Gene K02E10.7 (Nematode worm)

K02E10.7

Species: Nematode worm
Alias: K02E10.7, CE31194, K02E10.7x=sck..pvla, aSWK254
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 2508959-2508960, WormBase Genetic Map location: X:-13.71,

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
K02E10.7.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 244 Kinase domain by global Sugen HMM Fasta, JSON
K02E10.7.AA Protein Genbank 731 None Fasta, JSON

Protein domain

Protein domains of K02E10.7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase K02E10.7.AA Other-Unique 87-324 11 5.1e-26 85.5 In-house 1-249 (249) Show / Hide 
Range on Protein: 87-324
Range on HMM: 1-249/249
Sequence Identity: 11% (29 aa)

SDKIASGRFGTVFLG-TITDSMLQVAIKEYHETFHDAVLTAHDEGSTLQKIISIEHPAIVQT--------FSVSHFQDIVYKVMEFHSWTLHEKRVYFEK
 ..| .|..|.|... .. .. ... .. .|   |.. ......  ... .. |.| .|...        |...| ...... |. ......|. ...|.
IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKRE-QIYHYQ-IIH-CIFYWTMNHCHLCFCYEHCPNMIFYIMYPWYHHHCECQCQCEH

IDRTNNDILDKGKYDESQTKLVLVQATRALEYLHAQNLCHGT---------LHTKNIFLQENMVKISDIESSQF--LNWLPFSQTPLHILPFIAPELHNQ
.. ....|... .. ... ..  ....  . . .  . ||.           |....  ..|..   ......   . | . ... .. |. . ...|..
WMNCCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEFSCRWCSPETFDYWPLGEKIDQYHFG

LSEVTSECDLWVKTTLIVLKGPNIKVTLLKKLGNYIFGSQPKKKFYNIQLYISLNCSC
 .. . .|..| . ...| ...... .. .. .. |. ... ....  ..| ..||..
CYHFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY
Kinase K02E10.7.AA MARK 353-422 29 8.7e-14 41.61 In-house 191-262 (262) Show / Hide 
Range on Protein: 353-422
Range on HMM: 191-262/262
Sequence Identity: 29% (21 aa)

SLGVCIFVMATGSCPFILES--RNTMMESIQAGILGSPVLASDKIQSLVEQLIHVNPSERMSLKSLIEDDWM
||||  ..| .|. ||   .   ..... |..|    |   |.....|. .|. |||.||.... . .. ||
SLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
S_TKc K02E10.7.AA S_TKc 84-422 15 1.4e-13 22.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 84-422
Range on HMM: 1-231/231
Sequence Identity: 15% (58 aa)

TGISDKIASGRFGTVFLGTITDSMLQVAIKEYHETFHDAVLTAHDEGSTLQKIISIEHPAIVQTFSVSHFQDIVYKVMEFHSW---TLHEKRVYFEKIDR
  | .|| .| ||.|.... ...  .||||. .        ..  | . |.|     || ||. . | .  | .| |||. .    .|..          
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDY---------

TNNDILDKGK------YDESQTKLVLVQATRALEYLHAQNLCHGTLHTKNIFLQENMVKISDIESSQFLNWLPFSQTPLHILPFIAPELHNQLSEVTS-E
    | ..|.      ..| ... .. |  .||||.| .. .|  |   ||.| |  .||.|  .. .|       |    . ..|||.       .  .
----IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCK

CDLW----------VKTTLIVLKGPNIKVTLLKKLGNYIFGSQPKKKFYNIQLYISLNCSCKDILDFLKSSKSAPCQNFDWKFLRNLKNSLGVCIFVMAT
|| |          .  ..          ...||.|                                                                
CDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG----------------------------------------------------------------

GSCPFILESRNTMMESIQAGILGSPVLASDKIQSLVEQLIHVNPSERMSLKSLIE-------DDWM
                            |.   ...... ...|..|..   . .       . |.
----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase K02E10.7.AA RSK 353-422 26 1.5e-10 35.13 In-house 197-278 (278) Show / Hide 
Range on Protein: 353-422
Range on HMM: 197-278/278
Sequence Identity: 26% (22 aa)

SLGVCIFVMATGSCPFIL---ESRNTMMESIQAGI--LGSP--VLASDKIQSLVEQLIHVNPSERMS-----LKSLIEDDWM
|||| .. | ||  ||     ..|.  |. || |   |..|     |.  ..|. .. |..|. | .     .. . .. |.
SLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase K02E10.7.AA MELK 353-422 27 1.7e-10 31.76 In-house 185-254 (254) Show / Hide 
Range on Protein: 353-422
Range on HMM: 185-254/254
Sequence Identity: 27% (19 aa)

SLGVCIFVMATGSCPFILESRNTMMESIQAGILGSPVLASDKIQSLVEQLIHVNPSERMSLKSLIEDDWM
|.|. ..|.  |  ||  .    |   |. |.   |   | . . |. ... |.|  |.|.| |.. .|.
SMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase K02E10.7.AA CAMKK-Unclassified 353-422 21 3e-10 29.25 In-house 318-392 (392) Show / Hide 
Range on Protein: 353-422
Range on HMM: 318-392/392
Sequence Identity: 21% (16 aa)

