Gene lin-45 (Nematode worm)

lin-45

Species: Nematode worm
Alias: CE25585, Y73B6A.5, lin-45, raf-1, aSWK425, Y73B6A.5a
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 6747394-6743228, WormBase Genetic Map location: IV:3.23454,

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
lin-45.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
lin-45.AA Protein Genbank 813 None Fasta, JSON

Protein domain

Protein domains of lin-45.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD lin-45.AA RBD 85-161 42 1.1e-36 130.0 Pfam 1-77 (77) Show / Hide 
Range on Protein: 85-161
Range on HMM: 1-77/77
Sequence Identity: 42% (33 aa)

KMIMVHLPFDQHSRVEVRPGETARDAISKLLKKRNITPQLCHVNASSDPKQESIELSLTMEEIASRLPG-NELWVHSE
|...||||..|...||||||.|.||...|..|.....|. |||....|| .|... .|......|.||| .||||...
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDP-HEGEKKPLDWHTDISWLPGPQELWVENL
RBD lin-45.AA RBD 85-161 41 1.2e-33 119.01 SMART 1-76 (76) Show / Hide 
Range on Protein: 85-161
Range on HMM: 1-76/76
Sequence Identity: 41% (32 aa)

KMIMVHLPFDQHSRVEVRPGETARDAISKLLKKRNITPQLCHVNASSDPKQESIELSLTMEEIASRLPGNELWVHSE
|...||||..|...|.||||.|..|...|..|||...|. |||.....| .|... .|......|.|||.||||...
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHP-HEGEKKPLDWHQPISYLPGQELWVENR
C1_1 lin-45.AA C1_1 171-220 25 7.2e-17 65.58 Pfam 1-55 (55) Show / Hide 
Range on Protein: 171-220
Range on HMM: 1-55/55
Sequence Identity: 25% (14 aa)

HAIVRR-TFIPPKSCDVCNNPI----WMMGFRCEFCQFKFHQRCSSFAPLYCDLL
| .|.. .|  |..|..|....    ...|..|. |....|.||....| .|.. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 lin-45.AA C1 171-217 27 1.2e-15 59.17 SMART 1-61 (61) Show / Hide 
Range on Protein: 171-217
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HAIVRRTFIPPKSCDVCNNPIWMM--------GFRCEFCQFKFHQRCSSFAPL-------YC
|  ....|  |. |..|. .|| |        |.||. |..|.|..|....|.        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 lin-45.AA C1_3 182-210 30 7e-06 16.41 Pfam 1-30 (30) Show / Hide 
Range on Protein: 182-210
Range on HMM: 1-30/30
Sequence Identity: 30% (9 aa)

KSCDVCNNPIWM-MGFRCEFCQFKFHQRCS
. |..|  ||   ....|  | | .|..| 
FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA
Kinase lin-45.AA RAF 481-745 61 9.40000000001e-192 627.41 In-house 1-282 (282) Show / Hide 
Range on Protein: 481-745
Range on HMM: 1-282/282
Sequence Identity: 61% (173 aa)

FIIQYKVGSGSFGTVYRGEFFGTVAIKKLNVVDPTPSQMAA---FKNEVAVLKKTRHLNVLLFMGWVREPE---IAIITQWCEGSSLYRHIHVQEPRVEF
.......|||||||||||...|.||.|.|||.||||.||.|   |||||||.|||||.|.|||||....|.   .||.|||||.||||.||||||.|..|
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

EMGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIR-----------MQDDNPYT
.| ..|||..||..||.|||.|||||||||.|||||..||. ||||||||.||||.|...|.||..|||..||||||||||           |||.|||.
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMT-VKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYS

PQSDVYSFGICMYEILSSHLPY-SNINNRDQILFMVGRGYLRPDRSKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLERLRD
.|||||||||.|||....|.|| ..|.|||||.||.||||||||.||.|.|.||.| .|...|..|.|.|||.|...|.|.  
FQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase lin-45.AA RAF 481-743 49 4.1e-169 568.13 In-house 1-275 (275) Show / Hide 
Range on Protein: 481-743
Range on HMM: 1-275/275
Sequence Identity: 49% (138 aa)

FIIQYKVGSGSFGTVYRGEFFGTVAIKKLNVVDPTP-SQMAAFKNEVAVLKKTRHLNVLLFMGWVREP---EIAIITQWCEGSSLYRHIHVQEPRVEFEM
. |....|.|.|||||||...|.||.| ||...||| .|..||||||...||||| |..||||....|   ..||.||||.||.||.|||||.. ..|.|
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKT-EKFDM

GAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVK-TKWTVNGGQQQQQPTGSILWMAPEVIRMQ---------DDNPYTPQS
 ..|.| .|.  ||.|||.|||||||||..||||..... |.|.||||.||| ..|.... ||..||.|.|.|||||||||.         |.||...||
NWTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKV-VVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQS

DVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRPDRSKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLERL
|||.||...||......||..|....||..||.|||||.||||.|...||.| .|...|......|||.| ......
DVYAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase lin-45.AA TKL 487-743 25 2e-88 300.05 In-house 1-364 (364) Show / Hide 
Range on Protein: 487-743
Range on HMM: 1-364/364
Sequence Identity: 25% (95 aa)

VGSGSFGTVYRGEFFG-----------TVAIKKLNVV------------------------DPTPSQMAAFKNEVA-VLKKTRHLNVLLFMG--------
.|||.||.||.|.. |           .||.||...                         ||..|..  |..|.. .....|| |...|||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-WVREP-----EIAIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMNYLHS--------KNIIHRDLKTNNIFLMDDMS-------------
 .. .|     ...|....|.| ||. ..|         .  .... .....|||||||        ..|||||||..||.. ...              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

TVKIGDFGLATVKTKWTV---------------NGGQQQQQPTGSILWMAPEVIRMQDD-------------NPYTPQSDVYSFGICMYEILSSHLPYSN
..||.||||...... .                |....   . |.. ||||||.|.|..              .|....|||||||...|||.  .||..
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

INNRDQI------LFMVGRG--YLRPDRS---------KIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLERL
......|      .......   ||| .             .|.|.|| ||   |   | ..|| | |.|.||
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase lin-45.AA Pkinase 481-743 24 2.6e-64 224.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 481-743
Range on HMM: 1-293/293
Sequence Identity: 24% (74 aa)

FIIQYKVGSGSFGTVYRGEFFGT---VAIKKLNVVDPTPSQMAAFKN--EVAVLKKTRHLNVLLFMGWVR-EPEIAIITQWCEGS----SLYRHIHVQEP
. |  |.||||||.||..   ||   ||.|......  ...  .  .  |....|. .| |.. . .|.. ...| ... .|||     .|...|.. . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

RVEF--EMGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMST---VKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQDDNPYTPQ
.  |  ..  ......|.  |..|.||..|||||||  ||.. ... .   |||.||||| ..       ..  . ..|.. .|||||||  ....|.| 
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPK

SDVYSFGICMYEILSSHLPYSNI----NNRDQILFMVGRGYLRPDRSKIRHDT------------------PKSMLKLYDNCIMFDRNERPVFGEVLER-
.|..|.|. .|| |. ..|...     | .||.  .. ... .....    ..                  ....... ..|. .| ..|| . ..|.  
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
Kinase lin-45.AA TKL-Unique 483-743 32 7.4e-64 218.47 In-house 1-290 (290) Show / Hide 
Range on Protein: 483-743
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)

IQYKVGSGSFGTVYRGEF-FGTVAIKKLNV-VDPTPSQMAAFKNEVAVLKKTR-HLNVLLFMGWVR-----EPEIAIITQWCEGSSLYRHIH-------V
.  |.|.|..|.||.|.. .  ||||....  |. .. |  |.||| ..|| . | |....||.       .|.  |..  |.|.||| ..|        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

QEPRVEFEMGAIIDILKQVSLGMNYLHSKN--IIHRDLKTNNIFLMDD-----MSTVKIGDFGLATVKTKW---TVN---GGQQQQQPTGSILWMAPEVI
 ..  .. |  .... .....||.|||...  |||||||. |. .  .     .. .|| ||||.....|    |.|   |.   | . ||..||||||.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWN-IKICDFGLSKFNSKINKMTNNEHKGTR-NQTRCGSFRWMAPEVL

RMQDDNPYTPQSDVYSFGICMYEILSSHL------PYSNINNRDQILFMVGRGYLRPDRSKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLERL
||   . |. .||||||||...||.....      ||... ...|.. ||    ..  | .|  . ||.  .| . |   |  .|| | |...||
RMNF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase lin-45.AA S_TKc 481-747 23 5.1e-58 199.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 481-747
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

FIIQYKVGSGSFGTVYRGEFFG---TVAIKKLNVVDPTPSQMAAFKNEVAVLKKTRHLNVLLFMGWVREPEIAIITQWCEG--SSLYRHIHVQEPRVE--
. |  |.|.|.||.||..   .    ||||...           ...|...||| .| |.  . .. .. .. ...  |.|   .|...|. . ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FEMGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQDDNPYTP-QSDVYSF
 |    .  ...|. ....|.||..|||||||  ||.| .   ..||.|||||..                |.  .|||||.      .|..  .|..|.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----------TTFCGTPWYMAPEVL------GYGKCKCDWWSC

GICMYEILSSHLPYSNINNRDQILFMVGRGYLRPDRSKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLE-----RLRDII
|...|| |.   |..   . .... ..|               ..... . ..|  .| ..||   |.|.     ..   .
GCILYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase lin-45.AA TK 481-743 15 2e-50 166.84 In-house 1-486 (486) Show / Hide 
Range on Protein: 481-743
Range on HMM: 1-486/486
Sequence Identity: 15% (75 aa)

FIIQYKVGSGSFG---TVYRGEFFG----------------------------TVAIKKLNVV-DPTPSQMAA--------------FKNEVAVLK--KT
 ..  | |.| ||   .||.|| .|                            .||.| |    . .. .. .              . .| ....  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHLNVLLFMGWVREPE-------------IAIITQWCEGSS----LYRHIHVQEPRVE------------------------------------------
.| |.. . | . ..|             . |.. .... .    |  . .   |.                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FEMGAIIDILKQVSLGMNYLHSK------NIIHRDLKTNNIFLMDDMS----------TVKIGDFGLA-
                               . |   . .  |.. || |||||      |..|||| . |. . ...           ..||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----------TVKTKWTVNGGQ------------------QQQQPTGSILWMAPEVIRMQD------DNPYTPQSDVYSFGICMYEILS--SHLPYSNI
             .  ......                   ||..    | |||||... .       .. .|..|||.|||..|.||..     .| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NN--------RDQILFMVGRG-----------YLRPDRSKIRHDTP-------------KSMLKLYDNCIMFDRNERPVFGEVLERL
.|         .... .. ||             |  . .  | ..             . .  |   |  .| ..|| | ...|.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase lin-45.AA Dicty4 481-745 33 2.3e-50 166.24 In-house 1-277 (277) Show / Hide 
Range on Protein: 481-745
Range on HMM: 1-277/277
Sequence Identity: 33% (97 aa)

FIIQYKVGSGSFGTVYRGEFFGT-VAIKKL--NVVDPTPSQMAAFKNEVAVLKKTRHLNVLLFMGWVR----EP-EIAIITQWCEGSSLYRHIHV----Q
  |. . |.||||.||.|   |. ||.|||  . ..   . . .|..||. ..| || |..||||       .| .. | |  .   .||. .|     |
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

EPRVEFEMGAIID---ILKQVSLGMNYLHSKN--IIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQ-QQQPTGSILWMAPEVIRMQDDNPY
 .... . . |.    . . . .|||.||. |  |||||||. |. |.|.  .||..||||.... | . .  .. |  . |. .|||||| . |   ||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNL-LVDKNWRVKVCDFGLSQYMKKHEDH--KDNQMTACGTPCWMAPEVMMHQ---PY

TPQSDVYSFGICMYEILSSHLPYS-NINNRDQILFMVGRGYLRPDRSKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLER--LRD
.  .|||||||  .|||    ||.  . . .|. . |..  |||   .|  ..|.|  .|   |   | . || | |...|  |  
NEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRP---PIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase lin-45.AA MLK 481-743 27 1.2e-48 166.83 In-house 1-291 (291) Show / Hide 
Range on Protein: 481-743
Range on HMM: 1-291/291
Sequence Identity: 27% (82 aa)

FIIQYKVGSGSFGTVYRGEFFGTV------AIKKLN-VVDPTPSQM----AAFKNEVAVLKKTRHLN----VLLFMGWVREP-E-IAIITQWCEGSSLYR
. .. ..|||||| |..|.. ..       |.|. .   .   |..     .|. |.  |.. .|.|    .  |.|   .|    .|....|||.|||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

HIHVQEPRVE-----------FEMGAIIDILKQVSLGMNYLHSKN---IIHRDLKTNNIFLMD-----DMSTVKIGDFGLAT-VKTK---WTVNGGQQQQ
 .| ...  .             .. .... .|.. ||.||||.    |||||||  || ...     .  |.|| |||... ....    . |      
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNA-----

QPTGSILWMAPEVIRMQDDNPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRPDRSKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVL
   |.  |||||||     ..|.  .||.|.|....|.|.  .||.....  .|...|.   |||    |. . |... ||. .|   | ..|| | ...
---GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRP---PIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIV

ERL
. |
QHL
Kinase lin-45.AA STE 481-690 23 2.3e-42 147.08 In-house 1-273 (359) Show / Hide 
Range on Protein: 481-690
Range on HMM: 1-273/359
Sequence Identity: 23% (65 aa)

FIIQYKVGSGSFGTVYRG----EFFGT--------------VAIKKLNVVDPTP---------------SQMAAFKNEVAVLKKTR--HLNVLLFMGWVR
. .. |.|.|.|||||..      ...              .|||..|. . ..               ..|  ...|. ..|| .  | |.  . |   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

--------EPEIAIITQWCEGSSLYRHIH-VQEPR----------VEFEMGAIIDILKQVSLG-MNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLA
        . |. |.  ...| ||   |. . ..             |.   |. |..|.  | ..||||..|||||.|  ||.|      ||. |||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

TVKTKWTV------------NGGQQQQQPTGSILWMAPEVIRMQD---DNPYTPQSDVYSFGICMYEILSSHLPYSNINN
.  |.               ...|. .  .|.  |||||||. ..   |..|. ..|..|.|... | .  . |... ..
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHP
Kinase lin-45.AA TyrKc 481-743 26 3.4e-40 140.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 481-743
Range on HMM: 1-280/280
Sequence Identity: 26% (79 aa)

FIIQYKVGSGSFGTVYRGEFFGTVAIKKLNVVDPTPSQMAAFKNEVAVLKKT--RHLNVLLFMGWVRE--------PEIAIITQWCEGSSLYRHIHVQEP
     | |.| ||.||.|.   .||.|.|.        ...| .|  ...|   .| |.. . | ...        . . |..  ... .|  ...  .|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RVEFEMGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKW-------TVNGGQQQQQPT--GSILWMAPEVIRMQDDNP
.  . |   ...  |.. ||.||||||.||||| . |. . ..  ||||.||||.   .          .   .. ..      | |||||.|   ... 
K--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGK

YTPQSDVYSFGICMYEILSS-HLPYSN-----INNRDQILFMVGRGYLRPDRSKIRHD-----TPKSMLKLYDNCIMFDRNERPVFGEVLERL
.|..|||.|||.||.||..    ||..     ..|.. ..  | .|| .|    .         |. | ..   | ..| ..|| | |. |..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase lin-45.AA RIPK 582-743 34 3.8e-40 134.51 In-house 112-290 (290) Show / Hide 
Range on Protein: 582-743
Range on HMM: 112-290/290
Sequence Identity: 34% (62 aa)

ILKQVSLGMNYLHSKN--IIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNG---------GQQQQQPTGSILWMAPEVIRMQDDNP---YTPQSD
.....|.||.||||.|  |||||||. || | |    ||| |||||| ..  ....         ... ... | .  |.|| .|    .|    || .|
MIHEISCGMCYLHSMNPPIIHRDLKPENI-LVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYD

VYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRPDRSKIRHDTPKS-----MLKLYDNCIMFDRNERPVFGEVLERL
||||.| |.|.|.   ||..  .  .|.. . .|  ||. . .   .|.      | .|   |   | |.|| | |. |. 
VYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGH-RPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase lin-45.AA Pkinase_Tyr 481-625 30 4.5e-38 129.56 Pfam 1-158 (270) Show / Hide 
Range on Protein: 481-625
Range on HMM: 1-158/270
Sequence Identity: 30% (48 aa)

FIIQYKVGSGSFGTVYRGEFF-------GTVAIKKLNVVDPTPSQ--MAAFKNEVAVLKKT-RHLNVLLFMGWVR---EP-EIAIITQWCEGSSLYRHIH
 ..  | |.|.||.||.|. .        .||.|.|.  . ...|  ...| .|....|.  .| |.. ..| .    || .| |..  ... .|. . .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VQ-EPRVEFEMGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLA
 . |..  . |  ....  |.. ||.||.|||.||||| . |. . ... .|||.|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLA
Kinase lin-45.AA KSR 481-610 41 5.3e-34 113.3 In-house 1-132 (272) Show / Hide 
Range on Protein: 481-610
Range on HMM: 1-132/272
Sequence Identity: 41% (55 aa)

FIIQYKVGSGSFGTVYRGEFFGTVAIKKLNVV-DPTPSQ-MAAFKNEVAVLKKTRHLNVLLFMG-WVREPEIAIITQWCEG-SSLYRHIHVQEPRVEFEM
  .   .| | ||.|.|| ..| |||| ..       .. . .|| ||. .|.||| |. ||||  .  |  ||..  | |  .|| ||||.  |  . |
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVR--REKLDM

GAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFL
   ..| .|   || ||| | ||| |||. |||.
NRTMQIAQQICQGMGYLHAKGIIHKDLKSKNIFY
Kinase lin-45.AA Pkinase_Tyr 648-743 31 4.2e-14 48.38 Pfam 180-270 (270) Show / Hide 
Range on Protein: 648-743
Range on HMM: 180-270/270
Sequence Identity: 31% (31 aa)

WMAPEVIRMQDDNPYTPQSDVYSFGICMYEILS-SHLP-YSNINNRDQILFMV-GRGYLRPDRSKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLERL
|||||.|.      .| .|||.|||..|.||..    | | .. | . .. ..  .||      .. ...|. . .|   | ..| ..|| | |..|.|
WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYR----MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase lin-45.AA KSR 658-743 22 7e-09 26.4 In-house 189-272 (272) Show / Hide 
Range on Protein: 658-743
Range on HMM: 189-272/272
Sequence Identity: 22% (20 aa)

DDNPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILFMVGRG-YLRPDRSKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLERL
...|....||||.||   ||..   .|. .     .|.. ...|  .|.. . .     . |  .   |  .. .||| |   .  |
MCLPFSHHSDVYAFGTIWYEMICGEWPFKY-QCAESIIWQMCQGEGMRQVLRNVQ--CGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase lin-45.AA RIPK 487-554 18 5.6e-05 12.88 In-house 1-82 (290) Show / Hide 
Range on Protein: 487-554
Range on HMM: 1-82/290
Sequence Identity: 18% (15 aa)

VGSGSFGTVYRG--EFFGTVAIKKL---NVVDPT--PSQMAAFKNEVAVLKKTRHLNVLLFMGWVREP------E-IAIITQ
||.|.||.|..      |....||      .. .   ..  . | |.. ..| |. ...   | ....      . ..| ..
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVME