Gene gcy-9 (Nematode worm)
gcy-9
Sequence
Protein domains of gcy-9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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ANF_receptor | gcy-9.AA | ANF_receptor | 110-427 | 16 | 1.3e-25 | 91.44 | Pfam | 32-364 (364) | Show / Hide |
Range on Protein: 110-427 Range on HMM: 32-364/364 Sequence Identity: 16% (57 aa) ESC---NKYSGVEHAAFLHYLKNASVYFGPGCNNEMLVIGRLAPRWNVPIIAHMSGDDALSD--RVQFPTLGSVALTSASEMAKATVTYLNL-NNWDQIG ..| .| |..... |.. . .||.| .. ..|.| ||.|.| . . ...|.| . ..|.. .. ..... ..| | ... .|.... DCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYPYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVA IVRPSVGY--ERLS---VYSLQHQIKK-RDINLNV-ILDIEPFSSPEEIISTGKLTT-LKSMARIIVVELGMDIHSV----TNFMLAIHRSEIKNEEFVF .. . | | . .|. .. ....... . . . .. ... |. .|. ||.||. .. . .|...|. . ....|. VIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIVM--CCYPDDMGLLQRQIMQQAHELGMMSGGYVW VIPWLAHQN--DHYPWEAANVDKQEVKLAFENTIIITAHGYDKKFFDDFQMKFSAVTGVLANHYATLSY-MSLYDALFLYGLALRDAFEDGGGYNVHM-- . .. . . .|. . .|. . . |.......| | ..|..| ..... . . .| . .||| ||. ||... .... . IYTDWWMHSYDMQ-WWYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKK------TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCD ----NGSLIWSRMTN-RQFIGMTGQVLMNNKAIRVPSYATYHAING .|. . ..| | ..| |.||.| .. . |.|.| . IMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD |
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Kinase | gcy-9.AA | RGC | 575-848 | 29 | 5.5e-118 | 398.28 | In-house | 1-300 (300) | Show / Hide |
Range on Protein: 575-848 Range on HMM: 1-300/300 Sequence Identity: 29% (90 aa) NGVKLAIKRYQQV---RNITFPKSELRLLKELKICENDNLNKFYGISFNQQNE-----FIVMWVLCSRGSLEDILFNDELKLGRNFQVSFAKDVVKGLNF .|.. .||...| |...|..|..|.||... ...||||||.|.......| ....| .||||||.|||.||..|. ..|. || .|.|||... EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY LHTSPLLHHGMLCLQNCLVDSNWTVKLTNFATEAVIFEKLDHNELRPFINTDSESADDVSDPTKDFARKKYLQQAPEIIREIVTTKTIPE------GSQS ||.||. .||.|. ||.|||.| ||.|.| .........| ...|. .. |............ .||.|..|||..|| .. .... |.|. LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPP-CK-SDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQK ADIYALGMVLYQILFRVEPFHERNKSINK--LMETLAMANDD------DQLIRPTFPSSNTGEG-----YNLQLLSCIEACWLEIPEMRPP-IKKVRTMV .|.|..|...|.|..| .|.... .... .. .... ... .. ..|..|| ...|. | ||.....|| | ||.||. ....|... GDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQL NA . KT |
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Kinase | gcy-9.AA | RGC | 575-848 | 29 | 5.5e-118 | 398.28 | In-house | 1-300 (300) | Show / Hide |
Range on Protein: 575-848 Range on HMM: 1-300/300 Sequence Identity: 29% (90 aa) NGVKLAIKRYQQV---RNITFPKSELRLLKELKICENDNLNKFYGISFNQQNE-----FIVMWVLCSRGSLEDILFNDELKLGRNFQVSFAKDVVKGLNF .|.. .||...| |...|..|..|.||... ...||||||.|.......| ....| .||||||.|||.||..|. ..|. || .|.|||... EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY LHTSPLLHHGMLCLQNCLVDSNWTVKLTNFATEAVIFEKLDHNELRPFINTDSESADDVSDPTKDFARKKYLQQAPEIIREIVTTKTIPE------GSQS ||.||. .||.|. ||.|||.| ||.|.| .........| ...|. .. |............ .||.|..|||..|| .. .... |.|. LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPP-CK-SDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQK ADIYALGMVLYQILFRVEPFHERNKSINK--LMETLAMANDD------DQLIRPTFPSSNTGEG-----YNLQLLSCIEACWLEIPEMRPP-IKKVRTMV .|.|..|...|.|..| .|.... .... .. .... ... .. ..|..|| ...|. | ||.....|| | ||.||. ....|... GDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQL NA . KT |
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Kinase | gcy-9.AA | TKL | 580-846 | 16 | 2.1e-16 | 55.6 | In-house | 30-364 (364) | Show / Hide |
Range on Protein: 580-846 Range on HMM: 30-364/364 Sequence Identity: 16% (59 aa) AIKRYQQVRNITFPKSE-----------------------LRLLKELKICE---NDNLNKFYGISFNQQN------------EFIVMWVLCSRGSLEDIL |.|.. . . | |.. .. .|.... .|. .|.|.... .. .. .|..|||...| AVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYL FNDELKLGRNFQVSFAKDVVKGLNFLHT-------SPLLHHGMLCLQNCLVDSNWT--------------VKLTNFATEAVIFEKLDHNELR-------P . ...|.|. .|.|.||. | . | | .|.|||.||| .|.. | . ..... . | . H-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAE FINTDSESADDVSDPTKDFARKKYLQQAPEIIR-EIVTTKTI--------PEGSQSADIYALGMVLYQILFRVEPF---HERNKSINKLMETLAMANDDD . ... |. . . |||..| .. .|. | |...|.|. |.||. || | .|. ... .... . . .. . | --------HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDP-FEEMFMMVCD QLIRPTFPSSNTG-------EGYNLQLLSCIEACWLEIPEMRPPIKKVRTMV ||. |. . .. . .. || . || || ... KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | gcy-9.AA | TKL-Unique | 632-696 | 31 | 2.3e-07 | 22.2 | In-house | 82-161 (290) | Show / Hide |
Range on Protein: 632-696 Range on HMM: 82-161/290 Sequence Identity: 31% (25 aa) CSRGSLEDILF---------NDELKLGRNFQVSFAKDVVKGLNFLHTSPL-LHHGMLCLQNCLVDSN-----WTVKLTNF |..||| | | |...|| . .|..|.|...|...||.. |. | .| |||.| | .|. | CPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDF |
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Kinase | gcy-9.AA | Dicty4 | 631-692 | 30 | 3e-07 | 20.43 | In-house | 83-154 (277) | Show / Hide |
Range on Protein: 631-692 Range on HMM: 83-154/277 Sequence Identity: 30% (22 aa) LCSRGSLEDILFN------DELKLG--RNFQ-VSFAKDVVKGLNFLHT-SPLLHHGMLCLQNCLVDSNWTVK ....|.|. .| . .. || . . |.|...|.| ||. | | | | ||| ||.|| YMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVK |
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Kinase | gcy-9.AA | Dicty5 | 609-698 | 24 | 4.1e-07 | 20.53 | In-house | 58-150 (260) | Show / Hide |
Range on Protein: 609-698 Range on HMM: 58-150/260 Sequence Identity: 24% (23 aa) DNLNKFYGISFNQQNE-FIVMWVLCSRGSLEDILFNDEL----KLGRNFQVSFAKDVVKGLNFLHTSPLLHHGMLCLQNCLVDSNWTVKLTNFAT .|. ..|| .. |.| .|..||| . | . . |...| |. ... .|| | . . | |. ||..|. | | PNFIRCYGAHQYNDKYPFHVTE-YCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSM-NFLITENWKIKIIDFGT |
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S_TKc | gcy-9.AA | S_TKc | 544-846 | 12 | 5.2e-07 | -74.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 544-846 Range on HMM: 1-231/231 Sequence Identity: 12% (42 aa) SLASKSQSSGSFSGSMNSKQNGLIAAKQAVSNGVKLAIKRYQQVRNITFPKSELRLLKELKICENDNLNKFYGISFNQQNEFIVMWVLCSR--GSLEDIL . .|.|. . . .. | . |||. ..|...||. .|. |.|.. . ... . .|. |.| |.. YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYI FNDELK-----LGRNFQVSFAKDVVKGLNFLHTSPLLHHGMLCLQNCLVDSNWTVKLTNF--ATEAVIFEKLDHNELRPFINTDSESADDVSDPTKDFAR . . . .... ....|...| | | .| |.|. ..|.. | |.. KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------------- KKYLQ----QAPEIIREIVTTKTIPEGSQ-SADIYALGMVLYQILFRVEPFHERNKSINKLMETLAMANDDDQLIRPTFPSSNTGEGYNLQLLSCIEACW . . |||.. . ..|....| .|| | . ||. ...... . .... |. |. TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------------------SPEAKDFIRKCL LEIPEMRPPIKKVRT---------MV || || . .. . . QKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | gcy-9.AA | DRK | 633-696 | 33 | 7.4e-07 | 19.3 | In-house | 80-144 (258) | Show / Hide |
Range on Protein: 633-696 Range on HMM: 80-144/258 Sequence Identity: 33% (22 aa) SRGSLEDILFNDELKLGRNFQVSFAKDVVKGLNFLHTS-PLLHHGMLCLQNCLVDSNWTVKLTNF .|||| || .. ... . . |. ||...|| . | | | | ||| .| || | PRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADF |
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Kinase | gcy-9.AA | TK | 595-696 | 10 | 7.5e-07 | 18.19 | In-house | 87-295 (486) | Show / Hide |
Range on Protein: 595-696 Range on HMM: 87-295/486 Sequence Identity: 10% (23 aa) SELRLLKELK--ICENDNLNKFYGISFNQQ-----------NEFIVMWVLCSRGS----LEDILFNDELK------------------------------ .|.. .| .. ... .|. ..||... .. .... ... |. | | | . | EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY ---------------------------------------------LGRNFQVSFAKDVVKGLNFLHTSPL-----LHHGMLCLQNCLVDSNWT------- | .. .. .. .|. .|| . . |. |. ||||..| . SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDG ----VKLTNF .|.. | CGPVCKIADF |
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Kinase | gcy-9.AA | Ciliate-E2-Unclassified | 740-837 | 21 | 2e-06 | 18.73 | In-house | 233-310 (352) | Show / Hide |
Range on Protein: 740-837 Range on HMM: 233-310/352 Sequence Identity: 21% (21 aa) QAPEIIRE-IVTTKTIPEGSQSADIYALGMVLYQILFRVEPFHERNKSINKLMETLAMANDDDQLIRPTFPSSNTGEGYNLQLLSCIEACWLEIPEMRP .|||.... ... ..||..||..||..|| || .|. ... ..| |. . |..||.. | .. ...|.. . TAPEVLQGQNYDHSKA----YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NN--------A--------YRKQLYQNIKQKNIQFPKFPW |
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Kinase | gcy-9.AA | UTK | 596-696 | 18 | 3e-06 | 17.49 | In-house | 59-169 (296) | Show / Hide |
Range on Protein: 596-696 Range on HMM: 59-169/296 Sequence Identity: 18% (21 aa) ELRLLKELKICENDNLNKFYGISFNQQNEFIVMWVLCSRGSLEDILFNDELKLG-RNFQVS------FAKDVVKGLNFLHTSPLLHHGMLCLQNCLVDSN || ..| .. . |. ...|. .... ... . ....|.| . | . ... . .... .| |. |...||. . |. |. .||||... ELQMMKQFH--WHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFV-HRDLAARNCLVHMH -------WTVKLTNF ...|. .| RMMWHCMMVCKIADF |
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TyrKc | gcy-9.AA | TyrKc | 532-846 | 17 | 8.9e-05 | -145.38 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 532-846 Range on HMM: 1-280/280 Sequence Identity: 17% (62 aa) IKMLE------------GKSKSEHSLASKSQSSGSFSGSMNSKQNGLIAAKQAVSNGVKLAIKRYQQVRNITFPKSELRLLKELKI---C--ENDNLNKF |.... |. | .. |.| . . ...|..| ...|. .. ITLGKKLGEGAFGEVYKGTWK------------------------------------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRL YGISFNQ-------QNEFIVMWVLCSRGSLEDILFNDELKLGRNFQVSFAKDVVKGLNFLHTSPLLHHGMLCLQNCLVDSNWTVKLTNFATEAVIFEK-L ||. | . .||| ... |.| | | . . || .||. .. .| ..|| .. | | ||||..| ||| . | | .. YGVCTQQGRNFMYIEPLMIVM-EYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRD-LAARNCLVGENHTVKISDFGLSRDIYDDDQ DHNELRPFINTDSESADDVSDPTKDF----ARK-----KYLQQAPEIIREIV-TTKTIPEGSQSADIYALGMVLYQILFRVEPFHER-NKSINKLMETLA .|. ... .| . . ||| |.. . |||. |... | ... |. . .. .. . |. QG----------------ESKDYYRKKEHKGGKTMLPIRWM--APECINYGKFTTKS--------DVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQE MANDDDQLIRPTFPSS--------NTGEGYNLQLLSCIEACWLEIPEMRPPIKKVRTMV . .. .| |. | . . | |.. .. || | ||.|| . .. VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQI-----MKQCWHEDPEDRPTFSEIHECF |
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Kinase | gcy-9.AA | TK | 828-846 | 31 | 0.018587 | 3.19 | In-house | 468-486 (486) | Show / Hide |
Range on Protein: 828-846 Range on HMM: 468-486/486 Sequence Identity: 31% (6 aa) CWLEIPEMRPPIKKVRTMV || . || || . .. . CWHYDPEDRPTFSQLHEQL |
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Kinase | gcy-9.AA | Dicty4 | 759-782 | 44 | 0.037113 | 3.19 | In-house | 196-220 (277) | Show / Hide |
Range on Protein: 759-782 Range on HMM: 196-220/277 Sequence Identity: 44% (11 aa) QSADIYALGMVLYQILFRVEPFH-E ..|| | |.||..|| | ||. . EKADVYSFGIVLWEILTRQEPYQKH |
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Kinase | gcy-9.AA | TKL-Unique | 758-771 | 42 | 0.059958 | 2.88 | In-house | 206-219 (290) | Show / Hide |
Range on Protein: 758-771 Range on HMM: 206-219/290 Sequence Identity: 42% (6 aa) SQSADIYALGMVLY |...|.|. |.||. SEKSDVYSFGIVLW |
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Kinase | gcy-9.AA | UTK | 827-846 | 25 | 0.097228 | 1.73 | In-house | 277-296 (296) | Show / Hide |
Range on Protein: 827-846 Range on HMM: 277-296/296 Sequence Identity: 25% (5 aa) ACWLEIPEMRPPIKKVRTMV .|| |..|| .. .. . RCWHYDPQERPDFEDLVQQM |
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Kinase | gcy-9.AA | Dicty5 | 825-850 | 26 | 0.168751 | 0.92 | In-house | 235-260 (260) | Show / Hide |
Range on Protein: 825-850 Range on HMM: 235-260/260 Sequence Identity: 26% (7 aa) IEACWLEIPEMRPPIKKVRTMVNANL |..|| . | || |.. . . IKKCWQQKPHNRPSFKEICKYFESII |
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Kinase | gcy-9.AA | Dicty5 | 759-785 | 37 | 0.186292 | 0.77 | In-house | 182-208 (260) | Show / Hide |
Range on Protein: 759-785 Range on HMM: 182-208/260 Sequence Identity: 37% (10 aa) QSADIYALGMVLYQILFRVEPFHERNK | .|.|. | ||. .. | ||. . |. QKCDVYSFGIVLWEMFTRKEPYDNINN |
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CYCc | gcy-9.AA | CYCc | 886-1098 | 42 | 3.8e-110 | 373.16 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 886-1098 Range on HMM: 1-231/231 Sequence Identity: 42% (102 aa) EAQKQADRLLNSMLPKSIAEDLKIGK-PVLPQLYSCATVLFSDIRGFTRISSTSTPLQVCKLRQKIIVVTFLNDMFSGFDAIIAKHD-----AYKVETIG ......||||..|||...|..|| |. || |..|.|.|.||.||.|||... . .. . ||..|||... || ||..|. .||||||| MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLC---------SWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIG DAYMIVSGVPTENG-------------------NSHAQNIADVALKMRAFICNFKLAHR----PEELMMVRIGFHSGPVAAGVVGLAAPRYCLFGDTVNT ||||.|||.||.|. |||.|||.||.|. ....|.. |. |.. ...|||.|.|||..||||...||||.||||||. DAYMVVSGCPTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNM ASRMESTGVANKIQISEGAYNLLHCFFPQFQMVERGKIEVKV ||||||||....|..|| .|..| |.. ||.....|..|... ASRMESTGDPGQIHVSEETYWCL-CLD-QFERRRCGQFEFEP |
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Guanylate_cyc | gcy-9.AA | Guanylate_cyc | 913-1097 | 41 | 5.7e-70 | 243.57 | Pfam | 1-199 (214) | Show / Hide |
Range on Protein: 913-1097 Range on HMM: 1-199/214 Sequence Identity: 41% (86 aa) VLPQLYSCATVLFSDIRGFTRISSTST----PLQVCKLRQKIIVVTFLNDMFSGFDAIIAKH--DAYKVETIGDAYMIVSGVPTE-----NGNSHAQNIA | .| | | |..|.||.|||...| .. |.| .|..|||... || ....| . |||.||||.||.|||.| . .. .||. .| VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQ---------CVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMA DVALKMRAFICNFKLAHRPEEL-----MMVRIGFHSGPVAAGVVG--LAAPRYCLFGDTVNTASRMESTGVAN--KIQISEGAYNLLHCFF-PQFQM--V | ||.| .. . | . | ..||| |.||| |||.| . ||||..|||||.|||||||||.. ||..|| .| .| | . .||. DMALDMMEYCQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQ ERGKIEVK .|| |.|| HRGEIPVK |
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HNOBA | gcy-9.AA | HNOBA | 860-907 | 42 | 2.5e-08 | 31.67 | Pfam | 190-234 (234) | Show / Hide |
Range on Protein: 860-907 Range on HMM: 190-234/234 Sequence Identity: 42% (21 aa) DQMMKMME-EYTANLENMVRDRTALLEEAQKQADRLLNSMLPKSIAEDL ...|. || . ...||.| | .||| |. |.|| ||.|||.|. | YKLMCRMEQQLKDKLEQMHR----ELEEEKKKTDDLLYSMFPKSVANRL |