SLGVCIFVMATGSCPFILESRNTMME-SIQAGILGSPV----LASDKIQSLVEQLIHVNPSERMSLKSLIEDDWM
|||| .. |...| ||  .. . . .  |.....  |       |.  ..| . ..  || .| ... .....| 
SLGVTFYCMVYHSLPFWHKNLQELFHQMICQKEINFPPQYHPHCSHEFKDLIQKMCDKNPKKRITIDQMLVHPWF
Kinase K02E10.7.AA Ciliate-E2 353-422 16 8.6e-10 29.78 In-house 281-365 (365) Show / Hide 
Range on Protein: 353-422
Range on HMM: 281-365/365
Sequence Identity: 16% (15 aa)

SLGVCIFVMATGSCPFILESRNTMMESIQAGILG------------------SPVLASDKIQSLVEQ----LIHVNPSERMS-LKSLIEDDWM
||||... | .|  ||        .. |. . .                   |.   |.. . |  .    .. ..|..|..  . ...  |.
SLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase K02E10.7.AA Ciliate-E2-Unclassified 353-422 17 2.2e-09 28.72 In-house 255-352 (352) Show / Hide 
Range on Protein: 353-422
Range on HMM: 255-352/352
Sequence Identity: 17% (17 aa)

SLGVCIFVMATGSCPFILESRNT----------------MMESIQAGIL------------GSPVLASDKIQSLVEQLIHVNPSERMSLKSLIEDDWM
||||... | .| .||  ....                 . . |.....            ...  | | |. |  ... .||..|.... ...  |.
SLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase K02E10.7.AA CAMKL 353-422 20 2.4e-09 25.81 In-house 221-297 (297) Show / Hide 
Range on Protein: 353-422
Range on HMM: 221-297/297
Sequence Identity: 20% (16 aa)

SLGVCIFVMATGSCPFILESRN---------TMMESIQAGILGSPVLASDKIQSLVEQLIHVNPSERMSLKSLIEDDWM
|.||  ..| .|  ||  .. |           .. .. .    ..  |   ..|  ..  |||..|.... . .. ||
SCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase K02E10.7.AA Ciliate-E2 187-277 18 1.2e-08 25.82 In-house 139-280 (365) Show / Hide 
Range on Protein: 187-277
Range on HMM: 139-280/365
Sequence Identity: 18% (27 aa)

DKGKYDESQTKLVLVQATR---------------ALEYLHAQN-LCHGTLHTKNIFLQENMVKISDIESSQFLN-------------WLPFSQ----TPL
| ....| . | .  | ..               |||||| .|  .|  .   ||..    .||.|   |....             |..| .    .  
D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTP

H----------------ILPFIAPELHNQLSE--------VTSECDLW
                  ... ||| .|  ..         . .||.|
GYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIW
Kinase K02E10.7.AA RAF 190-236 41 3.9e-08 22.15 In-house 99-146 (282) Show / Hide 
Range on Protein: 190-236
Range on HMM: 99-146/282
Sequence Identity: 41% (20 aa)

KYDESQTKLVLVQATRALEYLHAQNLCHGTLHTKNIFLQENM-VKISD
|.| ...  .. |   ...|||| |  |  | ..||||.| | ||| |
KFDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGD
Kinase K02E10.7.AA CAMK 353-422 16 1.4e-07 19.73 In-house 319-425 (425) Show / Hide 
Range on Protein: 353-422
Range on HMM: 319-425/425
Sequence Identity: 16% (18 aa)

SLGVCIFVMATGSCPFILE-------------SRNTMMESIQAGIL--GSPVLAS----------------------DKIQSLVEQLIHVNPSERMSLKS
|.||  ..| .|  ||  .             . . ..| |..|     .| .                        .  ..|. ..  |.|..||... 
SCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQ

LIEDDWM
  .. ||
CLNHPWM
Kinase K02E10.7.AA TyrKc 84-421 15 4e-06 -123.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 84-421
Range on HMM: 1-280/280
Sequence Identity: 15% (59 aa)

TGISDKIASGRFGTVFLGTITDSMLQVAIKEYHETFHDAVLTAHDEGSTLQKIISI--EHPAIVQTFSVSHFQ-------DIVYKVMEFHSW-----TLH
    .|. .| ||.|..|| .   .|||.|  .|     .   ..| . . |   .  .|| ||. . |   |       . .. |||. ..      |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCK---LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EKRVYFEKIDRTNNDILDKGKYDESQTKLVLVQATRALEYLHAQNLCHGTLHTKNIFLQENM-VKISD------IESSQFL----NWLPFSQTPLHI--L
..|                     ..     .|. .  |||| .|. |  | . |. . ||  |||||      |..             ...      |
KHRPK----------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

PF--IAPELHNQLSEVTSECDLW--------VKTTLIVLKGP-----NIKVTLLKKLGNYIFGSQPKK----KFYNIQLYISLNCSCKDILDFLKSSKSA
|    |||   . .. |.. | |        . |                  ..... .     ||.                                 
PIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------

PCQNFDWKFLRNLKNSLGVCIFVMATGSCPFILESRNTMMESIQAGILGSPVLASDKIQSLVEQLIHVNPSERMSLKSLIEDDW
                                                 . | ..|.. .. .|  | .|..| . . .  ...
-------------------------------------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase K02E10.7.AA Pkinase 353-422 12 7e-06 21.85 Pfam 197-293 (293) Show / Hide 
Range on Protein: 353-422
Range on HMM: 197-293/293
Sequence Identity: 12% (12 aa)

SLGVCIFVMATGSCPFILE------SRNTMMESIQAGILGSPVLAS---------------------DKIQSLVEQLIHVNPSERMSLKSLIEDDWM
|.|. .. |..|  ||  .      . . |.. |  ..| ..   .                     .  ..... .....|..| . . . ...|.
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase K02E10.7.AA Ciliate-E2-Unclassified 183-263 19 3.7e-05 13.88 In-house 127-237 (352) Show / Hide 
Range on Protein: 183-263
Range on HMM: 127-237/352
Sequence Identity: 19% (22 aa)

NDILDKGKYDESQTK-----LVLVQATRALEYLHAQN-LCHGTLHTKNIFLQENM----VKISDIESSQFLN----------------WLPFSQTPLHIL
.... . . .| |.|       . |   .||||| .|  .|  .   ||....|.    .||.|  .| ...                .   ..|    .
HNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTP

PFI----APEL
 ..    |||.
NYMPQYTAPEV
Kinase K02E10.7.AA Pkinase 86-217 24 0.000162 17.05 Pfam 3-131 (293) Show / Hide 
Range on Protein: 86-217
Range on HMM: 3-131/293
Sequence Identity: 24% (34 aa)

ISDKIASGRFGTVFLGTITDSMLQVAIKEYHETFHDAVLTAHD----EGSTLQKIISIEHPAIVQTFSVSHFQDIVYKVMEFHSWTLHEKRVYFEKIDRT
|  || || ||.|....  ..  .||.|.      .     ..    | . .... .  || ||... . .  | .| |||..  .|.     |. | . 
IGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N--HPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYIST-

NNDILDKGKY--DESQTKLVLVQATRALEYLHAQNLCH
     ..|..  .| . | .. |  |.|||.|... .|
----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH
Kinase K02E10.7.AA CAMK 175-277 16 0.000253 9.05 In-house 152-318 (425) Show / Hide 
Range on Protein: 175-277
Range on HMM: 152-318/425
Sequence Identity: 16% (28 aa)

FEKIDRTNN--------DILDKGKYDESQTKLVLVQATRALEYLHAQNLCHGTLHTKNIFLQENM------------------VKISDIESSQFLNWLP-
|..| .  .        ||...|...|.... .  |   |..|.| .| .|  |   || |..|.                  .||.|   .....    
FDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGEN

-----------------------FSQTPLHILPFIA-PELHNQ-------------LSEVTSECDLW
                         .|.   ....| ||. |.                .. .|| |
NFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMW
Kinase K02E10.7.AA RAF 84-101 44 0.000726 8.08 In-house 1-18 (282) Show / Hide 
Range on Protein: 84-101
Range on HMM: 1-18/282
Sequence Identity: 44% (8 aa)

TGISDKIASGRFGTVFLG
  .. .| ||.||||. |
VMVMTRIGSGSFGTVYRG
Kinase K02E10.7.AA MELK 185-231 25 0.002044 7.18 In-house 88-134 (254) Show / Hide 
Range on Protein: 185-231
Range on HMM: 88-134/254
Sequence Identity: 25% (12 aa)

ILDKGKYDESQTKLVLVQATRALEYLHAQNLCHGTLHTKNIFLQENM
|. . . .|..|. .. |   |. |.|.|   |  |   |....|..
IIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDH
Kinase K02E10.7.AA CAMKL 206-236 35 0.004479 5.49 In-house 139-172 (297) Show / Hide 
Range on Protein: 206-236
Range on HMM: 139-172/297
Sequence Identity: 35% (12 aa)

ALEYLHAQNLCHGTLHTKNIFLQENM---VKISD
|..|.| .. .|  .   || | ||.   .||.|
AVNYCHSHGIVHRDIKPENILLDENGNNNIKIID
Kinase K02E10.7.AA CAMK 89-113 24 0.013808 3.35 In-house 1-37 (425) Show / Hide 
Range on Protein: 89-113
Range on HMM: 1-37/425
Sequence Identity: 24% (9 aa)

KIASGRFGTVFLGTITDSM------------LQVAIK
.. .|.||.|.|.. . .              .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIK