Gene K10D3.5 (Nematode worm)

K10D3.5

Species: Nematode worm
Alias: H37N21.1, aSWK234, K10D3.5, H37N21.1plusseqaddedfromK10D3.5, CE06174
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 7152658-7148341, WormBase Genetic Map location: I:1.8,

Classification

Group: Other
Family: NRBP

Sequence

Name Sequence Type Origin Length Description Download
K10D3.5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
K10D3.5.AA Protein Sugen 649 None Fasta, JSON

Protein domain

Protein domains of K10D3.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase K10D3.5.AA NRBP 50-311 75 1.1e-177 596.58 In-house 1-261 (261) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-261/261
Sequence Identity: 75% (197 aa)

QRDVPGIDVAYLAMDNETGNEVVWNEVQFSERKNFRAQEEKINAVFDNLTQLVHTNLVKFHKYWTDSKSEKPRIIFITEYMSSGSMSAFLQRTRKAGSSL
||||||||.||||||.|.|.|||||||||||||||.||||||..|||||.||.|.|.|||||||||.|.||||.||||||||||||..||..|.|.....
QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM

SIKAWKKWTTQILSALNYLHSSDPPIIHGNLTCNTVFIQQNGLIKIGCVAPDAINHHVKTCRENMRYMHYIAPEYEILDNTELTSAADIYSFGICSLEIA
..||||.|.|||||||.||||.|||||||||||.|.|||.|||||||||.||||.|||.||||.||.||..||||.||..|.||.|.||||||.|.||.|
NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEMA

VIGGLSGCQNGSSEGPVTEDVIEKAIRSLEDPMQQDFIRQCLRKDPAERPSARELLFHQILF
|....||||||.||. |||..|..||.|||||||.||||.||.||||.||||||||||||||
VLEIQSGCQNGESEY-VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase K10D3.5.AA WNK 60-196 35 3.8e-25 78.09 In-house 16-148 (261) Show / Hide 
Range on Protein: 60-196
Range on HMM: 16-148/261
Sequence Identity: 35% (49 aa)

YLAMDNETGNEVVWNEVQFSERKNFRAQEEKINAVFDNLTQLVHTNLVKFHKYWTDSKSEKPRIIFITEYMSSGSMSAFLQRTRKAGSSLSIKAWKKWTT
| ..|.||. || |.|.|  ..|  ..    .    . | .| | | |.| .||  .   |  |. .|| | || .  .|.| .|    . .|  ..|  
YRGLDTETWVEVAWCELQ--DQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKRFKK----MKPKVLRSWCR

QILSALNYLHSSDP-PIIHGNLTCNTVFIQ-QNGLIKIG
|||. |..||.  | ||||  | |  .||   .| .|||
QILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIG
Kinase K10D3.5.AA S_TKc 58-310 21 8.5e-13 10.77 SMART 14-231 (231) Show / Hide 
Range on Protein: 58-310
Range on HMM: 14-231/231
Sequence Identity: 21% (58 aa)

VAYLAMDNETGNEVVWNEVQFSERKNFRAQEEKINAVFDNLTQLVHTNLVKFHKYWTDSKSEKPRIIFITEYMSS--GSMSAFLQRTRKAG--SSLSIKA
. |.. ...|| .|   ..            |.|    . | .  | |.||.. .. |      .. ...||..   |..  .... .. |  . ..   
KVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

WKKWTTQILSALNYLHSSDPPIIHGNLTCNTVFIQQNGLIKIG-----CVAPDAINHHVKTCRENMRY---MHYIAPEYEILDNTELTS-AADIYSFGIC
 .... ||..||.|.||    |||  |    ... .   |||.     ..               . .    .|.||  |.|     .  ..|..|.|..
ARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAP--EVL---GYGKCKCDWWSCGCI

SLEIAVIGGLSGCQNGSSEGPVTEDVIEKAIRSLEDPMQQDFIRQCLRKDPAERPSARELLF-------HQIL
  | .. |    .         ..... | |.   .|   ||||.||.|||..||.| |.|        |. .
LYEMLC-GYPPFP---------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase K10D3.5.AA TKL 103-181 23 4.6e-11 36.08 In-house 84-167 (364) Show / Hide 
Range on Protein: 103-181
Range on HMM: 84-167/364
Sequence Identity: 23% (22 aa)

HTNLVKFHKYWTDSKS---------EKPRIIFITEYMSSGS-MSAFLQRTRKAGSSLSIKAWKKWTTQILSALNYLHSSD------PPIIHGNLT
| |.|.|  | .....         ... . ...||.. ||  . ..           .    .|  .| ...|||||..      ||||| .|.
HPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLK
Kinase K10D3.5.AA Ciliate-E2-Unclassified 101-244 18 5.3e-11 34.42 In-house 76-259 (352) Show / Hide 
Range on Protein: 101-244
Range on HMM: 76-259/352
Sequence Identity: 18% (35 aa)

LVHTNLVKFHKYWTDSKSEKPRIIFITEYMSSGSMSAFLQ-------------RTRKAGSSLSIKAWK-----KWTTQILSALNYLHSSDPPIIHGNLTC
| | .... ...... . ..  |....||.  |... ...             ...| .  .. .. |     ... |||..|.|||..   ||| ....
LNHPHPFIVKMFYCFQDKQN--IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKP

NTVFIQQNG---LIKIGC--VAPDAI-----------------NHHVKTCRENMRYMH-YIAPEYEILDNTELT--SAADIYSFGIC
. .....||    ||| .   .   .                 ... .|.  . .||  | |||.    | . .   ..||.|.|..
ENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVI
Kinase K10D3.5.AA STE 270-310 26 2.6e-10 32.73 In-house 295-359 (359) Show / Hide 
Range on Protein: 270-310
Range on HMM: 295-359/359
Sequence Identity: 26% (17 aa)

VIEKAIRSLED----------------------PMQQDFIRQCLRKDPAERPSARELLF--HQIL
.... . .|.|                      |  .|||..||.||| .||.| .||   |  .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase K10D3.5.AA GCN2 283-310 60 1.5e-09 29.19 In-house 484-511 (511) Show / Hide 
Range on Protein: 283-310
Range on HMM: 484-511/511
Sequence Identity: 60% (17 aa)

QQDFIRQCLRKDPAERPSARELLFHQIL
|||.||.||  ||..||||..|| |  |
QQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase K10D3.5.AA PEK 281-310 46 1.6e-09 28.52 In-house 626-655 (655) Show / Hide 
Range on Protein: 281-310
Range on HMM: 626-655/655
Sequence Identity: 46% (14 aa)

PMQQDFIRQCLRKDPAERPSARELLFHQIL
| |.|||...| .||..|||| ..| |  .
PKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase K10D3.5.AA TK 103-196 11 2.2e-09 26.84 In-house 102-293 (486) Show / Hide 
Range on Protein: 103-196
Range on HMM: 102-293/486
Sequence Identity: 11% (23 aa)

HTNLVKFHKYWTDSK--------SEKPRIIFITEYMSSGS----MSAFLQRTRKAGS-------------------------------------------
| |.|... . |...        .... .. ..|||. |.       .|.. |. ..                                           
HPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYD

---------SLSIKAWKK-------------------WTTQILSALNYLHSSDP----PIIHGNLTCNTVFIQQNGL-----------IKIG
         .|. |                       .  || ... ||||        ..|..| .  . . .|.            .||.
DDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA
Kinase K10D3.5.AA Pkinase 103-177 25 4.8e-09 33.07 Pfam 59-131 (293) Show / Hide 
Range on Protein: 103-177
Range on HMM: 59-131/293
Sequence Identity: 25% (21 aa)

HTNLVKFHKYWTDSKSEKPRIIFITEYMSSG----SMSAFLQRTRKAGSSL--SIKAWKKWTTQILSALNYLHSSDPPIIH
| | |... ...|    |..| ...||.  |    . ......  ... ..  | .  |.. .|||..|.|.||    |||
HPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIH
Kinase K10D3.5.AA TyrKc 76-310 18 1.7e-08 -85.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 76-310
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

VQFSER--------------------KNFRAQEEKINAVFD---NLTQL--VHTNLVKFHKYWTDSK---SEKPRIIFITEYMSSGSMSAFLQRTRKAGS
... .                     |  ..    . .  .    ...|   | |.|... . |...    . . .  ..|||. |.   .|...|.   
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

SLSIKAWKKWTTQILSALNYLHSSDPPIIHGNLTCNTVFIQQNGLIKIG-----CVAPDA----INHHVKTCRE--NMRYM---HYIAPEYEILDNTELT
 |. |   .. .|| .  .||||   ..||  | .  . .  |. .||.         |      .. ... .|  . ..|      ||  | ..  . |
-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP--ECINYGKFT

SAADIYSFGICSLEIAVIGGLSGCQ-----NGSSEGPVTEDVIEKAIRSLEDP------------MQQDFIRQCLRKDPAERPSARELLFHQIL
.. |..|||.|  ||   |.             .|  | |.| .   .   .             | |  ..|| . ||..||. .|.  |...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE--VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase K10D3.5.AA STE-Unique 281-310 53 7.2e-08 23.43 In-house 587-616 (616) Show / Hide 
Range on Protein: 281-310
Range on HMM: 587-616/616
Sequence Identity: 53% (16 aa)

PMQQDFIRQCLRKDPAERPSARELLFHQIL
| ||.||. ||...|  |||| .|| |  |
PEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase K10D3.5.AA Ciliate-E2 97-195 23 1.2e-07 22.27 In-house 85-197 (365) Show / Hide 
Range on Protein: 97-195
Range on HMM: 85-197/365
Sequence Identity: 23% (29 aa)

NLTQLVHTNLVKFHKYWT--DSKSEKPRIIFITEYMSSGSMSAFLQ-----RTRK---AGSSLSIKAWKKWTTQILS---------------ALNYLHSS
.| || | |..|.. ..   | ..    | ...|| . |..  ...     |. .   .  ....|  |. ..|||.               ||.|||| 
ILEQLNHPNIIKMYECFQEKDDNN----IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK

DPPIIHGNLTCNTVFIQQNGLIKI
 . ||| ..  . ...     |||
NN-IIHRDIKPENILF-----IKI
Kinase K10D3.5.AA Ciliate-E2 284-310 28 1.6e-07 21.89 In-house 334-365 (365) Show / Hide 
Range on Protein: 284-310
Range on HMM: 334-365/365
Sequence Identity: 28% (9 aa)

QDFIRQ----CLRKDPAERPS-ARELLFHQIL
.|.|..    .| ||| .|.. . ..| |...
KDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase K10D3.5.AA Ciliate-E2-Unclassified 283-310 28 2e-06 18.53 In-house 321-352 (352) Show / Hide 
Range on Protein: 283-310
Range on HMM: 321-352/352
Sequence Identity: 28% (9 aa)

QQDFIR----QCLRKDPAERPSARELLFHQIL
..|||.    ..| |.| .|... ..| |...
AKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase K10D3.5.AA STE-Unique 155-196 40 5e-06 16.85 In-house 406-452 (616) Show / Hide 
Range on Protein: 155-196
Range on HMM: 406-452/616
Sequence Identity: 40% (19 aa)

KKWTTQILSALNYLHSSDPPIIHGNLTCNTVFIQQNG-----LIKIG
.. |.||| .|.||||   ||||..|  . .|. | |      .||.
IWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKIC
Kinase K10D3.5.AA WNK 273-310 28 6e-06 15.22 In-house 224-261 (261) Show / Hide 
Range on Protein: 273-310
Range on HMM: 224-261/261
Sequence Identity: 28% (11 aa)

KAIRSLEDPMQQDFIRQCLRKDPAERPSARELLFHQIL
...   ..|   ..| .|.|..  ||||...|| |. .
NSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase K10D3.5.AA Pkinase 284-310 48 1.1e-05 21.16 Pfam 267-293 (293) Show / Hide 
Range on Protein: 284-310
Range on HMM: 267-293/293
Sequence Identity: 48% (13 aa)

QDFIRQCLRKDPAERPSARELLFHQIL
.|||. ||.|||..||.|...| |  .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase K10D3.5.AA STE 96-195 19 1.3e-05 15.94 In-house 80-188 (359) Show / Hide 
Range on Protein: 96-195
Range on HMM: 80-188/359
Sequence Identity: 19% (23 aa)

DNLTQLV--HTNLVKFHKYWTDS---KSEKPRIIFITEYMSSGSMSAFLQRTRKAGSSLS----------IKAWKKWTTQILSA-LNYLHSSDPPIIHGN
. . ..   | | ||.. .  .    ....  .  . |||. || . ..... . | .|.           .  .. . ||| . |.||||    |||  
KIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRD

LTCNTVFIQQNGLIKI
. .  ...     .|.
IKPANILL-----VKL
Kinase K10D3.5.AA PEK 155-196 34 0.000174 10.69 In-house 430-474 (655) Show / Hide 
Range on Protein: 155-196
Range on HMM: 430-474/655
Sequence Identity: 34% (16 aa)

KKWTTQILSALNYLHSSDPPIIHGNLTCNTVFIQQNGL-----IKIG
.... |||..|||.||    .||  |.   .|. ..|      .|||
WRIFRQILEGLNYIHSQG--MIHRDLKPSNIFLDCDGQHHQMQVKIG
Kinase K10D3.5.AA TKL 225-308 16 0.000184 11.99 In-house 243-364 (364) Show / Hide 
Range on Protein: 225-308
Range on HMM: 243-364/364
Sequence Identity: 16% (22 aa)

EILDNT----------------ELTSAADIYSFGICSLEIAV--IGGLSGCQNGSSEGPVTEDV--------------IEKAIRSLEDPMQ---------
|.|...                | . ..|.|||||.  ||.   .             |  ..               .  . ..|  |.          
EVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKM

----------QDFIRQCLRKDPAERPSARELLFHQ
           . . .|   || .|||. |.| . 
CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase K10D3.5.AA TK 233-308 18 0.000641 8.18 In-house 372-486 (486) Show / Hide 
Range on Protein: 233-308
Range on HMM: 372-486/486
Sequence Identity: 18% (21 aa)

TSAADIYSFGICSLEIAVIG-GLSGCQNGSSE----GPVTEDVIEKAIR--------------SLEDP---------------------MQQDFIRQCLR
|.. |..|||..  ||   | .  . .  ...    | . ..|.|.  |               .. |                     . .|...|| .
TTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWH

KDPAERPSARELLFHQ
.||..||. ..|.   
YDPEDRPTFSQLHEQL
Kinase K10D3.5.AA Pkinase_Tyr 117-180 27 0.000744 13.68 Pfam 75-137 (270) Show / Hide 
Range on Protein: 117-180
Range on HMM: 75-137/270
Sequence Identity: 27% (18 aa)

KSEKP-RIIFITEYMSSGSMSAFLQRTRKAGSSLSIKAWKKWTTQILSALNYLHSSDPPIIHGNL
. ..| .|. ..|||  |..  .|.. |  . .|..|   .. .|| ....||.|    .||  |
DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDL
Kinase K10D3.5.AA GCN2 160-196 43 0.004505 6.11 In-house 316-350 (511) Show / Hide 
Range on Protein: 160-196
Range on HMM: 316-350/511
Sequence Identity: 43% (16 aa)

QILSALNYLHSSDPPIIHGNLTCNTVFIQQNGLIKIG
|||..|||.||    .||  |   ..|. ..| .|||
QILEGLNYIHSQG--MIHRDLKPSNIFLDCCGNVKIG
Kinase K10D3.5.AA WNK 235-250 50 0.013799 4.07 In-house 184-199 (261) Show / Hide 
Range on Protein: 235-250
Range on HMM: 184-199/261
Sequence Identity: 50% (8 aa)

AADIYSFGICSLEIAV
. |.|.|| | || |.
SVDVYAFGMCMLEMAT
Kinase K10D3.5.AA Pkinase_Tyr 285-310 38 0.021965 8.7 Pfam 247-270 (270) Show / Hide 
Range on Protein: 285-310
Range on HMM: 247-270/270
Sequence Identity: 38% (10 aa)

DFIRQCLRKDPAERPSARELLFHQIL
| ..|| ..||..||. .|.  |..|
DLMKQCWHYDPEDRPTFSEI--HEQL
Kinase K10D3.5.AA STE 225-249 22 0.036987 3.57 In-house 232-262 (359) Show / Hide 
Range on Protein: 225-249
Range on HMM: 232-262/359
Sequence Identity: 22% (7 aa)

EILDN------TELTSAADIYSFGICSLEIA
|....       . .  .||.|.|.. .| |
EVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase K10D3.5.AA Ciliate-E2 225-244 24 0.297963 0.03 In-house 257-285 (365) Show / Hide 
Range on Protein: 225-244
Range on HMM: 257-285/365
Sequence Identity: 24% (7 aa)

EILDNTE---------LTSAADIYSFGIC
||| . .          . ..||.|.|..
EILNGKKYDNQQKQKGYDYKCDIWSLGVI
Kinase K10D3.5.AA Pkinase 218-243 30 0.791136 4.01 Pfam 176-200 (293) Show / Hide 
Range on Protein: 218-243
Range on HMM: 176-200/293
Sequence Identity: 30% (8 aa)

HYIAPEYEILDNTELTSAADIYSFGI
.|.|||  |..... ....|..|.|.
WYMAPEV-IRGGQYYGPKVDMWSCGC
Kinase K10D3.5.AA Pkinase_Tyr 225-244 30 3.748707 1.14 Pfam 184-203 (270) Show / Hide 
Range on Protein: 225-244
Range on HMM: 184-203/270
Sequence Identity: 30% (6 aa)

EILDNTELTSAADIYSFGIC
| . . . |.. |..|||..
ECINYGKFTTKSDVWSFGVL