Gene old-1 (Nematode worm)

old-1

Species: Nematode worm
Alias: tkr-1, C08H9.5, old-1, aSWK394, CE02991
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 9868665-9866552, WormBase Genetic Map location: n/a,

Classification

Group: TK
Family: KIN16

Sequence

Name Sequence Type Origin Length Description Download
old-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 287 Kinase domain by global Sugen HMM Fasta, JSON
old-1.AA Protein Genbank 502 None Fasta, JSON

Protein domain

Protein domains of old-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase old-1.AA KIN16 175-461 52 1.8e-235 698.55 In-house 1-332 (332) Show / Hide 
Range on Protein: 175-461
Range on HMM: 1-332/332
Sequence Identity: 52% (175 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKN-EEKESRLEVAVKLPLNEYNQIQQELIYDELKVMCAVGKHPNILALVGGITFGER------KMIVSEFVENGD
.....|||||.||..|||.|..||.|| .|...||||||| |.|.....||..||||||||||.|||||.|||||..| ..|       |||.|.||.||
LEFEEPLGSGHFGVVRKGLLHMKNPKNEKEHKNRLEVAVKSPANPHDICQQKMIYDELKVMCAIGKHPNVLALVGAVTKNMRQGGRHMLMIVTEYVECGD

LLSFLRDNRIYFTNDQWTLETEQD-------------------------------SLSLVDLLSFAFQIAKGMEYLIHVPC-VHRDLALRNVLIKKNRII
|..|||..| .|.|.|.  ..|..                               ||...||||||.|||.|||.|.|||| ||||||.|||.||.|.||
LRKFLRQHRNNFQNHQVCWDNERQSGYNINNKERKHYVFKNFCENEQLVIKDIFDSLCTSDLLSFAYQIANGMEWLAHVPCCVHRDLACRNVFIKRNKII

RIADFGLARRHKNKDYYKTQS-VDTPLPIHWMAPESIDK-----LLFTQKSDVWSYGVCLYELFSLGKSPYENVIKYDQRDFYWKYVLSYLNEGKRLAQP
|||||||||.|.|||||...| .|||||..|||||...      . ||.|||||||||||||.||||..||.|......||.|..||. ||..|.||.||
RIADFGLARWHENKDYYRMKSSMDTPLPMRWMAPECFEEEQERKMKFTEKSDVWSYGVCLYEIFSLGETPYPNCPNNNCRDDYFQYVMEYLRKGNRLPQP

AHADAEIYNVMKLCWDLDMNSRTTFLDCIEFF
.|...|||..||.||..|...|.|| .|.|||
EHCHPEIYDFMKMCWNFDPEKRPTFSECVEFF
Kinase old-1.AA TyrKc 175-461 36 1.4e-127 431.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 175-461
Range on HMM: 1-280/280
Sequence Identity: 36% (114 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNEEKESRLEVAVKLPLNEYNQIQQELIYDELKVMCAVG-KHPNILALVGGITFG-------ERKMIVSEFVENG
|..|. ||.|.||...|| ..            ..||||   ..     .| ...|...|| .| .||||..|.| .| .       |  ||| |....|
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

DLLSFLRDNRIYFTNDQWTLETEQDSLSLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNRIIRIADFGLARRHKNK-------DYYKTQ---S
||...||..|                |.. |||||..|||.||||| . .|.||||| ||.|...|....|.||||.| ....       |||...   .
DLKDYLRKHRPK--------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

VDTPLPIHWMAPESIDKLLFTQKSDVWSYGVCLYELFSLGKSPYENVIKYDQRDFYWKYVLSYLNEGKRLAQPAH--------ADAEIYNVMKLCWDLDM
 .|.||| |||||.|..  || ||||||.|||..|.|..|..||...|.    .  .. |. |. .|.|. ||..        . .|.|..|| ||. | 
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

NSRTTFLDCIEFF
..| || ...|.|
EDRPTFSEIHECF
Kinase old-1.AA Pkinase_Tyr 175-461 38 1.9e-116 394.99 Pfam 1-270 (270) Show / Hide 
Range on Protein: 175-461
Range on HMM: 1-270/270
Sequence Identity: 38% (113 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNEEKESRLEVAVKLPLNEYNQIQ--QELIYDELKVMCAVGKHPNILALVGGIT-FGER--KMIVSEFVENGDLL
|..|. ||.|.|| ..|| ..      .... ...||||   . . . |  .|    |.|.|.  |.||||. |.| .|  ||    .|| |....||||
ITFGKKLGEGAFGEVYKGTWKG-----DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

SFLRDNRIYFTNDQWTLETEQDSLSLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNRIIRIADFGLARRHKNKDYYKTQSVDTPLPIHWMAPE
..||..|           .....|.. |||....|||||||||   .|.||||| ||.|...|....|.|||||| . |.||| ... ...||| |||||
DYLRKHR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPE

SIDKLLFTQKSDVWSYGVCLYELFSLGKSP-YENVIKYDQRDFYWKYVLSYL-NEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFF
.|    || ||||||.||...|.|..|..| |...  ..        |. |.  .| |...| .. .|||..||.||. | . | || ...|..
CINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE--------VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase old-1.AA TK 175-461 25 4.8e-97 325.89 In-house 1-486 (486) Show / Hide 
Range on Protein: 175-461
Range on HMM: 1-486/486
Sequence Identity: 25% (122 aa)

ISKGRPLGSGEFG---IIRKGFLRSKNSKNEEK----------------ESRLEVAVKLPLNEYNQIQQELIY----------------DELKVMCA-VG
|  |. ||.|.||    ..|| .|..| .|...                . . .||||    . .. |.| .                  |.|.||. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHPNILALVGGITFGERK------------MIVSEFVENGD----LLSFLRDNRIYFTNDQWTLE-----------------------------------
.||||. |.| .| || |            ||| |....||    |...||..| .|.. | . .                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------TEQDSLSLVDLLS-------------------FAFQIAKGMEYLIHVPC------VHRDLALRNVLIKKNRI-----------IRIADFG----
      .. ..|.. |||.                   ...|||.|||||   .|      |||||| ||.|. .| .           ..|||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LARRHKN-KDYYKTQSVDT----------------------PLPIHWMAPESID---------KLLFTQKSDVWSYGVCLYELFSLG-KSPYENVI
    |||.. . .|||...| .|                       ||| |||||...         .  || ||||||.||...|.|..| . .|... 
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

KYDQRDF-YWKYVLSYLNEG--------------KRLAQPAHAD--------------AEIYNVMKLCWDLDMNSRTTFLDCIEFF
  |   . . . |. || .|               |..||.|.               .|.| .|. ||..| . | || .. |..
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase old-1.AA TK-Unique 175-461 31 8.1e-71 241.58 In-house 1-294 (294) Show / Hide 
Range on Protein: 175-461
Range on HMM: 1-294/294
Sequence Identity: 31% (96 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNEEKESRLEVAVKLPLNEYNQIQQELIYDELKVMCAVGKHPNILALVGGITFG-ERKMIVSEFVENGDLLSFLR
.  |. .|.|.|| . .| .....   .. . .  ||||.   . .. ..    .|...| ..|.||||. ..|  |.  |. ||. |....|.|...||
LEVGDVIGEGAFGQVWRGEVWGIW---KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

DNRIY-----------FTNDQWTLETEQDSLSLVDLLSFAFQIAKGMEYLIH--VPCVHRDLALRNVLIKKNRIIRIADFGLARRHKNKDYYKTQSVDTP
 .| .           |. .  . . . ...|. ||..||.|||.|||||      .|||||. ||||.  . .. |.|||.||.  .   | ..    .
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

LPIHWMAPESID--KLLF-TQKSDVWSYGVCLYELFSLGKSPYENVIKYDQRDFYWKYVLSYLNEGKRLAQPAHA-DAEIYNVMKLCWDLDMNSRTTFLD
.|| ||||||.   .  . | ||||||.|| ..|.|.||. || .. . |        ..  . .|.|. ||.|    |.||.|| || ..  .| .| .
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD--------IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQ

CIEFF
..  .
IKHRL
Kinase old-1.AA UTK 175-402 35 2.5e-61 208.58 In-house 1-243 (296) Show / Hide 
Range on Protein: 175-402
Range on HMM: 1-243/296
Sequence Identity: 35% (89 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNEEKESRLEVAVKLPLNEYN-QIQQE---LIYDELK---VMCAVGKHPNILALVGGITFGERKMIVSEFVENGD
.  ||.||.|.||...|. ..  .    | .  . ||||   .. . | ..|    .  | .   .| ..  |||.| |||  | .|  |||.|. ||||
VQLGRQLGQGAFGEVHKARFTQCS----EHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGD

LLSFLRDNRIYFTNDQWTLETEQDSLSLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNR-------IIRIADFG---LARRHKN--------K
|.|.||..|  .         ....|.| ..|..| .|| ||.||    .|||||| ||.|. ..|       ...|||||   ..|| ..         
LRSYLRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWE

DYYKTQSVDTPLPIHWMAPESIDKL-LFTQKSDVWSYGVCLYELFSLGKSPYEN
.|| ........|| |||||....   ||.||||||.|| ..|... |. ||..
SYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPG
Kinase old-1.AA PDGFR 285-461 44 2.7e-58 185.58 In-house 189-358 (358) Show / Hide 
Range on Protein: 285-461
Range on HMM: 189-358/358
Sequence Identity: 44% (80 aa)

TLETE-QDSLSLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNRIIRIADFGLARRHKNKDYYKTQSVDTPLPIHWMAPESIDKLLFTQKSDVW
.|. . .  |.. |||.|..|.|||||.|    ||||||| ||||. . ... | ||||||  .|   |      . ||. |||||||   ..| .||||
ELMEDDSNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKG-NARLPVKWMAPESIFDCVYTTQSDVW

SYGVCLYELFSLGKSPYENVIKYDQRDFYWKYVLSYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFF
|||. | |.|||| .||  .   ..  || .       || | |||.|| .||| .|. |||.|   | ||    .| 
SYGILLWEIFSLGGNPYPGMPVDSK--FYKM-----IKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase old-1.AA FGFR 230-461 35 7e-58 195.84 In-house 54-293 (293) Show / Hide 
Range on Protein: 230-461
Range on HMM: 54-293/293
Sequence Identity: 35% (89 aa)

ELKVMCAVGKHPNILALVGGITFGERKMIVSEFVENGDLLSFLRDNRIYF--TNDQWT-------LETEQD-------SLSLVDLLSFAFQIAKGMEYLI
|. .|  .|||.||. | |  | .    .. |. . | |  ||| .|                  . .||         |.  || |.|.|.|.||||| 
EMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARRPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLA

HVPCVHRDLALRNVLIKKNRIIRIADFGLARRHKNKDYYKTQSVDTPLPIHWMAPESIDKLLFTQKSDVWSYGVCLYELFSLGKSPYENVIKYDQRDFYW
   |.||||| ||||.  . .. |.||||||  .. |||.  . .  ||| |||||. .   .| .|||||||| | | . .| .||  .    .     
SRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTT-NGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEE-----

KYVLSYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFF
    .|| ||.|.  |..   ||| .|  ||      | ||   .| .
--LYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase old-1.AA Src 175-461 32 1.2e-55 187.49 In-house 1-255 (255) Show / Hide 
Range on Protein: 175-461
Range on HMM: 1-255/255
Sequence Identity: 32% (93 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNEEKESRLEVAVKLPLNEYNQIQQELIYDELKVMCAVGKHPNILALVGGITFGERKMIVSEFVENGDLLSFLRD
|   | ||.| ||   .|  . .           .||||  | . .  ..|    | ..|  . .|.....|    . .|   || |. ..| || .|..
IKLCRKLGQGQFGEVWMGYWNGN----------TKVAVKT-LKPGT-MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK

NRIYFTNDQWTLETEQDSLSLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNRIIRIADFGLARRHK-NKDYYKTQSVDTPLPIHWMAPESIDK
            ..|  .|.| .|...| |.|.||.||     .||||| ||||. .| .  .|||||||  | ..| |  .. .  .|| |.||| |. 
------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH-GAKFPIKWTAPEAINY

LLFTQKSDVWSYGVCLYELFSLGKSPYENVIKYDQRDFYWKYVLSYLNEGKRLAQPAHADAEIYN-VMKLCWDLDMNSRTTFLDCIEFF
  ||.||||||.|. |.|... |. ||.   . .        ||  .  | |. .|..  .|.|. .|. ||. |   | ||    .|.
GRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHE--------VLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase old-1.AA KIN6 240-461 32 1.4e-55 182.09 In-house 77-305 (305) Show / Hide 
Range on Protein: 240-461
Range on HMM: 77-305/305
Sequence Identity: 32% (77 aa)

HPNILALVGGITFGERKMIVSEFVENGDLLSFLRDNRIYFTN---------DQWTLE--TEQDSLSLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVL
|| .  . | .|  .   .| |. ...||| .||. . |  |         ..   .  .    ... ||..||.||. |||||    |.||||| ||||
HPHLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQYMMNLDDLGINYHCPDENSRYDDMMCIRHKDLYMFAWQICDGMEYLHSKNCIHRDLAARNVL

IKKNR---IIRIADFGLAR-RHKNKDYYKTQSVDTPLPIHWMAPESIDKLLFTQKSDVWSYGVCLYELFSLGKSPYENVI-KYDQRDFYWKYVLSYLNEG
. .        | ||||.|     .  |.. . .  ||| |||||.. .  |  ||||||.|| ..|.|||| .||. ..   .        ..  .  |
VTEGCRMKTCKISDFGLCRYPYMDQFQYTSKG-GRYLPIKWMAPECLKHYEFSYKSDVWSFGVLMFEMFSLGDVPYPEMQRPTE--------MIEHHRSG

KRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFF
.|...|  .  |||..|..||  ..  |  | .    |
RRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase old-1.AA EGFR 175-462 33 1.4e-53 176.19 In-house 1-258 (258) Show / Hide 
Range on Protein: 175-462
Range on HMM: 1-258/258
Sequence Identity: 33% (97 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNEEKESRLEVAVKLPLNEYNQIQQELIYDELKVMCAVGKHPNILALVGGITFGERKMIVSEFVENGDLLSFLRD
. |.. |||| || . ||         | .. .  ||.|   .. .. ..| . || .||  | .||... |. |.  ..  ..|  .   | || ..| 
LKKVKVLGSGAFGTVYKGIWIP-----EGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASV-DHPHLVRLL-GVCMHSQMQLVTQYMPYGCLLDYVRQ

NRIYFTNDQWTLETEQDSLSLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNRIIRIADFGLAR-RHKNKDYYKTQSVDTPLPIHWMAPESIDK
..              | .   .|| ...||||||.||     |||||| ||||.|.   ..|.|||||.  ..... |. |.  .  || ||| |.| .
HK--------------DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKM--PIKWMALECIHH

LLFTQKSDVWSYGVCLYELFSLGKSPYENVIKYDQRDFYWKYVLSYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFFE
  .| .|||||||| . ||   |..||...   .  |.        | .|.||.||      .| ||  || .| ..| ||   .| |.
RCYTHQSDVWSYGVTCWELMTFGQKPYDGIPAREIPDL--------LEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase old-1.AA VEGFR 289-461 42 5.9e-51 175.6 In-house 166-332 (332) Show / Hide 
Range on Protein: 289-461
Range on HMM: 166-332/332
Sequence Identity: 42% (74 aa)

EQDSLSLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNRIIRIADFGLARR--HKNKDYYKTQSVDTPLPIHWMAPESIDKLLFTQKSDVWSYG
..| | ..||....||.|.|||.|    |.||||| ||.|.  | .. | ||||||    |. | |...   . ||| |||||||    .| .|||||||
WKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPD-YVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYG

VCLYELFSLGKSPYENVIKYDQRDFYWKYVLSYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFF
| | | ||||.|||   .. |. .|. .     |..| |.  |  .  ||| .|  ||  . ..| .| .  | .
VFLWEIFSLGGSPYP-GVQIDE-EFCNR-----LKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase old-1.AA S_TKc 175-461 20 1.8e-30 108.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 175-461
Range on HMM: 1-231/231
Sequence Identity: 20% (62 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNEEKESRLEVAVKLPLNEYNQIQQELIYDELKVMCAVGKHPNILALVGGITFGERKMIVSEFVEN--GDLLSFL
  ..|..|.| ||  .|.  ..         .  .||.|           | |. |....    .||||  | . .   ..  .| |....  |||....
YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI

RDNRIYFTNDQWTLETEQDSLSLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNRIIRIADFGLARRHKNKDYYKTQSVDTPLPIHWMAPESID
....   ..           ..  .  ... ||....||.     .||||   |.|. .   | |.||||||.                  ..|||| . 
KKRGRHGLR---------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL-

KLLFTQ-KSDVWSYGVCLYELFSLGKSPYENVIKYDQRDFYWKYVLSYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIE---------FF
   ..  |.|.|| |..|||... |. |..      | .  .| ..               . |  . .. |.. | . | |  .. .         .|
--GYGKCKCDWWSCGCILYEMLC-GYPPFP------QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase old-1.AA Pkinase 175-461 22 2.8e-28 101.06 Pfam 1-293 (293) Show / Hide 
Range on Protein: 175-461
Range on HMM: 1-293/293
Sequence Identity: 22% (72 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNEEKESRLEVAVKLPLNEYNQIQQELIYD----ELKVMCAVGKHPNILALVGGITFGERKMIVSEFVENG----
. .||..||| ||  .|.  .. .          .||||  ..  ..  ......    |...|  . .||||. | .  . . .  .| |..|.|    
YHIGRKIGSGSFGCVYKCHHKGTGK---------IVAVKI-IKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVM

DLLSFLRDNRIYFTNDQWTLETEQDSL--SLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNRII----RIADFGLARR--HKNKDYYKTQSVD
|| ....               .. ..  |  .. ... ||..|.||.    ..|||| . |.||..|  |    .|.|||||.   . |.  ..|  . 
DLFDYIST-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT

TPLPIHWMAPESID-KLLFTQKSDVWSYGVCLYELFSLGKSPYENVIKYDQRDFYWKYVLSYLNEGKRLAQPAHAD---------------------AEI
    ...|||| |      ..|.|.||.|. |||... |. |. . .  .  . . .... ... |..|  .   .                      | 
----PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHC--WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

YNVMKLCWDLDMNSRTTFLDCIEF--F
  ..| |...|...| |. .. .   |
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase old-1.AA VEGFR 230-279 32 2e-06 20.13 In-house 52-104 (332) Show / Hide 
Range on Protein: 230-279
Range on HMM: 52-104/332
Sequence Identity: 32% (17 aa)

ELKVMCAVGKHPNILALVGGITF---GERKMIVSEFVENGDLLSFLRDNRIYF
|||..  .|.| |   . |  |    .   |. .|..  | |...||. | ||
ELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTKRMYF
Kinase old-1.AA PDGFR 230-276 42 1.3e-05 13.6 In-house 52-98 (358) Show / Hide 
Range on Protein: 230-276
Range on HMM: 52-98/358
Sequence Identity: 42% (20 aa)

ELKVMCAVGKHPNILALVGGITFGERKMIVSEFVENGDLLSFLRDNR
|||.|   |.| ||  | |  | |    |. |.   |||| .|. .|
ELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR
Kinase old-1.AA UTK 422-461 26 6.2e-05 12.82 In-house 255-296 (296) Show / Hide 
Range on Protein: 422-461
Range on HMM: 255-296/296
Sequence Identity: 26% (11 aa)

EG--KRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFF
.|   |...|..  ...|..|. ||  |   | .| |  ...
NGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM