Gene mkk-4 (Nematode worm)

mkk-4

Species: Nematode worm
Alias: aSWK324, mkk-4, F42G10.2, CE10328
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 9996925-9999200, WormBase Genetic Map location: n/a,

Classification

Group: STE
Family: STE7
Subfamily: MEK4

Sequence

Name Sequence Type Origin Length Description Download
mkk-4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON
mkk-4.AA Protein Genbank 363 None Fasta, JSON

Protein domain

Protein domains of mkk-4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase mkk-4.AA MEK4 66-330 72 4.5e-221 728.59 In-house 1-275 (275) Show / Hide 
Range on Protein: 66-330
Range on HMM: 1-275/275
Sequence Identity: 72% (198 aa)

LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIG-----HREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRVYMV
|||||.||||.||||.||.|||.||..|||||||||..     |.||.|||.|||...|||..|.|||||||.|.||||||||||||||||..||.||||
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

KNSRLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERITS---SDKYDVRSDVWSLGI
..||..||..|||||||||||.|||...|||||||||||||.|..|.||||||||||||..|.||||||||.||.|||||..   .|.||.|||||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TLYEIATGKFPYQEWN--SLFDQIATVVSGDPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFY
|.||.|||||||..||  |.||||..||.|||||||.|..|.||| |...||||||||||.||||||.||.|.||
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase mkk-4.AA STE7 66-330 47 6.00000000001e-167 560.93 In-house 1-288 (288) Show / Hide 
Range on Protein: 66-330
Range on HMM: 1-288/288
Sequence Identity: 47% (140 aa)

LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGD--CWICMELMD-ISMDLLYKRVYMV--
|...| .|.||.|.|||||||..||..||||||..| ...|| ..|.|.|.. |... |.||.||||...|||  .|||||.|| ...|..||||..|  
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--KNSRLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESF-AKTHDAGCQPYLAPERIT-SSDKYDVRSDVWSLG
  |..|..|...|.|.|.....|.||....||||||||||||||.  | ||||||||||||..|  |.|...||||| |||||. ....|||||||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

ITL-YEIATGKFPYQEWNS-----------------LFDQIATVVSG-DPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKS-FDFY
||. .|.|||..||..||.                  |.|.  .| . .||.|.      ..| ... |.|.||.||...||||. |.  ..|.
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP------KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase mkk-4.AA MEK3 66-330 45 4e-110 372.15 In-house 1-264 (264) Show / Hide 
Range on Protein: 66-330
Range on HMM: 1-264/264
Sequence Identity: 45% (123 aa)

LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRVYMVKNSRL
.  .   | | .| | ||||. .|  .||||||   .  .|| |.| . |    |   |  |.||||.| ||| |||||.|| . | .|..||  .. . 
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRM-TVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHI

NENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERI---TSSDKYDVRSDVWSLGITLYEI
 |.. | | .  | || |..  ||.|||||||||.|.   | ||.||||| |.| .| ||| |||| || |||||   ...  |||.|||||||||. |.
PEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEM

ATGKFPYQEWNSLFDQIATVVSGDPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFY
|.| .||  |   |.|   || . || |  ..    .|   . ||| || |.   ||.|  |    | 
AIGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKG---FSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase mkk-4.AA MEK7 66-330 41 1.1e-99 337.46 In-house 1-269 (269) Show / Hide 
Range on Protein: 66-330
Range on HMM: 1-269/269
Sequence Identity: 41% (113 aa)

LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRVYMVKNSRL
|. .| .|.|  |.| |||||..|  .|||  | .     |  | |.  | . ..   | ||. .|..  . | |||||.|   .| | ||..  |    
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTG-NKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFI

NENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERITS----SDKYDVRSDVWSLGITLYE
 | ..|...| .. ||.|||    |.|||||||||| |  | .||||||| | . .| |.|  ||| .| |||||.      .|||.|.|||||||||.|
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVE

IATGKFPYQEWNSLFDQIATVVSG--DPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFY
 |||..||.  .  |. .  .     .|| | .      .|    .|.. ||.|| | ||||. |   .|.
LATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMK-YNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase mkk-4.AA STE 66-330 29 1.2e-96 327.36 In-house 1-359 (359) Show / Hide 
Range on Protein: 66-330
Range on HMM: 1-359/359
Sequence Identity: 29% (107 aa)

LQDLGAIGNGNFGTVYKMRHKE---------------TGKLIAVKRIRCNNIG---------------HREQIRLLREHDTIVKSEK-GPNIVKFYGAIF
..... ||.|.|||||| ....               ||...|.|... .|                 | |. ..|.| ..  |. .  |||||.||. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SEG-------DCWICMELMD-ISMDLLYKRVYMVKN---------SRLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICG
 ||       ..|||||.||  | | ..|..|....         .|..|.....|.. .. .| |.. ...|||||.||.|||.     |||||||.||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLEESFA----------------KT-HDAGCQPYLAPERITS-----SDKYDVRSDVWSLGITLYEIATGKFPYQEWNSL---------------FDQIA
||..| |                |. ...|.. . |||.|.      ...||...|.||||.|. | |||| |. . . .               |.|. 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

TVVSGDPPILHPDSDD--------------FHYSLPLVKFINTCLTKDRRHRPKYDTLKS--FDFY
 .| |.|| | .. ..               ..| ..  ||| ||.|| ..||... | .    | 
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase mkk-4.AA STE7-Unclassified 66-330 36 1e-77 264.49 In-house 1-301 (301) Show / Hide 
Range on Protein: 66-330
Range on HMM: 1-301/301
Sequence Identity: 36% (111 aa)

LQDLGAIGNGNFGTVYKMRHKE------TGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGD---CWICMELMDI-SMD---L
|. |. .|.|..|||.| .||       .|| .| | |.  .     .  .|||  |. | .  |.||..||| ..|.      ||||.||  | |    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

LYKRVYM---VKNSRLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESF--AKTHDAGCQPYLAPERITSS----
.||..|    .. ....| |.| |.     .|.||.....|||||.||.||||.  | ||.||||.||||| .   |||  .||| | .|||| .     
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKT-WVGCQMYMSPERIQGQMPHR

DKYDVRSDVWSLGITLYEIATGKFPYQ------EWNSLFD-------QIATVVSGDP-PILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKS-FD
  | |.||.||||.|. | ||||.||         |  |.       .. . . . | |.|  | .|  .|  .  ||. |. |. | || .  |    .
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

FY
. 
WI
Kinase mkk-4.AA S_TKc 66-330 28 3.2e-69 237.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 66-330
Range on HMM: 1-231/231
Sequence Identity: 28% (79 aa)

LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDI----SMDLLYKRVYMVK
 . |  || | ||.||| |||.||.. |.|.|.         ....|| .   |  . |||||.|... . .. ...||..|      .|.. || .  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

NSRLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERITSSDKYDV-RSDVWSLGITLY
.....| .. ...  ...||.|. .  .|||||.||.|||.|    .|.||||.. ||      |.  |   |.||| .    .|.  ..|.||.|..||
RFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

EIATGKFPYQEWNSLFDQIATVVSGDPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKS-------FDFY
| ..|. |..      ...  ..                | ..  ||. ||.|| ..||    .           . 
EMLCGYPPFP----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase mkk-4.AA MEK5 66-330 40 4.3e-58 199.31 In-house 1-254 (254) Show / Hide 
Range on Protein: 66-330
Range on HMM: 1-254/254
Sequence Identity: 40% (110 aa)

LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRVYMVKNSRL
..   ..| || |||||  |  .||..||| |   .|    | ... | . . | .  | |. |||| | |    || | ||     .|...        
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL-DITLELQKQIMSELEILYKCD-SPYIIGFYGAFFVENRISICTEFMDGGSLDMYRCI--------

NENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERITSSDKYDVRSDVWSLGITLYEIATG
 | ..| .||  |  | ||  .|||.||||||||.||   | .||||||.  || .| ..|   |   |.||||| | |.| . |||||||| . |.|||
PEHILGRMTVAIVKGLNYL-WNLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERI-SGDQYGIHSDVWSLGIFFMEMATG

KFPYQEWNSLFDQ--------IATVVSGDPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFY
.||| . .   ||        .  .|  .|| |  |    ..| | |.||| |. |  . ||| . |    | 
RFPYPQIQR--DQGELMPIQLLQCIVDEHPPRLPVD----KFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase mkk-4.AA MEK1 66-268 41 1.2e-55 188.46 In-house 1-195 (297) Show / Hide 
Range on Protein: 66-268
Range on HMM: 1-195/297
Sequence Identity: 41% (84 aa)

LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMD-ISMDLLYKRVYMVKNSR
.. .| .| || | | |.||..|| ..| | |.   |    .  ..||   . .    | || |||| .|.|.  |||| ||  |.|.. |..      |
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHL-EIKPAIRNQIIRELQVLHECNS-PYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-----GR

LNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERITSSDKYDVRSDVWSLGITLYEIAT
. |...|...|  .  | ||. . ||.|||||||||||   | .||||||. ||| .| |     |   |..|||.. .  | |.||.||.|. | |.| 
IPEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQGT-HYTVQSDIWSMGLSLVEMAI

GKFP
|..|
GRYP
Kinase mkk-4.AA Pkinase 66-319 28 1.4e-54 192.47 Pfam 1-282 (293) Show / Hide 
Range on Protein: 66-319
Range on HMM: 1-282/293
Sequence Identity: 28% (83 aa)

LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIRLLR--EHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDIS---MDLLYKRVYMV
.. .. || |.||.||| .|| |||. |||.|.  .. . ......|  |     .  . ||||..|..  ........||...     |||     |. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF---DYIS

--KNSRL--NENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAV----KLCDFGICGQ--LEESFAKTHDAGCQPYLAPERITSSDKYDVRS
  .. ..   |... ..   .. .|.|. .  .|||||.||.|||.| .| .    |.||||.. |  .  .   |. .|  .|.||| | .. .|. ..
TWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSLGITLYEIATGKFPYQEW---NSLFDQIATVVSGDPPILHPDSDDFHY------------------SLPLVKFINTCLTKDRRHRP
|.||.|..||| ..|..|...     .  ||.. ..   .|.|| |..  .                   | .. .||. ||.||   ||
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase mkk-4.AA STE20 66-330 29 2.7e-49 170.1 In-house 1-288 (288) Show / Hide 
Range on Protein: 66-330
Range on HMM: 1-288/288
Sequence Identity: 29% (88 aa)

LQDLGAIGNGNFGTVYKMRHKETGKL----IAVKRIRCNNI----GHREQIRLLREHDTIVKSEKGPNIVKFYGAIFSE----GDCWICMELMDI-SMDL
 ..|  ||.|..|.||| .||.||..    .|.|..  ..      ..| |  . | .   ..   |||||.||. . .     . ||.||...  |   
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDI--QKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTD

LYKRVYMVKNS----RLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEE----SFA-K-THDAGCQPYLAPERITS
..|.... ...    ..||  .  |.  .. .|||| .. .|||||.|  |||..  | |||.||| |.||..    ... |  .  |   ..||| |  
IMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQC

----SDKYDVRSDVWSLGITLYEIATGKFPYQEWNSLFDQIATVVSGDPPILHPDSDDF--HYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFY
      .|| ..|.||||||. | |.|. || . . .   . .. ....| ..  .|    ..|  .  |...||.||   ||  . | .  | 
MEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPM-RAMFMIPKNQNPPPTLKDD-KPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase mkk-4.AA TKL 72-271 21 1.3e-40 141.21 In-house 1-291 (364) Show / Hide 
Range on Protein: 72-271
Range on HMM: 1-291/364
Sequence Identity: 21% (64 aa)

IGNGNFGTVYKMRHKE--------TGKLIAVKRIRCNN-----------------------IGHREQIRLLREHDTIVKSE-KGPNIVKFYGAIFSEGD-
|| | ||.||| ...         ||| .|||... .|                         . ...|  .|  . ..|  . ||||.|.|. ..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------CWICMELMDI-S-MDLLYKRVYMVKNSRLNENVVGHITVCTVDALDYLKKELK-------IIHRDVKPSNILVDGTGA----------
            ..| ||...  |  ..|              ..  ..   .  ...||  .         ||||| |..|||||  .           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

----VKLCDFGICGQLEESF--------------------AKTHDAGCQPYLAPERITSSD---------------KYDVRSDVWSLGITLYEIATGKFP
    .|.||||..  ...|.                    .. .  |   ..||| .  ..               .|. ..||.| || |.||.|.. |
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

YQE
|..
YYD
Kinase mkk-4.AA TyrKc 66-329 23 1.5e-14 12.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 66-329
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSE--KGPNIVKFYGAIFSE-------GDCWICMELMDISMDLLYKR
.. .  .|.|.||.||| . |      ||| .. .      .  ..||   | ..   . ||||..||.. ..       .  .| ||.|.   ||.   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREA-RIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLK---

VYMVKNSRLNENVVGHITVCTVDALDYLK---------KELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEES-FA----KTHDA----GCQP-----
 |  |. .          .|. | |..            . ..||||    |.||.  . || .||| .  ...   .    .. ..    |.       
DYLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YLAPERITSSDKYDVRSDVWSLGITLYEIAT-GKFPYQEW----NSLFDQIATVVSGDPPILHPD-----SDDFHYSLPLVKFINTCLTKDRRHRPKYDT
 .||| |    |.   ||||| |....|| | |. || .      | .. |. | .|. .   |.     .   . .  . . . .|   |   ||   .
WMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSE

LKSFDF
.   .|
I-HECF
Kinase mkk-4.AA Pkinase_Tyr 199-285 28 4.2e-11 38.24 Pfam 141-232 (270) Show / Hide 
Range on Protein: 199-285
Range on HMM: 141-232/270
Sequence Identity: 28% (27 aa)

NILVDGTGAVKLCDFGICGQL---EES-FAKTHDAGCQPYLAPERITSSDKYDVRSDVWSLGITLYEIAT-GKFP-YQEWNSLFDQIATV-VSG
|.||. .. || |||| .  .   ..   ....     . .||| |  .  . . ||||| |....|| | |. | |... | .. .. .  .|
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDG
Kinase mkk-4.AA Pkinase_Tyr 66-146 28 0.000906 13.39 Pfam 1-89 (270) Show / Hide 
Range on Protein: 66-146
Range on HMM: 1-89/270
Sequence Identity: 28% (26 aa)

LQDLGAIGNGNFGTVYKMRHK----ETGKLIAVKRIRCNNIGHRE--QIRLLREHDTIVKSE-KGPNIVKFYGAIF-SEGD--CWICMELM
.. .  .| |.||.||| . |    .|.   ||| ..  .  |..  .  ..|    | |.  . ||||..||..   ..    .| ||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYM
Kinase mkk-4.AA MEK1 275-330 23 0.020876 3.44 In-house 246-297 (297) Show / Hide 
Range on Protein: 275-330
Range on HMM: 246-297/297
Sequence Identity: 23% (13 aa)

LFDQIATVVSGDPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFY
.|. .  .| . || |    ..  .|  .. |.. || |    |    .|..  | 
IFEMLDYIVNEPPPKL----PHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI