Gene gcy-12 (Nematode worm)

gcy-12

Species: Nematode worm
Alias: F08B1.2, gcy-12, aSWK300, CE27920
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 5312087-5317262, WormBase Genetic Map location: n/a,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
gcy-12.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 317 Kinase domain by global Sugen HMM Fasta, JSON
gcy-12.AA Protein Genbank 1280 None Fasta, JSON

Protein domain

Protein domains of gcy-12.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor gcy-12.AA ANF_receptor 140-525 19 1.5e-19 69.95 Pfam 1-364 (364) Show / Hide 
Range on Protein: 140-525
Range on HMM: 1-364/364
Sequence Identity: 19% (79 aa)

VVSGALVAAIVEINQDKD-LIPAYQLKYVFGNTC---GNDSHSTRLFMEHWQAGARVFIGPEKNC--KTEAAMAASQNLPIISYRCNDQDISRD-DYHYR
 . .|.  || .||.| . | | . |.|.. ..|    .    .   ....  |. ..|||   .   . | .|.  |.|.||. | .   . . .  | 
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYP

TFARTVPPAGEI-FKAFMSLMKQ-YNWRKFSVVYDVKKGQVKNELFETLKR---MVETENKFEEHKFEIMNVSKLEFSKMDISSQQDIQSIENAIKS--T
.|.||||..     .|......  ..|....|.||      ... .        | . .. ..||  .. ..       | |.. .|.....  ||   .
YFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYD------DDDYYYWRGGCYFMEAFQDELREHGGNCVYYA---YVSMVIPWDDDFMDYLKKIKDIIK

MQTTRIYLTFDNVRLF---RTMLSIMGEMGLTQQDYMLIYVDT--NYDWLNVYHSMNNHFLRNTMTYLHHSWDANNSSDRKMLDYARSALSII-PTPVKL
|..  |.. .   ..    |  .  . |.|..  .|  ||.|.  .  .   .                  |  .   . | .... . | .  . |   
MKARVIVMCCYPDDMGLLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-W------------------WYDDDMDNDKFREAMKGVLGFTMH-P-SP

NSQRFYNFWKKAGDYMHHFGVQKADNLKGNRIACYLYDAVYLYAKAIHELVEE---YGNDDSY-DPTADGKAIIDRIVN-KKYRSIQGFDMRIDERGNSK
  |.|.  |||             ..   |..| |.|||||||| |.|..  .    .|. .. ... .|....... |  ..  . | |...|..|  .
EFQEFMQRWKK-------------TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKW-HGWQLLHYMWNKVNFEGVTG-DVQFDDNGGRR

GNFSLLSWQKV
 ....  .. .
PDYMYWIMNWD
Kinase gcy-12.AA RGC 689-953 31 6.30000000001e-112 378.14 In-house 1-300 (300) Show / Hide 
Range on Protein: 689-953
Range on HMM: 1-300/300
Sequence Identity: 31% (98 aa)

KGTLVGLKDLMYGR--KPKDLTREAKKELRAMRQLAHPNVNNFLGIIVCQY------SVTVVREYCSKGSLHDILRNENLKLDHMYVASFVDDLVKGMVY
.|..| .|......  ...|.||....||. |||| |.|.|.|.|.....        ...| ||||.|||.|||.|...|.|.|. .||. |.|||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

IHDSELKMHGNLKSTNCLITSRWTLQIADFGL-----RELREGIMYD--------SSYNI-----WENFLWTAPEAMTINGSLAISNPP------TPKAD
.|.|....||||||.||.. ||| ..|.||||     .....|....        ....      ....|||||| . .... . ..|.      |.|.|
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

AYSFGIIFHEIFTREG-----PYKIYVQRGDVNGEAAPKKDSVECR-ALVEKTVRRVYSDPYFRPD---TSDLEVQNYVKEVMAACWHHDPYQRPE-FKT
 ||||||..||.||.|     |.....      ||..   . . .. . ..|.  . .  |  ..|   . ..|. ... ..| .||..|| .||. |..
VYSFGIIMYEIITRKGPWDLEPFCMWP------GEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGH-MIECNPCLLHLMRDCWAEDPEERPDMFDQ

IKNKLKP
|...|| 
IRKQLKT
Kinase gcy-12.AA RGC 689-953 31 6.30000000001e-112 378.14 In-house 1-300 (300) Show / Hide 
Range on Protein: 689-953
Range on HMM: 1-300/300
Sequence Identity: 31% (98 aa)

KGTLVGLKDLMYGR--KPKDLTREAKKELRAMRQLAHPNVNNFLGIIVCQY------SVTVVREYCSKGSLHDILRNENLKLDHMYVASFVDDLVKGMVY
.|..| .|......  ...|.||....||. |||| |.|.|.|.|.....        ...| ||||.|||.|||.|...|.|.|. .||. |.|||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

IHDSELKMHGNLKSTNCLITSRWTLQIADFGL-----RELREGIMYD--------SSYNI-----WENFLWTAPEAMTINGSLAISNPP------TPKAD
.|.|....||||||.||.. ||| ..|.||||     .....|....        ....      ....|||||| . .... . ..|.      |.|.|
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

AYSFGIIFHEIFTREG-----PYKIYVQRGDVNGEAAPKKDSVECR-ALVEKTVRRVYSDPYFRPD---TSDLEVQNYVKEVMAACWHHDPYQRPE-FKT
 ||||||..||.||.|     |.....      ||..   . . .. . ..|.  . .  |  ..|   . ..|. ... ..| .||..|| .||. |..
VYSFGIIMYEIITRKGPWDLEPFCMWP------GEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGH-MIECNPCLLHLMRDCWAEDPEERPDMFDQ

IKNKLKP
|...|| 
IRKQLKT
Kinase gcy-12.AA TKL-Unique 705-875 29 1.4e-29 101.52 In-house 36-235 (290) Show / Hide 
Range on Protein: 705-875
Range on HMM: 36-235/290
Sequence Identity: 29% (60 aa)

KDLTREAKKELRAMRQLA-HPNVNNFLGIIV----CQYSVTVVREYCSKGSLHDILR---------NENLKLDHMYVASFVDDLVKGMVYIHDSEL-KMH
.....| ..|.. |  |  |||.  . |. .     .     | |||. |||.| |          |.|.||.   . ... | ..|| |.| .|   .|
NEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIH

GNLKSTNCLITSR-----WTLQIADFGLRELREGIMYDSSYNI--------WENFLWTAPEAMTINGSLAISNPPTPKADAYSFGIIFHEIFTREG----
..|||.| |....     |  .|.||||. ..  |.  .. ..          .|.| ||| .. |    .|.    |.| |||||.  ||.||.     
RDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-CQYSE----KSDVYSFGIVLWEIATRKITKTY

--PYK
  ||.
KKPYQ
Kinase gcy-12.AA TKL 702-875 23 6.6e-22 75.66 In-house 63-290 (364) Show / Hide 
Range on Protein: 702-875
Range on HMM: 63-290/364
Sequence Identity: 23% (55 aa)

RKPKDLTREAKKELRAMRQLAHPNVNNFLGIIVCQYS-------------VTVVREYCSKGSLHDILRNENLKLDHMYVASFVDDLVKGMVYIHDSEL--
.... .  . ..|.. |..| |||.  |.|.  |  .                | |||..|||...|        .    ... |  .|| | | ..   
PEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKW

-----KMHGNLKSTNCLITSRWT--------------LQIADFGLRELREGI--MYDSSYNIWE----------------NFLWTAPEAMT---INGSLA
       | .||| |.|. . ||              . |.||||    ..   | |..... |                .. | |||..     . . .
CTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKV

I------SNPPTPKADAYSFGIIFHEIFTREGPYK
.      . . ..|.| |||||.. ||.||. ||.
GIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY
Kinase gcy-12.AA DRK 706-812 34 6.9e-17 53.76 In-house 39-146 (258) Show / Hide 
Range on Protein: 706-812
Range on HMM: 39-146/258
Sequence Identity: 34% (37 aa)

DLTREAKKELRAMRQLAHPNVNNFLGIIVCQYSVTVVREYCSKGSLHDILRNENLKLDHMYVASFVDDLVKGMVYIHDSE-LKMHGNLKSTNCLITSRWT
..  | ..|   | || |||.  |.|      .. .. || ..|||  || .| ...|   . .   |  ||| | | ..   .|  ||| | |.   | 
NFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQ

LQIADFGL
  .|||||
VKVADFGL
Kinase gcy-12.AA TK 713-874 15 9.9e-17 51.88 In-house 87-395 (486) Show / Hide 
Range on Protein: 713-874
Range on HMM: 87-395/486
Sequence Identity: 15% (49 aa)

KELRAMRQLA-----HPNVNNFLGIIVCQ------------YSVTVVREYCSKGS----LHDILRNENLKLDHMYVAS----------------------
.|...| ..      |||. ...|... .              . .| ||...|.    |.| ||.   |  |.   .                      
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

----------------------------------------------------FVDDLVKGMVYIHDSELK-----MHGNLKSTNCLITSRWT--------
                                                    .  .. .|| |.|.   .      |..|   |||.... .        
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGC

---LQIADFGLR------ELR---------------------------EGIMYDSSYNIWENFLWTAPEAMT--INGSLAISNPPTPKADAYSFGIIFHE
     ||||||         |                           .   | .. . .  . |.|||...  .  .    .  |.| | .|||.  .|
GPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWE

IFTRE-GPY
|||.  .||
IFTYGQEPY
Kinase gcy-12.AA MLK 709-812 28 3.2e-14 45.84 In-house 50-179 (291) Show / Hide 
Range on Protein: 709-812
Range on HMM: 50-179/291
Sequence Identity: 28% (37 aa)

REAKKELRAMRQLAHPN----VNNFLGIIVCQ-YSVTVVREYCSKGSLHDILRNEN-------------LKLDHMYVASFVDDLVKGMVYIHDSELK--M
.. ..| |  | | |||    .  |.|.. .. . . .| |||..|||...|....                ||  ....  .  .|| | |  . |   
WDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPII

HGNLKSTNCLITS------RWTLQIADFGL
|  ||| | ||.         || |.|||.
HRDLKSHNILIDEICHDMHHGTLKICDFGT
TyrKc gcy-12.AA TyrKc 682-951 23 5e-14 4.17 SMART 16-280 (280) Show / Hide 
Range on Protein: 682-951
Range on HMM: 16-280/280
Sequence Identity: 23% (69 aa)

MRGLASYKGTLVGLKDLMYGRKPKDLTREAKKELRAMRQL--AHPNVNNFLGIIVCQ-------YSVTVVREYCSKGSLHDILRNENLKLDHMYVASFVD
..| ..   . |  | |  .       ..  .|.| |..|   |||. ...|... |         . .| ||...|.|.| ||.   || .    ||  
YKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCW

DLVKGMVYIHDSELKMHGNLKSTNCLITSRWTLQIADFGL-RELREG-------IMYDSSY--NIW--ENFLWTAPEAMTINGSLAISNPPTPKADAYSF
.  .|| |.|.  .  |  |   |||.... |  |.|||| |.. ..        .|...   .        |.|||..       .    |.| | .||
QIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKF---TTKSDVWSF

GIIFHEIFTREGPYKIYV--QRGDVNGEAAPKKDSVECRALVEK----TVRRVYSDPYFRPDTSDLEVQNYVKEVMAACWHHDPYQRPEFKTIKNKL
|.   ||||. ..    .  |    | |.  . .. . .   .                    .  .    . ..|  |||.|| .|| |..|. ..
GVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS--------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
S_TKc gcy-12.AA S_TKc 672-955 15 1.1e-13 23.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 672-955
Range on HMM: 1-231/231
Sequence Identity: 15% (48 aa)

WSKAPVQGTG-----MRGLASYKGTLVGLKDLMYGRKPKDLTREAKKELRAMRQLAHPNVNNFLGIIVCQYSVTVVREYCSK--GSLHDILRNENLK---
. .  . | |     ...     | .| .| .          . ...|.. ...  |||. .......   .. .| |||.   |.|.|.... . .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDHMYVASFVDDLVKGMVYIHDSELKMHGNLKSTNCLITSRWTLQIADFGLRELREGIMYDSSYNIWENFLWTAPEAMTINGSLAISNPPTP-KADAY
  ..   .....  ..... |.|.    .|  ||  | |...  .. |.||||  .         . .     . ||| .          . .. |.| .
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----------GYGKCKCDWW

SFGIIFHEIFTREGPYKIYVQRGDVNGEAAPKKDSVECRALVEKTVRRVYSDPYFRPDTSDLEVQNYVKEVMAACWHHDPYQRPEFKTIKN-----KLKP
|.|.|. | .... |.                    .  .. .| .                     .|. .  |.. || .||    . .     |. |
SCGCILYEMLCGYPPFP-------------------QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

LF
 |
WF
Kinase gcy-12.AA Frk 704-869 29 1.5e-12 39.42 In-house 38-197 (260) Show / Hide 
Range on Protein: 704-869
Range on HMM: 38-197/260
Sequence Identity: 29% (50 aa)

PKDLTREAKKELRAMRQLAHPNVNNFLGIIVCQYSVTVVREYCSKGSLHDILRNENLKLDHMYVASFVD---DLVKGMVYIHDSELKMHGNLKSTNCLIT
|.|. |||.     |..| || . .   .   .  . .. |   .||| . |.  | |  .. .   ||    .  || |. .    .|  |   | |. 
PNDFLREAQ----IMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNY-IHRDLAARNVLVG

SRWTLQIADFGLRE--LREGI-MYDSSYNIWENFLWTAPEAMTINGSLAISNPPTPKADAYSFGIIFHEIFT
    ..||||||    ... . .|.|  ..     ||||||.  | . .|      |.| .||||.  || |
EHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYN-KFTI------KSDVWSFGILLTEIIT
Kinase gcy-12.AA Dicty4 712-812 29 1.2e-08 25.16 In-house 46-160 (277) Show / Hide 
Range on Protein: 712-812
Range on HMM: 46-160/277
Sequence Identity: 29% (34 aa)

KKELRAMRQLAHPNVNNFLGIIVCQ----YS--VTVVREYCSKGSLHDILRN------ENLKLDHMYVAS---FVDDLVKGMVYIHDSE-LKMHGNLKST
.||   | .. |||.  |.|   |      .  .  | ||..||.|. .|..      .. |||   . .      | ..|| . | .     |  ||| 
RKEVHIMCKIRHPNICLFMG--ACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSH

NCLITSRWTLQIADFGL
| |.   |.  ..||||
NLLVDKNWRVKVCDFGL
Kinase gcy-12.AA TK 928-951 41 1.2e-08 24.25 In-house 463-486 (486) Show / Hide 
Range on Protein: 928-951
Range on HMM: 463-486/486
Sequence Identity: 41% (10 aa)

EVMAACWHHDPYQRPEFKTIKNKL
..|  |||.|| .|| |......|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase gcy-12.AA Dicty5 742-811 33 1.5e-08 25.55 In-house 77-149 (260) Show / Hide 
Range on Protein: 742-811
Range on HMM: 77-149/260
Sequence Identity: 33% (25 aa)

VREYCSKGSLHDILRNENL----KLDHMYVASFVDDLVKGMVYIHDSELKMHGNLKSTNCLITSRWTLQIADFG
| |||..||| . |.         .      ..  |  ..| ..| |    |  ||| | ||| .|.  | |||
VTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLH-SMNIIHRDLKSMNFLITENWKIKIIDFG
Kinase gcy-12.AA Pkinase_Tyr 926-951 42 1.5e-08 29.57 Pfam 245-270 (270) Show / Hide 
Range on Protein: 926-951
Range on HMM: 245-270/270
Sequence Identity: 42% (11 aa)

VKEVMAACWHHDPYQRPEFKTIKNKL
. ..|  |||.|| .|| |. | ..|
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase gcy-12.AA Pkinase 705-812 22 4.4e-08 29.65 Pfam 39-158 (293) Show / Hide 
Range on Protein: 705-812
Range on HMM: 39-158/293
Sequence Identity: 22% (27 aa)

KDLTREAKK--ELRAMRQLAHPNVNNFLGIIVCQYSVTVVREYCSKG----SLHDILR-NENLKL--DHMYVASFVDDLVKGMVYIHDSELKMHGNLKST
..  ... .  |.. |. | |||.  ....     .. .| ||| .|    .|.|...  .. ..  .   . ...  ...|. |.|. .  .|  ||. 
SWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPE

NCLITSRWTL----QIADFGL
|.|| .. ..     |.||||
NILIDNNGHIDACVKICDFGL
Kinase gcy-12.AA Frk 928-955 50 9.7e-08 22.53 In-house 233-260 (260) Show / Hide 
Range on Protein: 928-955
Range on HMM: 233-260/260
Sequence Identity: 50% (14 aa)

EVMAACWHHDPYQRPEFKTIKNKLKPLF
|.|  |||.|| .|| | |.. ||.  |
EIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase gcy-12.AA Dicty5 848-875 50 1.1e-07 22.51 In-house 177-204 (260) Show / Hide 
Range on Protein: 848-875
Range on HMM: 177-204/260
Sequence Identity: 50% (14 aa)

SNPPTPKADAYSFGIIFHEIFTREGPYK
..| . |.| |||||.  |.|||  ||.
GQPYHQKCDVYSFGIVLWEMFTRKEPYD
Kinase gcy-12.AA TKL-Unique 927-951 48 1.9e-07 22.56 In-house 266-290 (290) Show / Hide 
Range on Protein: 927-951
Range on HMM: 266-290/290
Sequence Identity: 48% (12 aa)

KEVMAACWHHDPYQRPEFKTIKNKL
.. . .|||||| ||| | .| ..|
RDLIQQCWHHDPSQRPSFDEIIHRL
Kinase gcy-12.AA DRK 833-874 42 2.5e-07 20.89 In-house 168-202 (258) Show / Hide 
Range on Protein: 833-874
Range on HMM: 168-202/258
Sequence Identity: 42% (18 aa)

WTAPEAMTINGSLAISNPPTPKADAYSFGIIFHEIFTREGPY
|||||          . . | ||| |||.|.  |. ||. ||
WTAPEVLR-------NQRYTEKADVYSFAIVLWECVTRQDPY
Kinase gcy-12.AA Pkinase_Tyr 713-812 30 3.2e-07 25.07 Pfam 52-157 (270) Show / Hide 
Range on Protein: 713-812
Range on HMM: 52-157/270
Sequence Identity: 30% (33 aa)

KELRAMRQL-AHPNVNNFLGIIVCQYS---VTVVREYCSKGSLHDILRNE---NLKLDHMYVASFVDDLVKGMVYIHDSELKMHGNLKSTNCLITSRWTL
.|.. |.||  |||. ...|....|     . .| ||. .|.|.| ||.    . .|..    ..  .  ||| | ..  .  |  |   |||.|.  . 
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNC-IHRDLAARNCLVTENNVV

QIADFGL
 |.||||
KICDFGL
Kinase gcy-12.AA Dicty4 832-874 46 6e-07 19.39 In-house 182-217 (277) Show / Hide 
Range on Protein: 832-874
Range on HMM: 182-217/277
Sequence Identity: 46% (20 aa)

LWTAPEAMTINGSLAISNPPTPKADAYSFGIIFHEIFTREGPY
.|.||| |        ..| . ||| |||||.  ||.||. ||
CWMAPEVM-------MHQPYNEKADVYSFGIVLWEILTRQEPY
Kinase gcy-12.AA MLK 833-877 34 1e-06 19.47 In-house 199-240 (291) Show / Hide 
Range on Protein: 833-877
Range on HMM: 199-240/291
Sequence Identity: 34% (16 aa)

WTAPEAMTINGSLAISNPPTPKADAYSFGIIFHEIFTREGPYK-IY
| |||. .     . ... . |.| .|.|... |..||| ||| .|
WMAPEVIQQ----FRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHY
Kinase gcy-12.AA TKL 926-951 46 1e-06 20.05 In-house 339-364 (364) Show / Hide 
Range on Protein: 926-951
Range on HMM: 339-364/364
Sequence Identity: 46% (12 aa)

VKEVMAACWHHDPYQRPEFKTIKNKL
.|. |  ||.||| .|| |..|. .|
MKKLMQDCWDHDPEKRPSFQEILKRL
Kinase gcy-12.AA MLK 930-951 45 1.3e-05 15.53 In-house 270-291 (291) Show / Hide 
Range on Protein: 930-951
Range on HMM: 270-291/291
Sequence Identity: 45% (10 aa)

MAACWHHDPYQRPEFKTIKNKL
|  ||. || .|| |. |  .|
MKQCWNQDPHKRPSFRQIVQHL
Kinase gcy-12.AA Dicty4 930-953 38 8.6e-05 12.1 In-house 252-277 (277) Show / Hide 
Range on Protein: 930-953
Range on HMM: 252-277/277
Sequence Identity: 38% (10 aa)

MAACWHHDPYQRPEFKTIKNK--LKP
.. ||.||| .|| |. | ..  |  
IQWCWDHDPQHRPSFEEIIQRRILEH
Kinase gcy-12.AA DRK 930-953 33 0.001206 8.26 In-house 235-258 (258) Show / Hide 
Range on Protein: 930-953
Range on HMM: 235-258/258
Sequence Identity: 33% (8 aa)

MAACWHHDPYQRPEFKTIKNKLKP
|  ||  || .|| .  .   |  
MNDCWNEDPQHRPSMQECLERLEA
Kinase gcy-12.AA Dicty5 932-955 33 0.004765 6.33 In-house 237-260 (260) Show / Hide 
Range on Protein: 932-955
Range on HMM: 237-260/260
Sequence Identity: 33% (8 aa)

ACWHHDPYQRPEFKTIKNKLKPLF
.||   | .|| || |   .. . 
KCWQQKPHNRPSFKEICKYFESII
Kinase gcy-12.AA Pkinase 852-951 12 0.006863 11.3 Pfam 190-293 (293) Show / Hide 
Range on Protein: 852-951
Range on HMM: 190-293/293
Sequence Identity: 12% (15 aa)

TPKADAYSFGIIFHEIFTREGPYKIYVQRGDVNGEAAPKKDS-----VECRALVEKTVRRVYSDPYFRPDT--------------SDLEVQNYVKEVMAA
.||.| .|.|.|..| ....                 | ...     .. ....... .. .. ... ...                 ..    |...  
GPKVDMWSCGCILYEMLCGR----------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKW

CWHHDPYQRPEFKTIKNK--L
|.. ||..|| .. |..   .
CLCKDPKKRPTAEQILQHPWF
CYCc gcy-12.AA CYCc 991-1195 42 6.9e-100 339.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 991-1195
Range on HMM: 1-231/231
Sequence Identity: 42% (99 aa)

DEQRRSQHLLQRMLPSSVAEQLLAGQ-DVIPEAFPPVTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYD-----VYKVETIGDAYMVVSGV
.|... ..|| .||| .||.|| .|.  |.|.....|||.|.||||||... ..|||.||..|| .|| ||.||.|..     .|||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PQYKTM------------------EYHAEQIAMMAIHILSAVRSFSIPHR----SCEPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGE
|   .                    .||..||..| ........| ..|.    . .||..|||.||||.|.|||| .||||..||||||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

ALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKG
. .||.|..|...|   | .| . ..|   ...
PGQIHVSEETYWCL-CLD-QFERRRCGQFEFEP
Guanylate_cyc gcy-12.AA Guanylate_cyc 1018-1206 40 5.7e-85 293.39 Pfam 1-214 (214) Show / Hide 
Range on Protein: 1018-1206
Range on HMM: 1-214/214
Sequence Identity: 40% (86 aa)

VIPEAFPPVTIYFSDIVGFTTISGEST----PMEVVTFLNKLYTLFDSIIRRY--DVYKVETIGDAYMVVSGVPQY----KTMEYHAEQIAMMAIHILSA
| .. . .|||.|.|||||| .. ...    ||..|..||..|| ||......  ..|||.||||.||.|||.|..    .  ..|| ..| ||  .. .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VRSFSIPHRSCEP-----LMIRIGMHTGPCVAGVVG--KTMPRYTLFGDTVNTASRMESNGEAL--RIHCSSSTQKVLTSID-QGFLL--EERGSLAIKG
.... ..|   ||     ...|||.||||.||||.|    ||||...|||||.||||||.|...  .|| | .| ..|.  .   | .  ..||.  .||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGQ---MTTYWLNG
||.   |.||.|.|
KGKMGEMETYFLHG
HNOBA gcy-12.AA HNOBA 988-1012 44 0.000126 18.3 Pfam 210-234 (234) Show / Hide 
Range on Protein: 988-1012
Range on HMM: 210-234/234
Sequence Identity: 44% (11 aa)

ELKDEQRRSQHLLQRMLPSSVAEQL
||  | ...  ||  |.| |||..|
ELEEEKKKTDDLLYSMFPKSVANRL