Gene ire-1 (Nematode worm)

ire-1

Species: Nematode worm
Alias: ire-1, C41C4.4, CE01519, aSWK225
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 8124768-8112175, WormBase Genetic Map location: n/a,

Classification

Group: Other
Family: IRE

Sequence

Name Sequence Type Origin Length Description Download
ire-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
ire-1.AA Protein Genbank 983 None Fasta, JSON

Protein domain

Protein domains of ire-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ ire-1.AA PQQ 43-80 31 8.6e-08 29.17 Pfam 1-37 (37) Show / Hide 
Range on Protein: 43-80
Range on HMM: 1-37/37
Sequence Identity: 31% (12 aa)

STILVSTIDGRLRALDSETGEIKWTLQEEPVLRSPSAV
 .. | | ||...||| .||..||. ...|. .. ...
GDVYVHTWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
PQQ ire-1.AA PQQ 38-69 39 2.7e-07 31.46 SMART 1-33 (33) Show / Hide 
Range on Protein: 38-69
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

EEKTSS-TILVSTIDGRLRALDSETGEIKWTLQ
  ...  |. |.| ||.|.|||..||...|| .
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ ire-1.AA PQQ 118-150 27 0.000917 19.75 SMART 1-33 (33) Show / Hide 
Range on Protein: 118-150
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

PCKGNDGILYAGSKKDVWFGIDPKTGLKVEYIL
|.. .||..|.|.. . .. .|.||| ..  . 
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ ire-1.AA PQQ 175-206 18 0.000538 20.52 SMART 1-33 (33) Show / Hide 
Range on Protein: 175-206
Range on HMM: 1-33/33
Sequence Identity: 18% (6 aa)

PANQKQ-TIFLGRTEYRVSMFDEKNRGKTWNAT
|.  .  |...|...... ..| |.  ..|...
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ ire-1.AA PQQ 223-260 23 1.9e-07 28.03 Pfam 1-37 (37) Show / Hide 
Range on Protein: 223-260
Range on HMM: 1-37/37
Sequence Identity: 23% (9 aa)

FKHYASSSHGYILTFDRETGEMRWEQDLKQPVVALYLL
 . |. . .|||  .|..||...|. ....|... .. 
GDVYVHTWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
PQQ ire-1.AA PQQ 217-249 27 2e-07 31.9 SMART 1-33 (33) Show / Hide 
Range on Protein: 217-249
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

EVNTWPFKHYASSSHGYILTFDRETGEMRWEQD
 | .|. ..|.....||. ..|..||...|...
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ ire-1.AA PQQ 308-339 24 0.600625 4.06 SMART 1-33 (33) Show / Hide 
Range on Protein: 308-339
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

TNQFFP-ALFVGESSFGLYAIEALVDHQTITYS
.  ...  ..|| ..  |||. |   . . || 
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
Kinase ire-1.AA IRE 537-794 46 4.5e-165 554.68 In-house 1-292 (292) Show / Hide 
Range on Protein: 537-794
Range on HMM: 1-292/292
Sequence Identity: 46% (137 aa)

SDILGTGCEGTVVYRGTFDGRE-VAVKRVVSEFVKFAHREADLLR--ESDTHPHVIRYFCMESDSQFRYLALELCIASLNDYVEQ---------------
..|||.||.||.|..|...||. ||||....||..|..|| ..|.  |||.||.||||.|.|.|.||.||||||| .||.|||||               
NNILGRGCNGTLVFKGIWNGRIPVAVKQMQKEFNPFISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNN

--KEVQ----QNVT-IALRDIMKQATDGLAHLHASKIVHRDMKPQNVLITM--ASQRG-EMRAVISDFGLCKRVQPGKNSISRGIASGLAGTDGWIAPEV
  |...    |... |......||...||.|||...|||||.||.|.||.|  ..|.| ..|..||||||||....|..|..|.|.||..||.||..||.
NNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNRFMISDFGLCKMLVEGRYSFTRNIRSGPTGTWGWHPPEM

LIS---ASTSYPVDIFSLGCIFYYVLTSGTHPFG-KSLHRQANIVNGEYTLNKLADLDDWS--LADDLISSMLNVEPLHRLTADAVLNHPFF
| .   ......|||||.||.||||.|.|.|||| ..|||||||..|.|.|..|.....|.  .|.|||..|....|..|.|....||||||
LQEFCQKRKTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYNLDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKECLNHPFF
S_TKc ire-1.AA S_TKc 534-794 25 2.4e-55 191.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 534-794
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

YSPSDILGTGCEGTVVYRGTF--DGREVAVKRVVSEFVKFAHREADLLRESDTHPHVIRYFCMESDSQFRYLALELCIA---SLNDYVEQKEVQQN---V
|   ...| |  | .||...   .||.||.|..     . . || ..|..   ||...... .  | .. |. .|.|     .| || ...  . .    
YEILRKIGKGAFG-KVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TIALRDIMKQATDGLAHLHASKIVHRDMKPQNVLITMASQRGEMRAVISDFGLCKRVQPGKNSISRGIASGLAGTDGWIAPEVLISASTSY-PVDIFSLG
.   | .|.|  ..|...|  .|.||| ||.|.|..        .  |.||||....            . . ||  ..|||||   . .. ..|. |.|
PEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

CIFYYVLTSGTHPFGKSLHRQANIVNGEYTLNKLADLDDWSLADDLISSMLNVEPLHRLTADAVLN-------HPFF
||.|  |. |  ||   ...  ...               . | |.|. .|...| .|.||  .|.       ||.|
CILYEMLC-GYPPFP-QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase ire-1.AA Pkinase 534-794 23 2e-50 178.61 Pfam 1-293 (293) Show / Hide 
Range on Protein: 534-794
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

YSPSDILGTGCEGTVVYRGTFDGRE--VAVKRVVSEFVKFAHR-------EADLLRESDTHPHVIRYFCMESDSQFRYLALELCIA-----SLNDYVEQK
|    ..| |  |.| |...  | .  ||||..  .  |   .       |. ....   ||...|....  |..  |. .|.|       .| ||..  
YHIGRKIGSGSFGCV-YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

EVQQNVTI-----ALRDIMKQATDGLAHLHASKIVHRDMKPQNVLITMASQRGEMRAVISDFGLCKRVQPGKNSISRGIASGLAGTDGWIAPEVLI-SAS
  ... ..      ....|.|   ||...|. .|.|||.||.|.||    . .. .  |.||||.| ..      . . .....|| ...||||.  .  
--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQY

TSYPVDIFSLGCIFYYVLTSGTHPFGKSL----HRQANIVNGEYTLNKLADLDDW-----------------------SLADDLISSMLNVEPLHRLTAD
 ...||..|.|||.|..|. |  ||  .     .    ..  . .. .  . | .                       . . |.|...|.. |  |.||.
YGPKVDMWSCGCILYEMLC-GRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

AVLNHPFF
 .|.||.|
QILQHPWF
Kinase ire-1.AA Ciliate-E2 534-794 21 2.4e-45 153.63 In-house 1-365 (365) Show / Hide 
Range on Protein: 534-794
Range on HMM: 1-365/365
Sequence Identity: 21% (81 aa)

YSPSDILGTGCEGTVVYRGT------------------------FDGREVAVKRVVSEFVKFAHREADLLR---------------ESDTHPHVIRYF-C
|    ..|.|. |.| .                           ... ..|.|..    ...  .| ...|               |.. ||..|... |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

MES-DSQFRYLALELCIA-SLNDYVEQKEVQQN---------VTIALRDIMKQATD---------------GLAHLHASK-IVHRDMKPQNVLITMASQR
 .. | .  || .|.|   .| || ...  ..|         .    ..|||| ..               .| .||  . |.||| ||.|.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

GEMRAVISDFGLCKRVQPG----------KNSISRG-----------------IASGLAGTDGWIAPEVLISAS---------TSYPVDIFSLGCIFYYV
      |.||||.|....           |. .  .                 ..  ..|| |  |||.| . .          .| .||.|||.|.|. 
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

LTSGTHPFGKSLHRQANIVNGEYTLNKLA-------------DLDDWSLA-DDLISS----MLNVEPLHRLT-ADAVLNHPFF
|. | .||      | .| .... ...               . ..||.   |||.     ||...|  |.| .. .||||.|
LF-GKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase ire-1.AA CAMK 539-794 17 3.3e-36 113.66 In-house 1-425 (425) Show / Hide 
Range on Protein: 539-794
Range on HMM: 1-425/425
Sequence Identity: 17% (73 aa)

ILGTGCEGTVVYRGT-FDG------------REVAVKRVV------------------------------SEFV-KFAHREADLLRESDT------HPHV
.||.|  |.|       ..            ..||.| .                               ...  |.  || ....          ||..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRYFCMESDSQF-------------------RYLAL---ELCIA-----SLNDYVEQK-----------EVQQNVTI---ALRDIMKQATDGLAHLHASK
|. . .  |...                    |. .   |.|        | ||. ..            | ..  .     | ...|  ......|  .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDMKPQNVLIT--MASQ----------RGEMRAVISDFGLCKRVQPGKNSI------------------SRGIASGLAGTDGWIA-PEVLISAS---
||||| || |.|..  . ..                 |.|||. ....||.|.                   .    .   || . .| |||| . .   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------TSYPVDIFSLGCIFYYVLTSGTHPFGKSLHRQA---------------NIVNGEYTLN--KLAD-----LDDWSL-------------A
            ....|. |.|.|  |.. .|. ||  . . .                .| .|.|.    .. .      ..|               .
MQNATDEEKPYYGPKCDMWSCGVIL-YIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

DDLISSMLNVEPLHRLTADAVLNHPFF
 |||..||.|.| .|.|.. .||||..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase ire-1.AA Ciliate-E2-Unclassified 585-794 23 2.6e-32 109.39 In-house 80-352 (352) Show / Hide 
Range on Protein: 585-794
Range on HMM: 80-352/352
Sequence Identity: 23% (64 aa)

HPHVIRYFCMESDSQFRYLALELCIA-SLNDYVEQKEV---------------QQNVTIALR-----DIMKQATDGLAHLHASK-IVHRDMKPQNVLITM
||.....| .. | |  |. .|.|   .| .| ....                ..    . .     ....|  .|| .|| .. |.||| ||.|.|.. 
HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDN

ASQRGEMRAVISDFGLCKRVQ----------PGKNSISRGIASGLAGTDGWI----APEVLISASTS----YPVDIFSLGCIFYYVLTSGTHPFG---KS
  .    .  |.|||..|. |          . .. ... ...  .|| . .    ||||| .   .    | .||.|||.|.|. |. |..||.   . 
NGK--NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF-GYYPFYDNNCE

LHR--------------QANIVNGEYTLNKLADL----DDWS-LADDLIS----SMLNVEPLHRLTADAVLNHPFF
 |.              . .. .   . .. ..     ..||  | |.|.    .||.. |  |.|.. .||||.|
QHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase ire-1.AA PLK1 585-794 31 8.4e-28 88.26 In-house 58-253 (253) Show / Hide 
Range on Protein: 585-794
Range on HMM: 58-253/253
Sequence Identity: 31% (67 aa)

HPHVIRYFCMESDSQFRYLALELCIASLNDYVEQKEVQQNVT-IALRDIMKQATDGLAHLHASKIVHRDMKPQNVLITMASQRGEMRAVISDFGLCKRVQ
|.|.....    |.|. |. ||||  . .  .| .   . .|    |  |.|  .|  .||  ||.|||.|  |. .       ...  | ||||  ...
HRHIVKFHHFFEDKQNVYIVLELC--RRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLND-----HLQVKIGDFGLATKCE

PGKNSISRGIASGLAGTDGWIAPEVLISASTSYPVDIFSLGCIFYYVLTSGTHPFGKSLHRQA--NIVNGEYTLNKLADLDDWSLADDLISSMLNVEPLH
      .      |.||  .||||||  .  |. |||.|.|||.| .|  |  ||  .  ..    | . ||.. . .       | .|| .||. .| .
-----YDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLF-GQPPFETKCLKETYSRIKKNEYRIPSHIS----QPAAQLIRKMLDPDPTR

RLTADAVLNHPFF
| |...|||  ||
RPTIEQVLNDEFF
Kinase ire-1.AA STE 534-725 19 8.7e-28 95.25 In-house 1-256 (359) Show / Hide 
Range on Protein: 534-725
Range on HMM: 1-256/359
Sequence Identity: 19% (53 aa)

YSPSDILGTGCEGTVVYR-----------GTF-----DGREVAVKRVV--------------------SEFVKFAHREADLLRESDT-HPHVIRYFCMES
.   ...| |  |||..            |        |. .|.|..                     .| ..   .| .......  ||....|.... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DS-------QFRYLALELCIA-SLNDYVEQK-EVQQ-------------NVTIALRDIMKQATDG-LAHLHASKIVHRDMKPQNVLITMASQRGEMRAVI
.        .  ....|.. . || | ...| ....                ||   | .|   | |..||  .|.||| ||.|.|.          . .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAY--ICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKL

SDFGLCKRVQPGKNSISRGI--------ASG-----LAGTDGWIAPEVLIS------ASTSYPVDIFSLGC
.|||.|.....   .| . .         ..     ..||  | ||||.           .. .|| ||||
CDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGC
Kinase ire-1.AA AGC 639-728 20 1.4e-26 64.38 In-house 165-296 (395) Show / Hide 
Range on Protein: 639-728
Range on HMM: 165-296/395
Sequence Identity: 20% (29 aa)

GLAHLHA-SKIVHRD-MKPQNVLITMASQRGEMRAVISDFGLCKRVQPGKNSISRGI-------------------------------------------
.| .||   .|.||| .|| |.|..           ..||||||..  ...  .  .                                           
ALEYLHSHMGIIHRDYLKPENILLDED-----GHIKLTDFGLCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKK

---ASGLAG--TDGWIAPEVLISASTSYPVDIFS--LGCIFY
   .. . |  |   .|||.|     ....|. |  |||..|
RDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY
Kinase ire-1.AA TKL 540-792 15 4.4e-26 90.92 In-house 1-364 (364) Show / Hide 
Range on Protein: 540-792
Range on HMM: 1-364/364
Sequence Identity: 15% (58 aa)

LGTGCEGTVVYRGTFDG----------REVAVKRVVSEFVKF----------------------------AHREADLLRESDT-HPHVIRYFCMESDSQF
.| |  | .||.|.. |          ..||||.  |. ...                             ..|  ..  | . ||.....     ....
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------RYLALELC-IASLNDYVEQKEVQQNVTIALRDIMKQATDGLAHLHASK--------IVHRDMKPQNVLITMASQ---------RGEM
              ..  |.|   || .|.            . ......  |...||...        |.||| |..|.|.    .           . 
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

RAVISDFGLCKRVQPGKNSISRG--------------IASGLAGTDGWIAPEVLISA----------------STSYPVDIFSLGCIFYYVLTSGTHPFG
.. |.||||...... .|.   .                .   || .| |||||  .                . |  .|..| | ... .||  . |. 
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYY

KSLHRQAN---------IVNGEYTLNKLAD------------LDDWSLADDLISSMLNVEPLHRLTADAVLNHP
.  ...           .....  |  . .             | .    .|.    . .|  |.... .| . 
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ire-1.AA Ciliate-E2a 630-728 31 2.6e-23 65.48 In-house 104-207 (275) Show / Hide 
Range on Protein: 630-728
Range on HMM: 104-207/275
Sequence Identity: 31% (34 aa)

RDIMKQAT-DGLAHLHASKIVHRDMKPQNVLIT-MASQR-GEMRAVISDFGLCKRVQPGKNSISRGIASGLAGTDGWIAPEVLISAST------SYPVDI
.|||.| . .||...|  .|.||| ||.|.|..   ..       .|.|||| .....     .        || | .||||| .  .      .. .|.
CDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD----EKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM

FSLGCIFY
.|.|.|||
WSCGVIFY
Kinase ire-1.AA CMGC 534-687 15 7.1e-20 61.15 In-house 1-259 (513) Show / Hide 
Range on Protein: 534-687
Range on HMM: 1-259/513
Sequence Identity: 15% (42 aa)

YSPSDILGTGCEGTVVYRGTF----------------DGREVAVKRVVSEFVKFAH---------------READLLRES----------------DTHP
|   . .| |  | |||...                 ....||.|.. ..| .  .               ||  .|..                 . |.
YEIIKKIGEGTYG-VVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

HVIRYFCMESDSQFR-----------------YLALELCIASLNDYVEQKE--------------------------VQQNVTIALRDIMKQATDGLA--
.... . .  ... .                 ||  |..  .| .| ...                           ..  .  . | .|.|   ||.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

HLHASK--IVHRDMKPQNVLITMASQR---------------GEMRAVISDFGLCKRVQPGKN
..|  .  |.|||.||.|.||.   .                  .|  | ||||.. . | ..
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSD
Kinase ire-1.AA AGC 769-794 33 1.5e-11 24.64 In-house 360-395 (395) Show / Hide 
Range on Protein: 769-794
Range on HMM: 360-395/395
Sequence Identity: 33% (12 aa)

DLISSMLNVEPLHRLT----------ADAVLNHPFF
|||. .|...| .||.          |. . |||.|
DLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase ire-1.AA Ciliate-E2a 769-794 50 2.7e-11 29.53 In-house 250-275 (275) Show / Hide 
Range on Protein: 769-794
Range on HMM: 250-275/275
Sequence Identity: 50% (13 aa)

DLISSMLNVEPLHRLTADAVLNHPFF
||.. ||.. | .|.||   ||||.|
DLMKKMLEKDPKKRITAQQALNHPWF
Kinase ire-1.AA TyrKc 534-794 19 8.7e-11 -48.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 534-794
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

YSPSDILGTGCEGTVVYRGTFDGREVAVKRVVSEFVKFA-HREADLLRES-DTHPHVIRYF--CMES-----DSQFRYLALELCIA-SLNDYVEQKEVQQ
 .  ..|| |. | .||.|| . ..|||| . ..  . . .||| ....    ||...| .  |...      ..  .. .|..   .|.||   .. . 
ITLGKKLGEGAFG-EVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

NVTIA-LRDIMKQATDGLAHLHASKIVHRDMKPQNVLITMASQRGEMRAVISDFGLCKRVQPG------KNSIS-----RGIA-SGLAGTDGWIAPEVLI
 .. . | ... |. .| ..||  ...|||    |.|..        .. ||||||.. .  .      |  ..      | .   .     | |||.. 
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR----WMAPECIN

SASTSYPVDIFSLGCIFYYVLTSGTHPFG------KSLHRQANIVNGEYTLNKLADL-------DDWSLADDLISSMLNVEPLHRLTADAVLNHPFF
    .   |..| |   . ..| |  |        .|  .  . |   | . . ..            . . ....  . .|  | |  ..  | .|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase ire-1.AA CMGC 734-794 17 5.5e-10 28.05 In-house 416-513 (513) Show / Hide 
Range on Protein: 734-794
Range on HMM: 416-513/513
Sequence Identity: 17% (17 aa)

GTHPFGKSLHRQANIVNGEYTLNKLADLDDW-------------------------------------SLADDLISSMLNVEPLHRLTADAVLNHPFF
.... .  ...| |.  ...  ... .|  |                                     ..| ||.. ||  .|  |.||.  |.||.|
NHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase ire-1.AA CMGC 705-728 32 1.1e-05 13.65 In-house 293-326 (513) Show / Hide 
Range on Protein: 705-728
Range on HMM: 293-326/513
Sequence Identity: 32% (11 aa)

APEVLISASTS----------YPVDIFSLGCIFY
|||.|....            .|.|. |.||||.
APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFA
Kinase ire-1.AA STE 769-794 39 0.00012 12.48 In-house 332-359 (359) Show / Hide 
Range on Protein: 769-794
Range on HMM: 332-359/359
Sequence Identity: 39% (11 aa)

DLISSMLNVEPLHRLTADAVLN--HPFF
| |.  |. .| .| ||.  |.  |||.
DFINKCLQKDPNKRPTASQLLKSEHPFI
Ribonuc_2-5A ire-1.AA Ribonuc_2-5A 799-925 48 1.4e-72 252.24 Pfam 1-137 (137) Show / Hide 
Range on Protein: 799-925
Range on HMM: 1-137/137
Sequence Identity: 48% (66 aa)

KRLAYFSDVSDRVEKEEDN--SPVVRRIETDARIVVC-GGWREKICDALKEDLRKF-RT---YKSFSVRDLLRAMRNKKHHYREL-PEDVRQSLGDIPDQ
|||... |||||.|.|...  ||...  |...| ||. | |..||. |...|..|. |.   |.. ||||||||||||||||.|. ||.....|||.||.
KRLRFLCDVSDRFEIEDRDPPSPILQALERTSRCVVGFGDWHKKIDKAFMDDMGKYYRKRKNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLPDG

FLHYFTSRFPRLLLHVYKATE--YCSGEAVFKRYYSD
||.|||.|||.||.|.|.. .  .|..| .|..||..
FLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYKP
PUG ire-1.AA PUG 857-914 37 6.8e-25 89.95 SMART 1-66 (66) Show / Hide 
Range on Protein: 857-914
Range on HMM: 1-66/66
Sequence Identity: 37% (25 aa)

FSVRDLLRAMRNKKHHYREL--------PEDVRQSLGDIPDQFLHYFTSRFPRLLLHVYKATEYCS
 |||||||.|||..||.||.        ...... .|..|..| .|||..||.|..|.. . ..|.
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK