINEILVMRENKHANIVNYLDSYLVC---DELWVVMEYLAGGSL
..| ..||.|| |.||... ..|  ..|.||. .... .          .    ..|  || .|.  .| ||| |... | .   |.. . ||| .||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

TDVVTECQ----MEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGS-VKLTDFGFCAQLSPEQRKRTT----------MVGTPY--------
 ..    .    ..   |    . .|..| .||| ..|||||| .||||  ||  .||.||| . .|. . .. ..          | ||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVVTRKQ---YGPKVDVWSLGIMAIEMVEGEPPYLNE--NPLRAIYLIATNGKPDFPGRDSMT------LLFKDFVDSALEVQVENRWSASQLLTH
||||||... .   || |.|.||||   |||. | ||. |   |.  |.. |... ||  | ...|.         .||..  .| . . |..|.||| |
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase pak-1.AA SLK 295-546 38 6.5e-70 235.02 In-house 1-259 (259) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-259/259
Sequence Identity: 38% (99 aa)

YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQ--MEDGIIA
.  .  .| || | || | .  ...  | | ...||. . |  . || .. | || |||. ...| . ..||...|. .|| .  .. | .  ...  |.
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

AVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVV---TRKQ--YGPKVDVWSLGIMAIEMVEGEP
 ||.....||..|||..|||||.|  |||. ||| |.| |||  |..  . .|| | .|||||||||||   | |   |  |.|.|||||  ||| ..||
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL
|. . ||.| .  |.    |        .  ||||.  .|. ...|||...||. |...
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase pak-1.AA Pkinase_Tyr 295-489 27 1.5e-26 90.51 Pfam 1-216 (270) Show / Hide 
Range on Protein: 295-489
Range on HMM: 1-216/270
Sequence Identity: 27% (59 aa)

YRKVDKIGSGASGSVYTAIEI----STEAEVAIKQMNLKDQPK---KELIINEILVMREN-KHANIVNYLDSYL-VCDE--LWVVMEYLAGGSLTDVVTE
 ..  |.|.|| |.|| ..      .|. .||.| .. .  ..   .|  ..|. .|..  .| |||...   .   .   ...|||| ..|.| |   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

C-----QMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQL--SPEQ-RKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSL
      .     .   |... ...|.|.|.. ||||.   |.|.. .. || .||| .  .    .  |||.       |||||.   . .  | |||| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GIMAIEMVE-GEPP-Y
|.   |..  || | |
GVLMWEIFTYGEQPTY
Kinase pak-1.AA TyrKc 295-546 22 2.9e-23 84.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 295-546
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMREN--KHANIVNYLDSYLVC-------DELWVVMEYLAGGSLTDVVTECQ
 .. .|.|.|| | || .. .    .||.| ..      .| ...|. .|..   .| |||. .   .         . |..|||| ..|.| |   ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPE----QRKRTTMV----GTP-----YWMAPEVVTRKQYGPKV
           |  . .  |.|||...||||.   |.|.| .. || .||| .  .  .     .| . ..    |.       |||||.   . . .| 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWSLGIMAIEMVE-GEPPYLN-----ENPLRAIYLIATNGKPDFPGRDS------MTLLFKDFVDSALEVQVENRWSASQLLTHPFL
|||| |..  |.   |..|| .      .. ..| .. . . .. |  |       ..    .   .  . . |.| . |..  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF