Gene gcy-25 (Nematode worm)
gcy-25
Sequence
Protein domains of gcy-25.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| ANF_receptor | gcy-25.AA | ANF_receptor | 53-161 | 17 | 9.6e-07 | 24.71 | Pfam | 33-156 (364) | Show / Hide |
Range on Protein: 53-161 Range on HMM: 33-156/364 Sequence Identity: 17% (22 aa) SC---HNFNGLENAANLNYQYSVDLLIGAACDEETQTVSRLALRWHKLYLS----SAPLST--KEKESTTIALKPHSLAGTAEVILAMCKS-MKWKEIGI .| . ... .|. . . |. .|| | ... .|.|.| |.. .| . |. |.. ... . | .. ....... . .||.... CCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYPYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAV IYSEETK--YT-----AHAIYDMLAE ||..... . ..|..| |.| IYDDDDYYYWRGGCYFMEAFQDELRE |
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| ANF_receptor | gcy-25.AA | ANF_receptor | 351-386 | 26 | 0.296803 | 5.3 | Pfam | 327-364 (364) | Show / Hide |
Range on Protein: 351-386 Range on HMM: 327-364/364 Sequence Identity: 26% (10 aa) LWNHVTN-TETQGYSGPVFIGN-DGVRLPYYEMHMWRD | .. | .. .| .|.| . .| | .|. . |. | LLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD |
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| Kinase | gcy-25.AA | RGC | 523-791 | 27 | 8.60000000001e-105 | 354.45 | In-house | 1-300 (300) | Show / Hide |
Range on Protein: 523-791 Range on HMM: 1-300/300 Sequence Identity: 27% (82 aa) NKQKVSVKRHVQR---RAITFSRQEMEMLNQLKYMSHTNINPFTGICFNQGSE-----LIVMWQFTTRYSLEDLIFVKEQKFGRNFQSTFIKHIVHGINY ....| .|.|.|| |...|.|..| .|.|.. . | |.|.| |.|... .| ....|.. .| ||.|... . | ..|.. ||..||.|..| EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY IHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILKERTNHKELAP----SSAFDVD-----AIHYKYLQLAPEHISAILEKLEEP------RGTVEGD .|.|.|..|| | .||||||.||||.||||.. .|... |....| ....... . ..|.|. ||||. . ... .. ||| .|| LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD IYQLAMCIYQILFYMRPFAERQESIKV--YSGEIFLKLPELAHLLSSQSTAPLHPKVPEGNS-----FTMRLLSIIQQCWLYKPAARPA-LIKITDAVNR .| .....|.|.. ..|. .. .... |. . .. |...........|..|...|... . ..||.....|| .|. || . .| ..... VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT |
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| Kinase | gcy-25.AA | RGC | 523-791 | 27 | 8.60000000001e-105 | 354.45 | In-house | 1-300 (300) | Show / Hide |
Range on Protein: 523-791 Range on HMM: 1-300/300 Sequence Identity: 27% (82 aa) NKQKVSVKRHVQR---RAITFSRQEMEMLNQLKYMSHTNINPFTGICFNQGSE-----LIVMWQFTTRYSLEDLIFVKEQKFGRNFQSTFIKHIVHGINY ....| .|.|.|| |...|.|..| .|.|.. . | |.|.| |.|... .| ....|.. .| ||.|... . | ..|.. ||..||.|..| EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY IHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILKERTNHKELAP----SSAFDVD-----AIHYKYLQLAPEHISAILEKLEEP------RGTVEGD .|.|.|..|| | .||||||.||||.||||.. .|... |....| ....... . ..|.|. ||||. . ... .. ||| .|| LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD IYQLAMCIYQILFYMRPFAERQESIKV--YSGEIFLKLPELAHLLSSQSTAPLHPKVPEGNS-----FTMRLLSIIQQCWLYKPAARPA-LIKITDAVNR .| .....|.|.. ..|. .. .... |. . .. |...........|..|...|... . ..||.....|| .|. || . .| ..... VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT |
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| S_TKc | gcy-25.AA | S_TKc | 507-794 | 13 | 2e-06 | -82.27 | SMART | 11-231 (231) | Show / Hide |
Range on Protein: 507-794
Range on HMM: 11-231/231
Sequence Identity: 13% (40 aa)
SYSSIFSGNVAEHAIVNKQKVSVKRHVQRRAITFSRQEMEMLNQLKYMSHTNINPFTGICFNQGSELIVMWQFTTR--YSLEDLIFVKEQK-----FGRN
.... . . . ...| .|. |.|...| . | || . ... . ..| . . .| |.| . . |
AFGKVYKCRHKK----TGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-
FQSTFIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILKERTNHKELAPSSAFDVDAIHYKYLQ----LAPEHISAILEKLEEPRGT
... |. ...|.|. .| | .| .|. ..|..|||. .| . . .||| . . |.
HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------------------TTFCGTPWYMAPEVL---------GYGK
VEGDIYQLAMCIYQILFYMRPFAERQESIKVYSGEIFLKLPELAHLLSSQSTAPLHPKVPEGNSFTMRLLSIIQQCWLYKPAARPALIKITD----AVNR
. |.. . ..| | || ... | . ....|..|. . |. || .. . .
CKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH
EFG
..
PWF
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| Kinase | gcy-25.AA | RIPK | 763-789 | 22 | 2e-05 | 14.38 | In-house | 264-290 (290) | Show / Hide |
Range on Protein: 763-789 Range on HMM: 264-290/290 Sequence Identity: 22% (6 aa) RLLSIIQQCWLYKPAARPALIKITDAV .. . .|.|| . | .||. . ... . QMIELMQRCWQQDPNDRPCFQECEEWT |
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| Kinase | gcy-25.AA | Ciliate-C3 | 606-644 | 38 | 2.7e-05 | 15.32 | In-house | 103-140 (140) | Show / Hide |
Range on Protein: 606-644 Range on HMM: 103-140/140 Sequence Identity: 38% (15 aa) KHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDF | |. |.|.| | ||| . .|| .. | .|. || KQILQAIDYLHEHNI-VHGDIKFSNILINSKDEIKIIDF |
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| Kinase | gcy-25.AA | PLK1 | 604-646 | 37 | 0.00015 | 10.58 | In-house | 104-145 (253) | Show / Hide |
Range on Protein: 604-646 Range on HMM: 104-145/253 Sequence Identity: 37% (16 aa) FIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDFGI ... ||.|. |.|| | .| | | | .. ||. |||. YMYQIVEGCQYLHNNKI-IHRDLKLGNLFLNDHLQVKIGDFGL |
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| Kinase | gcy-25.AA | Ciliate-A7 | 698-723 | 26 | 0.000454 | 10.63 | In-house | 256-281 (360) | Show / Hide |
Range on Protein: 698-723 Range on HMM: 256-281/360 Sequence Identity: 26% (7 aa) GDIYQLAMCIYQILFYMRPFAERQES .|.... ....||||...||... .. CDVFAFGVSFFQILFQQNPFCCEACH |
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| Kinase | gcy-25.AA | SAK | 592-651 | 31 | 0.000581 | 9.08 | In-house | 93-151 (254) | Show / Hide |
Range on Protein: 592-651 Range on HMM: 93-151/254 Sequence Identity: 31% (19 aa) KEQKFGRNFQSTFIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILK . . |. . |...|| |. |.| | .| | ||| .. .|. |||. || RMRPFTEEEARHFMHQIVIGMLYLHSHGI-MHRDLTLSNILLTRDMHCKIADFGLATQLK |
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| Kinase | gcy-25.AA | Musk | 767-789 | 30 | 0.00085 | 8.17 | In-house | 260-282 (282) | Show / Hide |
Range on Protein: 767-789 Range on HMM: 260-282/282 Sequence Identity: 30% (7 aa) IIQQCWLYKPAARPALIKITDAV . .|| .|| || .| . . LMRRCWQKNPADRPFFCQIHHCI |
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| TyrKc | gcy-25.AA | TyrKc | 511-724 | 14 | 0.00086 | -161.32 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 511-724
Range on HMM: 1-280/280
Sequence Identity: 14% (42 aa)
IFSGNVA--------EHAIVNKQKVSVKRHVQRRAITFSRQEMEMLNQLKYMSHT-----NINPFTGICFNQG------SELIVMWQFTTRYSLEDLIFV
| | . ... . ..| || ...... .. |.. || . |.| || | . . .| | .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK
KEQKFGRNFQSTFIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILKER----TNHKELAPSSAFDVD-----------AIHYK---
.. |. | | | .|.| . .| | || |.. .|| .||| ... ... ... . . .| |.
HRPKLCMKDLLSFCWQIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT
----------------------YLQ-----LAPEHISAILEKL---EEPRG-------TVEGDIYQLAMCIYQILFYMRP-FAERQESI
| . .... . ... . | . ..||. . . .|| |.| | .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | gcy-25.AA | UTK | 762-789 | 21 | 0.001549 | 7.97 | In-house | 269-296 (296) | Show / Hide |
Range on Protein: 762-789 Range on HMM: 269-296/296 Sequence Identity: 21% (6 aa) MRLLSIIQQCWLYKPAARPALIKITDAV ... . ..|| | |. || ..... HPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | gcy-25.AA | UTK | 604-645 | 30 | 0.002598 | 7.19 | In-house | 123-170 (296) | Show / Hide |
Range on Protein: 604-645 Range on HMM: 123-170/296 Sequence Identity: 30% (15 aa) FIKHIVHGINYIHNSSIKVHGALYLSNCVVDSY-------WVVKLTDFG . .| .| .|.|. . ||. | || |.. .|.|. ||| MAWDIARGMQYLHSCGF-VHRDLAARNCLVHMHRMMWHCMMVCKIADFG |
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| Kinase | gcy-25.AA | TK | 767-789 | 34 | 0.002964 | 5.91 | In-house | 464-486 (486) | Show / Hide |
Range on Protein: 767-789 Range on HMM: 464-486/486 Sequence Identity: 34% (8 aa) IIQQCWLYKPAARPALIKITDAV ..|||| |.|. || . .. LMQQCWHYDPEDRPTFSQLHEQL |
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| Kinase | gcy-25.AA | TK | 604-645 | 25 | 0.006892 | 4.66 | In-house | 239-296 (486) | Show / Hide |
Range on Protein: 604-645 Range on HMM: 239-296/486 Sequence Identity: 25% (15 aa) FIKHIVHGINYIHNSSIK-----VHGALYLSNCVVDSYWV-----------VKLTDFG . | | |.| .. ||. | || |.. | .|..||| MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG |
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| Kinase | gcy-25.AA | Musk | 630-645 | 43 | 0.09138 | 1.35 | In-house | 156-171 (282) | Show / Hide |
Range on Protein: 630-645 Range on HMM: 156-171/282 Sequence Identity: 43% (7 aa) NCVVDSYWVVKLTDFG || . . .|| ||| NCLINEHMDVKIADFG |
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| CYCc | gcy-25.AA | CYCc | 827-1032 | 32 | 1.6e-57 | 198.37 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 827-1032 Range on HMM: 1-231/231 Sequence Identity: 32% (76 aa) LEQDMSVTENLLYQLLPKSVADSIRSGK-TVVPEQHSSVTLLVVDVCQFTKFCEAFIPVHILETLQELYSSFDNIVQKNK-----AFKVENVGDAYLICS |.. .. ||.|.||..||.. ..|. .|.|. ...||.| |.. ||..|.. | . . |...|. || |. ... . ||| .|||| ..| MEKQK--NDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVS GIPEMSG-------------------FRHLREICKISLKLQAFMKTFKVRHR----PSHTLQIKMGITSGAVAAGILGSTAPRFCIFGDTVNMACRMAST |.|. . .| ..|. ..|. .||||.|.|. | ..|.. .|| .| |..| | ..|| |.|||||||| || || GCPTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMEST GNPGSIQLSELTANTLMEKFPSFMLEERGMIDVKG |.|| |..|| | . | .. .|.. ..| ..... GDPGQIHVSEETYWCL-CLD-QFERRRCGQFEFEP |
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| Guanylate_cyc | gcy-25.AA | Guanylate_cyc | 856-1043 | 30 | 7.2e-47 | 166.83 | Pfam | 1-214 (214) | Show / Hide |
Range on Protein: 856-1043 Range on HMM: 1-214/214 Sequence Identity: 30% (66 aa) VVPEQHSSVTLLVVDVCQFTKFCEAFI----PVHILETLQELYSSFDNIVQKN--KAFKVENVGDAYLICSGIPEM-----SGFRHLREICKISLKLQAF |..... .||.. |. ||.||.. |. ... | ..|..|| .. .. .||. .||.|...||.|. .. |.. .. ..|... . VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY MKTFKVRHRP-SH----TLQIKMGITSGAVAAGILG--STAPRFCIFGDTVNMACRMASTGNPG--SIQLSELTANTLMEKF-PSFML--EERGMIDVKG .... | | . ..|. .|| .| | ||..| . ||.|..|||||.| || |||.|| |..|| |. |.... ..| . ..|| | ||| CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG KGA---CLTFWLTG || |..|.| KGKMGEMETYFLHG |
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