Gene kin-14 (Nematode worm)

kin-14

Species: Nematode worm
Alias: CE05682, aSWK368, F22D6.1, kin-14
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 7087501-7083995, WormBase Genetic Map location: n/a,

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
kin-14.AA Protein Genbank 418 None Fasta, JSON
kin-14.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 279 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of kin-14.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 kin-14.AA SH2 28-109 25 7.5e-24 86.48 SMART 1-87 (87) Show / Hide 
Range on Protein: 28-109
Range on HMM: 1-87/87
Sequence Identity: 25% (23 aa)

NEWFHGVLQRQDADELLVKP----GSFLLRASEVHGKMSMILSVRHDGKLHNIAVNSDTGENFWFEG---HREKSIDQLVQWHMTTSTP
 .|.|| . |..|..|| .|    |.||.| ||   . . .||||..|| ... ....    .....   ..  |. .||....... .
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES-NPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 kin-14.AA SH2 30-103 29 7.5e-16 48.37 Pfam 1-81 (81) Show / Hide 
Range on Protein: 30-103
Range on HMM: 1-81/81
Sequence Identity: 29% (24 aa)

WFHGVLQRQDADELLVK----PGSFLLRASEVHGKMSMILSVRHDG---KLHNIAVNSDTGE-NFWFEGHREKSIDQLVQWH
|.|| ..||.| .|| .    .|.||.| ||   . .  ||||.||   . . . .... ..  . ...|.  |. .||. .
WYHGKISRQEAERLLMNPGNPDGTFLVRESES-TPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
Kinase kin-14.AA Fer 134-401 43 1.3e-145 490.07 In-house 1-283 (283) Show / Hide 
Range on Protein: 134-401
Range on HMM: 1-283/283
Sequence Identity: 43% (128 aa)

VIFIKKLGEGAFGEVSLAE-----CE---IGGRKVETAVKTMRCQ-MTRDTRAAFMKEARLMRK-YSHPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVME
|...||||||||||| ...     .    . ..||. .||...|  .|.. .. ||.|||.||. |.||..|...|            .|| .|.|||||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYG-----------VCVDEQPIMIVME

MCPHGSLLSFLRKNKGK-TTLSERLRFCIESADGLAYLEKKQCLHRDIAARNCLLSI-TDQIK--ISDFGLSDDKRTEMHDDT----LDKVPVKWLAPEV
.|..|||.|.|.|||.|  .. |..|.|...|.|..||..|.|.||||||||||..   ...|  |||||.|........| .    ..|||..|||||.
FCNGGSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPET

MQDKLYSLKSDVWAFGVLMWEIYADGADPYPG------MTNL--VTRAKIFCDDYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKLK
.|...|| |.|||.|||..|||...||.||||      |||.   .|..| ...|.|..|. .||.| .| .||||.| |.||.|||....|||
WQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase kin-14.AA Pkinase_Tyr 134-400 40 3.7e-113 383.86 Pfam 1-270 (270) Show / Hide 
Range on Protein: 134-400
Range on HMM: 1-270/270
Sequence Identity: 40% (114 aa)

VIFIKKLGEGAFGEVSLAECE--IGGRKVETAVKTMRCQMTRDT--RAAFMKEARLMRKY-SHPHIVRIIGKIIVKHLPKVGLAVDAHP--LMIVMEMCP
..|.||||||||||| ....    .. |.. |||... . . .   |..||.||..|... .||.||| .| ..           .  |  ..|||| .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT----------DQGEPNQIYIVMEYMP

HGSLLSFLRKN---KGKTTLSERLRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISDFGLSDDK----RTEMHDDTLDKVPVKWLAPEVMQDK
||.||..|||.   |.. |... | .|.. |.|..||| |.| |||.||||||.. . ..||.||||. |        ..  .  |.|.||.|||.....
HGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYG

LYSLKSDVWAFGVLMWEIYADGADP-YPGMTNLVTRAKIFCDDYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKL
 .. |||||.||||||||.  |. | ||||.|    ..|. | |||  || .|. | .. .||||.. |.|| |.. .|..|
KFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDL-MKQCWHYDPEDRPTFSEIHEQL
Kinase kin-14.AA TyrKc 134-400 36 8.8e-100 338.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 134-400
Range on HMM: 1-280/280
Sequence Identity: 36% (109 aa)

VIFIKKLGEGAFGEVSLAECEIGGRKVETAVKTMRCQMTRDTRAAFMKEARLMRKY--SHPHIVRIIGKIIVK--HLPKVGLAVDAHPLMIVMEMCPHGS
. ..||||||||||| ...       .. |||...       |..||.|||.|.|.  .||.|||..| .. .          . ..||||||| .|||.
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN------FMYIEPLMIVMEYMPHGD

LLSFLRKNKGKTTLSERLRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISDFGLSDDKRTE--------MHDDT---LDK--VPVKWLAPEVM
|...|||...| .... | ||.  |.| .||..|.| |||.||||||..   ..|||||||| |   .        . . .     |  .|..|.|||..
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

QDKLYSLKSDVWAFGVLMWEIYADGADPYPG-----MTNLVTRAKIFCDDYRMTFPET--------TPPTISEIALKQCWAKLPSDRATMKTVHHKL
... .. |||||.|||.||||. .|. ||||     |.|   ....  . |||  |.          |. . .   ||||.  |.|| |....|...
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV-KQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase kin-14.AA TK 134-400 22 7.9e-99 331.96 In-house 1-486 (486) Show / Hide 
Range on Protein: 134-400
Range on HMM: 1-486/486
Sequence Identity: 22% (111 aa)

VIFIKKLGEGAFG---EVSLAECEIGGR-----------------------KVETAVKTMR--CQMTRDTRAA-----------FMKEARLMRKYS----
....||||||.||   || ..| . ...                       |...|||...  . |. . . .           |..||. | . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHIVRIIGKIIVKHLPK---VGLAVDAHPLMIVMEMCPHGS----LLSFLRKNKGK------------------------------------------
 ||.|||..| .  .       |   |. .|.|||||..|||.    |...|||...|                                          
HHPNIVRLYGVCTQGEPKPCFEV-V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQ

---------------------------------TTLSERLRFCIESADGLAYLEKK------QCLHRDIAARNCLLSITDQ-----------IKISDFGL
                                  |. ..| .|   |.|..||..|      .. |||.||||||..  ..           .||.||||
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

S---------------DDKRTEMHDDT-------------------LDKVPVKWLAPEVMQDKL---------YSLKSDVWAFGVLMWEIYADGADPYPG
|               |  |.. ....                    .|.|..|.|||...|.          .. |||||.||||||||.  |. ||.|
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYG

-MTN---------------------------------LVTRAKIFCDD---YRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKL
 |.|                                 .   .   | |   ||| .|. .||.. .. ..|||.. |.|| |....|..|
GMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-HPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase kin-14.AA UTK 134-400 29 3.9e-67 228.69 In-house 1-296 (296) Show / Hide 
Range on Protein: 134-400
Range on HMM: 1-296/296
Sequence Identity: 29% (90 aa)

VIFIKKLGEGAFGEVSLAEC-EIGGRKVETAVKTMRCQ---MTRDTRA---AFMKEAR---LMRKYS-HPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVM
|.. ..||.||||||..|.  .. ..  | .|.   ||   .......    ||.|||   .| . . ||...| .           |. ..  |.|||.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLV-----------GVCTQEEPWMIVT

EMCPHGSLLSFLRKNKGKTT-------LSERLRFCIESADGLAYLEKKQCLHRDIAARNCLLSIT-------DQIKISDFG---LSDDKRT--------E
|... |.|.|.||... ..        | .|| ..   |.|..||. ... |||.||||||.           ..||.|||   .| .  |        |
EYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWE

MHDDTLDK---VPVKWLAPEVMQDK-LYSLKSDVWAFGVLMWEIYADGADPYPGMTNLVTRAKIFCDD-YRMTFPETTPPTISEIALKQCWAKLPSDRAT
    . .    .|..| |||.. .   ...|||||.|||..|||.. |. |||||.|  . . .   . |||  |.  | .. .. .. ||.. |..| .
SYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHR-CWHYDPQERPD

MKTVHHKL
....  ..
FEDLVQQM
Kinase kin-14.AA TK-Unique 134-400 30 3.3e-56 192.28 In-house 1-294 (294) Show / Hide 
Range on Protein: 134-400
Range on HMM: 1-294/294
Sequence Identity: 30% (92 aa)

VIFIKKLGEGAFGEVSLAECEIGG----RKVETAVKTMRCQMTRDTRAAFMKEARLMRKYS-HPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHG
. . ...||||||.|  .| . .     ...  |||. .   |  ....|.||...|..   ||.||...|         .    |  | ||.|| || |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLG---------CCTKSD-EPWMIIMEYCPCG

SLLSFLRKNKGK-----------------------TTLSER--LRFCIESADGLAYLEK--KQCLHRDIAARNCLLSITDQIKISDFGLSD--DKRTEMH
.|...||.....                       ...|..  ..|... | |..||..  |.. |||..|||.||.   ..||.|||...  .....  
NLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYS

DDTL-DKVPVKWLAPEVMQ--DKLY-SLKSDVWAFGVLMWEIYADGADPYPGMTNLVTRAKIFCDDYRMTFPETT-PPTISEIALKQCWAKLPSDRATMK
  .   ..|..|.|||...  .. | . |||||.||||||||   || ||||| .   . . . | |||  ||   .... .. .|.|| . |..| .  
MMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNL-MKSCWQWEPEERPSFR

TVHHKL
.. |.|
QIKHRL
Kinase kin-14.AA Tec 134-402 33 1e-54 188.1 In-house 1-254 (254) Show / Hide 
Range on Protein: 134-402
Range on HMM: 1-254/254
Sequence Identity: 33% (93 aa)

VIFIKKLGEGAFGEVSLAECEIGGRKVETAVKTMR-CQMTRDTRAAFMKEARLMRKYSHPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHGSLLS
  |.| || | || | |..      . ..|.|...   |  .    |. ||. | | |||  |.             |  .   |. || |   ||.||.
LTFMKELGSGQFGVVHLGKWRH---QYDVAIKMIKEGSMSEE---DFIEEAKVMMKLSHPKLVQLY-----------GVCSQQRPIYIVTEYMEHGCLLN

FLRKNKGKTTLSE--RLRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISDFGLSDDKRTEMHDDTLDKV----PVKWLAPEVMQDKLYSLKSD
.||..|..   .    |  |..   | ||||... .||| |||||| . .  .|.||||..   |  . |.    |    |||| .|||..   || |||
YLREHKHHFQKNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMT---RYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSD

VWAFGVLMWEIYADGADPYPGMTNLVTRAKIFCDDYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKLKD
||||||||||..  |  ||. |.|. .  ..    .|.  |.  . .| .|  ..||   | .| | .    ....
VWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQG-HRLYRPHLCSMHIYQI-MYHCWHEKPEERPTFQQLLRQITE
Kinase kin-14.AA Csk 134-400 37 5.2e-53 179.24 In-house 1-251 (251) Show / Hide 
Range on Protein: 134-400
Range on HMM: 1-251/251
Sequence Identity: 37% (102 aa)

VIFIKKLGEGAFGEVSLAECEIGGRKVETAVKTMRCQ--MTRDTRAAFMKEARLMRKYSHPHIVRIIGKIIVKHLPKVGLAVDAHP--LMIVMEMCPHGS
.   .. |.| || | . |    .|||  ||| ..|    . .   ||. ||  | . .||  |. || |.             ..  | ||||    |.
LHLGECIGHGEFGDVMQGEYQ--NRKV--AVKCIKCDGNGMAQ---AFLAEASVMTQLRHPNLVQLIGVIL------------HQKNHLYIVMEYMSKGN

LLSFLRKNKGKTTLSER--LRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISDFGLSDDKRTEMHDDTLDKVPVKWLAPEVMQDKLYSLKSDV
|. .||   |.. .. |  | | .  . | .|||.|.  ||| |||| |.|  .  |.|||||. . ... .| |  | |.|| ||| .  | .| ||||
LVDYLR-SRGRHVITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDV

WAFGVLMWEIYADGADPYPGMTNLVTRAKIFCDDYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKL
| ||.|.||||  |  ||| .  |    |     |||  ||  || . ..  ||||.  | .| | . |  .|
WSFGILLWEIYSFGRVPYPRIP-LKDVVKHVEKGYRMEAPEGCPPHVYKV-MKQCWHLNPAKRPTFRQVREQL
Kinase kin-14.AA Abl 134-400 34 1.9e-52 173.03 In-house 1-252 (252) Show / Hide 
Range on Protein: 134-400
Range on HMM: 1-252/252
Sequence Identity: 34% (94 aa)

VIFIKKLGEGAFGEVSLAECEIGGRKVETAVKTMRCQMTRDTRAAFMKEARLMRKYSHPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHGSLLSF
..  .||| | .|||  .     .  |  ||||.. .  .     |.||| .|..  || .|...           |      |  |. |  ..| || .
IMMKHKLGGGQYGEVYEGVWKRHDCTV--AVKTLKEDTME--VHEFLKEAAIMKEMKHPNLVQLL-----------GVCTREPPFYIITEFMCYGNLLDY

LRKNKGKTTLSE--RLRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISDFGLSDDKRTEMHD-DTLDKVPVKWLAPEVMQDKLYSLKSDVWAF
||.. ....|.    |      | |. ||||.. .|||.||||||..  . .|. ||||.   . ..       | |.|| ||| .  . .| |||||||
LREC-DREELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAF

GVLMWEIYADGADPYPGMTNLVTRAKIFCDDYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKL
|||.|||   |  ||||. .|    .   ..|||  ||  || . |. ..|||   ..|| . | .||..
GVLLWEIATYGMSPYPGI-DLSHVYHKLEKGYRMERPEGCPPKVYEL-MRQCWQWSHTDRPSFKEIHHAM
Kinase kin-14.AA Ack 134-400 35 2.8e-49 164.41 In-house 1-266 (266) Show / Hide 
Range on Protein: 134-400
Range on HMM: 1-266/266
Sequence Identity: 35% (100 aa)

VIFIKKLGEGAFGEVSLAECEI-GGRKVETAVKTMRCQMTRDT--RAAFMKEARLMRKYSHPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHGSL
.   .|||.| || |  .|    ||  .. |||  |  .   .     |..|.  | .  |||.||  |         | |....  || |.|..| |||
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYG---------VVLDQPM--LMMVTELAPCGSL

LSFLRKNKG--KTTLSERLRFCIESADGLAYLEKKQCLHRDIAARNCLLSITD-QIKISDFGLS------DD-KRTEMHDDTLDKVPVKWLAPEVMQDKL
|  ||| ..  .....  ..||   |.|..||| | |.||| |||| ||   |  .||.||||.      .|  |.|.|     |||  | ||| .  . 
LDCLRKHCRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNL--KVPFAWCAPECLRHRQ

YSLKSDVWAFGVLMWEIYADGADPYPGMTNLVTRAKIFCDDYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKL
 | .||||.||| .||    | .|. |.. .    ||  .  | . |.  |. | .. ..|||.. | || |   .  .|
FSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQM-MMQCWQHHPADRPTFSAIRDQL
Kinase kin-14.AA Frk 134-404 33 2.6e-48 165.45 In-house 1-260 (260) Show / Hide 
Range on Protein: 134-404
Range on HMM: 1-260/260
Sequence Identity: 33% (93 aa)

VIFIKKLGEGAFGEVSLAECEIGGRKVETAVKTMRCQMTRDTRAAFMKEARLMRKYSHPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHGSLLSF
. .|..|| | ||||     .    ..  ||||..      .   |..||..|.|  || ....     |.            |..|. |.  ||||. .
IQLIRRLGSGQFGEVWEGLWNN---TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVE-----------EPIYIITELMRHGSLQEY

LR--KNKG-KTTLSERLRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISDFGLSD--DKRTE--MHDDTLDKVPVKWLAPEVMQDKLYSLKSD
|.  ..|| .  . . .      | |.||||..  .|||.|||| |.     .|| ||||     |  |      .  ..|.|| ||| .. . ...|||
LQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSD

VWAFGVLMWEIYADGADPYPGMTNLVTRAKIFCDDYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKLKDLS
||.||.|. ||   |  |||||||     ..   .|||  |   |... || | .|| . |  | |  |.. ||.|  
VWSFGILLTEIITYGRMPYPGMTNAEV-LQMVDHGYRMPQPPNCPQQLYEIML-ECWHSDPMKRPTFETLQWKLEDYF
Kinase kin-14.AA Src 217-400 37 2.4e-46 155.46 In-house 68-255 (255) Show / Hide 
Range on Protein: 217-400
Range on HMM: 68-255/255
Sequence Identity: 37% (72 aa)

PLMIVMEMCPHGSLLSFLR-KNKGK-TTLSERLRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISDFGLSDDKRTEMHDDTL-----DKVPVK
|  || |   ||||| .|. . .|.   | . . .    |.| ||||...  ||| |||| | . .   |. ||||   . ..  ||        |.|.|
PIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLA--RLIKEDDDEYCARHGAKFPIK

WLAPEVMQDKLYSLKSDVWAFGVLMWEIYADGADPYPGMTNLVTRAKIFCDDYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKL
| |||  .   .. ||||| ||.|..||   |  |||||||  .  ..    |||  |.. |. . |....||| | | .| | .. ...|
WTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQV-ERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase kin-14.AA S_TKc 134-408 21 4.7e-41 143.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 134-408
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

VIFIKKLGEGAFGEVSLAECEIGGRKVETAVKTMRCQMTRDTRAAFMKEARLMRKYSHPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPH--GSLL
  ...|.|.||||.| ..       . . |.| ..          ...| ....|  ||.||.... .              . | .|||.|..  |.|.
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------------DHLYMVMEYCDGDLGDLF

SFLRKNKGK-----TTLSERLRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISDFGLSDDKRTEMHDDTLDKVPVKWLAPEVMQDKLYSL-KS
....|....      .  .  ... . ...|.|. ... .|||.   | ||.   .|||.||||.          |   .   ..||||.    |.  |.
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKC

DVWAFGVLMWEIYADGADPYPGMTNLVTRAKIFCDDYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHH-KLKDLSMPMS
|.|..|....| .. |  |.|   .. .  |. .           .|   .  ...|. | |..| |   . .  ..  ..|  
DWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase kin-14.AA Pkinase 134-336 23 8.1e-26 92.36 Pfam 1-204 (293) Show / Hide 
Range on Protein: 134-336
Range on HMM: 1-204/293
Sequence Identity: 23% (52 aa)

VIFIKKLGEGAFGEVSLAECEIGGRKVETAVKTMRCQMTRD--TRAAFM-KEARLMRKYSHPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHG--
  ...|.|.|.||.| ..     |..|  |||... . ...   ....   |...|.. .||.|||...              . |.  .||| |..|  
YHIGRKIGSGSFGCVYKCHHKGTGKIV--AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----------KDHIY-MVMEYCEGGLY

--SLLSFLR-KNKGKT--TLSERLRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQI----KISDFGLSDDKRTEMHDDTLDKVPV---KWLAPEVM
  .| .... ...|.   .  |  ... . . ||.|. .. ..|||.   |.|.. ...|    ||.||||.  ..     ..  ....    ..|||| 
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVI

Q-DKLYSLKSDVWAFGVLMWE
. .. |. |.|.|..|....|
RGGQYYGPKVDMWSCGCILYE
Kinase kin-14.AA Src 134-197 31 3.7e-10 30.68 In-house 1-59 (255) Show / Hide 
Range on Protein: 134-197
Range on HMM: 1-59/255
Sequence Identity: 31% (20 aa)

VIFIKKLGEGAFGEVSLAECEIGGRKVETAVKTMRCQMTRDTRAAFMKEARLMRKYSHPHIVRI
. ...|||.| ||||  .       ... ||||..        .|| .|| .| | .|...|..
IKLCRKLGQGQFGEVWMGYWN---GNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQL